10-4102

antibody from ABEOMICS Inc.
Targeting: DDX58 DKFZp434J1111, FLJ13599, RIG-1, RIG-I, RIG1
Provider product page for 10-4102

Antibody data

Product number
10-4102 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-RIG-I Antibody
Antibody type
Monoclonal
Description
RIG-I or Probable ATP-dependent RNA helicase DDX58 or simply DDX58 is a RNA helicase enzyme with two isoforms (106 and 101 kDa). RIG-I belongs to the DEAD/H box family and is involved in several cellular responses including RNA binding and alteration of RNA secondary structure. RIG-1 acts as sensor of viral nucleic acids thus activating a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. Generally it remains as a monomer but upon activation by viral dsRNA it homomultimerizes and interacts with mitochondria antiviral signaling protein (MAVS/IPS1) which activating a cascade of reactions to produce specific interferon. RIG-1 is mostly expressed in vascular smooth cells.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant human
RIG-I protein (amino acids 1-220) w
as used as the immunogen for this a
ntibody.
Isotype
IgG
Antibody clone number
ABM40B5
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
DDX58 protein structure - 10-4102 shown in red.