BS8250

antibody from Bioworld Technology, Inc
Targeting: PHC3 EDR3, FLJ12729, FLJ12967, HPH3
Provider product page for BS8250
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8250 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PHC3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PHC3.
Description
Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Loss of heterozygosity of the PHC3 gene was observed in human osteosarcoma tumors, suggesting that loss of PHC3 protein may contribute to tumorigenesis. There are six isoforms of PHC3 that are expressed as a result of alternative splicing events.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PHC3 protein structure - BS8250 shown in red.