CAMK2N2

This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]

Description

Calcium/calmodulin dependent protein kinase II inhibitor 2

Tissue specificity

Group enriched (brain, pancreas, pituitary gland)

Subcell location

Nucleoplasm, Centrosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

3 (184259213 - 184261553)

Ensembl ID

ENSG00000163888  (ver. 103.38)

Orthologs

Mouse Camk2n2: ENSMUSG00000051146

UniProt

Q96S95

neXtProt

NX_Q96S95

Human splice variants
Mouse splice variants

Protein structure