CHRD

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]

Description

Chordin

Tissue specificity

Tissue enhanced (liver)

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (184380073 - 184390736)

Ensembl ID

ENSG00000090539  (ver. 103.38)

Orthologs

Mouse Chrd: ENSMUSG00000006958

UniProt

Q9H2X0

neXtProt

NX_Q9H2X0

Human splice variants
Mouse splice variants

Protein structure