250214

antibody from Abbiotec

Targeting: C1S

ELISA (Recommended by provider)

Antibody Data

Product number

250214

Provider

Abbiotec

Proper citation

Abbiotec Cat#250214, RRID:AB_1038464

Product name

C1s (49) Antibody

Antibody type

Monoclonal

Antigen

Human plasma C1s Proenzyme

Description

C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2. This antibody is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

200 µl

Storage

Store at 4C. Product is guaranteed 6 months from the date of shipment.