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- Antibody Data
- Antigen structure
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- Product number
- AF2060 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Complement Component C1s Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Complement Component C1s in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human C1r is observed.
- Reactivity
- Human
- Host
- Sheep
- Conjugate
- Unconjugated
- Antigen sequence
P09871- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references EDTA/gelatin zymography method to identify C1s versus activated MMP-9 in plasma and immune complexes of patients with systemic lupus erythematosus.
Effect of the Anti-C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody-Induced Complement Activation-A Preclinical In Vitro Study.
Activation of the classical complement pathway by Bacillus anthracis is the primary mechanism for spore phagocytosis and involves the spore surface protein BclA.
Ugarte-Berzal E, Martens E, Boon L, Vandooren J, Blockmans D, Proost P, Opdenakker G
Journal of cellular and molecular medicine 2019 Jan;23(1):576-585
Journal of cellular and molecular medicine 2019 Jan;23(1):576-585
Effect of the Anti-C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody-Induced Complement Activation-A Preclinical In Vitro Study.
Wahrmann M, Mühlbacher J, Marinova L, Regele H, Huttary N, Eskandary F, Cohen G, Fischer GF, Parry GC, Gilbert JC, Panicker S, Böhmig GA
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Sep;17(9):2300-2311
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Sep;17(9):2300-2311
Activation of the classical complement pathway by Bacillus anthracis is the primary mechanism for spore phagocytosis and involves the spore surface protein BclA.
Gu C, Jenkins SA, Xue Q, Xu Y
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4421-31
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4421-31
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