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Western blot
Immunoelectron microscopyAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Immunoelectron microscopy [1]
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- Product number
- 679602 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#679602, RRID:AB_2566241
- Product name
- Purified anti-IGF2BP2
- Antibody type
- Monoclonal
- Antigen
- Full length recombinant human IGF2BP2 protein (NP_006539) produced in HEK 293T cells.
- Description
- IGF2BP2 belongs to the family of Insulin-like growth factor-II mRNA binding proteins (IMP1, IMP2, and IMP3). Members in this family contain four hnRNP K homology (KH) domains and two RNA recognition motifs (RRM) domains. They are involved in the RNA cytoplasmic localization, stability, and translation. Recent studies suggest that IGF2BP2 and IGF2BP1 bind to target mRNAs via all four KH domains. Studies showed that the expression of IGF2BP2 is associated with liposarcoma, liver cancer, and endometrial adenocarcinomas. Genome-wide association studies have also identified IGF2BP2 as one of the several factors for developing type 2 diabetes.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- O93C8
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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- Experimental details
- Total cell lysate from Jurkat (lane 1, 15 µg), mouse thymus (lane 2, 15 µg), and HeLa (lane 3, 15 µg) were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified anti-IGF2BP2 (clone O93C8) antibody. Proteins were visualized using a goat anti-mouse-IgG secondary antibody conjugated to HRP and chemiluminescence detection.
- Conjugate
- Unconjugated
