FNab06936

antibody from FineTest Biotech
Targeting: PTPN22 Lyp, Lyp1, Lyp2, PTPN8
Provider product page for FNab06936
Western blot
ELISA
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
FNab06936 - Provider product page
Provider
FineTest Biotech
Product name
PTPN22 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
Acts as negative regulator of T-cell receptor(TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules(PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue(PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue(PubMed:16461343). Dephosphorylates the immune system activator SKAP2(PubMed:21719704). Positively regulates toll-like receptor(TLR)-induced type 1 interferon production(PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon(By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy(PubMed:23991106).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
protein tyrosine phosphatase, non-r
eceptor type 22(lymphoid)
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
PTPN22 protein structure - FNab06936 shown in red.