Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5626 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- BCAS2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 180-225 of Human BCAS2.
- Description
- BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligandindependent manner) with TRÉÇ (thyroid hormone receptor ÉÇ), ERÏ« (estrogen receptor Ï«), ERÉÇ, PR (progesterone receptor), and PPARÎÛ (Peroxisome proliferator-activated receptor ÎÛ). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of BCAS2 pAb at 1:500 dilutionLane1:HEK293T cell lysateLane2:Mouse heart tissue lysateLane3:PC12 cell lysate