Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-Z173M - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse Anti-Human INSR CT-1(C-terminal) Monoclonal Antibody, clone NBI2
- Antibody type
- Monoclonal
- Description
- The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular ÉÇ subunit and an extracellular Ï« subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucoseuptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domaincontaining intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. The human insulin receptor gene maps to chromosome 19p13.3-p13.2 and encodes a 1382 amino acid protein that cleaves to form Ï« and ÉÇ subunits. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Type 2 diabetes is a condition where cells become resistant to insulin action.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- NBI2
- Vial size
- 200 _g
- Storage
- At least 2 years at 2 - 4 °C (lyophilized). After reconstitution store at -20 °C or -80 °C. Avoid freeze-thaw cycles.
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