CABT-Z173M

antibody from Creative Diagnostics

Targeting: INSR CD220

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-Z173M

Provider

Creative Diagnostics

Product name

Mouse Anti-Human INSR CT-1(C-terminal) Monoclonal Antibody, clone NBI2

Antibody type

Monoclonal

Description

The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular ÉÇ subunit and an extracellular Ï« subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucoseuptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domaincontaining intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. The human insulin receptor gene maps to chromosome 19p13.3-p13.2 and encodes a 1382 amino acid protein that cleaves to form Ï« and ÉÇ subunits. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Type 2 diabetes is a condition where cells become resistant to insulin action.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

NBI2

Vial size

200 _g

Storage

At least 2 years at 2 - 4 °C (lyophilized). After reconstitution store at -20 °C or -80 °C. Avoid freeze-thaw cycles.