Antibody data
- Antibody Data
- Antigen structure
- References [59]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 12855-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12855-1-AP, RRID:AB_2110381
- Product name
- KGA/GAC antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KGA/GAC antibody (Cat. #12855-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis.
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.
Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase.
Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase.
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice.
Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats.
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.
Upregulation of GLS1 Isoforms KGA and GAC Facilitates Mitochondrial Metabolism and Cell Proliferation in Epstein-Barr Virus Infected Cells.
The cross-talk between DDR1 and STAT3 promotes the development of hepatocellular carcinoma.
Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis.
In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
A New Therapeutic Strategy Targeting Protein Deacetylation for Spinal Cord Injury.
BPTES inhibits anthrax lethal toxin-induced inflammatory response.
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.
Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis.
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation.
TNFα increases STAT3-mediated expression of glutaminase isoform KGA in cultured rat astrocytes.
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts.
GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway.
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC.
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells.
Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells.
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.
Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.
Blocking glutamate carboxypeptidase II inhibits glutamate excitotoxicity and regulates immune responses in experimental autoimmune encephalomyelitis.
Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.
Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.
Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
A small subunit processome protein promotes cancer by altering translation.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
A cell engineering strategy to enhance the safety of stem cell therapies.
The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Modulation of immune function by glutamatergic neurons in the cerebellar interposed nucleus via hypothalamic and sympathetic pathways.
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.
Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism.
The NF-κB member p65 controls glutamine metabolism through miR-23a.
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance.
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Karunakaran U, Elumalai S, Moon JS, Won KC
Redox biology 2021 Sep;45:102029
Redox biology 2021 Sep;45:102029
Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.
Huang T, Fu X, Wang N, Yang M, Zhang M, Wang B, Chen T, Majaz S, Wang H, Wong CW, Liu J, Guan M
British journal of pharmacology 2021 Nov;178(21):4352-4367
British journal of pharmacology 2021 Nov;178(21):4352-4367
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
Miao Y, Geng Y, Yang L, Zheng Y, Dai Y, Wei Z
The Journal of nutritional biochemistry 2021 Nov 26;101:108923
The Journal of nutritional biochemistry 2021 Nov 26;101:108923
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
Sulistomo HW, Nemoto T, Kage Y, Fujii H, Uchida T, Takamiya K, Sumimoto H, Kataoka H, Bito H, Takeya R
Cerebral cortex (New York, N.Y. : 1991) 2021 Mar 5;31(4):2205-2219
Cerebral cortex (New York, N.Y. : 1991) 2021 Mar 5;31(4):2205-2219
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.
Wu X, Sheng H, Wang L, Xia P, Wang Y, Yu L, Lv W, Hu J
Aging 2021 Mar 26;13(7):10034-10057
Aging 2021 Mar 26;13(7):10034-10057
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis.
Yang L, Zheng Y, Miao YM, Yan WX, Geng YZ, Dai Y, Wei ZF
Acta pharmacologica Sinica 2021 Jul 15;
Acta pharmacologica Sinica 2021 Jul 15;
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.
Jones B, Balasubramaniam M, Lebowitz JJ, Taylor A, Villalta F, Khoshbouei H, Grueter C, Grueter B, Dash C, Pandhare J
Scientific reports 2021 Jan 14;11(1):1422
Scientific reports 2021 Jan 14;11(1):1422
Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase.
Beręsewicz-Haller M, Krupska O, Bochomulski P, Dudzik D, Chęcińska A, Hilgier W, Barbas C, Zablocki K, Zablocka B
International journal of molecular sciences 2021 Aug 7;22(16)
International journal of molecular sciences 2021 Aug 7;22(16)
Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase.
Yang R, Guo Z, Zhao Y, Ma L, Li B, Yang C
Cell death discovery 2021 Aug 5;7(1):204
Cell death discovery 2021 Aug 5;7(1):204
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Ruiz-Rodado V, Lita A, Dowdy T, Celiku O, Saldana AC, Wang H, Yang CZ, Chari R, Li A, Zhang W, Song H, Zhang M, Ahn S, Davis D, Chen X, Zhuang Z, Herold-Mende C, Walters KJ, Gilbert MR, Larion M
Cancer & metabolism 2020;8:23
Cancer & metabolism 2020;8:23
Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice.
Chen S, Lin Z, Tan KL, Chen R, Su W, Zhao H, Tan Q, Tan W
Frontiers in psychiatry 2020;11:564843
Frontiers in psychiatry 2020;11:564843
Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats.
Zhao X, Ding J, Pan H, Zhang S, Pan D, Yu H, Ye Z, Hua T
The Journal of physiology 2020 Sep;598(17):3727-3745
The Journal of physiology 2020 Sep;598(17):3727-3745
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.
Jin H, Wang S, Zaal EA, Wang C, Wu H, Bosma A, Jochems F, Isima N, Jin G, Lieftink C, Beijersbergen R, Berkers CR, Qin W, Bernards R
eLife 2020 Oct 5;9
eLife 2020 Oct 5;9
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.
Byun JK, Park M, Lee S, Yun JW, Lee J, Kim JS, Cho SJ, Jeon HJ, Lee IK, Choi YK, Park KG
Molecular cell 2020 Nov 19;80(4):592-606.e8
Molecular cell 2020 Nov 19;80(4):592-606.e8
Upregulation of GLS1 Isoforms KGA and GAC Facilitates Mitochondrial Metabolism and Cell Proliferation in Epstein-Barr Virus Infected Cells.
Krishna G, Soman Pillai V, Valiya Veettil M
Viruses 2020 Jul 27;12(8)
Viruses 2020 Jul 27;12(8)
The cross-talk between DDR1 and STAT3 promotes the development of hepatocellular carcinoma.
Lin Y, Jin H, Wu X, Jian Z, Zou X, Huang J, Guan R, Wei X
Aging 2020 Jul 27;12(14):14391-14405
Aging 2020 Jul 27;12(14):14391-14405
Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis.
Henderson J, Duffy L, Stratton R, Ford D, O'Reilly S
Journal of cellular and molecular medicine 2020 Dec;24(23):14026-14038
Journal of cellular and molecular medicine 2020 Dec;24(23):14026-14038
In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
Wong CC, Xu J, Bian X, Wu JL, Kang W, Qian Y, Li W, Chen H, Gou H, Liu D, Yat Luk ST, Zhou Q, Ji F, Chan LS, Shirasawa S, Sung JJ, Yu J
Gastroenterology 2020 Dec;159(6):2163-2180.e6
Gastroenterology 2020 Dec;159(6):2163-2180.e6
A New Therapeutic Strategy Targeting Protein Deacetylation for Spinal Cord Injury.
Liu X, Ma B, Zhang H, Chai R, Xiang L
Neuroscience 2020 Dec 15;451:197-206
Neuroscience 2020 Dec 15;451:197-206
BPTES inhibits anthrax lethal toxin-induced inflammatory response.
Wang J, Yang D, Shen X, Wang J, Liu X, Lin J, Zhong J, Zhao Y, Qi Z
International immunopharmacology 2020 Aug;85:106664
International immunopharmacology 2020 Aug;85:106664
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, Xiao Q, Wang B, Wu W, Sun Y, Zhou Y, Tang C, Liu F, Wang L, Feng C, Liu M, Li S, Zhang Y, Xu H, Yao H, Shi L, Yang H
Cell 2020 Apr 30;181(3):590-603.e16
Cell 2020 Apr 30;181(3):590-603.e16
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.
Zhang P, Wang Q, Lin Z, Yang P, Dou K, Zhang R
OncoTargets and therapy 2019;12:11751-11763
OncoTargets and therapy 2019;12:11751-11763
Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis.
Cui H, Xie N, Jiang D, Banerjee S, Ge J, Sanders YY, Liu G
American journal of respiratory cell and molecular biology 2019 Oct;61(4):492-500
American journal of respiratory cell and molecular biology 2019 Oct;61(4):492-500
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Zimmerman KA, Song CJ, Li Z, Lever JM, Crossman DK, Rains A, Aloria EJ, Gonzalez NM, Bassler JR, Zhou J, Crowley MR, Revell DZ, Yan Z, Shan D, Benveniste EN, George JF, Mrug M, Yoder BK
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1841-1856
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1841-1856
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM
American journal of respiratory cell and molecular biology 2019 Nov;61(5):597-606
American journal of respiratory cell and molecular biology 2019 Nov;61(5):597-606
Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation.
Chen J, Zhou R, Liang Y, Fu X, Wang D, Wang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12200-12212
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12200-12212
TNFα increases STAT3-mediated expression of glutaminase isoform KGA in cultured rat astrocytes.
Milewski K, Bogacińska-Karaś M, Hilgier W, Albrecht J, Zielińska M
Cytokine 2019 Nov;123:154774
Cytokine 2019 Nov;123:154774
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC
Nature communications 2019 Nov 13;10(1):5151
Nature communications 2019 Nov 13;10(1):5151
Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts.
Bai L, Bernard K, Tang X, Hu M, Horowitz JC, Thannickal VJ, Sanders YY
American journal of respiratory cell and molecular biology 2019 Jan;60(1):49-57
American journal of respiratory cell and molecular biology 2019 Jan;60(1):49-57
GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway.
Xi J, Sun Y, Zhang M, Fa Z, Wan Y, Min Z, Xu H, Xu C, Tang J
Experimental cell research 2019 Aug 1;381(1):1-9
Experimental cell research 2019 Aug 1;381(1):1-9
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, Valsecchi F, Primiano G, Calder EL, Carelli V, Denton TT, Beal MF, Gross SS, Manfredi G, D'Aurelio M
Cell metabolism 2018 May 1;27(5):1007-1025.e5
Cell metabolism 2018 May 1;27(5):1007-1025.e5
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
Ge J, Cui H, Xie N, Banerjee S, Guo S, Dubey S, Barnes S, Liu G
American journal of respiratory cell and molecular biology 2018 Mar;58(3):378-390
American journal of respiratory cell and molecular biology 2018 Mar;58(3):378-390
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Wang YQ, Wang HL, Xu J, Tan J, Fu LN, Wang JL, Zou TH, Sun DF, Gao QY, Chen YX, Fang JY
Nature communications 2018 Feb 7;9(1):545
Nature communications 2018 Feb 7;9(1):545
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Hu M, Liu L, Yao W
Gene 2018 Dec 15;678:261-269
Gene 2018 Dec 15;678:261-269
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cai WF, Zhang C, Wu YQ, Zhuang G, Ye Z, Zhang CS, Lin SC
Cell research 2018 Aug;28(8):865-867
Cell research 2018 Aug;28(8):865-867
PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC.
Kim MJ, Choi YK, Park SY, Jang SY, Lee JY, Ham HJ, Kim BG, Jeon HJ, Kim JH, Kim JG, Lee IK, Park KG
Molecular cancer research : MCR 2017 Sep;15(9):1230-1242
Molecular cancer research : MCR 2017 Sep;15(9):1230-1242
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Li W, Chen C, Zhao X, Ye H, Zhao Y, Fu Z, Pan W, Zheng S, Wei L, Nong T, Li Z, Chen R
Journal of cellular and molecular medicine 2017 Nov;21(11):2896-2908
Journal of cellular and molecular medicine 2017 Nov;21(11):2896-2908
Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells.
Munksgaard Thorén M, Vaapil M, Staaf J, Planck M, Johansson ME, Mohlin S, Påhlman S
Oncotarget 2017 Jul 25;8(30):48983-48995
Oncotarget 2017 Jul 25;8(30):48983-48995
Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells.
Huang T, Liu R, Fu X, Yao D, Yang M, Liu Q, Lu WW, Wu C, Guan M
Stem cells (Dayton, Ohio) 2017 Feb;35(2):411-424
Stem cells (Dayton, Ohio) 2017 Feb;35(2):411-424
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.
Pérez-Escuredo J, Dadhich RK, Dhup S, Cacace A, Van Hée VF, De Saedeleer CJ, Sboarina M, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P
Cell cycle (Georgetown, Tex.) 2016;15(1):72-83
Cell cycle (Georgetown, Tex.) 2016;15(1):72-83
Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.
Guo Y, Deng Y, Li X, Ning Y, Lin X, Guo S, Chen M, Han M
PloS one 2016;11(9):e0162658
PloS one 2016;11(9):e0162658
Blocking glutamate carboxypeptidase II inhibits glutamate excitotoxicity and regulates immune responses in experimental autoimmune encephalomyelitis.
Ha D, Bing SJ, Ahn G, Kim J, Cho J, Kim A, Herath KH, Yu HS, Jo SA, Cho IH, Jee Y
The FEBS journal 2016 Sep;283(18):3438-56
The FEBS journal 2016 Sep;283(18):3438-56
Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.
Kahlert UD, Cheng M, Koch K, Marchionni L, Fan X, Raabe EH, Maciaczyk J, Glunde K, Eberhart CG
International journal of cancer 2016 Mar 1;138(5):1246-55
International journal of cancer 2016 Mar 1;138(5):1246-55
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.
Lee SY, Jeon HM, Ju MK, Jeong EK, Kim CH, Park HG, Han SI, Kang HS
Oncotarget 2016 Feb 16;7(7):7925-39
Oncotarget 2016 Feb 16;7(7):7925-39
Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.
Fuchsberger T, Martínez-Bellver S, Giraldo E, Teruel-Martí V, Lloret A, Viña J
Scientific reports 2016 Aug 12;6:31158
Scientific reports 2016 Aug 12;6:31158
Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
Karner CM, Esen E, Okunade AL, Patterson BW, Long F
The Journal of clinical investigation 2015 Feb;125(2):551-62
The Journal of clinical investigation 2015 Feb;125(2):551-62
A small subunit processome protein promotes cancer by altering translation.
Yang HW, Kim TM, Song SS, Menon L, Jiang X, Huang W, Black PM, Park PJ, Carroll RS, Johnson MD
Oncogene 2015 Aug 20;34(34):4471-81
Oncogene 2015 Aug 20;34(34):4471-81
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
A cell engineering strategy to enhance the safety of stem cell therapies.
Oricchio E, Papapetrou EP, Lafaille F, Ganat YM, Kriks S, Ortega-Molina A, Mark WH, Teruya-Feldstein J, Huse JT, Reuter V, Sadelain M, Studer L, Wendel HG
Cell reports 2014 Sep 25;8(6):1677-1685
Cell reports 2014 Sep 25;8(6):1677-1685
The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Corbet C, Draoui N, Polet F, Pinto A, Drozak X, Riant O, Feron O
Cancer research 2014 Oct 1;74(19):5507-19
Cancer research 2014 Oct 1;74(19):5507-19
Modulation of immune function by glutamatergic neurons in the cerebellar interposed nucleus via hypothalamic and sympathetic pathways.
Xu FF, Huang Y, Wang XQ, Qiu YH, Peng YP
Brain, behavior, and immunity 2014 May;38:263-71
Brain, behavior, and immunity 2014 May;38:263-71
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
Masamha CP, Xia Z, Yang J, Albrecht TR, Li M, Shyu AB, Li W, Wagner EJ
Nature 2014 Jun 19;510(7505):412-6
Nature 2014 Jun 19;510(7505):412-6
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.
Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik JH
The EMBO journal 2013 Oct 2;32(19):2589-602
The EMBO journal 2013 Oct 2;32(19):2589-602
Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism.
Shimmura C, Suzuki K, Iwata Y, Tsuchiya KJ, Ohno K, Matsuzaki H, Iwata K, Kameno Y, Takahashi T, Wakuda T, Nakamura K, Hashimoto K, Mori N
Molecular autism 2013 Mar 26;4(1):6
Molecular autism 2013 Mar 26;4(1):6
The NF-κB member p65 controls glutamine metabolism through miR-23a.
Rathore MG, Saumet A, Rossi JF, de Bettignies C, Tempé D, Lecellier CH, Villalba M
The international journal of biochemistry & cell biology 2012 Sep;44(9):1448-56
The international journal of biochemistry & cell biology 2012 Sep;44(9):1448-56
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
Cell 2012 Mar 30;149(1):49-62
Cell 2012 Mar 30;149(1):49-62
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM
Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 5;109(23):8983-8
Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 5;109(23):8983-8
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance.
Ko YH, Lin Z, Flomenberg N, Pestell RG, Howell A, Sotgia F, Lisanti MP, Martinez-Outschoorn UE
Cancer biology & therapy 2011 Dec 15;12(12):1085-97
Cancer biology & therapy 2011 Dec 15;12(12):1085-97
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Colombo SL, Palacios-Callender M, Frakich N, De Leon J, Schmitt CA, Boorn L, Davis N, Moncada S
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 2;107(44):18868-73
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 2;107(44):18868-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12855-1-AP(GLS antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GLS (IP:12855-1-AP, 4ug; Detection:12855-1-AP 1:500) with mouse brain tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KGA/GAC antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KGA/GAC. This antibody recognizes human,mouse,rat antigen. The KGA/GAC antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.