AMM03245G

antibody from Leading Biology

Targeting: MLLT11 AF1Q

Western blot (Recommended by provider)

Antibody Data

Product number

AMM03245G

Provider

Leading Biology

Product name

AF1Q Antibody (monoclonal) (M01)

Antibody type

Monoclonal

Description

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

2A9-1B7

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.