Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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Validation data
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- Product number
- 15940-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15940-1-AP, RRID:AB_2204663
- Product name
- TIPE2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TIPE2 antibody (Cat. #15940-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A novel prognostic factor TIPE2 inhibits cell proliferation and promotes apoptosis in pancreatic ductal adenocarcinoma (PDAC).
Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.
TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.
TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
Decreased expression of TIPE2 in the eye under high-glucose conditions tested in vivo and in vitro.
TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Expression of TIPE family members in human colorectal cancer.
Erythropoietin Protects against Diffuse Alveolar Hemorrhage in Mice by Regulating Macrophage Polarization through the EPOR/JAK2/STAT3 Axis.
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
The SCFβ-TrCP E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2.
Mesenteric lymph drainage alleviates hemorrhagic shock-induced spleen injury and inflammation.
Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice.
TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice.
TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells.
TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.
Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism.
Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.
TIPE2 is negatively correlated with tissue factor and thrombospondin-1 expression in patients with bronchial asthma.
Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is associated with immune phases of patients with chronic hepatitis B.
Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.
TIPE2 (Tumor Necrosis Factor α-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal.
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.
TIPE2, a novel regulator of immunity, protects against experimental stroke.
Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy.
Sun Y, Cao S, Li Z, Liu X, Xu J, Tian Y, Shen S, Zhou Y
International journal of medical sciences 2021;18(9):2051-2062
International journal of medical sciences 2021;18(9):2051-2062
Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.
Zou Z, Li M, Zhou Y, Li J, Pan T, Lai L, Wang Q, Zhang L, Wang Q, Song Y, Zhang Y
Frontiers in immunology 2021;12:642715
Frontiers in immunology 2021;12:642715
TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.
Feng F, Liu C, Bian H, Cai W, Zhou Y, Zhou L, Zhuang Z
Frontiers in oncology 2021;11:680985
Frontiers in oncology 2021;11:680985
TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
Bi J, Cheng C, Zheng C, Huang C, Zheng X, Wan X, Chen YH, Tian Z, Sun H
Science advances 2021 Sep 17;7(38):eabi6515
Science advances 2021 Sep 17;7(38):eabi6515
Decreased expression of TIPE2 in the eye under high-glucose conditions tested in vivo and in vitro.
Suo LG, Qin RX, Cui YY, Qin XJ
International immunopharmacology 2021 Jun;95:107517
International immunopharmacology 2021 Jun;95:107517
TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Li W, Li Y, Guan Y, Du Y, Zhao M, Chen X, Zhu F, Guo C, Jia Y, Li Y, Wang X, Wang X, Shi Y, Wang Q, Li Y, Zhang L
Autophagy 2021 Jun;17(6):1410-1425
Autophagy 2021 Jun;17(6):1410-1425
Expression of TIPE family members in human colorectal cancer.
Zhong M, Chen Z, Yan Y, Bahet A, Cai X, Chen H, Ran H, Qu K, Han Z, Zhuang G, Zhang S, Wang Y
Oncology letters 2021 Feb;21(2):118
Oncology letters 2021 Feb;21(2):118
Erythropoietin Protects against Diffuse Alveolar Hemorrhage in Mice by Regulating Macrophage Polarization through the EPOR/JAK2/STAT3 Axis.
Yang Z, Yan L, Cao H, Gu Y, Zhou P, Shi M, Li G, Jiao X, Li N, Li X, Sun K, Shao F
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1752-1764
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1752-1764
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, Tang A, Ruan Q, Yang X, Chen YH, Wan X
The Journal of experimental medicine 2020 Feb 3;217(2)
The Journal of experimental medicine 2020 Feb 3;217(2)
The SCFβ-TrCP E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2.
Lou Y, Han M, Song Y, Zhong J, Zhang W, Chen YH, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 15;204(8):2122-2132
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 15;204(8):2122-2132
Mesenteric lymph drainage alleviates hemorrhagic shock-induced spleen injury and inflammation.
Zhang H, Zhai JY, Du HB, Zhang LM, Li LF, Bian AQ, Jiang LN, Zhao ZG
Acta cirurgica brasileira 2019;34(9):e201900903
Acta cirurgica brasileira 2019;34(9):e201900903
Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice.
Miao Y, Wang N, Shao W, Xu Z, Yang Z, Wang L, Ju C, Zhang R, Zhang F
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2019 Sep;14(3):519-529
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2019 Sep;14(3):519-529
TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice.
Gao S, Lu A, Amra S, Guo P, Huard J
Human molecular genetics 2019 May 15;28(10):1608-1619
Human molecular genetics 2019 May 15;28(10):1608-1619
TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells.
Wang Q, Ma L, Liu T, Ge C, Zhou Q, Wei C, Shi W
The Journal of infectious diseases 2019 Aug 9;220(6):1008-1018
The Journal of infectious diseases 2019 Aug 9;220(6):1008-1018
TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.
Lin Z, Liu W, Xiao C, Fan Y, Zhuang G, Qi Z
Oncology reports 2018 Sep;40(3):1307-1316
Oncology reports 2018 Sep;40(3):1307-1316
Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism.
Li T, Wang W, Gong S, Sun H, Zhang H, Yang AG, Chen YH, Li X
Molecular immunology 2018 Jul;99:154-162
Molecular immunology 2018 Jul;99:154-162
Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.
Liu W, Fan Y, Shi Y, Lin Z, Huang X, Huang W, Shen D, Qi Z
BMC cancer 2018 Aug 29;18(1):857
BMC cancer 2018 Aug 29;18(1):857
TIPE2 is negatively correlated with tissue factor and thrombospondin-1 expression in patients with bronchial asthma.
Shi G, Zhao JW, Sun XX, Ma JF, Wang P, He FC, Ming L
Experimental and therapeutic medicine 2018 Apr;15(4):3449-3454
Experimental and therapeutic medicine 2018 Apr;15(4):3449-3454
Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is associated with immune phases of patients with chronic hepatitis B.
Fan YC, Zhang YY, Wang N, Sun YY, Wang K
Oncotarget 2017 May 9;8(19):30781-30792
Oncotarget 2017 May 9;8(19):30781-30792
Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.
Fayngerts SA, Wang Z, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH
Nature immunology 2017 Dec;18(12):1353-1360
Nature immunology 2017 Dec;18(12):1353-1360
TIPE2 (Tumor Necrosis Factor α-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal.
Oho M, Nakano R, Nakayama R, Sakurai W, Miyamoto A, Masuhiro Y, Hanazawa S
The Journal of biological chemistry 2016 Oct 21;291(43):22650-22660
The Journal of biological chemistry 2016 Oct 21;291(43):22650-22660
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.
Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z
Nature immunology 2013 Aug;14(8):793-803
Nature immunology 2013 Aug;14(8):793-803
TIPE2, a novel regulator of immunity, protects against experimental stroke.
Zhang Y, Wei X, Liu L, Liu S, Wang Z, Zhang B, Fan B, Yang F, Huang S, Jiang F, Chen YH, Yi F
The Journal of biological chemistry 2012 Sep 21;287(39):32546-55
The Journal of biological chemistry 2012 Sep 21;287(39):32546-55
Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy.
Zhang S, Zhang Y, Wei X, Zhen J, Wang Z, Li M, Miao W, Ding H, Du P, Zhang W, He M, Yi F
Biochimica et biophysica acta 2010 Nov;1802(11):1078-86
Biochimica et biophysica acta 2010 Nov;1802(11):1078-86
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 15940-1-AP(TNFAIP8L2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TNFAIP8L2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TNFAIP8L2. This antibody recognizes human,mouse,rat antigen. The TNFAIP8L2 antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TNFAIP8L2 (IP:15940-1-AP, 3ug; Detection:15940-1-AP 1:500) with mouse cerebellum tissue lysate 4000ug.
- Sample type
- tissue