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Protein structure
FLNA
Filamin AABP-280, FLN, FLN1, OPD1, OPD2
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Top validated antibodies |
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| Novus Biologicals |  H00002316-M01 |
11 references | Monoclonal |
WB
EL
ICC
IHC
PLA
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| Abnova Corporation | H00002316-M01 |
7 references | Monoclonal |
WB
EL
IHC
PLA
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| Invitrogen Antibodies | MA5-11705 |
5 references | Monoclonal |
WB
ICC
IHC
OA
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| GeneTex | GTX61826 |
3 references | Monoclonal |
WB
ICC
IHC
FC
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| Proteintech Group | 67133-1-Ig |
3 references | Monoclonal |
WB
EL
ICC
IHC
|
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