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- Antibody Data
- Antigen structure
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- Product number
- 19811-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19811-1-AP, RRID:AB_10638446
- Product name
- TLR4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TLR4 antibody (Cat. #19811-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Xinfeng Capsule Inhibits Pyroptosis and Ameliorates Myocardial Injury in Rats with Adjuvant Arthritis via the GAS5/miR-21/TLR4 Axis.
Radix Sophorae Flavescentis of Sophora flavescens Aiton inhibits LPS-induced macrophage pro-inflammatory response via regulating CFHR2 expression.
Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy.
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway.
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway.
Turmeric-Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing.
Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota.
Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway.
Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
Purification and structural characterization of two polysaccharides with anti-inflammatory activities from Plumbago zeylanica L.
Schaftoside reduces inflammation in Aspergillus fumigatus keratitis through the inhibition of the TLR4/MyD88 pathway.
Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice.
L-Theanine alleviates heat stress through modulation of gut microbiota and immunity.
Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites.
Electroacupuncture Inhibits Neuroinflammation Induced by Astrocytic Necroptosis Through RIP1/MLKL/TLR4 Pathway in a Mouse Model of Spinal Cord Injury.
BMSC-derived exosomes regulate the Treg/Th17 balance through the miR-21-5p/TLR4/MyD88/NF-κB pathway to alleviate dry eye symptoms in mice.
DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-κB and TGF-β/Smad signalling pathway.
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides.
Galectin-3 modulates microglial activation and neuroinflammation in early brain injury after subarachnoid hemorrhage.
Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-κB pathway.
Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells.
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Gut microbiota regulates host melatonin production through epithelial cell MyD88.
Gentianine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibition of TLR4/NLRP3-mediated pyroptosis.
Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway.
Polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp Ameliorates Dextran Sodium Sulfate-Induced Enteritis in Rats.
The protective effect of Schisandra chinensis (Turcz.) Baill. polysaccharide on DSS-induced ulcerative colitis in mice via the modulation of gut microbiota and inhibition of NF-κB activation.
Efficacy of Jiangzhi Xiaoban tablet on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet.
Astilbin protects from sepsis-induced cardiac injury through the NRF2/HO-1 and TLR4/NF-κB pathway.
In vitro and in vivo immunomodulatory activity of acetylated polysaccharides from Cyclocarya paliurus leaves.
Sinigrin improves cerebral ischaemia-reperfusion injury by inhibiting the TLR4 pathway-mediated oxidative stress.
Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4/NF-κB/MAPK Singnaling Pathways.
Protein 4.1R regulates M1 macrophages polarization via glycolysis, alleviating sepsis-induced liver injury in mice.
Buyang Huanwu Decoction suppresses cardiac inflammation and fibrosis in mice after myocardial infarction through inhibition of the TLR4 signalling pathway.
Ultrasonic-assisted extraction of a low molecular weight polysaccharide from Nostoc commune Vaucher and its structural characterization and immunomodulatory activity.
Yemazhui () ameliorates lipopolysaccharide-induced acute lung injury modulation of the toll-like receptor 4/nuclear factor kappa-B/nod-like receptor family pyrin domain-containing 3 protein signaling pathway and intestinal flora in rats.
Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis.
Very low-carbohydrate diet with higher protein ratio improves lipid metabolism and inflammation in rats with diet-induced nonalcoholic fatty liver disease.
A Flavonoid Glycoside Compound from Siraitia grosvenorii with Anti-Inflammatory and Hepatoprotective Effects In Vitro.
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid.
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1/NF-κB/STAT3 axis.
Huangqi Baihe Granules alleviate hypobaric hypoxia-induced acute lung injury in rats by suppressing oxidative stress and the TLR4/NF-κB/NLRP3 inflammatory pathway.
Esculin targets TLR4 to protect against LPS-induced septic cardiomyopathy.
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.
C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways.
BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer.
Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema.
Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation.
Interferon-induced transmembrane protein 3 in the hippocampus: a potential novel target for the therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy.
Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1-to-M2 transformation.
Dendrobium officinale alleviates high-fat diet-induced nonalcoholic steatohepatitis by modulating gut microbiota.
Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction.
Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization.
Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles.
Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo.
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis.
The effects of Shikonin on the hypertrophic scar of rabbit ears via the TLR4/NF-κB signaling pathway.
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
The Gut Microbiota of Pregnant Rats Alleviates Fetal Growth Restriction by Inhibiting the TLR9/MyD88 Pathway.
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Inhibition of TLR4 Signaling by Isorhapontigenin Targeting of the AHR Alleviates Cerebral Ischemia/Reperfusion Injury.
Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-κB pathways.
The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.
Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway.
Partial Replacement of Diet with Dehulled Adlay Ameliorates Hepatic Steatosis, Inflammation, Oxidative Stress, and Gut Dysbiosis in Rats with Nonalcoholic Fatty Liver Disease.
Arctium lappa L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway.
Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury.
Neutrophil extracellular traps boost laser-induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF-1α pathway.
Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF-κB and Nrf2/HO-1/GPX4 pathways to reduce inflammation and ferroptosis.
Dendrobium huoshanense Polysaccharide Improves High-Fat Diet Induced Liver Injury by Regulating the Gut-Liver Axis.
Aqueous Extract of Brassica rapa L.'s Impact on Modulating Exercise-Induced Fatigue via Gut-Muscle Axis.
Yanghepingchuan granule improves airway inflammation by inhibiting autophagy via miRNA328-3p/high mobility group box 1/Toll-like receptor 4 targeting of the pathway of signaling in rat models of asthma.
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Gentiana Scabra Bge Extract (GSE) Protects Against Alcoholic Liver Disease by Regulating the TLR4/NF-κB Pathway in Mice.
Schwann Cell-Derived Exosomes and Methylprednisolone Composite Patch for Spinal Cord Injury Repair.
Artemether Attenuates Gut Barrier Dysfunction and Intestinal Flora Imbalance in High-Fat and High-Fructose Diet-Fed Mice.
Dendritic Cell-Derived Exosomes Stimulated by Treponema pallidum Induce Endothelial Cell Inflammatory Response through the TLR4/MyD88/NF-κB Signaling Pathway.
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Bisphenol P exposure in C57BL/6 mice caused gut microbiota dysbiosis and induced intestinal barrier disruption via LPS/TLR4/NF-κB signaling pathway.
Effects of Therapeutic Platelet-Rich Plasma on Overactive Bladder via Modulating Hyaluronan Synthesis in Ovariectomized Rat.
Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility.
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Protective effect of Paecilomyces cicadae TJJ11213 exopolysaccharide on intestinal mucosa and regulation of gut microbiota in immunosuppressed mice.
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
Determination of the optimal concentration and duration of C5aR antagonist application in an inflammatory model of human dental pulp cells.
Activation of estrogen receptor α inhibits TLR4 signaling in macrophages and alleviates the instability of atherosclerotic plaques in the postmenopausal stage.
Effects of Caprylic Acid and Eicosapentaenoic Acid on Lipids, Inflammatory Levels, and the JAK2/STAT3 Pathway in ABCA1-Deficient Mice and ABCA1 Knock-Down RAW264.7 Cells.
Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway.
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes.
Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis.
Vancomycin Pretreatment on MPTP-Induced Parkinson's Disease Mice Exerts Neuroprotection by Suppressing Inflammation Both in Brain and Gut.
Baicalin ameliorates multidrug-resistant Pseudomonas aeruginosa induced pulmonary inflammation in rat via arginine biosynthesis.
Annao Pingchong decoction alleviate the neurological impairment by attenuating neuroinflammation and apoptosis in intracerebral hemorrhage rats.
RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury.
Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Fucoxanthin alleviated atherosclerosis by regulating PI3K/AKT and TLR4/NFκB mediated pyroptosis in endothelial cells.
Programmed cell death 10 increased blood-brain barrier permeability through HMGB1/TLR4 mediated downregulation of endothelial ZO-1 in glioblastoma.
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis.
The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing.
Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity.
Apolipoprotein A-1 protected hepatic ischaemia-reperfusion injury through suppressing macrophage pyroptosis via TLR4-NF-κB pathway.
Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway.
Muse cells decrease the neuroinflammatory response by modulating the proportion of M1 and M2 microglia in vitro.
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
SIGIRR-caspase-8 signaling mediates endothelial apoptosis in Kawasaki disease.
Metabotropic glutamate receptor-8 relieves neonatal maternal separation-induced visceral hypersensitivity in rats by regulating expression of TNF-α.
Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.
Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.
The Effect of an Essential Oil Blend on Growth Performance, Intestinal Health, and Microbiota in Early-Weaned Piglets.
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
8-O-acetyl shanzhiside methylester protects against sleep deprivation-induced cognitive deficits and anxiety-like behaviors by regulating NLRP3 and Nrf2 pathways in mice.
Amuc Prevents Liver Inflammation and Oxidative Stress in Mice Challenged with Salmonella Typhimurium.
Ang-(1-7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarization.
Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis.
Anti-glycation and anti-inflammatory activities of anthocyanins from purple vegetables.
Oxymatrine attenuated isoproterenol-induced heart failure via the TLR4/NF-κB and MAPK pathways in vivo and in vitro.
Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.
Sulforaphane Ameliorates Nonalcoholic Fatty Liver Disease Induced by High-Fat and High-Fructose Diet via LPS/TLR4 in the Gut-Liver Axis.
Phenylalanine diminishes M1 macrophage inflammation.
Chemical constituents from Eupatorium fortunei and their anti-inflammatory evaluation by in silico and experimental approaches.
Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma.
Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway via the microRNA-410-3p.
Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFκB/NLRP3 inflammation signal pathway.
L-F001, a multifunctional fasudil-lipoic acid dimer, antagonizes hypoxic-ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway.
Assessment of intestinal status in MPL(W515L) mutant myeloproliferative neoplasms mice model.
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
Anti-inflammatory effect and component analysis of Chaihu Qingwen granules.
Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke.
Hesperitin attenuates alcoholic steatohepatitis by regulating TLR4/NF-κB signaling in mice.
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis.
Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment.
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Danzhi Jiangtang capsule reduces renal injury in rats with diabetes induced by high fat diet and streptozotocin downregulating toll-like receptor 4-nuclear factor-κB pathway and apoptosis.
NEAT1 Regulates Calcium Oxalate Crystal-Induced Renal Tubular Oxidative Injury via miR-130/IRF1.
Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.
rFGF4 alleviates lipopolysaccharide-induced acute lung injury by inhibiting the TLR4/NF-κB signaling pathway.
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
The dichloromethane extract of Callicarpa longissima rich in diterpenoid phenols exerts anti-inflammatory effect via inhibiting the TLR4/NF-κB signaling pathway.
Astragalus polysaccharide attenuates bleomycin-induced pulmonary fibrosis by inhibiting TLR4/ NF-κB signaling pathway and regulating gut microbiota.
Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota.
Heat-Killed Lacticaseibacillus paracasei Repairs Lipopolysaccharide-Induced Intestinal Epithelial Barrier Damage via MLCK/MLC Pathway Activation.
RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.
Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression.
Antibiotic Therapy and Vaginal Microbiota Transplantation Reduce Endometriosis Disease Progression in Female Mice via NF-κB Signaling Pathway.
Maternal nucleotide supplementation improves the intestinal morphology and immune function in lipopolysaccharide-challenged newborn piglets.
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
TLR4 Modulates Senescence and Paracrine Action in Placental Mesenchymal Stem Cells via Inhibiting Hedgehog Signaling Pathway in Preeclampsia.
Electroacupuncture at Zusanli Alleviates Sepsis by Regulating the TLR4-MyD88-NF-Kappa B Pathway and Diversity of Intestinal Flora.
Correlation Analysis of Umbilical Cord Blood Metabolic Phenotype and Inflammation in Patients with Gestational Diabetes Mellitus Complicated with Overweight and Obesity.
Impact of Yiqi Huoxue Decoction on the Relationship between Remodeling of Cardiac Nerves and Macrophages after Myocardial Infarction in Rats.
Synergistic Effect of Polydatin and Polygonatum sibiricum Polysaccharides in Combating Atherosclerosis via Suppressing TLR4-Mediated NF-κB Activation in ApoE-Deficient Mice.
Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury.
Jatrorrhizine Alleviates DSS-Induced Ulcerative Colitis by Regulating the Intestinal Barrier Function and Inhibiting TLR4/MyD88/NF-κB Signaling Pathway.
Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells.
Selenium-enriched Bifidobacterium longum DD98 effectively ameliorates dextran sulfate sodium-induced ulcerative colitis in mice.
Hexavalent Chromium Exposure Induces Intestinal Barrier Damage via Activation of the NF-κB Signaling Pathway and NLRP3 Inflammasome in Ducks.
Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments.
Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system.
Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice.
AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFκB-p65 Pathway Following Intracerebral Hemorrhage.
Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Network pharmacology-based prediction of active compounds in the Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support in vitro and in vivo.
Patchouli alcohol as a selective estrogen receptor β agonist ameliorates AD-like pathology of APP/PS1 model mice.
Grifola frondosa Polysaccharide Ameliorates Early Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway.
Protective effects of (R)-enantiomers but not (S)-enantiomers of β2-adrenergic receptor agonists against acute colitis: The role of β2AR.
Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway.
Investigation and modulation of interleukin-6 following subarachnoid hemorrhage: targeting inflammatory activation for cerebral vasospasm.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Ulinastatin Alleviates Rhabdomyolysis-Induced Acute Kidney Injury by Suppressing Inflammation and Apoptosis via Inhibiting TLR4/NF-κB Signaling Pathway.
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
Lipopolysaccharide reduces melanin synthesis in vitiligo melanocytes by regulating autophagy.
Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats.
Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.
Macrophage CD36 and TLR4 Cooperation Promotes Foam Cell Formation and VSMC Migration and Proliferation Under Circadian Oscillations.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro.
Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes.
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression.
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides.
Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation.
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway.
6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling.
Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis.
Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation.
RNase 7 Inhibits Uropathogenic Escherichia coli-Induced Inflammation in Bladder Cells under a High-Glucose Environment by Regulating the JAK/STAT Signaling Pathway.
Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice.
Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study.
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro.
Chronic intermittent hypoxia induces the pyroptosis of renal tubular epithelial cells by activating the NLRP3 inflammasome.
Toll-like receptors 2 and 4 differentially regulate the self-renewal and differentiation of spinal cord neural precursor cells.
Small extracellular vesicles from hypoxic mesenchymal stem cells alleviate intervertebral disc degeneration by delivering miR-17-5p.
Treadmill training improves respiratory function in rats after spinal cord injury by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway.
Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury.
TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy.
Preconditioning with procyanidin B2 protects MAC-T cells against heat exposure-induced mitochondrial dysfunction and inflammation.
Effects of Artemisinin on Escherichia coli-Induced Mastitis in Bovine Mammary Epithelial Cells and Mice.
Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
Voluntary alcohol binge-drinking in adolescent C57Bl6 mice induces delayed appearance of behavioural defects in both males and females.
Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ(1) signaling pathway in diabetic atherosclerosis.
2-PMAP Ameliorates Cerebral Vasospasm and Brain Injury after Subarachnoid Hemorrhage by Regulating Neuro-Inflammation in Rats.
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.
KDM2B overexpression prevents myocardial ischemia-reperfusion injury in rats through regulating inflammatory response via the TLR4/NF-κB p65 axis.
The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling pathway in newborn calf.
Preventive effect of sanguinarine on intestinal injury in mice exposed to whole abdominal irradiation.
TLR4-Myd88 pathway upregulated caveolin-1 expression contributes to coronary artery spasm.
Pharmacological inhibition of TLR4-NF-κB signaling by TAK-242 attenuates hydrocephalus after intraventricular hemorrhage.
Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome.
Neuroprotection of chicoric acid in a mouse model of Parkinson's disease involves gut microbiota and TLR4 signaling pathway.
Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6 expression in Sprague-Dawley rats.
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway.
1,25(OH)(2)D(3) alleviates LPS-induced preeclampsia-like rats impairment in the protective effect by TLR4/NF-kB pathway.
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-κB signaling pathway in diabetic rats.
Antimicrobial Peptide LCN2 Inhibited Uropathogenic Escherichia coli Infection in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway.
Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice.
miR-30e-5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4.
Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway.
N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.
San-Wu-Huang-Qin decoction attenuates tumorigenesis and mucosal barrier impairment in the AOM/DSS model by targeting gut microbiome.
EB1089 promotes the expression of vitamin D receptor in the intestinal epithelial cell line HT-29 and reduces lipopolysaccharide-induced inflammatory response.
Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model.
Critical Role of TLR4 on the Microglia Activation Induced by Maternal LPS Exposure Leading to ASD-Like Behavior of Offspring.
BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury.
Maslinic Acid Attenuates Ischemia/Reperfusion Injury-Induced Myocardial Inflammation and Apoptosis by Regulating HMGB1-TLR4 Axis.
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
Bu-Zhong-Yi-Qi Granule Enhances Colonic Tight Junction Integrity via TLR4/NF-κB/MLCK Signaling Pathway in Ulcerative Colitis Rats.
DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway.
Isoquercetin Improves Inflammatory Response in Rats Following Ischemic Stroke.
Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation.
Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.
Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1.
Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways.
Introduction of Colonic and Fecal Microbiota From an Adult Pig Differently Affects the Growth, Gut Health, Intestinal Microbiota and Blood Metabolome of Newborn Piglets.
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway.
Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.
Hypothermic oxygenated perfusion with defatting cocktail further improves steatotic liver grafts in a transplantation rat model.
Effects of different intensities of continuous training on vascular inflammation and oxidative stress in spontaneously hypertensive rats.
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein.
MiR-214-3p plays a protective role in diabetic neuropathic rats by regulating Nav1.3 and TLR4.
MicroRNA Bta-miR-24-3p Suppressed Galectin-9 Expression through TLR4/NF-ĸB Signaling Pathway in LPS-Stimulated Bovine Endometrial Epithelial Cells.
Insulin Downregulated the Infection of Uropathogenic Escherichia coli (UPEC) in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway.
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Protective effect of Apelin/APJ system on lipopolysaccharide-related cardiac dysfunction.
The role of TLR4/MyD88/NF-κB pathway in periodontitis-induced liver inflammation of rats.
Preventive electroacupuncture ameliorates D-galactose-induced Alzheimer's disease-like inflammation and memory deficits, probably via modulating the microbiota-gut-brain axis.
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.
Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration.
Dietary Ursolic Acid Prevents Alcohol-Induced Liver Injury via Gut-Liver Axis Homeostasis Modulation: The Key Role of Microbiome Manipulation.
Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.
The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation.
Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.
Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines.
Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice.
Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR signaling pathway in mice.
A combination of lycopene and human amniotic epithelial cells can ameliorate cognitive deficits and suppress neuroinflammatory signaling by choroid plexus in Alzheimer's disease rat.
Cattle Encephalon Glycoside and Ignotin Protects Neurons Against Microglia-Induced Neuroinflammation via Elevating BDNF Expression and Inhibiting TLR4/NF-κB Pathway.
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Downregulating lncRNA PRNCR1 ameliorates LPS-induced pulmonary vascular endothelial cell injury by modulating miR-330-5p/TLR4 axis.
Protection Mechanisms Underlying Oral Administration of Chlorogenic Acid against Cadmium-Induced Hepatorenal Injury Related to Regulating Intestinal Flora Balance.
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion.
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.
Enhanced uropathogenic Escherichia coli-induced infection in uroepithelial cells by sugar through TLR-4 and JAK/STAT1 signaling pathways.
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways.
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells.
Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats.
Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway.
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κB/Inflammatory Signaling Pathway.
Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway.
Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway.
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy.
Astragaloside IV Improves High-Fat Diet-Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway.
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways.
Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo.
Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages.
DHZCP Modulates Microglial M1/M2 Polarization via the p38 and TLR4/NF-κB Signaling Pathways in LPS-Stimulated Microglial Cells.
Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota.
Splenectomy enhances the Ly6C(low) phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
Danshen (Salvia miltiorrhiza) restricts MD2/TLR4-MyD88 complex formation and signalling in acute myocardial infarction-induced heart failure.
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Mechanisms of the lipopolysaccharide-induced inflammatory response in alveolar epithelial cell/macrophage co-culture.
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
Hypoglycemic Effect of Ginsenoside Rg5 Mediated Partly by Modulating Gut Microbiota Dysbiosis in Diabetic db/db Mice.
Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways.
Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects.
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway.
HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats.
A Comparison of Splenic Pathologic Change and Immune Function in HBV-Related Portal Hypertension and Chinese Budd-Chiari Syndrome Patients with Hypersplenism.
Upregulation of microRNA-204 improves insulin resistance of polycystic ovarian syndrome via inhibition of HMGB1 and the inactivation of the TLR4/NF-κB pathway.
The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis.
The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis.
Jiao-tai-wan inhibits inflammation of the gut-brain-axis and attenuates cognitive impairment in insomnic rats.
Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway.
Critical role of toll-like receptor 4 (TLR4) in ricin toxin-induced inflammatory responses in macrophages.
BabaoDan cures hepatic encephalopathy by decreasing ammonia levels and alleviating inflammation in rats.
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model.
Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats.
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
Glycyrrhizin mitigates radiation-induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway.
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Deciphering the chemical profile and pharmacological mechanisms of Baihu-Guizhi decoction using ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry coupled with network pharmacology-based investigation.
Silencing of PTX3 alleviates LPS-induced inflammatory pain by regulating TLR4/NF-κB signaling pathway in mice.
Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.
TLR4 inhibition ameliorates mesencephalic substantia nigra injury in neonatal rats exposed to lipopolysaccharide via regulation of neuro-immunity.
Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway.
Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes.
Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice.
Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice.
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
TAK‑242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF‑κB signaling pathway in a neonatal hypoxic‑ischemic encephalopathy rat model.
Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway.
Monophosphoryl lipid A alleviated radiation-induced testicular injury through TLR4-dependent exosomes.
Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model.
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice.
Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease.
The Functional Role of Fecal Microbiota Transplantation on Dextran Sulfate Sodium-Induced Colitis in Mice.
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38(-/-) Mice.
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord.
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Inhibiting Intestinal Damage via Increasing the Proliferation of Crypt Cells.
Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization.
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
miR-140-5p Attenuates Neuroinflammation and Brain Injury in Rats Following Intracerebral Hemorrhage by Targeting TLR4.
Melatonin protects against lipopolysaccharide-induced epididymitis in sheep epididymal epithelial cells in vitro.
Protective Effect and Mechanism of Boswellic Acid and Myrrha Sesquiterpenes with Different Proportions of Compatibility on Neuroinflammation by LPS-Induced BV2 Cells Combined with Network Pharmacology.
Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway.
Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis.
M1 macrophages regulate TLR4/AP1 via paracrine to promote alveolar bone destruction in periodontitis.
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Bacterial β-glucuronidase alleviates dextran sulfate sodium-induced colitis in mice: A possible crucial new diagnostic and therapeutic target for inflammatory bowel disease.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells.
The role of toll-like receptor 4 and mast cell in the ameliorating effect of electroacupuncture on visceral hypersensitivity in rats.
Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway.
Triptolide Suppresses Growth of Breast Cancer by Targeting HMGB1 in Vitro and in Vivo.
Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis.
HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration.
Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome.
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress.
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice.
Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells.
HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA.
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease.
Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1/AMPK activation.
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation.
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105.
The Protective Mechanism of CAY10683 on Intestinal Mucosal Barrier in Acute Liver Failure through LPS/TLR4/MyD88 Pathway.
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population.
Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice.
Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway.
Production of interleukin-1β related to mammalian target of rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the mouse cornea.
Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis.
Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia.
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Liver injury induced in Balb/c mice by PM(2.5) exposure and its alleviation by compound essential oils.
Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway.
Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus).
Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-κB signaling pathway.
Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway.
Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Toll-like receptor 4 shRNA attenuates lipopolysaccharide-induced epithelial-mesenchymal transition of intrahepatic biliary epithelial cells in rats.
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia.
Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway.
DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway.
Gene transfer of a naked plasmid (pUDK-HGF) encoding human hepatocyte growth factor attenuates skin/muscle incision and retraction-induced chronic post-surgical pain in rats.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Lycopene mitigates β-amyloid induced inflammatory response and inhibits NF-κB signaling at the choroid plexus in early stages of Alzheimer's disease rats.
Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.
Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice.
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Kafirin from Sorghum bicolor inhibition of inflammation in THP-1 human macrophages is associated with reduction of intracellular reactive oxygen species.
Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats.
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
Loganin prevents BV-2 microglia cells from Aβ(1-42) -induced inflammation via regulating TLR4/TRAF6/NF-κB axis.
Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages.
Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats.
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
Anti-β(2)GPI/β(2)GPI induces neutrophil extracellular traps formation to promote thrombogenesis via the TLR4/MyD88/MAPKs axis activation.
Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats.
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells.
TLR4 Influences Hepatitis B Virus Related Hepatocellular Carcinoma by Regulating the Wnt/β-Catenin Pathway.
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
Toll‑like receptor 4 is expressed and functional in late endothelial progenitor cells.
fat-1 mice prevent high-fat plus high-sugar diet-induced non-alcoholic fatty liver disease.
Comparative study of macrophages in naked mole rats and ICR mice.
oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca(2+) /K(+) channel flow.
Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway.
Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis.
1, 25(OH)(2)D(3)-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation.
Glucocorticoid-induced leucine zipper overexpression inhibits lipopolysaccharide-induced retinal inflammation in rats.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway.
Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model.
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways.
Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation.
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Longistatin in tick saliva blocks advanced glycation end-product receptor activation.
Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy.
Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis.
Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells.
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Fu W, Cao Y, Liu J, Huang C, Shu K, Zhu N
Drug design, development and therapy 2024;18:2421-2433
Drug design, development and therapy 2024;18:2421-2433
Radix Sophorae Flavescentis of Sophora flavescens Aiton inhibits LPS-induced macrophage pro-inflammatory response via regulating CFHR2 expression.
Wu X, Li L, Jinhabure, Xiaofeng, Eerdunchaolu
Journal of ethnopharmacology 2024 Sep 15;331:118210
Journal of ethnopharmacology 2024 Sep 15;331:118210
Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy.
Tong J, Yao G, Chen Y, Xie H, Zheng X, Sun L, Huang Z, Xie Z
Inflammation 2024 Oct;47(5):1728-1743
Inflammation 2024 Oct;47(5):1728-1743
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway.
He J, He Z, Wang H, Zhang C, Pei T, Yan S, Yan Y, Wang F, Chen Y, Yuan N, Wang M, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116556
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway.
Wu X, Zhou L, Li Z, Rong K, Gao S, Chen Y, Zuo J, Tang W
Bioorganic chemistry 2024 May;146:107303
Bioorganic chemistry 2024 May;146:107303
Turmeric-Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing.
Wu B, Pan W, Luo S, Luo X, Zhao Y, Xiu Q, Zhong M, Wang Z, Liao T, Li N, Liu C, Nie C, Yi G, Lin S, Zou M, Li B, Zheng L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307630
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307630
Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota.
Xu J, Lu L, Jiang S, Qin Z, Huang J, Huang M, Jin J
European journal of pharmacology 2024 May 15;971:176516
European journal of pharmacology 2024 May 15;971:176516
Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway.
Qin Q, Shan Z, Xing L, Jiang Y, Li M, Fan L, Zeng X, Ma X, Zheng D, Wang H, Wang H, Liu H, Liang S, Wu L, Liang S
Journal of translational medicine 2024 May 13;22(1):446
Journal of translational medicine 2024 May 13;22(1):446
Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis.
Du Y, Wang J, Zhang J, Li N, Li G, Liu X, Lin Y, Wang D, Kang K, Bian L, Zhao X
CNS neuroscience & therapeutics 2024 Mar;30(3):e14681
CNS neuroscience & therapeutics 2024 Mar;30(3):e14681
Purification and structural characterization of two polysaccharides with anti-inflammatory activities from Plumbago zeylanica L.
Zhang X, Gao M, Zhao X, Qi Y, Xu L, Yin L, Peng J
International journal of biological macromolecules 2024 Mar;260(Pt 1):129455
International journal of biological macromolecules 2024 Mar;260(Pt 1):129455
Schaftoside reduces inflammation in Aspergillus fumigatus keratitis through the inhibition of the TLR4/MyD88 pathway.
Lu D, Liu W, Yang H, Zong Y, Sun J, Sun X, Song S, Liu M, Kan J, Che C
Cytokine 2024 Mar;175:156483
Cytokine 2024 Mar;175:156483
Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice.
Wang Q, He Z, Zhu J, Hu M, Yang L, Yang H
BMC biotechnology 2024 Mar 8;24(1):13
BMC biotechnology 2024 Mar 8;24(1):13
L-Theanine alleviates heat stress through modulation of gut microbiota and immunity.
Liu S, Wang B, Lin L, Xu W, Gong ZH, Xiao WJ
Journal of the science of food and agriculture 2024 Mar 15;104(4):2059-2072
Journal of the science of food and agriculture 2024 Mar 15;104(4):2059-2072
Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites.
He X, Liang J, Li X, Wang Y, Zhang X, Chen D, Wu L, Wang S
Journal of ethnopharmacology 2024 Mar 1;321:117402
Journal of ethnopharmacology 2024 Mar 1;321:117402
Electroacupuncture Inhibits Neuroinflammation Induced by Astrocytic Necroptosis Through RIP1/MLKL/TLR4 Pathway in a Mouse Model of Spinal Cord Injury.
Zhao H, Zong X, Li L, Li N, Liu C, Zhang W, Li J, Yang C, Huang S
Molecular neurobiology 2024 Jun;61(6):3258-3271
Molecular neurobiology 2024 Jun;61(6):3258-3271
BMSC-derived exosomes regulate the Treg/Th17 balance through the miR-21-5p/TLR4/MyD88/NF-κB pathway to alleviate dry eye symptoms in mice.
Zhao D, Ji H, Zhao H, Xu Y, He A, He Y
In vitro cellular & developmental biology. Animal 2024 Jun;60(6):644-656
In vitro cellular & developmental biology. Animal 2024 Jun;60(6):644-656
DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-κB and TGF-β/Smad signalling pathway.
Lin J, Li B, Xu Q, Liu YS, Kang YL, Wang X, Wang Y, Lei Y, Bai YL, Li XM, Zhou J
Journal of endocrinological investigation 2024 Jun;47(6):1531-1544
Journal of endocrinological investigation 2024 Jun;47(6):1531-1544
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Bai X, Deng J, Duan Z, Fu R, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Wang Y, Wang S, Wang Y, Wang C, Tang Y, Zhang C, Hou S, Yu D, Lin N
Cellular signalling 2024 Jun;118:111137
Cellular signalling 2024 Jun;118:111137
Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides.
Guan G, Cao H, Tang Z, Zhang K, Zhong M, Lv R, Wan W, Guo F, Wang Y, Gao Y
Journal of ethnopharmacology 2024 Jun 28;328:118108
Journal of ethnopharmacology 2024 Jun 28;328:118108
Galectin-3 modulates microglial activation and neuroinflammation in early brain injury after subarachnoid hemorrhage.
Shen Y, Zhang W, Chang H, Li Z, Lin C, Zhang G, Mao L, Ma C, Liu N, Lu H
Experimental neurology 2024 Jul;377:114777
Experimental neurology 2024 Jul;377:114777
Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-κB pathway.
Liu F, Yang Y, Dong H, Zhu Y, Feng W, Wu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155651
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155651
Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells.
Zeng F, Li Y, Zhang X, Shen L, Zhao X, Beta T, Li B, Chen R, Huang W
International journal of biological macromolecules 2024 Jan;254(Pt 2):127700
International journal of biological macromolecules 2024 Jan;254(Pt 2):127700
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Wang R, Feng W, Wang Y, Jiang Y, Lin Y, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Gut microbiota regulates host melatonin production through epithelial cell MyD88.
Liu B, Fan L, Wang Y, Wang H, Yan Y, Chen S, Hung I, Liu C, Wei H, Ge L, Ren W
Gut microbes 2024 Jan-Dec;16(1):2313769
Gut microbes 2024 Jan-Dec;16(1):2313769
Gentianine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibition of TLR4/NLRP3-mediated pyroptosis.
Li YX, Lv L, Li SL, Qian HH
International immunopharmacology 2024 Jan 5;126:111214
International immunopharmacology 2024 Jan 5;126:111214
Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway.
Du Y, Yan T, Wu B, He B, Jia Y
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117190
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117190
Polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp Ameliorates Dextran Sodium Sulfate-Induced Enteritis in Rats.
Li Y, Chen Y, Li C, Wu G, He Y, Tan L, Zhu K
International journal of molecular sciences 2024 Jan 29;25(3)
International journal of molecular sciences 2024 Jan 29;25(3)
The protective effect of Schisandra chinensis (Turcz.) Baill. polysaccharide on DSS-induced ulcerative colitis in mice via the modulation of gut microbiota and inhibition of NF-κB activation.
Guo X, Liu L, Zhao W, Li X, Wang X, Ning A, Cao J, Zhang W, Cao L, Zhong M
Journal of the science of food and agriculture 2024 Jan 15;104(1):196-206
Journal of the science of food and agriculture 2024 Jan 15;104(1):196-206
Efficacy of Jiangzhi Xiaoban tablet on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet.
Huihui L, Jun F, Jianhe L, Choufu C, Guoheng HU
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Feb;44(1):88-94
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Feb;44(1):88-94
Astilbin protects from sepsis-induced cardiac injury through the NRF2/HO-1 and TLR4/NF-κB pathway.
Fang Z, Wang G, Huang R, Liu C, Yushanjiang F, Mao T, Li J
Phytotherapy research : PTR 2024 Feb;38(2):1044-1058
Phytotherapy research : PTR 2024 Feb;38(2):1044-1058
In vitro and in vivo immunomodulatory activity of acetylated polysaccharides from Cyclocarya paliurus leaves.
Zhang Y, Zhao M, He J, Chen L, Wang W
International journal of biological macromolecules 2024 Feb;259(Pt 1):129174
International journal of biological macromolecules 2024 Feb;259(Pt 1):129174
Sinigrin improves cerebral ischaemia-reperfusion injury by inhibiting the TLR4 pathway-mediated oxidative stress.
Guo S, Lei Q, Yang Q, Chen R
Chemical biology & drug design 2024 Feb;103(2):e14480
Chemical biology & drug design 2024 Feb;103(2):e14480
Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4/NF-κB/MAPK Singnaling Pathways.
Liu QH, Zhang K, Feng SS, Zhang LJ, Li SY, Wang HY, Wang JH
International journal of molecular sciences 2024 Feb 3;25(3)
International journal of molecular sciences 2024 Feb 3;25(3)
Protein 4.1R regulates M1 macrophages polarization via glycolysis, alleviating sepsis-induced liver injury in mice.
Sang SY, Wang YJ, Liang T, Liu Y, Liu JJ, Li H, Liu X, Kang QZ, Wang T
International immunopharmacology 2024 Feb 15;128:111546
International immunopharmacology 2024 Feb 15;128:111546
Buyang Huanwu Decoction suppresses cardiac inflammation and fibrosis in mice after myocardial infarction through inhibition of the TLR4 signalling pathway.
Zhang G, Han X, Xu T, Liu M, Chen G, Xie L, Xu H, Hua Y, Pang M, Hu C, Wu Y, Liu B, Zhou Y
Journal of ethnopharmacology 2024 Feb 10;320:117388
Journal of ethnopharmacology 2024 Feb 10;320:117388
Ultrasonic-assisted extraction of a low molecular weight polysaccharide from Nostoc commune Vaucher and its structural characterization and immunomodulatory activity.
Pan Y, Liu C, Jiang S, Guan L, Liu X, Wen L
Ultrasonics sonochemistry 2024 Aug;108:106961
Ultrasonics sonochemistry 2024 Aug;108:106961
Yemazhui () ameliorates lipopolysaccharide-induced acute lung injury modulation of the toll-like receptor 4/nuclear factor kappa-B/nod-like receptor family pyrin domain-containing 3 protein signaling pathway and intestinal flora in rats.
Li R, Yang H, Xue Y, Xianqin L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Apr;44(2):303-314
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Apr;44(2):303-314
Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis.
Liu H, Zhou L, Wang X, Zheng Q, Zhan F, Zhou L, Dong Y, Xiong Y, Yi P, Xu G, Hua F
Biochemical pharmacology 2024 Apr;222:116050
Biochemical pharmacology 2024 Apr;222:116050
Very low-carbohydrate diet with higher protein ratio improves lipid metabolism and inflammation in rats with diet-induced nonalcoholic fatty liver disease.
Wu IT, Yeh WJ, Huang WC, Yang HY
The Journal of nutritional biochemistry 2024 Apr;126:109583
The Journal of nutritional biochemistry 2024 Apr;126:109583
A Flavonoid Glycoside Compound from Siraitia grosvenorii with Anti-Inflammatory and Hepatoprotective Effects In Vitro.
Wu J, Huang H, Gong L, Tian X, Peng Z, Zhu Y, Wang W
Biomolecules 2024 Apr 7;14(4)
Biomolecules 2024 Apr 7;14(4)
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Zeng Z, Fu Y, Li M, Shi Y, Ding Q, Chen S
Journal of ethnopharmacology 2024 Apr 6;323:117674
Journal of ethnopharmacology 2024 Apr 6;323:117674
Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid.
Guo X, Wan P, Shen W, Sun M, Peng Z, Liao Y, Huang Y, Liu R
Journal of translational medicine 2024 Apr 30;22(1):401
Journal of translational medicine 2024 Apr 30;22(1):401
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Ullah H, Shi X, Taj A, Cheng L, Yan Q, Sha S, Ahmad, Kang J, Haris M, Ma X, Ma Y
Biology 2024 Apr 30;13(5)
Biology 2024 Apr 30;13(5)
Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1/NF-κB/STAT3 axis.
Guo L, Yue M, Ma C, Wang Y, Hou J, Li H
Heliyon 2024 Apr 30;10(8):e29361
Heliyon 2024 Apr 30;10(8):e29361
Huangqi Baihe Granules alleviate hypobaric hypoxia-induced acute lung injury in rats by suppressing oxidative stress and the TLR4/NF-κB/NLRP3 inflammatory pathway.
Zeng Y, Cao W, Huang Y, Zhang H, Li C, He J, Liu Y, Gong H, Su Y
Journal of ethnopharmacology 2024 Apr 24;324:117765
Journal of ethnopharmacology 2024 Apr 24;324:117765
Esculin targets TLR4 to protect against LPS-induced septic cardiomyopathy.
Su Z, Gao M, Weng L, Xu T
International immunopharmacology 2024 Apr 20;131:111897
International immunopharmacology 2024 Apr 20;131:111897
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
Hu Y, Hu C, Yin J, Zhong J, Deng Y, Yang G
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.
Hao Z, Zhang Z, Zhao Y, Wang D
The American journal of Chinese medicine 2023;51(2):355-372
The American journal of Chinese medicine 2023;51(2):355-372
C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways.
Chen Y, Liu Y, Li H, Huna R, Tan X, Li N, Zhang Y, Jiao X, Liu M
Journal of applied oral science : revista FOB 2023;31:e20220404
Journal of applied oral science : revista FOB 2023;31:e20220404
BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer.
Wu H, Xiang Z, Huang G, He Q, Song J, Dou R, Yang C, Wang S, Xiong B
International journal of biological sciences 2023;19(2):465-483
International journal of biological sciences 2023;19(2):465-483
Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema.
Cui Y, Hu J, Li Y, Au R, Fang Y, Cheng C, Xu F, Li W, Wu Y, Zhu L, Shen H
Drug design, development and therapy 2023;17:3453-3472
Drug design, development and therapy 2023;17:3453-3472
Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation.
Wang L, Peng G, Chen L, Guo M, Wang B, Zhang Y, Zhou J, Zhong M, Ye J
Frontiers in behavioral neuroscience 2023;17:1162009
Frontiers in behavioral neuroscience 2023;17:1162009
Interferon-induced transmembrane protein 3 in the hippocampus: a potential novel target for the therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy.
Li N, Ma RH, Zhang EF, Ge F, Fang DY, Zhang J, Zhang YN, Gao Y, Hou LC, Jin HX
Frontiers in molecular neuroscience 2023;16:1182005
Frontiers in molecular neuroscience 2023;16:1182005
Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1-to-M2 transformation.
Zhang C, Liao W, Li W, Li M, Xu X, Sun H, Xue Y, Liu L, Qiu J, Zhang C, Zhang X, Ye J, Du J, Deng DYB, Deng W, Li T
Frontiers in physiology 2023;14:1131701
Frontiers in physiology 2023;14:1131701
Dendrobium officinale alleviates high-fat diet-induced nonalcoholic steatohepatitis by modulating gut microbiota.
Tian G, Wang W, Xia E, Chen W, Zhang S
Frontiers in cellular and infection microbiology 2023;13:1078447
Frontiers in cellular and infection microbiology 2023;13:1078447
Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction.
Chai R, Ye Z, Xue W, Shi S, Wei Y, Hu Y, Wu H
Frontiers in cell and developmental biology 2023;11:1252942
Frontiers in cell and developmental biology 2023;11:1252942
Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization.
Jiang K, Lu S, Li D, Liu M, Jin H, Lei B, Wang S, Long K, He S, Zhong F
Journal of gastroenterology 2023 Sep;58(9):894-907
Journal of gastroenterology 2023 Sep;58(9):894-907
Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles.
Chu Z, Huang Q, Ma K, Liu X, Zhang W, Cui S, Wei Q, Gao H, Hu W, Wang Z, Meng S, Tian L, Li H, Fu X, Zhang C
Bioactive materials 2023 Sep;27:257-270
Bioactive materials 2023 Sep;27:257-270
Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo.
Sun X, Hu X, Zhang Q, Zhao L, Sun X, Yang L, Jin M
International immunopharmacology 2023 Sep;122:110544
International immunopharmacology 2023 Sep;122:110544
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Wang Z, Zhu D, Zhang Y, Xia F, Zhu J, Dai J, Zhuge X
Microbial cell factories 2023 Sep 9;22(1):177
Microbial cell factories 2023 Sep 9;22(1):177
Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis.
Zhao Q, Hao Y, Yang X, Mao J, Tian F, Gao Y, Tian X, Yan X, Qiu Y
Journal of hazardous materials 2023 Sep 5;457:131816
Journal of hazardous materials 2023 Sep 5;457:131816
The effects of Shikonin on the hypertrophic scar of rabbit ears via the TLR4/NF-κB signaling pathway.
Liu C, Zhang H, Cui X, Wang S, Zhou Q
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Sep 30;69(9):161-166
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Sep 30;69(9):161-166
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Guo H, Wu H, Hou Y, Hu P, Du J, Cao L, Yang R, Dong X, Li Z
International journal of biological macromolecules 2023 Sep 30;249:126039
International journal of biological macromolecules 2023 Sep 30;249:126039
The Gut Microbiota of Pregnant Rats Alleviates Fetal Growth Restriction by Inhibiting the TLR9/MyD88 Pathway.
Tang H, Li H, Li D, Peng J, Zhang X, Yang W
Journal of microbiology and biotechnology 2023 Sep 28;33(9):1213-1227
Journal of microbiology and biotechnology 2023 Sep 28;33(9):1213-1227
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu G, Han B
Veterinary research 2023 Sep 14;54(1):78
Veterinary research 2023 Sep 14;54(1):78
Inhibition of TLR4 Signaling by Isorhapontigenin Targeting of the AHR Alleviates Cerebral Ischemia/Reperfusion Injury.
Liu J, Mu D, Xu J, Liu Y, Zhang G, Tang Y, Wang D, Wang F, Liang D, Hou Y
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13270-13283
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13270-13283
Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-κB pathways.
Yin J, Hu T, Xu L, Zhang L, Zhu J, Ye Y, Pang Z
International immunopharmacology 2023 Oct;123:110763
International immunopharmacology 2023 Oct;123:110763
The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.
Hao J, Song Z, Su J, Li L, Zou L, Zou K
Cellular signalling 2023 Oct;110:110806
Cellular signalling 2023 Oct;110:110806
Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway.
Liang Y, Zhou Y, Wang J, He Y
Immunity, inflammation and disease 2023 Oct;11(10):e1003
Immunity, inflammation and disease 2023 Oct;11(10):e1003
Partial Replacement of Diet with Dehulled Adlay Ameliorates Hepatic Steatosis, Inflammation, Oxidative Stress, and Gut Dysbiosis in Rats with Nonalcoholic Fatty Liver Disease.
Huang HC, Lee PN, Huang WC, Yang HY
Nutrients 2023 Oct 16;15(20)
Nutrients 2023 Oct 16;15(20)
Arctium lappa L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway.
Zeng F, Li Y, Zhang X, Feng J, Gu W, Shen L, Huang W
Heliyon 2023 Nov;9(11):e21562
Heliyon 2023 Nov;9(11):e21562
Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury.
Wang S, Wang R, Chen J, Yang B, Shu J, Cheng F, Tao Y, Shi K, Wang C, Wang J, Xia K, Zhang Y, Chen Q, Liang C, Tang J, Li F
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:27-42
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:27-42
Neutrophil extracellular traps boost laser-induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF-1α pathway.
Zeng J, Wang Y, Zhu M, Wu M, Zhou Y, Wang Q, Xu Y, Lin F, Wang J, Li Y, Liang S, Wang Z, Xie L, Liu X
The FEBS journal 2023 Nov;290(22):5395-5410
The FEBS journal 2023 Nov;290(22):5395-5410
Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF-κB and Nrf2/HO-1/GPX4 pathways to reduce inflammation and ferroptosis.
Shi P, Zhu W, Fu J, Liang A, Zheng T, Wen Z, Wu X, Peng Y, Yuan S, Wu X
Journal of cellular and molecular medicine 2023 Nov;27(21):3326-3338
Journal of cellular and molecular medicine 2023 Nov;27(21):3326-3338
Dendrobium huoshanense Polysaccharide Improves High-Fat Diet Induced Liver Injury by Regulating the Gut-Liver Axis.
Ma MH, Gao LL, Chen CB, Gu FL, Wu SQ, Li F, Han BX
Chemistry & biodiversity 2023 Nov;20(11):e202300980
Chemistry & biodiversity 2023 Nov;20(11):e202300980
Aqueous Extract of Brassica rapa L.'s Impact on Modulating Exercise-Induced Fatigue via Gut-Muscle Axis.
Wang C, Zhu H, Cheng Y, Guo Y, Zhao Y, Qian H
Nutrients 2023 Nov 9;15(22)
Nutrients 2023 Nov 9;15(22)
Yanghepingchuan granule improves airway inflammation by inhibiting autophagy via miRNA328-3p/high mobility group box 1/Toll-like receptor 4 targeting of the pathway of signaling in rat models of asthma.
Cao X, Wang K, Zhu H
Journal of thoracic disease 2023 Nov 30;15(11):6251-6264
Journal of thoracic disease 2023 Nov 30;15(11):6251-6264
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Liu X, Li H, Feng Y, Guo H, Li Y, Ke J, Long X
Arthritis research & therapy 2023 Nov 29;25(1):230
Arthritis research & therapy 2023 Nov 29;25(1):230
Gentiana Scabra Bge Extract (GSE) Protects Against Alcoholic Liver Disease by Regulating the TLR4/NF-κB Pathway in Mice.
Wang L, Jiang Y, Yu Q, Xiao C, Sun J, Weng L, Qiu Y
Frontiers in bioscience (Landmark edition) 2023 Nov 28;28(11):309
Frontiers in bioscience (Landmark edition) 2023 Nov 28;28(11):309
Schwann Cell-Derived Exosomes and Methylprednisolone Composite Patch for Spinal Cord Injury Repair.
Zhu B, Gu G, Ren J, Song X, Li J, Wang C, Zhang W, Huo Y, Wang H, Jin L, Feng S, Wei Z
ACS nano 2023 Nov 28;17(22):22928-22943
ACS nano 2023 Nov 28;17(22):22928-22943
Artemether Attenuates Gut Barrier Dysfunction and Intestinal Flora Imbalance in High-Fat and High-Fructose Diet-Fed Mice.
Ren X, Xu J, Xu Y, Wang Q, Huang K, He X
Nutrients 2023 Nov 21;15(23)
Nutrients 2023 Nov 21;15(23)
Dendritic Cell-Derived Exosomes Stimulated by Treponema pallidum Induce Endothelial Cell Inflammatory Response through the TLR4/MyD88/NF-κB Signaling Pathway.
Zhang R, Lian T, Liu J, Du F, Chen Z, Zhang R, Wang Q
ACS infectious diseases 2023 Nov 10;9(11):2299-2305
ACS infectious diseases 2023 Nov 10;9(11):2299-2305
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Guo F, Xiong H, Tsao R, Shahidi F, Wen X, Liu J, Jiang L, Sun Y
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Bisphenol P exposure in C57BL/6 mice caused gut microbiota dysbiosis and induced intestinal barrier disruption via LPS/TLR4/NF-κB signaling pathway.
Ma N, Ma D, Liu X, Zhao L, Ma L, Ma D, Dong S
Environment international 2023 May;175:107949
Environment international 2023 May;175:107949
Effects of Therapeutic Platelet-Rich Plasma on Overactive Bladder via Modulating Hyaluronan Synthesis in Ovariectomized Rat.
Lu JH, Chueh KS, Juan TJ, Mao JW, Lin RJ, Lee YC, Shen MC, Sun TW, Lin HY, Juan YS
International journal of molecular sciences 2023 May 4;24(9)
International journal of molecular sciences 2023 May 4;24(9)
Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility.
Zhang MF, Wan SC, Chen WB, Yang DH, Liu WQ, Li BL, Aierken A, Du XM, Li YX, Wu WP, Yang XC, Wei YD, Li N, Peng S, Li XL, Li GP, Hua JL
Zoological research 2023 May 18;44(3):505-521
Zoological research 2023 May 18;44(3):505-521
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Zhang Z, Guo L, Yang F, Peng S, Wang D, Lai X, Su B, Xie H
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
Protective effect of Paecilomyces cicadae TJJ11213 exopolysaccharide on intestinal mucosa and regulation of gut microbiota in immunosuppressed mice.
Tian J, Zhao X, Tang C, Wang X, Zhang X, Xiao L, Li W
Food research international (Ottawa, Ont.) 2023 Mar;165:112477
Food research international (Ottawa, Ont.) 2023 Mar;165:112477
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
Zhang J, Sun Y, Sun C, Shang D
Bioorganic chemistry 2023 Mar;132:106376
Bioorganic chemistry 2023 Mar;132:106376
Determination of the optimal concentration and duration of C5aR antagonist application in an inflammatory model of human dental pulp cells.
Hu J, Tan X, Wei X, Hu W, Gao L, Cao X, Yang H, Jiang Z, Li N, Teng L, Liu M
FEBS open bio 2023 Mar;13(3):570-581
FEBS open bio 2023 Mar;13(3):570-581
Activation of estrogen receptor α inhibits TLR4 signaling in macrophages and alleviates the instability of atherosclerotic plaques in the postmenopausal stage.
Meng Q, Bi Y, Feng H, Ding X, Zhang S, Chen Q, Wang L, Zhang Q, Li Y, Tong H, Wu L, Bian H
International immunopharmacology 2023 Mar;116:109825
International immunopharmacology 2023 Mar;116:109825
Effects of Caprylic Acid and Eicosapentaenoic Acid on Lipids, Inflammatory Levels, and the JAK2/STAT3 Pathway in ABCA1-Deficient Mice and ABCA1 Knock-Down RAW264.7 Cells.
Zhang X, Zhang P, Liu Y, Liu Z, Xu Q, Zhang Y, Liu L, Yang X, Li L, Xue C
Nutrients 2023 Mar 6;15(5)
Nutrients 2023 Mar 6;15(5)
Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway.
Wang SH, Huang SH, Hsieh MC, Lu IC, Chou PR, Tai MH, Wu SH
International journal of molecular sciences 2023 Mar 11;24(6)
International journal of molecular sciences 2023 Mar 11;24(6)
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Li K, Feng Z, Wang L, Ma X, Wang L, Liu K, Geng X, Peng C
Inflammation 2023 Jun;46(3):1061-1076
Inflammation 2023 Jun;46(3):1061-1076
A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes.
Ding H, Wang K, He LQ, Yang XY, Huang HH, Liu WL, Xiao C, Du ZX, Yu L, Zhang W
Journal of liposome research 2023 Jun;33(2):144-153
Journal of liposome research 2023 Jun;33(2):144-153
Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis.
Wang J, Hu D, Chen Q, Liu T, Zhou X, Xu Y, Zhou H, Gu D, Gao C
Materials today. Bio 2023 Jun;20:100679
Materials today. Bio 2023 Jun;20:100679
Vancomycin Pretreatment on MPTP-Induced Parkinson's Disease Mice Exerts Neuroprotection by Suppressing Inflammation Both in Brain and Gut.
Cui C, Hong H, Shi Y, Zhou Y, Qiao CM, Zhao WJ, Zhao LP, Wu J, Quan W, Niu GY, Wu YB, Li CS, Cheng L, Hong Y, Shen YQ
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2023 Jun;18(1-2):72-89
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2023 Jun;18(1-2):72-89
Baicalin ameliorates multidrug-resistant Pseudomonas aeruginosa induced pulmonary inflammation in rat via arginine biosynthesis.
Li L, Cui H, Zhang Y, Xie W, Lin Y, Guo Y, Huang T, Xue B, Guo W, Huang Z, Man T, Yu H, Zhai Z, Cheng M, Wang M, Lei H, Wang C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114660
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114660
Annao Pingchong decoction alleviate the neurological impairment by attenuating neuroinflammation and apoptosis in intracerebral hemorrhage rats.
Guo C, Zhou X, Wang X, Wang H, Liu J, Wang J, Lin X, Lei S, Yang Y, Liu K, Long H, Zhou D
Journal of ethnopharmacology 2023 Jun 28;310:116298
Journal of ethnopharmacology 2023 Jun 28;310:116298
RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury.
Liu PY, Chen CY, Lin YL, Lin CM, Tsai WC, Tsai YL, Lin GJ, Chen YG, Wang SY, Sun RN, Huang YC, Chang H, Chen YC
Cell death & disease 2023 Jun 21;14(6):369
Cell death & disease 2023 Jun 21;14(6):369
Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.
Song Y, Guo D, Liu JF, Ge LN, Liu P, Qu YM, Cong HY, Li T, Chang X, Wang YR, Shao LY, Du ZJ, Wang MY
International journal of oncology 2023 Jul;63(1)
International journal of oncology 2023 Jul;63(1)
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Wu B, Gan A, Wang R, Lin F, Yan T, Jia Y
Journal of chemical neuroanatomy 2023 Jul;130:102270
Journal of chemical neuroanatomy 2023 Jul;130:102270
Fucoxanthin alleviated atherosclerosis by regulating PI3K/AKT and TLR4/NFκB mediated pyroptosis in endothelial cells.
Cui S, Wu H, He Q, Wang L, Yi X, Feng G, Wu Q, Tao B, Han D, Hu Q, Xia H, Xu L
International immunopharmacology 2023 Jul;120:110370
International immunopharmacology 2023 Jul;120:110370
Programmed cell death 10 increased blood-brain barrier permeability through HMGB1/TLR4 mediated downregulation of endothelial ZO-1 in glioblastoma.
Wu S, Wang J, Liu J, Zhu H, Li R, Wan X, Lei J, Li Y, You C, Hu F, Zhang S, Zhao K, Shu K, Lei T
Cellular signalling 2023 Jul;107:110683
Cellular signalling 2023 Jul;107:110683
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis.
He G, He Y, Ni H, Wang K, Zhu Y, Bao Y
European journal of histochemistry : EJH 2023 Jul 26;67(3)
European journal of histochemistry : EJH 2023 Jul 26;67(3)
The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing.
Li T, Yang C, Cao H, Mo S, Li B, Huang Z, Zhang R, Wu J, Zhang K, Gao Y
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity.
Ye R, Guo Q, Huang J, Wang Z, Chen Y, Dong Y
Journal of nanobiotechnology 2023 Jul 12;21(1):222
Journal of nanobiotechnology 2023 Jul 12;21(1):222
Apolipoprotein A-1 protected hepatic ischaemia-reperfusion injury through suppressing macrophage pyroptosis via TLR4-NF-κB pathway.
Chen RX, Jiang WJ, Liu SC, Wang ZY, Wang ZB, Zhou T, Chen YA, Wang JF, Chang J, Wang YR, Zhang YD, Wang XH, Li XC, Li CX
Liver international : official journal of the International Association for the Study of the Liver 2023 Jan;43(1):234-248
Liver international : official journal of the International Association for the Study of the Liver 2023 Jan;43(1):234-248
Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway.
Ma T, Zhang H, Li T, Bai J, Wu Z, Cai T, Chen Y, Xia X, Du Y, Fu W
Phytotherapy research : PTR 2023 Jan;37(1):181-194
Phytotherapy research : PTR 2023 Jan;37(1):181-194
Muse cells decrease the neuroinflammatory response by modulating the proportion of M1 and M2 microglia in vitro.
Yin XY, Wang CC, Du P, Wang XS, Lu YC, Sun YW, Sun YH, Hu YM, Chen X
Neural regeneration research 2023 Jan;18(1):213-218
Neural regeneration research 2023 Jan;18(1):213-218
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Zhang JW, Zhang D, Yin HS, Zhang H, Hong KQ, Yuan JP, Yu BP
Gut microbes 2023 Jan-Dec;15(1):2197836
Gut microbes 2023 Jan-Dec;15(1):2197836
SIGIRR-caspase-8 signaling mediates endothelial apoptosis in Kawasaki disease.
Wen Z, Xia Y, Zhang Y, He Y, Niu C, Wu R, Zhang C, Jia C, Rong X, Chu M
Italian journal of pediatrics 2023 Jan 4;49(1):2
Italian journal of pediatrics 2023 Jan 4;49(1):2
Metabotropic glutamate receptor-8 relieves neonatal maternal separation-induced visceral hypersensitivity in rats by regulating expression of TNF-α.
Wang X, Shao L, Hua H, Chen Y
Annals of translational medicine 2023 Jan 31;11(2):118
Annals of translational medicine 2023 Jan 31;11(2):118
Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.
Wang L, Yan H, Chen X, Han L, Liu G, Yang H, Lu D, Liu W, Che C
Journal of microbiology and biotechnology 2023 Jan 28;33(1):43-50
Journal of microbiology and biotechnology 2023 Jan 28;33(1):43-50
Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.
Xu T, Zheng Y, Liu B, Kou M, Jiang Q, Liu J, Kang H, Yang M, Guo D, Qu L
Infection and immunity 2023 Jan 24;91(1):e0019322
Infection and immunity 2023 Jan 24;91(1):e0019322
The Effect of an Essential Oil Blend on Growth Performance, Intestinal Health, and Microbiota in Early-Weaned Piglets.
Shao Y, Peng Q, Wu Y, Peng C, Wang S, Zou L, Qi M, Peng C, Liu H, Li R, Xiong X, Yin Y
Nutrients 2023 Jan 14;15(2)
Nutrients 2023 Jan 14;15(2)
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
Yan M, Jin H, Pan C, Han X
Molecular neurobiology 2023 Feb;60(2):884-900
Molecular neurobiology 2023 Feb;60(2):884-900
8-O-acetyl shanzhiside methylester protects against sleep deprivation-induced cognitive deficits and anxiety-like behaviors by regulating NLRP3 and Nrf2 pathways in mice.
Li YJ, He XL, Zhang JY, Liu XJ, Liang JL, Zhou Q, Zhou GH
Metabolic brain disease 2023 Feb;38(2):641-655
Metabolic brain disease 2023 Feb;38(2):641-655
Amuc Prevents Liver Inflammation and Oxidative Stress in Mice Challenged with Salmonella Typhimurium.
Song Z, Si X, Zhang X, Chen J, Jia H, He Y, Liu H, Kou Z, Dai Z, Wu Z
The Journal of nutrition 2023 Feb;153(2):532-542
The Journal of nutrition 2023 Feb;153(2):532-542
Ang-(1-7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarization.
Gu G, Zhu B, Ren J, Song X, Fan B, Ding H, Shang J, Wu H, Li J, Wang H, Li J, Wei Z, Feng S
Cell & bioscience 2023 Feb 4;13(1):23
Cell & bioscience 2023 Feb 4;13(1):23
Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis.
Chen W, Chen Y, Cheng W, Li P, Shen J, Tong T, Lai L, Yan S, Huang Z, Li J, Huang S, Meng X
Biochemical and biophysical research communications 2023 Feb 26;646:86-95
Biochemical and biophysical research communications 2023 Feb 26;646:86-95
Anti-glycation and anti-inflammatory activities of anthocyanins from purple vegetables.
Gao Q, Ma R, Shi L, Wang S, Liang Y, Zhang Z
Food & function 2023 Feb 21;14(4):2034-2044
Food & function 2023 Feb 21;14(4):2034-2044
Oxymatrine attenuated isoproterenol-induced heart failure via the TLR4/NF-κB and MAPK pathways in vivo and in vitro.
Sun H, Bai J, Sun Y, Zhen D, Fu D, Wang Y, Wei C
European journal of pharmacology 2023 Feb 15;941:175500
European journal of pharmacology 2023 Feb 15;941:175500
Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.
Guo TT, Zhang Z, Sun Y, Zhu RY, Wang FX, Ma LJ, Jiang L, Liu HD
Nutrients 2023 Feb 13;15(4)
Nutrients 2023 Feb 13;15(4)
Sulforaphane Ameliorates Nonalcoholic Fatty Liver Disease Induced by High-Fat and High-Fructose Diet via LPS/TLR4 in the Gut-Liver Axis.
Xu Y, Huang X, Huangfu B, Hu Y, Xu J, Gao R, Huang K, He X
Nutrients 2023 Feb 1;15(3)
Nutrients 2023 Feb 1;15(3)
Phenylalanine diminishes M1 macrophage inflammation.
Zhang Q, Chen S, Guo Y, He F, Fu J, Ren W
Science China. Life sciences 2023 Dec;66(12):2862-2876
Science China. Life sciences 2023 Dec;66(12):2862-2876
Chemical constituents from Eupatorium fortunei and their anti-inflammatory evaluation by in silico and experimental approaches.
Miao L, Wei QH, Wang ST, Sun P, Zhang H
Fitoterapia 2023 Dec;171:105700
Fitoterapia 2023 Dec;171:105700
Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma.
Zhang L, Wu Q, Huang Y, Zheng J, Guo S, He L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115799
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115799
Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway via the microRNA-410-3p.
Feng ZJ, Wang LS, Ma X, Li K, Li XY, Tang Y, Peng CJ
Molecular immunology 2023 Dec;164:66-78
Molecular immunology 2023 Dec;164:66-78
Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFκB/NLRP3 inflammation signal pathway.
Du Y, He B, Wu B, Yan T, Jia Y
Journal of chemical neuroanatomy 2023 Dec;134:102349
Journal of chemical neuroanatomy 2023 Dec;134:102349
L-F001, a multifunctional fasudil-lipoic acid dimer, antagonizes hypoxic-ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway.
Zhou R, Wu L, Jin N, Sha S, Ouyang Y
Brain and behavior 2023 Dec;13(12):e3280
Brain and behavior 2023 Dec;13(12):e3280
Assessment of intestinal status in MPL(W515L) mutant myeloproliferative neoplasms mice model.
Zhu S, Xu K, Li S, Yu X, Liu Y, Zhang Q, Zeng L, Xu K, Fu C
International immunopharmacology 2023 Dec;125(Pt A):111091
International immunopharmacology 2023 Dec;125(Pt A):111091
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
Yang Q, Meng X, Chen J, Li X, Huang Y, Xiao X, Li R, Wu X
Cell death discovery 2023 Dec 5;9(1):440
Cell death discovery 2023 Dec 5;9(1):440
Anti-inflammatory effect and component analysis of Chaihu Qingwen granules.
Zhou Y, Li QX, Liao ZZ, Liu Y, Ouyang Y, Jiang WJ, Tang MT, Hu JF, Zhang W
Journal of ethnopharmacology 2023 Dec 5;317:116763
Journal of ethnopharmacology 2023 Dec 5;317:116763
Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke.
Chen X, Wang W, Li H, Zhang X
Brain research 2023 Dec 15;1821:148619
Brain research 2023 Dec 15;1821:148619
Hesperitin attenuates alcoholic steatohepatitis by regulating TLR4/NF-κB signaling in mice.
Yuan F, Xia GQ, Cai JN, Lv X, Dai M
Analytical biochemistry 2023 Dec 1;682:115339
Analytical biochemistry 2023 Dec 1;682:115339
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
Zhang W, Liu S, Kong L, Wu S, Zhong Z, Yu L, Yang Q, Zhang J, Li J, Zheng G
International journal of biological macromolecules 2023 Dec 1;252:126511
International journal of biological macromolecules 2023 Dec 1;252:126511
Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis.
Zhang ZT, Deng SM, Chen C, He QH, Peng XW, Liang QF, Zhuang GD, Wang SM, Tang D
Phytotherapy research : PTR 2023 Aug;37(8):3522-3542
Phytotherapy research : PTR 2023 Aug;37(8):3522-3542
Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment.
Ge X, Wen H, Fei Y, Xue R, Cheng Z, Li Y, Cai K, Li L, Li M, Luo Z
Biomaterials 2023 Aug;299:122184
Biomaterials 2023 Aug;299:122184
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, Duan H, Shi Y
Cellular signalling 2023 Aug;108:110712
Cellular signalling 2023 Aug;108:110712
Danzhi Jiangtang capsule reduces renal injury in rats with diabetes induced by high fat diet and streptozotocin downregulating toll-like receptor 4-nuclear factor-κB pathway and apoptosis.
Jing X, Zheng BI, Sihai W, Guoming S, Zhaohui F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Apr;43(2):312-321
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Apr;43(2):312-321
NEAT1 Regulates Calcium Oxalate Crystal-Induced Renal Tubular Oxidative Injury via miR-130/IRF1.
Yan Q, Hu Q, Li G, Qi Q, Song Z, Shu J, Liang H, Liu H, Hao Z
Antioxidants & redox signaling 2023 Apr;38(10-12):731-746
Antioxidants & redox signaling 2023 Apr;38(10-12):731-746
Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.
Xu Z, Zhang G, Zhang X, Lei Y, Sun Y, He Y, Yang F, Nan W, Xing X, Li Y, Lin J
The international journal of biochemistry & cell biology 2023 Apr;157:106386
The international journal of biochemistry & cell biology 2023 Apr;157:106386
rFGF4 alleviates lipopolysaccharide-induced acute lung injury by inhibiting the TLR4/NF-κB signaling pathway.
Wang X, Zhou L, Ye S, Liu S, Chen L, Cheng Z, Huang Y, Wang B, Pan M, Wang D, Wang L, Lei Z, Im YJ, Li X
International immunopharmacology 2023 Apr;117:109923
International immunopharmacology 2023 Apr;117:109923
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
Zhang X, Yang X, Zhang S, Wang J, Wang M, Ma T, Wan M, Lv X, Yan T, Jia Y
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
The dichloromethane extract of Callicarpa longissima rich in diterpenoid phenols exerts anti-inflammatory effect via inhibiting the TLR4/NF-κB signaling pathway.
Li LC, Fu YX, Ning DS, Yu LL, Zou ZQ, Pan ZH
Journal of ethnopharmacology 2023 Apr 6;305:116124
Journal of ethnopharmacology 2023 Apr 6;305:116124
Astragalus polysaccharide attenuates bleomycin-induced pulmonary fibrosis by inhibiting TLR4/ NF-κB signaling pathway and regulating gut microbiota.
Wei Y, Qi M, Liu C, Li L
European journal of pharmacology 2023 Apr 5;944:175594
European journal of pharmacology 2023 Apr 5;944:175594
Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota.
Wang X, Liu D, Li D, Yan J, Yang J, Zhong X, Xu Q, Xu Y, Xia Y, Wang Q, Cao H, Zhang F
Nutrition & metabolism 2023 Apr 4;20(1):22
Nutrition & metabolism 2023 Apr 4;20(1):22
Heat-Killed Lacticaseibacillus paracasei Repairs Lipopolysaccharide-Induced Intestinal Epithelial Barrier Damage via MLCK/MLC Pathway Activation.
Xie Z, Zhang G, Liu R, Wang Y, Tsapieva AN, Zhang L, Han J
Nutrients 2023 Apr 4;15(7)
Nutrients 2023 Apr 4;15(7)
RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
Yan L, Li Y, Tan T, Qi J, Fang J, Guo H, Ren Z, Gou L, Geng Y, Cui H, Shen L, Yu S, Wang Z, Zuo Z
International journal of molecular sciences 2023 Apr 10;24(8)
International journal of molecular sciences 2023 Apr 10;24(8)
Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.
Zhang H, Zuo Y, Zhao H, Zhao H, Wang Y, Zhang X, Zhang J, Wang P, Sun L, Zhang H, Liang H
Frontiers in nutrition 2022;9:989311
Frontiers in nutrition 2022;9:989311
Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression.
Wang W, Li Y, Han G, Li A, Kong X
Frontiers in nutrition 2022;9:931427
Frontiers in nutrition 2022;9:931427
Antibiotic Therapy and Vaginal Microbiota Transplantation Reduce Endometriosis Disease Progression in Female Mice via NF-κB Signaling Pathway.
Lu F, Wei J, Zhong Y, Feng Y, Ma B, Xiong Y, Wei K, Tan B, Chen T
Frontiers in medicine 2022;9:831115
Frontiers in medicine 2022;9:831115
Maternal nucleotide supplementation improves the intestinal morphology and immune function in lipopolysaccharide-challenged newborn piglets.
Li Q, Hung I, Bai K, Wang T
Frontiers in veterinary science 2022;9:1043842
Frontiers in veterinary science 2022;9:1043842
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
Gao Y, Hu M, Niu X, Li M, Xu L, Xiao Y, Zhang J, Wang H, Li L, Chu B, Lv P
Oxidative medicine and cellular longevity 2022;2022:8652741
Oxidative medicine and cellular longevity 2022;2022:8652741
TLR4 Modulates Senescence and Paracrine Action in Placental Mesenchymal Stem Cells via Inhibiting Hedgehog Signaling Pathway in Preeclampsia.
Zhong Y, Zhang Y, Liu W, Zhao Y, Zou L, Liu X
Oxidative medicine and cellular longevity 2022;2022:7202837
Oxidative medicine and cellular longevity 2022;2022:7202837
Electroacupuncture at Zusanli Alleviates Sepsis by Regulating the TLR4-MyD88-NF-Kappa B Pathway and Diversity of Intestinal Flora.
Zhan L, Liu H, Zheng J, Meng J, Fu D, Pang L, Ji C
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6706622
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6706622
Correlation Analysis of Umbilical Cord Blood Metabolic Phenotype and Inflammation in Patients with Gestational Diabetes Mellitus Complicated with Overweight and Obesity.
Chen Q, Li W, Deng Y, Li Y, Huang L, Zhao L, Li H
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6072286
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6072286
Impact of Yiqi Huoxue Decoction on the Relationship between Remodeling of Cardiac Nerves and Macrophages after Myocardial Infarction in Rats.
Liu Y, Guo S, Zhang Y, Wang H, Wu J, Lin W, Zhang B, Chen J, Li Y, Zhang Y, Wei F, Du T
Journal of healthcare engineering 2022;2022:4441603
Journal of healthcare engineering 2022;2022:4441603
Synergistic Effect of Polydatin and Polygonatum sibiricum Polysaccharides in Combating Atherosclerosis via Suppressing TLR4-Mediated NF-κB Activation in ApoE-Deficient Mice.
Ye G, Zhao Y, Zhu J, Zhang Z, Wang Q, Jiang X, Wang Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3885153
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3885153
Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury.
Zheng X, Fan Y, Li J, Ma T, Li Y, Wang Q, Yan Y, Liu W
Oxidative medicine and cellular longevity 2022;2022:3576892
Oxidative medicine and cellular longevity 2022;2022:3576892
Jatrorrhizine Alleviates DSS-Induced Ulcerative Colitis by Regulating the Intestinal Barrier Function and Inhibiting TLR4/MyD88/NF-κB Signaling Pathway.
Niu S, Jing M, Wen J, Wei S, Li H, Li X, Ma X, Zhao Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3498310
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3498310
Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells.
Kusama K, Satoyoshi A, Azumi M, Yoshie M, Kojima J, Mizuno Y, Ono M, Nishi H, Kajihara T, Tamura K
Frontiers in endocrinology 2022;13:966455
Frontiers in endocrinology 2022;13:966455
Selenium-enriched Bifidobacterium longum DD98 effectively ameliorates dextran sulfate sodium-induced ulcerative colitis in mice.
Hu Y, Jin X, Gao F, Lin T, Zhu H, Hou X, Yin Y, Kan S, Chen D
Frontiers in microbiology 2022;13:955112
Frontiers in microbiology 2022;13:955112
Hexavalent Chromium Exposure Induces Intestinal Barrier Damage via Activation of the NF-κB Signaling Pathway and NLRP3 Inflammasome in Ducks.
Xing C, Yang F, Lin Y, Shan J, Yi X, Ali F, Zhu Y, Wang C, Zhang C, Zhuang Y, Cao H, Hu G
Frontiers in immunology 2022;13:952639
Frontiers in immunology 2022;13:952639
Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments.
Xu X, Li N, Wu Y, Yan K, Mi Y, Yi N, Tan X, Kuang G, Lu M
Frontiers in pharmacology 2022;13:951860
Frontiers in pharmacology 2022;13:951860
Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system.
Luo P, Li X, Gao Y, Chen Z, Zhang Q, Wang Z, Tian X
Frontiers in pharmacology 2022;13:904926
Frontiers in pharmacology 2022;13:904926
Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice.
Li Y, Li X, Chen X, Sun X, Liu X, Wang G, Liu Y, Cui L, Liu T, Wang W, Wang Y, Li C
Frontiers in pharmacology 2022;13:850187
Frontiers in pharmacology 2022;13:850187
AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFκB-p65 Pathway Following Intracerebral Hemorrhage.
Deng S, Chen X, Lei Q, Lu W
Frontiers in immunology 2022;13:847360
Frontiers in immunology 2022;13:847360
Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.
Lv S, Zhang Z, Su X, Li W, Wang X, Pan B, Li H, Zhang H, Wang Y
Frontiers in endocrinology 2022;13:1106875
Frontiers in endocrinology 2022;13:1106875
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Xu BL, Wang YY, Jiang LL, Liu Z, Liu DR, Zhao H, Li SL, Wang XB
Frontiers in pharmacology 2022;13:1096137
Frontiers in pharmacology 2022;13:1096137
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Yin C, Cai J, Gou Y, Li D, Tang H, Wang L, Liu H, Luo B
Frontiers in immunology 2022;13:1078880
Frontiers in immunology 2022;13:1078880
Network pharmacology-based prediction of active compounds in the Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support in vitro and in vivo.
Tang D, Wang RY, Sun KW, Wu Y, Ding L, Mo Y
Frontiers in pharmacology 2022;13:1003479
Frontiers in pharmacology 2022;13:1003479
Patchouli alcohol as a selective estrogen receptor β agonist ameliorates AD-like pathology of APP/PS1 model mice.
Yan QY, Lv JL, Shen XY, Ou-Yang XN, Yang JZ, Nie RF, Lu J, Huang YJ, Wang JY, Shen X
Acta pharmacologica Sinica 2022 Sep;43(9):2226-2241
Acta pharmacologica Sinica 2022 Sep;43(9):2226-2241
Grifola frondosa Polysaccharide Ameliorates Early Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway.
Jiang T, Shen S, Wang L, Zhao M, Li Y, Huang S
Applied biochemistry and biotechnology 2022 Sep;194(9):4093-4104
Applied biochemistry and biotechnology 2022 Sep;194(9):4093-4104
Protective effects of (R)-enantiomers but not (S)-enantiomers of β2-adrenergic receptor agonists against acute colitis: The role of β2AR.
Deng L, Wang S, Zhang R, Huang J, Lin Y, Liu X, Lu Z, Li M, Tan W
International immunopharmacology 2022 Sep;110:108997
International immunopharmacology 2022 Sep;110:108997
Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway.
Liu C, Liu Y, Wang C, Guo Y, Cheng Y, Qian H, Zhao Y
Foods (Basel, Switzerland) 2022 Sep 30;11(19)
Foods (Basel, Switzerland) 2022 Sep 30;11(19)
Investigation and modulation of interleukin-6 following subarachnoid hemorrhage: targeting inflammatory activation for cerebral vasospasm.
Lucke-Wold B, Dodd W, Motwani K, Hosaka K, Laurent D, Martinez M, Dugan V, Chalouhi N, Lucke-Wold N, Barpujari A, von Roemeling C, Li C, Johnson RD, Hoh B
Journal of neuroinflammation 2022 Sep 16;19(1):228
Journal of neuroinflammation 2022 Sep 16;19(1):228
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Ulinastatin Alleviates Rhabdomyolysis-Induced Acute Kidney Injury by Suppressing Inflammation and Apoptosis via Inhibiting TLR4/NF-κB Signaling Pathway.
Wang J, Xu G, Jin H, Chai Y, Yang X, Liu Z, Hou S, Fan H
Inflammation 2022 Oct;45(5):2052-2065
Inflammation 2022 Oct;45(5):2052-2065
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
Baogui XU, Jiawen Z, Xiaoxiao T, Falei Y, Zhongliang L, Zuisu Y, Xianjun D
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
Lipopolysaccharide reduces melanin synthesis in vitiligo melanocytes by regulating autophagy.
Sun L, Sun J, Huo X, Feng Q, Li Y, Xie X, Geng S
Experimental dermatology 2022 Oct;31(10):1579-1585
Experimental dermatology 2022 Oct;31(10):1579-1585
Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats.
Chen J, Lin X, Yao C, Bingwa LA, Wang H, Lin Z, Jin K, Zhuge Q, Yang S
CNS neuroscience & therapeutics 2022 Oct;28(10):1519-1531
CNS neuroscience & therapeutics 2022 Oct;28(10):1519-1531
Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.
Hu J, Tong Y, Shen Z, Li Y, Cheng C, Au R, Xu F, Liu Y, Zhu L, Shen H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113571
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113571
Macrophage CD36 and TLR4 Cooperation Promotes Foam Cell Formation and VSMC Migration and Proliferation Under Circadian Oscillations.
Sun Z, Yuan W, Li L, Cai H, Mao X, Zhang L, Zang G, Wang Z
Journal of cardiovascular translational research 2022 Oct;15(5):985-997
Journal of cardiovascular translational research 2022 Oct;15(5):985-997
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro.
Wang N, Kong R, Han W, Bao W, Shi Y, Ye L, Lu J
International immunopharmacology 2022 Oct;111:109058
International immunopharmacology 2022 Oct;111:109058
Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes.
Yuan X, Wang R, Han B, Sun C, Chen R, Wei H, Chen L, Du H, Li G, Yang Y, Chen X, Cui L, Xu Z, Fu J, Wu J, Gu W, Chen Z, Fang X, Yang H, Su Z, Wu J, Li Q, Zhang M, Zhou Y, Zhang L, Ji G, Luo F
Nature communications 2022 Oct 26;13(1):6356
Nature communications 2022 Oct 26;13(1):6356
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Zhan L, Zheng J, Meng J, Fu D, Pang L, Ji C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113778
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113778
Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression.
Zhou X, Li X, Yi K, Liang C, Geng S, Zhu J, Xie C, Zhong C
Bioorganic chemistry 2022 Nov;128:106034
Bioorganic chemistry 2022 Nov;128:106034
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
Liang P, Wang L, Yang S, Pan X, Li J, Zhang Y, Liang Y, Li J, Zhou B
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides.
Li L, Yang S, Chen D, Wu Z, Zhang M, Yang F, Qin L, Zhou X
Molecules (Basel, Switzerland) 2022 Nov 29;27(23)
Molecules (Basel, Switzerland) 2022 Nov 29;27(23)
Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation.
Zhan H, Pu Q, Long X, Lu W, Wang G, Meng F, Liao Z, Lan X, Chen M
Antioxidants (Basel, Switzerland) 2022 Nov 22;11(12)
Antioxidants (Basel, Switzerland) 2022 Nov 22;11(12)
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
Purandare N, Kunji Y, Xi Y, Romero R, Gomez-Lopez N, Fribley A, Grossman LI, Aras S
iScience 2022 Nov 18;25(11):105342
iScience 2022 Nov 18;25(11):105342
Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway.
Zhou P, Lai J, Li Y, Deng J, Zhao C, Huang Q, Yang F, Yang S, Wu Y, Tang X, Huang F, Wang L, Huang X, Zou W, Wu J
International journal of molecular sciences 2022 Nov 14;23(22)
International journal of molecular sciences 2022 Nov 14;23(22)
6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling.
Chen WF, Shih YH, Liu HC, Cheng CI, Chang CI, Chen CY, Lin IP, Lin MY, Lee CH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154025
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154025
Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis.
Li Y, Zhang H, Chen C, Qiao K, Li Z, Han J, Han X, Li K, Lai K, Liu N, Li A, Xiao N, Zhang Y, Zhao X, Gao W, Zhang Y, Liu H, Sun T
Advanced materials (Deerfield Beach, Fla.) 2022 May;34(19):e2108476
Advanced materials (Deerfield Beach, Fla.) 2022 May;34(19):e2108476
Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation.
Duan X, Wen J, Zhang M, Wang C, Xiang Y, Wang L, Yu C, Deng G, Yan M, Zhang B, Fang P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112884
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112884
RNase 7 Inhibits Uropathogenic Escherichia coli-Induced Inflammation in Bladder Cells under a High-Glucose Environment by Regulating the JAK/STAT Signaling Pathway.
Ho CH, Liao PW, Fan CK, Liu SP, Cheng PC
International journal of molecular sciences 2022 May 5;23(9)
International journal of molecular sciences 2022 May 5;23(9)
Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice.
Mavlyutov TA, Myrah JJ, Chauhan AK, Liu Y, McDowell CM
Cell & bioscience 2022 May 26;12(1):72
Cell & bioscience 2022 May 26;12(1):72
Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study.
Ren X, Xing Y, He L, Xiu Z, Yang L, Han A, Jia Q, Dong Y
Journal of ethnopharmacology 2022 May 10;289:115029
Journal of ethnopharmacology 2022 May 10;289:115029
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
Xiong T, Zheng X, Zhang K, Wu H, Dong Y, Zhou F, Cheng B, Li L, Xu W, Su J, Huang J, Jiang Z, Li B, Zhang B, Lv G, Chen S
Journal of ethnopharmacology 2022 May 10;289:115001
Journal of ethnopharmacology 2022 May 10;289:115001
Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro.
Mao J, Zhan H, Meng F, Wang G, Huang D, Liao Z, Chen M
Phytotherapy research : PTR 2022 Mar;36(3):1268-1283
Phytotherapy research : PTR 2022 Mar;36(3):1268-1283
Chronic intermittent hypoxia induces the pyroptosis of renal tubular epithelial cells by activating the NLRP3 inflammasome.
Bai C, Zhu Y, Dong Q, Zhang Y
Bioengineered 2022 Mar;13(3):7528-7540
Bioengineered 2022 Mar;13(3):7528-7540
Toll-like receptors 2 and 4 differentially regulate the self-renewal and differentiation of spinal cord neural precursor cells.
Sanchez-Petidier M, Guerri C, Moreno-Manzano V
Stem cell research & therapy 2022 Mar 21;13(1):117
Stem cell research & therapy 2022 Mar 21;13(1):117
Small extracellular vesicles from hypoxic mesenchymal stem cells alleviate intervertebral disc degeneration by delivering miR-17-5p.
Zhou ZM, Bao JP, Peng X, Gao JW, Vlf C, Zhang C, Sun R, Kun-Wang, Wu XT
Acta biomaterialia 2022 Mar 1;140:641-658
Acta biomaterialia 2022 Mar 1;140:641-658
Treadmill training improves respiratory function in rats after spinal cord injury by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway.
Tang D, Wang X, Chen Y, Yang X, Hu S, Song N, Wang J, Cheng J, Wu S
Neuroscience letters 2022 Jun 21;782:136686
Neuroscience letters 2022 Jun 21;782:136686
Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury.
Zheng X, Mi T, Wang R, Zhang Z, Li W, Zhao J, Yang P, Xia H, Mao Q
Glia 2022 Jul;70(7):1317-1336
Glia 2022 Jul;70(7):1317-1336
TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy.
Tian W, Liu SY, Zhang M, Meng JR, Tang N, Feng YD, Sun Y, Gao YY, Zhou L, Cao W, Li XQ
Pharmacological research 2022 Jul;181:106262
Pharmacological research 2022 Jul;181:106262
Preconditioning with procyanidin B2 protects MAC-T cells against heat exposure-induced mitochondrial dysfunction and inflammation.
Wang H, Hao W, Yang L, Yan P, Wei S
Molecular immunology 2022 Jul;147:126-135
Molecular immunology 2022 Jul;147:126-135
Effects of Artemisinin on Escherichia coli-Induced Mastitis in Bovine Mammary Epithelial Cells and Mice.
Li Z, Hu J, Wang X, Du Y, Yin J, Gao J, Han B, Cui S, Liu Y, Liu J
Veterinary sciences 2022 Jul 26;9(8)
Veterinary sciences 2022 Jul 26;9(8)
Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
Li X, Chu L, Liu S, Zhang W, Lin L, Zheng G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153728
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153728
Voluntary alcohol binge-drinking in adolescent C57Bl6 mice induces delayed appearance of behavioural defects in both males and females.
Van Hees L, Didone V, Charlet-Briart M, Van Ingelgom T, Alexandre A, Quertemont E, Nguyen L, Laguesse S
Addiction biology 2022 Jan;27(1):e13102
Addiction biology 2022 Jan;27(1):e13102
Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ(1) signaling pathway in diabetic atherosclerosis.
Zhao L, Li Y, Xu T, Lv Q, Bi X, Liu X, Fu G, Zou Y, Ge J, Chen Z, Zhang W
Molecular medicine (Cambridge, Mass.) 2022 Jan 21;28(1):4
Molecular medicine (Cambridge, Mass.) 2022 Jan 21;28(1):4
2-PMAP Ameliorates Cerebral Vasospasm and Brain Injury after Subarachnoid Hemorrhage by Regulating Neuro-Inflammation in Rats.
Wu CH, Tsai HP, Su YF, Tsai CY, Lu YY, Lin CL
Cells 2022 Jan 12;11(2)
Cells 2022 Jan 12;11(2)
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.
Hu Z, Xiao M, Cai H, Li W, Fang W, Long X
Journal of cellular and molecular medicine 2022 Feb;26(3):925-936
Journal of cellular and molecular medicine 2022 Feb;26(3):925-936
KDM2B overexpression prevents myocardial ischemia-reperfusion injury in rats through regulating inflammatory response via the TLR4/NF-κB p65 axis.
Wei Z, Luo L, Hu S, Tian R, Liu Z
Experimental and therapeutic medicine 2022 Feb;23(2):154
Experimental and therapeutic medicine 2022 Feb;23(2):154
The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling pathway in newborn calf.
Feng R, Adeniran SO, Huang F, Li Y, Ma M, Zheng P, Zhang G
Theriogenology 2022 Feb;179:103-116
Theriogenology 2022 Feb;179:103-116
Preventive effect of sanguinarine on intestinal injury in mice exposed to whole abdominal irradiation.
Gu J, Zhao L, Chen YZ, Guo YX, Sun Y, Guo Q, Duan GX, Li C, Tang ZB, Zhang ZX, Qin LQ, Xu JY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112496
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112496
TLR4-Myd88 pathway upregulated caveolin-1 expression contributes to coronary artery spasm.
Zhao X, Tian J, Liu Y, Ye Z, Xu M, Huang R, Song X
Vascular pharmacology 2022 Feb;142:106947
Vascular pharmacology 2022 Feb;142:106947
Pharmacological inhibition of TLR4-NF-κB signaling by TAK-242 attenuates hydrocephalus after intraventricular hemorrhage.
Lin T, Ding L, Lin Y, Liu C, Wang C, Wu D, Li Z, Li M, Sun J
International immunopharmacology 2022 Feb;103:108486
International immunopharmacology 2022 Feb;103:108486
Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome.
Wang Q, Wang C, Abdullah, Tian W, Qiu Z, Song M, Cao Y, Xiao J
Journal of agricultural and food chemistry 2022 Feb 23;70(7):2241-2252
Journal of agricultural and food chemistry 2022 Feb 23;70(7):2241-2252
Neuroprotection of chicoric acid in a mouse model of Parkinson's disease involves gut microbiota and TLR4 signaling pathway.
Wang N, Feng BN, Hu B, Cheng YL, Guo YH, Qian H
Food & function 2022 Feb 21;13(4):2019-2032
Food & function 2022 Feb 21;13(4):2019-2032
Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6 expression in Sprague-Dawley rats.
Li J, Wang L, Zeng G, Li H, Luo J, Tian Q, Zhang Z
Immunopharmacology and immunotoxicology 2022 Dec;44(6):959-969
Immunopharmacology and immunotoxicology 2022 Dec;44(6):959-969
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway.
Cai Q, Sun Z, Xu S, Jiao X, Guo S, Li Y, Wu H, Yu X
Renal failure 2022 Dec;44(1):1169-1181
Renal failure 2022 Dec;44(1):1169-1181
1,25(OH)(2)D(3) alleviates LPS-induced preeclampsia-like rats impairment in the protective effect by TLR4/NF-kB pathway.
Ma Y, Yang Y, Lv M, Zhang Y, He Q, Zhang Y, Su H, Deng X, Qian Y
Placenta 2022 Dec;130:34-41
Placenta 2022 Dec;130:34-41
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
Zhang M, Zhang J, Wang C, Yan JK, Yi J, Ning J, Huo XK, Yu ZL, Zhang BJ, Sun CP, Ma XC
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Xia X, Lin H, Luo F, Wu X, Zhu L, Chen S, Luo H, Ye F, Peng X, Zhang Y, Yang G, Lin Q
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-κB signaling pathway in diabetic rats.
Li J, Liu X, Wu Y, Ji W, Tian Q, Li S
Biochemical and biophysical research communications 2022 Dec 17;634:75-82
Biochemical and biophysical research communications 2022 Dec 17;634:75-82
Antimicrobial Peptide LCN2 Inhibited Uropathogenic Escherichia coli Infection in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway.
Chen PC, Ho CH, Fan CK, Liu SP, Cheng PC
International journal of molecular sciences 2022 Dec 12;23(24)
International journal of molecular sciences 2022 Dec 12;23(24)
Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.
Tu Y, Yang Y, Wang Y, Wu N, Tao J, Yang G, You M
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120217
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120217
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Sha X, Dai Y, Chong L, Wei M, Xing M, Zhang C, Li J
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice.
Yuan Q, Wu Y, Wang G, Zhou X, Dong X, Lou Z, Li S, Wang D
Metabolic brain disease 2022 Aug;37(6):2039-2052
Metabolic brain disease 2022 Aug;37(6):2039-2052
miR-30e-5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4.
Song H, Xu N, Jin S
Experimental and therapeutic medicine 2022 Aug;24(2):492
Experimental and therapeutic medicine 2022 Aug;24(2):492
Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway.
Ding Q, Chen K, Liu X, Ding C, Zhao Y, Sun S, Zhang Y, Zhang J, Liu S, Liu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113242
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113242
N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.
Huang L, Gong L, Huo X, Lei L, Zhang Q, Hu Y, Kuang Q, Gui Y, Dai Y, Gu Y, Deng Y, Wang D, Guo D
Acta biochimica et biophysica Sinica 2022 Aug 25;55(1):23-33
Acta biochimica et biophysica Sinica 2022 Aug 25;55(1):23-33
San-Wu-Huang-Qin decoction attenuates tumorigenesis and mucosal barrier impairment in the AOM/DSS model by targeting gut microbiome.
Zhou Y, Feng Y, Cen R, Hou X, Yu H, Sun J, Zhou L, Ji Q, Zhao L, Wang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153966
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153966
EB1089 promotes the expression of vitamin D receptor in the intestinal epithelial cell line HT-29 and reduces lipopolysaccharide-induced inflammatory response.
Lu D, Yu M, Chen L, Ye J, Huang L, Zhu G, Lan B
Annals of translational medicine 2022 Apr;10(8):476
Annals of translational medicine 2022 Apr;10(8):476
Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model.
Yao H, Guo W, Suo L, Li G, Wang Y, Chen Y, Sun Y, Ding R
Behavioural brain research 2022 Apr 29;424:113813
Behavioural brain research 2022 Apr 29;424:113813
Critical Role of TLR4 on the Microglia Activation Induced by Maternal LPS Exposure Leading to ASD-Like Behavior of Offspring.
Xiao L, Yan J, Feng D, Ye S, Yang T, Wei H, Li T, Sun W, Chen J
Frontiers in cell and developmental biology 2021;9:634837
Frontiers in cell and developmental biology 2021;9:634837
BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury.
Dong W, Zhu Y, Zhang Y, Fan Z, Zhang Z, Fan X, Xu Y
Frontiers in cell and developmental biology 2021;9:617073
Frontiers in cell and developmental biology 2021;9:617073
Maslinic Acid Attenuates Ischemia/Reperfusion Injury-Induced Myocardial Inflammation and Apoptosis by Regulating HMGB1-TLR4 Axis.
Li Q, Xu M, Li Z, Li T, Wang Y, Chen Q, Wang Y, Feng J, Yin X, Lu C
Frontiers in cardiovascular medicine 2021;8:768947
Frontiers in cardiovascular medicine 2021;8:768947
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
Xu J, Zhan T, Zheng W, Huang YK, Chen K, Zhang XH, Ren P, Huang X
Acta cirurgica brasileira 2021;35(12):e351202
Acta cirurgica brasileira 2021;35(12):e351202
Bu-Zhong-Yi-Qi Granule Enhances Colonic Tight Junction Integrity via TLR4/NF-κB/MLCK Signaling Pathway in Ulcerative Colitis Rats.
Kang X, Jia M, Zhao L, Zhang S
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6657141
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6657141
DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway.
Zhang B, Lian W, Zhao J, Wang Z, Liu A, Du G
Oxidative medicine and cellular longevity 2021;2021:6521146
Oxidative medicine and cellular longevity 2021;2021:6521146
Isoquercetin Improves Inflammatory Response in Rats Following Ischemic Stroke.
Shi Y, Chen X, Liu J, Fan X, Jin Y, Gu J, Liang J, Liang X, Wang C
Frontiers in neuroscience 2021;15:555543
Frontiers in neuroscience 2021;15:555543
Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation.
Rahman SU, Gong H, Mi R, Huang Y, Han X, Chen Z
Frontiers in immunology 2021;12:784683
Frontiers in immunology 2021;12:784683
Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.
Xu Y, Xie L, Tang J, He X, Zhang Z, Chen Y, Zhou J, Gan B, Peng W
Frontiers in microbiology 2021;12:742033
Frontiers in microbiology 2021;12:742033
Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1.
Shi A, Li T, Zheng Y, Song Y, Wang H, Wang N, Dong L, Shi H
Frontiers in pharmacology 2021;12:693048
Frontiers in pharmacology 2021;12:693048
Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways.
Li X, Zou Y, Fu YY, Xing J, Wang KY, Wan PZ, Wang M, Zhai XY
Frontiers in pharmacology 2021;12:650283
Frontiers in pharmacology 2021;12:650283
Introduction of Colonic and Fecal Microbiota From an Adult Pig Differently Affects the Growth, Gut Health, Intestinal Microbiota and Blood Metabolome of Newborn Piglets.
Qi R, Zhang Z, Wang J, Qiu X, Wang Q, Yang F, Huang J, Liu Z
Frontiers in microbiology 2021;12:623673
Frontiers in microbiology 2021;12:623673
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway.
Xie X, Zhao J, Gao W, Chen J, Hu B, Cai X, Zheng Y
Theranostics 2021;11(7):3213-3228
Theranostics 2021;11(7):3213-3228
Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.
Yu H, Bai Y, Qiu J, He X, Xiong J, Dai Q, Wang X, Li Y, Sheng H, Xin R, Jiang L, Li Q, Li D, Zhang H, Zhang L, Chen Q, Peng J, Hu X, Zhang K
Frontiers in oncology 2021;11:736882
Frontiers in oncology 2021;11:736882
Hypothermic oxygenated perfusion with defatting cocktail further improves steatotic liver grafts in a transplantation rat model.
Lin F, Zhen F, Yan X, Shaojun Y, Guizhu P, Yanfeng W, Qifa Y
Artificial organs 2021 Sep;45(9):E304-E316
Artificial organs 2021 Sep;45(9):E304-E316
Effects of different intensities of continuous training on vascular inflammation and oxidative stress in spontaneously hypertensive rats.
Luo M, Cao C, Niebauer J, Yan J, Ma X, Chang Q, Zhang T, Huang X, Liu G
Journal of cellular and molecular medicine 2021 Sep;25(17):8522-8536
Journal of cellular and molecular medicine 2021 Sep;25(17):8522-8536
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Hu S, Li S, Liu Y, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R
Cellular signalling 2021 Oct;86:110084
Cellular signalling 2021 Oct;86:110084
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Qiu C, Wang M, Yu W, Rong Z, Zheng HS, Sun T, Liu SB, Zhao MG, Wu YM
Molecular neurobiology 2021 Oct;58(10):5272-5288
Molecular neurobiology 2021 Oct;58(10):5272-5288
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653
Chemico-biological interactions 2021 Oct 1;348:109653
Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein.
Zhong Z, Chen W, Gao H, Che N, Xu M, Yang L, Zhang Y, Ye M
Neurochemical research 2021 Nov;46(11):3050-3058
Neurochemical research 2021 Nov;46(11):3050-3058
MiR-214-3p plays a protective role in diabetic neuropathic rats by regulating Nav1.3 and TLR4.
Pang B, Qiao L, Wang S, Guo X, Xie Y, Han L
Cell biology international 2021 Nov;45(11):2294-2303
Cell biology international 2021 Nov;45(11):2294-2303
MicroRNA Bta-miR-24-3p Suppressed Galectin-9 Expression through TLR4/NF-ĸB Signaling Pathway in LPS-Stimulated Bovine Endometrial Epithelial Cells.
Oladejo AO, Li Y, Shen W, Imam BH, Wu X, Yang J, Ma X, Lv Y, Jiang W, Ding X, Wang S, Yan Z
Cells 2021 Nov 25;10(12)
Cells 2021 Nov 25;10(12)
Insulin Downregulated the Infection of Uropathogenic Escherichia coli (UPEC) in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway.
Ho CH, Liu SP, Fan CK, Tzou KY, Wu CC, Cheng PC
Microorganisms 2021 Nov 24;9(12)
Microorganisms 2021 Nov 24;9(12)
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Kong L, Ma Y, Wang Z, Liu N, Ma G, Liu C, Shi R, Du G
International immunopharmacology 2021 May;94:107507
International immunopharmacology 2021 May;94:107507
Protective effect of Apelin/APJ system on lipopolysaccharide-related cardiac dysfunction.
Hu J, Huo S, Dou S, Jiang W, Li Y
General physiology and biophysics 2021 May;40(3):161-171
General physiology and biophysics 2021 May;40(3):161-171
The role of TLR4/MyD88/NF-κB pathway in periodontitis-induced liver inflammation of rats.
Yue Y, Liu X, Li Y, Xia B, Yu W
Oral diseases 2021 May;27(4):1012-1021
Oral diseases 2021 May;27(4):1012-1021
Preventive electroacupuncture ameliorates D-galactose-induced Alzheimer's disease-like inflammation and memory deficits, probably via modulating the microbiota-gut-brain axis.
He C, Huang ZS, Yu CC, Wang XS, Jiang T, Wu M, Kong LH
Iranian journal of basic medical sciences 2021 Mar;24(3):341-348
Iranian journal of basic medical sciences 2021 Mar;24(3):341-348
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Zheng S, Cao P, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X
Food & function 2021 Mar 15;12(5):2323-2334
Food & function 2021 Mar 15;12(5):2323-2334
Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.
Huang X, Shen H, Liu Y, Qiu S, Guo Y
International immunopharmacology 2021 Jun;95:107505
International immunopharmacology 2021 Jun;95:107505
Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration.
Tsubokawa D, Kikuchi T, Lee JM, Kusakabe T, Yamamoto Y, Maruyama H
PLoS pathogens 2021 Jun;17(6):e1009649
PLoS pathogens 2021 Jun;17(6):e1009649
Dietary Ursolic Acid Prevents Alcohol-Induced Liver Injury via Gut-Liver Axis Homeostasis Modulation: The Key Role of Microbiome Manipulation.
Yan X, Ren X, Liu X, Wang Y, Ma J, Song R, Wang X, Dong Y, Fan Q, Wei J, Yu A, She G
Journal of agricultural and food chemistry 2021 Jun 30;69(25):7074-7083
Journal of agricultural and food chemistry 2021 Jun 30;69(25):7074-7083
Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.
Zhao J, Wan S, Sun N, Sun P, Sun Y, Khan A, Guo J, Zheng X, Fan K, Yin W, Li H
Veterinary research 2021 Jun 23;52(1):93
Veterinary research 2021 Jun 23;52(1):93
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.
Geng J, Shi Y, Zhang J, Yang B, Wang P, Yuan W, Zhao H, Li J, Qin F, Hong L, Xie C, Deng X, Sun Y, Wu C, Chen L, Zhou D
Nature communications 2021 Jun 10;12(1):3519
Nature communications 2021 Jun 10;12(1):3519
The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation.
Shao C, Yang X, Jing Y, Hou X, Huang Y, Zong C, Gao L, Liu W, Jiang J, Ye F, Shi J, Zhao Q, Li R, Zhang X, Wei L
Stem cell research & therapy 2021 Jun 10;12(1):342
Stem cell research & therapy 2021 Jun 10;12(1):342
Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.
Liu N, Liu C, Yang Y, Ma G, Wei G, Liu S, Kong L, Du G
Pharmacological research 2021 Jul;169:105650
Pharmacological research 2021 Jul;169:105650
Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.
Fang M, Wan W, Li Q, Wan W, Long Y, Liu H, Yang X
Life sciences 2021 Jul 15;277:119567
Life sciences 2021 Jul 15;277:119567
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
Xu N, Zhang C, Jing L, Mou S, Cao X, Yu Z
International immunopharmacology 2021 Jan;90:107136
International immunopharmacology 2021 Jan;90:107136
NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines.
Wang X, Yin Z, Cao P, Zheng S, Chen Y, Yu M, Liao C, Zhang Z, Duan Y, Han J, Zhang S, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110964
Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice.
Chen YZ, Li C, Gu J, Lv SC, Song JY, Tang ZB, Duan GX, Qin LQ, Zhao L, Xu JY
Dose-response : a publication of International Hormesis Society 2021 Jan-Mar;19(1):15593258211003798
Dose-response : a publication of International Hormesis Society 2021 Jan-Mar;19(1):15593258211003798
Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR signaling pathway in mice.
Peng KY, Gu JF, Su SL, Zhu Y, Guo JM, Qian DW, Duan JA
Journal of ethnopharmacology 2021 Jan 10;264:113052
Journal of ethnopharmacology 2021 Jan 10;264:113052
A combination of lycopene and human amniotic epithelial cells can ameliorate cognitive deficits and suppress neuroinflammatory signaling by choroid plexus in Alzheimer's disease rat.
Xu Z, Liu C, Wang R, Gao X, Hao C, Liu C
The Journal of nutritional biochemistry 2021 Feb;88:108558
The Journal of nutritional biochemistry 2021 Feb;88:108558
Cattle Encephalon Glycoside and Ignotin Protects Neurons Against Microglia-Induced Neuroinflammation via Elevating BDNF Expression and Inhibiting TLR4/NF-κB Pathway.
Gao Y, Zhang J, Li S, Zhang Y, Zhao Y, Chang C, Qiu Y, Yang G
Neurochemical research 2021 Feb;46(2):326-336
Neurochemical research 2021 Feb;46(2):326-336
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Qiu C, Yang LD, Yu W, Tian DD, Gao MR, Wang WJ, Li XB, Wu YM, Wang M
Metabolic brain disease 2021 Feb;36(2):273-283
Metabolic brain disease 2021 Feb;36(2):273-283
Downregulating lncRNA PRNCR1 ameliorates LPS-induced pulmonary vascular endothelial cell injury by modulating miR-330-5p/TLR4 axis.
Yu Y, Sun H, Zhu L, Ji L, Liu H
Journal of biochemical and molecular toxicology 2021 Feb;35(2):e22644
Journal of biochemical and molecular toxicology 2021 Feb;35(2):e22644
Protection Mechanisms Underlying Oral Administration of Chlorogenic Acid against Cadmium-Induced Hepatorenal Injury Related to Regulating Intestinal Flora Balance.
Ding Y, Li X, Liu Y, Wang S, Cheng D
Journal of agricultural and food chemistry 2021 Feb 10;69(5):1675-1683
Journal of agricultural and food chemistry 2021 Feb 10;69(5):1675-1683
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Lu C, Liu L, Chen S, Niu J, Li S, Xie W, Cheng X
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
Liu W, Fan Y, Ding H, Han D, Yan Y, Wu R, Lv Y, Zheng X
Journal of cellular and molecular medicine 2021 Dec;25(24):11310-11321
Journal of cellular and molecular medicine 2021 Dec;25(24):11310-11321
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion.
Liu DD, Luo P, Gu L, Zhang Q, Gao P, Zhu Y, Chen X, Guo Q, Zhang J, Ma N, Wang J
Journal of neuroinflammation 2021 Aug 9;18(1):174
Journal of neuroinflammation 2021 Aug 9;18(1):174
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.
Xia Y, Zhang G, Kou L, Yin S, Han C, Hu J, Wan F, Sun Y, Wu J, Li Y, Huang J, Xiong N, Zhang Z, Wang T
Brain : a journal of neurology 2021 Aug 17;144(7):2024-2037
Brain : a journal of neurology 2021 Aug 17;144(7):2024-2037
Enhanced uropathogenic Escherichia coli-induced infection in uroepithelial cells by sugar through TLR-4 and JAK/STAT1 signaling pathways.
Ho CH, Fan CK, Wu CC, Yu HJ, Liu HT, Chen KC, Liu SP, Cheng PC
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Apr;54(2):193-205
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Apr;54(2):193-205
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885
Food & function 2021 Apr 7;12(7):2874-2885
CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
Yin W, Li Y, Song Y, Zhang J, Wu C, Chen Y, Miao Y, Lin C, Lin Y, Yan D, Chen J, He R
Proceedings of the National Academy of Sciences of the United States of America 2021 Apr 20;118(16)
Proceedings of the National Academy of Sciences of the United States of America 2021 Apr 20;118(16)
Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways.
Zhou J, Zhang X, Wan L, Yu J, Li T, Lu Z, Fang N, Sun L, Ye F
Medical science monitor : international medical journal of experimental and clinical research 2021 Apr 14;27:e929438
Medical science monitor : international medical journal of experimental and clinical research 2021 Apr 14;27:e929438
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Sun Z, Nyanzu M, Yang S, Zhu X, Wang K, Ru J, Yu E, Zhang H, Wang Z, Shen J, Zhuge Q, Huang L
Oxidative medicine and cellular longevity 2020;2020:7879629
Oxidative medicine and cellular longevity 2020;2020:7879629
Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells.
Zheng P, Tian X, Zhang W, Yang Z, Zhou J, Zheng J, Cui H, Tang T, Luo J, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7210627
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7210627
Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats.
Wang P, Zhao M, Chen Z, Wu G, Fujino M, Zhang C, Zhou W, Zhao M, Hirano SI, Li XK, Zhao L
Oxidative medicine and cellular longevity 2020;2020:6978784
Oxidative medicine and cellular longevity 2020;2020:6978784
Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway.
Chen Y, Feng B, Yuan Y, Hu J, Zhao W, Jiang H, Li W, Fan Z, Du Z
Mediators of inflammation 2020;2020:6318520
Mediators of inflammation 2020;2020:6318520
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Gao W, Feng Z, Zhang S, Wu B, Geng X, Fan G, Duan Y, Li K, Liu K, Peng C
BioMed research international 2020;2020:1860637
BioMed research international 2020;2020:1860637
miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κB/Inflammatory Signaling Pathway.
Xie B, Lu C, Chen C, Zhou J, Deng Z
Mediators of inflammation 2020;2020:1231243
Mediators of inflammation 2020;2020:1231243
Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway.
Zhang B, Zhong Q, Chen X, Wu X, Sha R, Song G, Zhang C, Chen X
Frontiers in neuroscience 2020;14:847
Frontiers in neuroscience 2020;14:847
Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway.
Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J, Li M
Drug design, development and therapy 2020;14:4901-4913
Drug design, development and therapy 2020;14:4901-4913
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Lin L, Wang D, Qu S, Zhao H, Lin Y
Drug design, development and therapy 2020;14:1127-1141
Drug design, development and therapy 2020;14:1127-1141
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Gan P, Ding L, Hang G, Xia Q, Huang Z, Ye X, Qian X
Frontiers in pharmacology 2020;11:776
Frontiers in pharmacology 2020;11:776
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy.
Wei A, Xiao H, Xu G, Yu X, Guo J, Jing Z, Shi S, Song Y
Frontiers in pharmacology 2020;11:762
Frontiers in pharmacology 2020;11:762
Astragaloside IV Improves High-Fat Diet-Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway.
Liu YL, Zhang QZ, Wang YR, Fu LN, Han JS, Zhang J, Wang BM
Frontiers in pharmacology 2020;11:605064
Frontiers in pharmacology 2020;11:605064
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124
Frontiers in pharmacology 2020;11:544124
Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways.
Jiang H, Zeng L, Dong X, Guo S, Xing J, Li Z, Liu R
Frontiers in pharmacology 2020;11:205
Frontiers in pharmacology 2020;11:205
Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo.
Li Y, Wang Y, Chen Y, Wang Y, Zhang S, Liu P, Chen Z, Song P, Luo L, Luo Y, Dang Y, Zhao L
Frontiers in immunology 2020;11:1611
Frontiers in immunology 2020;11:1611
Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages.
Zhuang C, Liu G, Barkema HW, Zhou M, Xu S, Ur Rahman S, Liu Y, Kastelic JP, Gao J, Han B
Frontiers in microbiology 2020;11:1461
Frontiers in microbiology 2020;11:1461
DHZCP Modulates Microglial M1/M2 Polarization via the p38 and TLR4/NF-κB Signaling Pathways in LPS-Stimulated Microglial Cells.
Zhou L, Wang D, Qiu X, Zhang W, Gong Z, Wang Y, Xu X
Frontiers in pharmacology 2020;11:1126
Frontiers in pharmacology 2020;11:1126
Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota.
Li X, Liu Y, Wang Y, Li X, Liu X, Guo M, Tan Y, Qin X, Wang X, Jiang M
Frontiers in oncology 2020;10:710
Frontiers in oncology 2020;10:710
Splenectomy enhances the Ly6C(low) phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
Zheng Z, Wang H, Li L, Zhang S, Zhang C, Zhang H, Ji F, Liu X, Zhu K, Kong G, Li Z
International immunopharmacology 2020 Sep;86:106762
International immunopharmacology 2020 Sep;86:106762
Danshen (Salvia miltiorrhiza) restricts MD2/TLR4-MyD88 complex formation and signalling in acute myocardial infarction-induced heart failure.
Wang X, Guo D, Li W, Zhang Q, Jiang Y, Wang Q, Li C, Qiu Q, Wang Y
Journal of cellular and molecular medicine 2020 Sep;24(18):10677-10692
Journal of cellular and molecular medicine 2020 Sep;24(18):10677-10692
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385
Molecular medicine reports 2020 Sep;22(3):2373-2385
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
Guan L, Li C, Zhang Y, Gong J, Wang G, Tian P, Shen N
Life sciences 2020 Sep 1;256:117935
Life sciences 2020 Sep 1;256:117935
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Liu X, Cai HX, Cao PY, Feng Y, Jiang HH, Liu L, Ke J, Long X
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Zhang H, Lang W, Wang S, Li B, Li G, Shi Q
International immunopharmacology 2020 Nov;88:106974
International immunopharmacology 2020 Nov;88:106974
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Wang G, Zuo T, Li R
Drug development research 2020 Nov;81(7):859-866
Drug development research 2020 Nov;81(7):859-866
Mechanisms of the lipopolysaccharide-induced inflammatory response in alveolar epithelial cell/macrophage co-culture.
Li J, Qin Y, Chen Y, Zhao P, Liu X, Dong H, Zheng W, Feng S, Mao X, Li C
Experimental and therapeutic medicine 2020 Nov;20(5):76
Experimental and therapeutic medicine 2020 Nov;20(5):76
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Wang X, Zhou J, Yang J, Wang S, Yang L
Experimental and therapeutic medicine 2020 Nov;20(5):115
Experimental and therapeutic medicine 2020 Nov;20(5):115
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice.
Wang D, Weng Y, Zhang Y, Wang R, Wang T, Zhou J, Shen S, Wang H, Wang Y
The Science of the total environment 2020 Nov 25;745:141049
The Science of the total environment 2020 Nov 25;745:141049
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
Leng Y, Chen R, Chen R, He S, Shi X, Zhou X, Zhang Z, Chen AF
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646
Hypoglycemic Effect of Ginsenoside Rg5 Mediated Partly by Modulating Gut Microbiota Dysbiosis in Diabetic db/db Mice.
Wei Y, Yang H, Zhu C, Deng J, Fan D
Journal of agricultural and food chemistry 2020 May 6;68(18):5107-5117
Journal of agricultural and food chemistry 2020 May 6;68(18):5107-5117
Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways.
Gao L, Qian B, Chen H, Wang A, Li Q, Li J, Tan P, Xia X, Du Y, Fu W
Life sciences 2020 May 15;249:117517
Life sciences 2020 May 15;249:117517
Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects.
Liu Y, Liang X, Zou Y, Peng Y, McClements DJ, Hu K
Food & function 2020 May 1;11(5):4014-4025
Food & function 2020 May 1;11(5):4014-4025
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway.
Qu Z, Chen Y, Luo ZH, Shen XL, Hu YJ
The Journal of pharmacy and pharmacology 2020 Mar;72(3):385-395
The Journal of pharmacy and pharmacology 2020 Mar;72(3):385-395
HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats.
Wen S, Li X, Ling Y, Chen S, Deng Q, Yang L, Li Y, Shen J, Qiu Y, Zhan Y, Lai H, Zhang X, Ke Z, Huang W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4384-4402
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4384-4402
A Comparison of Splenic Pathologic Change and Immune Function in HBV-Related Portal Hypertension and Chinese Budd-Chiari Syndrome Patients with Hypersplenism.
Li S, Huang N, Dang X, Li L, Li Z, Zhang C, Jiang A, Kong G, Ji F, Yang J, Li Z
Viral immunology 2020 Mar;33(2):112-121
Viral immunology 2020 Mar;33(2):112-121
Upregulation of microRNA-204 improves insulin resistance of polycystic ovarian syndrome via inhibition of HMGB1 and the inactivation of the TLR4/NF-κB pathway.
Jiang B, Xue M, Xu D, Song Y, Zhu S
Cell cycle (Georgetown, Tex.) 2020 Mar;19(6):697-710
Cell cycle (Georgetown, Tex.) 2020 Mar;19(6):697-710
The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis.
Lin M, Huang J, Chen WC, Fan ZN, Qin X
Iranian journal of immunology : IJI 2020 Mar;17(1):52-63
Iranian journal of immunology : IJI 2020 Mar;17(1):52-63
The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis.
Zhang P, Yi L, Qu S, Dai J, Li X, Liu B, Li H, Ai K, Zheng P, Qiu S, Li Y, Wang Y, Xiang X, Chai X, Dong Z, Zhang D
Molecular therapy. Nucleic acids 2020 Mar 6;19:1027-1042
Molecular therapy. Nucleic acids 2020 Mar 6;19:1027-1042
Jiao-tai-wan inhibits inflammation of the gut-brain-axis and attenuates cognitive impairment in insomnic rats.
Su H, Zhang C, Zou X, Lu F, Zeng Y, Guan H, Ren Y, Yuan F, Xu L, Zhang M, Dong H
Journal of ethnopharmacology 2020 Mar 25;250:112478
Journal of ethnopharmacology 2020 Mar 25;250:112478
Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway.
Ma L, Sun Y, Li D, Li H, Jin X, Ren D
Aging 2020 Mar 22;12(6):5336-5351
Aging 2020 Mar 22;12(6):5336-5351
Critical role of toll-like receptor 4 (TLR4) in ricin toxin-induced inflammatory responses in macrophages.
Dong M, Yu H, Wang Y, Sun C, Chang Y, Yin Q, Zhao G, Xu N, Liu W
Toxicology letters 2020 Mar 15;321:54-60
Toxicology letters 2020 Mar 15;321:54-60
BabaoDan cures hepatic encephalopathy by decreasing ammonia levels and alleviating inflammation in rats.
Lu L, Wu C, Lu BJ, Xie D, Wang Z, Bahaji Azami NL, An YT, Wang HJ, Ye G, Sun MY
Journal of ethnopharmacology 2020 Mar 1;249:112301
Journal of ethnopharmacology 2020 Mar 1;249:112301
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model.
Wang D, Zhou M, Wang Y, Sun S
Canadian journal of physiology and pharmacology 2020 Jun;98(6):351-356
Canadian journal of physiology and pharmacology 2020 Jun;98(6):351-356
Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats.
Jiang LJ, Xu ZX, Wu MF, Dong GQ, Zhang LL, Gao JY, Feng CX, Feng X
Neural regeneration research 2020 Jul;15(7):1316-1325
Neural regeneration research 2020 Jul;15(7):1316-1325
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
Jin W, Zhang Y, Xue Y, Han X, Zhang X, Ma Z, Sun S, Chu X, Cheng J, Guan S, Li Z, Chu L
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
Glycyrrhizin mitigates radiation-induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway.
Zheng L, Zhu Q, Xu C, Li M, Li H, Yi PQ, Xu FF, Cao L, Chen JY
Journal of cellular and molecular medicine 2020 Jan;24(1):214-226
Journal of cellular and molecular medicine 2020 Jan;24(1):214-226
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Liu J, Yang HM, Li SZ
Brain research 2020 Jan 1;1726:146495
Brain research 2020 Jan 1;1726:146495
Deciphering the chemical profile and pharmacological mechanisms of Baihu-Guizhi decoction using ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry coupled with network pharmacology-based investigation.
Li W, Mao X, Wu H, Guo M, Su X, Lu J, Guo Q, Li T, Wang X, Su W, Zhang Y, Lin N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Feb;67:153156
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Feb;67:153156
Silencing of PTX3 alleviates LPS-induced inflammatory pain by regulating TLR4/NF-κB signaling pathway in mice.
Qi S, Zhao F, Li Z, Liang F, Yu S
Bioscience reports 2020 Feb 28;40(2)
Bioscience reports 2020 Feb 28;40(2)
Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.
Lin YH, Platt MP, Fu H, Gui Y, Wang Y, Gonzalez-Juarbe N, Zhou D, Yu Y
Molecular & cellular proteomics : MCP 2020 Dec;19(12):2030-2047
Molecular & cellular proteomics : MCP 2020 Dec;19(12):2030-2047
TLR4 inhibition ameliorates mesencephalic substantia nigra injury in neonatal rats exposed to lipopolysaccharide via regulation of neuro-immunity.
He W, Jiang M, Mao P, Yan F
Brain research bulletin 2020 Dec;165:90-96
Brain research bulletin 2020 Dec;165:90-96
Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway.
Liang T, Guo Y, Li M, Ding C, Sang S, Zhou T, Shao Q, Liu X, Lu J, Ji Z, Wang T, Kang Q
Immunology 2020 Dec;161(4):314-324
Immunology 2020 Dec;161(4):314-324
Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes.
Lin CH, Chen HY, Wei KC
Cells 2020 Dec 3;9(12)
Cells 2020 Dec 3;9(12)
Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice.
Wang X, Yu H, Wang C, Liu Y, You J, Wang P, Xu G, Shen H, Yao H, Lan X, Zhao R, Wu X, Zhang G
Toxicology 2020 Dec 15;446:152625
Toxicology 2020 Dec 15;446:152625
Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice.
Chen Q, Wang Y, Jiao F, Shi C, Pei M, Wang L, Gong Z
Scientific reports 2020 Dec 14;10(1):21850
Scientific reports 2020 Dec 14;10(1):21850
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
Lan Y, Yan R, Shan W, Chu J, Sun R, Wang R, Zhao Y, Wang Z, Zhang N, Yao J
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
TAK‑242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF‑κB signaling pathway in a neonatal hypoxic‑ischemic encephalopathy rat model.
Jiang L, Xu Z, Li H, Wu M, Wang F, Liu S, Tao J, Feng X
Molecular medicine reports 2020 Aug;22(2):1440-1448
Molecular medicine reports 2020 Aug;22(2):1440-1448
Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway.
Ge X, Meng X, Fei D, Kang K, Wang Q, Zhao M
3 Biotech 2020 Aug;10(8):369
3 Biotech 2020 Aug;10(8):369
Monophosphoryl lipid A alleviated radiation-induced testicular injury through TLR4-dependent exosomes.
Liu Z, Cao K, Liao Z, Chen Y, Lei X, Wei Q, Liu C, Sun X, Yang Y, Cai J, Gao F
Journal of cellular and molecular medicine 2020 Apr;24(7):3917-3930
Journal of cellular and molecular medicine 2020 Apr;24(7):3917-3930
Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model.
Tian C, Gao F, Li X, Li Z
Experimental and molecular pathology 2020 Apr;113:104373
Experimental and molecular pathology 2020 Apr;113:104373
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice.
Zuo B, Qi H, Lu Z, Chen L, Sun B, Yang R, Zhang Y, Liu Z, Gao X, You A, Wu L, Jing R, Zhou Q, Yin H
Nature communications 2020 Apr 14;11(1):1790
Nature communications 2020 Apr 14;11(1):1790
Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease.
Zhao J, Gao W, Cai X, Xu J, Zou D, Li Z, Hu B, Zheng Y
Theranostics 2019;9(10):2843-2855
Theranostics 2019;9(10):2843-2855
The Functional Role of Fecal Microbiota Transplantation on Dextran Sulfate Sodium-Induced Colitis in Mice.
He Y, Li X, Yu H, Ge Y, Liu Y, Qin X, Jiang M, Wang X
Frontiers in cellular and infection microbiology 2019;9:393
Frontiers in cellular and infection microbiology 2019;9:393
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Wang G, Xu B, Shi F, Du M, Li Y, Yu T, Chen L
Oxidative medicine and cellular longevity 2019;2019:7850324
Oxidative medicine and cellular longevity 2019;2019:7850324
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Li Z, Chen D, Jia Y, Feng Y, Wang C, Tong Y, Cui R, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:6565283
Oxidative medicine and cellular longevity 2019;2019:6565283
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
Du Y, Qian B, Gao L, Tan P, Chen H, Wang A, Zheng T, Pu S, Xia X, Fu W
Oxidative medicine and cellular longevity 2019;2019:3765898
Oxidative medicine and cellular longevity 2019;2019:3765898
Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38(-/-) Mice.
Li Q, Wu C, Liu Z, Zhang H, Du Y, Liu Y, Song K, Shi Q, Li R
Journal of immunology research 2019;2019:3737890
Journal of immunology research 2019;2019:3737890
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M
Mediators of inflammation 2019;2019:1082497
Mediators of inflammation 2019;2019:1082497
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
Li Y, Wang C, Lu J, Huang K, Han Y, Chen J, Yang Y, Liu B
International journal of medical sciences 2019;16(12):1593-1603
International journal of medical sciences 2019;16(12):1593-1603
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, Liu J
International journal of clinical and experimental pathology 2019;12(3):867-875
International journal of clinical and experimental pathology 2019;12(3):867-875
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
Xu W, Hu GQ, Da Costa C, Tang JH, Li QR, Du L, Pan YW, Lv SQ
OncoTargets and therapy 2019;12:3467-3480
OncoTargets and therapy 2019;12:3467-3480
Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord.
Xia YY, Xue M, Wang Y, Huang ZH, Huang C
Journal of pain research 2019;12:2851-2863
Journal of pain research 2019;12:2851-2863
TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease.
Wang Y, Zhu X, Yuan S, Wen S, Liu X, Wang C, Qu Z, Li J, Liu H, Sun L, Liu F
Frontiers in endocrinology 2019;10:603
Frontiers in endocrinology 2019;10:603
Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Inhibiting Intestinal Damage via Increasing the Proliferation of Crypt Cells.
Wang C, Zhang M, Guo H, Yan J, Liu F, Chen J, Li Y, Ren F
Molecular nutrition & food research 2019 Sep;63(18):e1900262
Molecular nutrition & food research 2019 Sep;63(18):e1900262
Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization.
Lu H, Cheng S, Wu C, Zheng S, Hong W, Liu L, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 Sep;62:152976
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 Sep;62:152976
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Zhong X, Xiao Q, Liu Z, Wang W, Lai CH, Yang W, Yue P, Ye Q, Xiao J
Molecular medicine reports 2019 Sep;20(3):2101-2110
Molecular medicine reports 2019 Sep;20(3):2101-2110
miR-140-5p Attenuates Neuroinflammation and Brain Injury in Rats Following Intracerebral Hemorrhage by Targeting TLR4.
Wang S, Cui Y, Xu J, Gao H
Inflammation 2019 Oct;42(5):1869-1877
Inflammation 2019 Oct;42(5):1869-1877
Melatonin protects against lipopolysaccharide-induced epididymitis in sheep epididymal epithelial cells in vitro.
Ge WB, Xiao LF, Duan HW, Li ZS, Jiang YT, Yang SS, Hu JJ, Zhang Y, Zhao XX
Immunology letters 2019 Oct;214:45-51
Immunology letters 2019 Oct;214:45-51
Protective Effect and Mechanism of Boswellic Acid and Myrrha Sesquiterpenes with Different Proportions of Compatibility on Neuroinflammation by LPS-Induced BV2 Cells Combined with Network Pharmacology.
Miao XD, Zheng LJ, Zhao ZZ, Su SL, Zhu Y, Guo JM, Shang EX, Qian DW, Duan JA
Molecules (Basel, Switzerland) 2019 Oct 31;24(21)
Molecules (Basel, Switzerland) 2019 Oct 31;24(21)
Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway.
Ye S, Zheng Q, Zhou Y, Bai B, Yang D, Zhao Z
Molecules (Basel, Switzerland) 2019 Oct 16;24(20)
Molecules (Basel, Switzerland) 2019 Oct 16;24(20)
Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis.
Gong DJ, Wang L, Yang YY, Zhang JJ, Liu XH
Renal failure 2019 Nov;41(1):750-761
Renal failure 2019 Nov;41(1):750-761
M1 macrophages regulate TLR4/AP1 via paracrine to promote alveolar bone destruction in periodontitis.
Zhu LF, Li L, Wang XQ, Pan L, Mei YM, Fu YW, Xu Y
Oral diseases 2019 Nov;25(8):1972-1982
Oral diseases 2019 Nov;25(8):1972-1982
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, Ma X, You H
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang YY, Yang H, Li S
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Bacterial β-glucuronidase alleviates dextran sulfate sodium-induced colitis in mice: A possible crucial new diagnostic and therapeutic target for inflammatory bowel disease.
He Y, Yu H, Ge Y, Li X, Jiang M, Liu Y, Li X, Wang Y, Guo M, Qin X, Wang X
Biochemical and biophysical research communications 2019 May 28;513(2):426-433
Biochemical and biophysical research communications 2019 May 28;513(2):426-433
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Cheng Z, Zhang M, Ling C, Zhu Y, Ren H, Hong C, Qin J, Liu T, Wang J
Molecules (Basel, Switzerland) 2019 Mar 20;24(6)
Molecules (Basel, Switzerland) 2019 Mar 20;24(6)
Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells.
Adegoke EO, Adeniran SO, Zeng Y, Wang X, Wang H, Wang C, Zhang H, Zheng P, Zhang G
Journal of applied toxicology : JAT 2019 Jun;39(6):832-843
Journal of applied toxicology : JAT 2019 Jun;39(6):832-843
The role of toll-like receptor 4 and mast cell in the ameliorating effect of electroacupuncture on visceral hypersensitivity in rats.
Yang J, Shang B, Shi H, Zhu S, Lu G, Dai F
Neurogastroenterology and motility 2019 Jun;31(6):e13583
Neurogastroenterology and motility 2019 Jun;31(6):e13583
Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway.
Jin YH, Li ZT, Chen H, Jiang XQ, Zhang YY, Wu F
European review for medical and pharmacological sciences 2019 Jun;23(11):5020-5025
European review for medical and pharmacological sciences 2019 Jun;23(11):5020-5025
Triptolide Suppresses Growth of Breast Cancer by Targeting HMGB1 in Vitro and in Vivo.
Jiang W, Chen M, Xiao C, Yang W, Qin Q, Tan Q, Liang Z, Liao X, Mao A, Wei C
Biological & pharmaceutical bulletin 2019 Jun 1;42(6):892-899
Biological & pharmaceutical bulletin 2019 Jun 1;42(6):892-899
Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis.
Pan LL, Niu W, Fang X, Liang W, Li H, Chen W, Zhang H, Bhatia M, Sun J
Molecular nutrition & food research 2019 Jul;63(13):e1801419
Molecular nutrition & food research 2019 Jul;63(13):e1801419
HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration.
Sun S, Cai B, Li Y, Su W, Zhao X, Gong B, Li Z, Zhang X, Wu Y, Chen C, Tsang SH, Yang J, Li X
Aging 2019 Jul 7;11(13):4323-4337
Aging 2019 Jul 7;11(13):4323-4337
Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome.
Sun P, Sun N, Yin W, Sun Y, Fan K, Guo J, Khan A, He Y, Li H
Veterinary research 2019 Jul 12;50(1):53
Veterinary research 2019 Jul 12;50(1):53
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, Zhang J, Chu L, Zhao S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress.
Cao W, Wang C, Chin Y, Chen X, Gao Y, Yuan S, Xue C, Wang Y, Tang Q
Food & function 2019 Jan 22;10(1):277-288
Food & function 2019 Jan 22;10(1):277-288
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Xu B, Zang SC, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Brain, behavior, and immunity 2019 Feb;76:223-235
Brain, behavior, and immunity 2019 Feb;76:223-235
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
Sun J, Ren XS, Kang Y, Dai HB, Ding L, Tong N, Zhu GQ, Zhou YB
Neuroscience bulletin 2019 Feb;35(1):34-46
Neuroscience bulletin 2019 Feb;35(1):34-46
Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice.
Wang Y, Xu X, Hu P, Jia N, Ji S, Yuan H
World neurosurgery 2019 Dec;132:e529-e534
World neurosurgery 2019 Dec;132:e529-e534
Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells.
Zhang H, Wang J, Yang L, Yang W, Luo T, Yuan Y, Gu J, Zou H, Bian J, Liu Z, Liu X
Journal of cellular biochemistry 2019 Dec;120(12):19541-19554
Journal of cellular biochemistry 2019 Dec;120(12):19541-19554
HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA.
Guo X, Shi Y, Du P, Wang J, Han Y, Sun B, Feng J
Life sciences 2019 Dec 15;239:117020
Life sciences 2019 Dec 15;239:117020
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease.
Li Y, Niu M, Zhao A, Kang W, Chen Z, Luo N, Zhou L, Zhu X, Lu L, Liu J
Journal of neuroinflammation 2019 Dec 12;16(1):263
Journal of neuroinflammation 2019 Dec 12;16(1):263
Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1/AMPK activation.
Yao E, Zhang G, Huang J, Yang X, Peng L, Huang X, Luo X, Ren J, Huang R, Yang L, Zhou Y, Zhuo R, Zhao Y, Jin X
Journal of cellular physiology 2019 Aug;234(10):18392-18407
Journal of cellular physiology 2019 Aug;234(10):18392-18407
A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.
Zhang J, Harada Y, Hayashi Y
Scientific reports 2019 Aug 19;9(1):12003
Scientific reports 2019 Aug 19;9(1):12003
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Zheng J, Fan R, Wu H, Yao H, Yan Y, Liu J, Ran L, Sun Z, Yi L, Dang L, Gan P, Zheng P, Yang T, Zhang Y, Tang T, Wang Y
Nature communications 2019 Apr 8;10(1):1604
Nature communications 2019 Apr 8;10(1):1604
Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation.
Zheng JD, He Y, Yu HY, Liu YL, Ge YX, Li XT, Li X, Wang Y, Guo MR, Qu YL, Qin XF, Jiang MS, Wang XH
World journal of gastroenterology 2019 Apr 21;25(15):1865-1878
World journal of gastroenterology 2019 Apr 21;25(15):1865-1878
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
Life sciences 2019 Apr 15;223:158-165
Life sciences 2019 Apr 15;223:158-165
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378
Frontiers in pharmacology 2018;9:1378
Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105.
Yang Y, Yang J, Liu XW, Ding JW, Li S, Guo X, Yang CJ, Fan ZX, Wang HB, Li Q, Wang HM, Yang J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(3):1049-1063
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(3):1049-1063
The Protective Mechanism of CAY10683 on Intestinal Mucosal Barrier in Acute Liver Failure through LPS/TLR4/MyD88 Pathway.
Wang Y, Chen H, Chen Q, Jiao FZ, Zhang WB, Gong ZJ
Mediators of inflammation 2018;2018:7859601
Mediators of inflammation 2018;2018:7859601
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Lin L, Li R, Cai M, Huang J, Huang W, Guo Y, Yang L, Yang G, Lan T, Zhu K
Oxidative medicine and cellular longevity 2018;2018:7808656
Oxidative medicine and cellular longevity 2018;2018:7808656
Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population.
Chen G, Xu M, Chen J, Hong L, Lin W, Zhao S, Zhang G, Dan G, Liu S
Journal of immunology research 2018;2018:7132868
Journal of immunology research 2018;2018:7132868
Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice.
Li R, Li J, Huang Y, Li H, Yan S, Lin J, Chen Y, Wu L, Liu B, Wang G, Lan T
International journal of biological sciences 2018;14(11):1411-1425
International journal of biological sciences 2018;14(11):1411-1425
Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway.
Chen Y, Wang L, Zhang L, Chen B, Yang L, Li X, Li Y, Yu H
Frontiers in cellular neuroscience 2018;12:372
Frontiers in cellular neuroscience 2018;12:372
Production of interleukin-1β related to mammalian target of rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the mouse cornea.
Xu R, Lin J, Zhao GQ, Li C, Che CY, Xu Q, Liu M
International journal of ophthalmology 2018;11(5):712-718
International journal of ophthalmology 2018;11(5):712-718
Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis.
Liu M, Li C, Zhao GQ, Lin J, Che CY, Xu Q, Wang Q, Xu R, Niu YW
International journal of ophthalmology 2018;11(4):548-552
International journal of ophthalmology 2018;11(4):548-552
Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
Du Y, Gu X, Meng H, Aa N, Liu S, Peng C, Ge Y, Yang Z
American journal of translational research 2018;10(12):4235-4246
American journal of translational research 2018;10(12):4235-4246
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia.
Lai M, Yao H, Shah SZA, Wu W, Wang D, Zhao Y, Wang L, Zhou X, Zhao D, Yang L
Frontiers in aging neuroscience 2018;10:116
Frontiers in aging neuroscience 2018;10:116
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
Liu F, Wen Y, Kang J, Wei C, Wang M, Zheng Z, Peng J
International journal of molecular medicine 2018 Sep;42(3):1436-1444
International journal of molecular medicine 2018 Sep;42(3):1436-1444
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Guo XF, Sinclair AJ, Kaur G, Li D
Prostaglandins, leukotrienes, and essential fatty acids 2018 Sep;136:47-55
Prostaglandins, leukotrienes, and essential fatty acids 2018 Sep;136:47-55
Liver injury induced in Balb/c mice by PM(2.5) exposure and its alleviation by compound essential oils.
Ya P, Xu H, Ma Y, Fang M, Yan X, Zhou J, Li F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:590-598
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:590-598
Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway.
Zhang F, Dong H, Lv T, Jin K, Jin Y, Zhang X, Jiang J
Journal of neuroinflammation 2018 Sep 20;15(1):273
Journal of neuroinflammation 2018 Sep 20;15(1):273
Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus).
Sun C, Chen Z, Wang H, Ding K
Medical science monitor : international medical journal of experimental and clinical research 2018 Sep 18;24:6564-6572
Medical science monitor : international medical journal of experimental and clinical research 2018 Sep 18;24:6564-6572
Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-κB signaling pathway.
Leng B, Tang F, Lu M, Zhang Z, Wang H, Zhang Y
Life sciences 2018 Sep 15;209:111-121
Life sciences 2018 Sep 15;209:111-121
Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway.
Adegoke EO, Wang C, Machebe NS, Wang X, Wang H, Adeniran SO, Zhang H, Zheng P, Zhang G
Environmental toxicology and pharmacology 2018 Oct;63:115-126
Environmental toxicology and pharmacology 2018 Oct;63:115-126
Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, Wu J, Wang G, Li J
Thrombosis research 2018 Nov;171:45-54
Thrombosis research 2018 Nov;171:45-54
Toll-like receptor 4 shRNA attenuates lipopolysaccharide-induced epithelial-mesenchymal transition of intrahepatic biliary epithelial cells in rats.
Tang S, Jiang X, Wu L, Chen S, Chen L, Jiang J, Yan P, Wang F, Tu K, Wang D, Gu J, Zhao L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Nov;107:1210-1217
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Nov;107:1210-1217
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia.
Chen S, Lyu C, Zhou J, Huang S, Zhang Y, Liu G, Liu K, Chen D, Hu Y, Zhou L, Gu Y
Neuroscience letters 2018 Nov 1;686:33-40
Neuroscience letters 2018 Nov 1;686:33-40
Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway.
Sun MF, Zhu YL, Zhou ZL, Jia XB, Xu YD, Yang Q, Cui C, Shen YQ
Brain, behavior, and immunity 2018 May;70:48-60
Brain, behavior, and immunity 2018 May;70:48-60
DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway.
Cong L, Yang S, Zhang Y, Cao J, Fu X
International journal of molecular medicine 2018 May;41(5):2619-2628
International journal of molecular medicine 2018 May;41(5):2619-2628
Gene transfer of a naked plasmid (pUDK-HGF) encoding human hepatocyte growth factor attenuates skin/muscle incision and retraction-induced chronic post-surgical pain in rats.
Hu C, Lu Y, Chen X, Wu Z, Zhang Q
European journal of pain (London, England) 2018 May;22(5):961-972
European journal of pain (London, England) 2018 May;22(5):961-972
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Lycopene mitigates β-amyloid induced inflammatory response and inhibits NF-κB signaling at the choroid plexus in early stages of Alzheimer's disease rats.
Liu CB, Wang R, Yi YF, Gao Z, Chen YZ
The Journal of nutritional biochemistry 2018 Mar;53:66-71
The Journal of nutritional biochemistry 2018 Mar;53:66-71
Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.
Ling C, Liang J, Zhang C, Li R, Mou Q, Qin J, Li X, Wang J
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice.
Wang SH, Yu TY, Tsai FC, Weston CJ, Lin MS, Hung CS, Kao HL, Li YI, Solé M, Unzeta M, Chen YL, Chuang LM, Li HY
Translational research : the journal of laboratory and clinical medicine 2018 Jul;197:12-31
Translational research : the journal of laboratory and clinical medicine 2018 Jul;197:12-31
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, Xiong Y, Wang Y, Ye Q
Molecular medicine reports 2018 Jul;18(1):815-826
Molecular medicine reports 2018 Jul;18(1):815-826
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Lian S, Wang D, Xu B, Guo W, Wang L, Li W, Ji H, Wang J, Kong F, Zhen L, Li S, Zhang L, Guo J, Yang H
Behavioural brain research 2018 Jul 2;346:1-10
Behavioural brain research 2018 Jul 2;346:1-10
Kafirin from Sorghum bicolor inhibition of inflammation in THP-1 human macrophages is associated with reduction of intracellular reactive oxygen species.
Sullivan AC, Pangloli P, Dia VP
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Jan;111:503-510
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Jan;111:503-510
Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats.
Xu S, Qin B, Shi A, Zhao J, Guo X, Dong L
European journal of pharmacology 2018 Jan 5;818:578-584
European journal of pharmacology 2018 Jan 5;818:578-584
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
Zhang M, Hu X, Li S, Lu C, Li J, Zong Y, Qi W, Yang H
Clinics and research in hepatology and gastroenterology 2018 Feb;42(1):72-81
Clinics and research in hepatology and gastroenterology 2018 Feb;42(1):72-81
Loganin prevents BV-2 microglia cells from Aβ(1-42) -induced inflammation via regulating TLR4/TRAF6/NF-κB axis.
Cui Y, Wang Y, Zhao D, Feng X, Zhang L, Liu C
Cell biology international 2018 Dec;42(12):1632-1642
Cell biology international 2018 Dec;42(12):1632-1642
Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages.
Qiu Z, Yuan H, Li N, Yang X, Hu X, Su F, Chen B
Molecular medicine reports 2018 Dec;18(6):5399-5408
Molecular medicine reports 2018 Dec;18(6):5399-5408
Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats.
Wang P, Dai H, Zhang C, Tian J, Deng Y, Zhao M, Zhao M, Bing G, Zhao L
Toxicology 2018 Dec 1;410:106-115
Toxicology 2018 Dec 1;410:106-115
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
Ning C, Gao X, Wang C, Huo X, Liu Z, Sun H, Yang X, Sun P, Ma X, Meng Q, Liu K
International immunopharmacology 2018 Aug;61:266-276
International immunopharmacology 2018 Aug;61:266-276
Anti-β(2)GPI/β(2)GPI induces neutrophil extracellular traps formation to promote thrombogenesis via the TLR4/MyD88/MAPKs axis activation.
Zha C, Zhang W, Gao F, Xu J, Jia R, Cai J, Liu Y
Neuropharmacology 2018 Aug;138:140-150
Neuropharmacology 2018 Aug;138:140-150
Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.
Liu H, Ma S, Xia H, Lou H, Zhu F, Sun L
Journal of ethnopharmacology 2018 Aug 10;222:201-207
Journal of ethnopharmacology 2018 Aug 10;222:201-207
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong H, Bai Y, Qin Y, Li J, Feng S, Zhao P
Molecular medicine reports 2018 Apr;17(4):5484-5491
Molecular medicine reports 2018 Apr;17(4):5484-5491
Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats.
Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, Tang F, Li Z, Zhou J, Gao D, Tian X, Yao J
Frontiers in pharmacology 2017;8:976
Frontiers in pharmacology 2017;8:976
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Zuo T, Zhu M, Xu W, Wang Z, Song H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells.
Sun H, Zhu X, Lin W, Zhou Y, Cai W, Qiu L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1227-1239
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1227-1239
TLR4 Influences Hepatitis B Virus Related Hepatocellular Carcinoma by Regulating the Wnt/β-Catenin Pathway.
Yin Y, Li F, Li S, Cai J, Shi J, Jiang Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(2):469-479
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(2):469-479
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, Li M, Xu L, Dong Z
Frontiers in neuroscience 2017;11:583
Frontiers in neuroscience 2017;11:583
Toll‑like receptor 4 is expressed and functional in late endothelial progenitor cells.
Yu M, Wang C, Zeng G, Zeng G, Zhou L, Chen T, Tan X, Wang Y
Molecular medicine reports 2017 Oct;16(4):5549-5554
Molecular medicine reports 2017 Oct;16(4):5549-5554
fat-1 mice prevent high-fat plus high-sugar diet-induced non-alcoholic fatty liver disease.
Guo XF, Gao JL, Li JM, Li D
Food & function 2017 Nov 15;8(11):4053-4061
Food & function 2017 Nov 15;8(11):4053-4061
Comparative study of macrophages in naked mole rats and ICR mice.
Cheng J, Yuan Z, Yang W, Xu C, Cong W, Lin L, Zhao S, Sun W, Bai X, Cui S
Oncotarget 2017 Nov 14;8(57):96924-96934
Oncotarget 2017 Nov 14;8(57):96924-96934
oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca(2+) /K(+) channel flow.
Su J, Zhou H, Liu X, Nilsson J, Fredrikson GN, Zhao M
Journal of cellular and molecular medicine 2017 May;21(5):929-940
Journal of cellular and molecular medicine 2017 May;21(5):929-940
Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway.
Li C, Yu Y, Li W, Liu B, Jiao X, Song X, Lv C, Qin S
Scientific reports 2017 Jul 19;7(1):5843
Scientific reports 2017 Jul 19;7(1):5843
Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis.
Zhou Q, Lin FF, Liu SM, Sui XF
Journal of ethnopharmacology 2017 Jul 12;206:274-282
Journal of ethnopharmacology 2017 Jul 12;206:274-282
1, 25(OH)(2)D(3)-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation.
Ma D, Zhang RN, Wen Y, Yin WN, Bai D, Zheng GY, Li JS, Zheng B, Wen JK
Biochemical and biophysical research communications 2017 Jan 8;482(2):366-374
Biochemical and biophysical research communications 2017 Jan 8;482(2):366-374
Glucocorticoid-induced leucine zipper overexpression inhibits lipopolysaccharide-induced retinal inflammation in rats.
Gu R, Lei B, Shu Q, Li G, Xu G
Experimental eye research 2017 Dec;165:151-163
Experimental eye research 2017 Dec;165:151-163
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway.
Sun H, Zhu X, Cai W, Qiu L
International journal of molecular sciences 2017 Apr 17;18(4)
International journal of molecular sciences 2017 Apr 17;18(4)
Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model.
Jurga AM, Rojewska E, Piotrowska A, Makuch W, Pilat D, Przewlocka B, Mika J
Neural plasticity 2016;2016:5238730
Neural plasticity 2016;2016:5238730
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways.
Slusarczyk J, Trojan E, Glombik K, Piotrowska A, Budziszewska B, Kubera M, Popiolek-Barczyk K, Lason W, Mika J, Basta-Kaim A
Journal of neurochemistry 2016 Mar;136(5):958-70
Journal of neurochemistry 2016 Mar;136(5):958-70
Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Wu J, Zhang H, Hu B, Yang L, Wang P, Wang F, Meng X
European journal of pharmacology 2016 Jun 5;780:106-14
European journal of pharmacology 2016 Jun 5;780:106-14
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation.
Xue L, Geng Y, Li M, Jin YF, Ren HX, Li X, Wu F, Wang B, Cheng WY, Chen T, Chen YJ
International immunopharmacology 2016 Jul;36:187-198
International immunopharmacology 2016 Jul;36:187-198
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, Han X, Xu Y, Zhao Y, Wang C, Peng J
International immunopharmacology 2016 Jul;36:132-141
International immunopharmacology 2016 Jul;36:132-141
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway.
Wang Y, Chen G, Yu X, Li Y, Zhang L, He Z, Zhang N, Yang X, Zhao Y, Li N, Qiu H
Inflammation 2016 Aug;39(4):1503-13
Inflammation 2016 Aug;39(4):1503-13
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
Longistatin in tick saliva blocks advanced glycation end-product receptor activation.
Anisuzzaman, Hatta T, Miyoshi T, Matsubayashi M, Islam MK, Alim MA, Anas MA, Hasan MM, Matsumoto Y, Yamamoto Y, Yamamoto H, Fujisaki K, Tsuji N
The Journal of clinical investigation 2014 Oct;124(10):4429-44
The Journal of clinical investigation 2014 Oct;124(10):4429-44
Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy.
Li Y, Zhang H, Zhang H, Kosturakis AK, Jawad AB, Dougherty PM
The journal of pain 2014 Jul;15(7):712-25
The journal of pain 2014 Jul;15(7):712-25
Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis.
Ren WH, Zhang LM, Liu HQ, Gao L, Chen C, Qiang C, Wang XL, Liu CY, Li SM, Huang C, Qi H, Zhi KQ
Medical oncology (Northwood, London, England) 2014 Aug;31(8):120
Medical oncology (Northwood, London, England) 2014 Aug;31(8):120
Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells.
Shi H, Dong L, Dang X, Liu Y, Jiang J, Wang Y, Lu X, Guo X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jun;62(6):581-7
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jun;62(6):581-7
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Shi H, Dong L, Jiang J, Zhao J, Zhao G, Dang X, Lu X, Jia M
Toxicology 2013 Jan 7;303:107-14
Toxicology 2013 Jan 7;303:107-14
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