66350-1-Ig

antibody from Proteintech Group

Targeting: TLR4 ARMD10, CD284, hToll, TLR-4

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66350-1-Ig

Provider

Proteintech Group

Product name

TLR4 antibody

Antibody type

Monoclonal

Description

TLR4 antibody (Cat. #66350-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3G9A4

Vial size

20ul, 150ul

References

Submitted references

Immunomodulatory Effect of Serum Exosomes From Crohn Disease on Macrophages via Let-7b-5p/TLR4 Signaling.

Gong L, Xiao J, Yi J, Xiao J, Lu F, Liu X
Inflammatory bowel diseases 2022 Jan 5;28(1):96-108

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Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice.

Liu X, Lin S, Zhong Y, Shen J, Zhang X, Luo S, Huang L, Zhang L, Zhou S, Tang J
Frontiers in pharmacology 2021;12:739603

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Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages.

Jiang R, Xu J, Zhang Y, Zhu X, Liu J, Tan Y
Frontiers in pharmacology 2021;12:680512

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Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi.

Li LC, Ning DS, Fu YX, Pan ZH
Fitoterapia 2021 Sep;153:104949

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Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p.

Bai Y, Liu X, Chen Q, Chen T, Jiang N, Guo Z
Scientific reports 2021 Oct 4;11(1):19637

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Ovotransferrin exerts bidirectional immunomodulatory activities via TLR4-mediated signal transduction pathways in RAW264.7 cells.

Ru Z, Xu M, Zhu G, Tu Y, Jiang Y, Du H
Food science & nutrition 2021 Nov;9(11):6162-6175

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Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage.

Sun L, He L, Wu W, Luo L, Han M, Liu Y, Shi S, Zhong K, Yang J, Li J
International journal of oral science 2021 Nov 16;13(1):39

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Anti-nociceptive effects of Sedum Lineare Thunb. on spared nerve injury-induced neuropathic pain by inhibiting TLR4/NF-κB signaling in the spinal cord in rats.

Wang XY, Ma HJ, Xue M, Sun YL, Ren A, Li MQ, Huang ZH, Huang C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111215

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Protective effect of scorpion venom heat-resistant synthetic peptide against PM_2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.

Xu X, Xu H, Ren F, Huang L, Xu J, Li F
Journal of neuroimmunology 2021 Jun 15;355:577567

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Effect of HMGB1 on monocyte immune function in respiratory syncytial virus bronchiolitis.

Niu M, Jiang Z, Xin X, Zhu J, Yang J, Diao M, Qi G, Qi B
Experimental and therapeutic medicine 2021 Jan;21(1):75

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Aureonitol Analogues and Orsellinic Acid Esters Isolated from Chaetomium elatum and Their Antineuroinflammatory Activity.

Ju F, Kuang QX, Li QZ, Huang LJ, Guo WX, Gong LQ, Dai YF, Wang L, Gu YC, Wang D, Deng Y, Guo DL
Journal of natural products 2021 Dec 24;84(12):3044-3054

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CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.

Liu B, Li H, Liu X, Li F, Chen W, Kuang Y, Zhao X, Li L, Yu B, Jin X, Li Q
Cellular signalling 2021 Aug;84:110012

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Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.

Chibaatar E, Le K, Abdoulaye IA, Wu S, Guo Y
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701

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Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.

Zhang K, Yang R, Chen J, Qi E, Zhou S, Wang Y, Fu Q, Chen R, Fang X
Frontiers in bioengineering and biotechnology 2020;8:428

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Lipopolysaccharide inhibits osteogenic differentiation of periodontal ligament stem cells partially through toll-like receptor 4-mediated ephrinB2 downregulation.

Wang W, Yuan C, Geng T, Liu Y, Zhu S, Zhang C, Liu Z, Wang P
Clinical oral investigations 2020 Oct;24(10):3407-3416

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Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.

Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541

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Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.

Yang K, Zhan L, Lu T, Zhou C, Chen X, Dong Y, Lv G, Chen S
Cytokine 2020 Mar 26;130:155058

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Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.

Le K, Wu S, Chibaatar E, Ali AI, Guo Y
ACS chemical neuroscience 2020 Mar 18;11(6):979-993

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Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.

Sun M, Sun B, Qiao S, Feng X, Li Y, Zhang S, Lin Y, Hou L
Fertility and sterility 2020 Jun;113(6):1275-1285.e2

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Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation.

Le K, Song Z, Deng J, Peng X, Zhang J, Wang L, Zhou L, Bi H, Liao Z, Feng Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1201-1213

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Therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy in mice.

Li N, Zhang EF, Zhang J, Zhang L, Liu YE, Jin HX, Gao Y, Hou LC
International immunopharmacology 2020 Apr;81:106280

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Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord.

Xia YY, Xue M, Wang Y, Huang ZH, Huang C
Journal of pain research 2019;12:2851-2863

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Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation.

Wang D, Dong X, Wang B, Liu Y, Li S
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10079-10088

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SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.

Le K, Chibaatar Daliv E, Wu S, Qian F, Ali AI, Yu D, Guo Y
International immunopharmacology 2019 Oct;75:105779

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Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.

Zhang L, Tao X, Fu Q, Ge C, Li R, Li Z, Zhu Y, Tian H, Li Q, Liu M, Hu H, Zeng B, Lin Z, Li C, Luo R, Song X
Oncology reports 2019 Nov;42(5):1843-1855

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Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway.

Feng PP, Deng P, Liu LH, Ai Q, Yin J, Liu Z, Wang GM
Evidence-based complementary and alternative medicine : eCAM 2017;2017:6421260

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Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy.

Li Y, Tatsui CE, Rhines LD, North RY, Harrison DS, Cassidy RM, Johansson CA, Kosturakis AK, Edwards DD, Zhang H, Dougherty PM
Pain 2017 Mar;158(3):417-429

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Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.

Tian Y, Li Z, Shen B, Zhang Q, Feng H
International immunopharmacology 2017 Apr;45:148-155