BS6795

antibody from Bioworld Technology, Inc
Targeting: ICOS AILIM, CD278
Provider product page for BS6795
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6795 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ICOS polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ICOS.
Description
The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells. CD80 and CD86 bind to the homologous T cell receptors CD28 and CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. ICOS (inducible co-stimulator) is related to CD28 and CTLA-4, and these three proteins are thought to compose a receptor family. ICOS stimulation enhances T cell responses and superinduces the synthesis of IL-10, but it does not induce IL-2 upregulation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ICOS protein structure - BS6795 shown in red.