Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 11149-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11149-1-AP, RRID:AB_2097686
- Product name
- CBP,EIF4E antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CBP,EIF4E antibody (Cat. #11149-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.
Decreased RNA-binding protein heterogeneous nuclear ribonucleoprotein U improves multiple myeloma sensitivity to lenalidomide.
Yin Yang 1 suppresses tumor invasion and metastasis in nasopharyngeal carcinoma by negatively regulating eIF4E transcriptional activity and expression.
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
N7-methylguanosin regulators-mediated methylation modification patterns and characterization of the immune microenvironment in lower-grade glioma.
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation.
Small-Molecule RAF265 as an Antiviral Therapy Acts against PEDV Infection.
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
RNA m(6)A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Proteomic analysis of Trypanosoma cruzi spliceosome complex.
The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo.
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Multifunctional viral protein γ34.5 manipulates nucleolar protein NOP53 for optimal viral replication of HSV-1.
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.
Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549.
Identification of the receptor tyrosine kinases (RTKs)-oriented functional targets of miR-206 by an antibody-based protein array.
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Ge L, Rui Y, Wang C, Wu Y, Wang H, Wang J
Cell death & disease 2024 Mar 6;15(3):192
Cell death & disease 2024 Mar 6;15(3):192
Decreased RNA-binding protein heterogeneous nuclear ribonucleoprotein U improves multiple myeloma sensitivity to lenalidomide.
Lin Z, Zhang Y, Liu X, Luo H, Li Q, Gao Q, Wang X, Wen J, Li L, Feng Y, Wang F, Huang J, Zhai X, Zhang L, Niu T, Zheng Y
British journal of haematology 2024 Aug;205(2):594-606
British journal of haematology 2024 Aug;205(2):594-606
Yin Yang 1 suppresses tumor invasion and metastasis in nasopharyngeal carcinoma by negatively regulating eIF4E transcriptional activity and expression.
Li M, Duan Y, Wei J, Chen S, Xue C, Zheng L, Deng H, Fan S, Xiong W, Li G, Tan M, Tang F, She K, Zhou M
American journal of cancer research 2023;13(8):3763-3780
American journal of cancer research 2023;13(8):3763-3780
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
Zhong WJ, Zhang J, Duan JX, Zhang CY, Ma SC, Li YS, Yang NS, Yang HH, Xiong JB, Guan CX, Jiang ZX, You ZJ, Zhou Y
Journal of translational medicine 2023 Mar 6;21(1):179
Journal of translational medicine 2023 Mar 6;21(1):179
N7-methylguanosin regulators-mediated methylation modification patterns and characterization of the immune microenvironment in lower-grade glioma.
Maimaiti A, Feng Z, Liu Y, Turhon M, Xie Z, Baihetiyaer Y, Wang X, Kasimu M, Jiang L, Wang Y, Wang Z, Pei Y
European journal of medical research 2023 Mar 30;28(1):144
European journal of medical research 2023 Mar 30;28(1):144
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7
Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation.
Li GN, Zhao XJ, Wang Z, Luo MS, Shi SN, Yan DM, Li HY, Liu JH, Yang Y, Tan JH, Zhang ZY, Chen RQ, Lai HL, Huang XY, Zhou JF, Ma D, Fang Y, Gao QL
Signal transduction and targeted therapy 2022 Sep 12;7(1):317
Signal transduction and targeted therapy 2022 Sep 12;7(1):317
Small-Molecule RAF265 as an Antiviral Therapy Acts against PEDV Infection.
Wang J, Tian WJ, Li CC, Zhang XZ, Fan K, Li SL, Wang XJ
Viruses 2022 Oct 15;14(10)
Viruses 2022 Oct 15;14(10)
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Liu M, Yue Z, Zhang B, Li F, Liu L, Li F
Metabolites 2022 Aug 25;12(9)
Metabolites 2022 Aug 25;12(9)
RNA m(6)A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.
Li J, Xie G, Tian Y, Li W, Wu Y, Chen F, Lin Y, Lin X, Wing-Ngor Au S, Cao J, He W, Wang H
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1578-1596
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1578-1596
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.
Zhang C, Shen L, Zhu Y, Xu R, Deng Z, Liu X, Ding Y, Wang C, Shi Y, Bei L, Wei D, Thorne RF, Zhang XD, Yu L, Chen S
Theranostics 2021;11(6):2691-2705
Theranostics 2021;11(6):2691-2705
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, Wang Z, Huang J, Wang W, Liu T, Xue W, Chen G
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;
bioRxiv : the preprint server for biology 2020 Nov 16;
Proteomic analysis of Trypanosoma cruzi spliceosome complex.
Barbosa RL, da Cunha JPC, Menezes AT, Melo RFP, Elias MC, Silber AM, Coltri PP
Journal of proteomics 2020 Jul 15;223:103822
Journal of proteomics 2020 Jul 15;223:103822
The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo.
Dong HJ, Wang ZH, Meng W, Li CC, Hu YX, Zhou L, Wang XJ
Viruses 2018 Nov 1;10(11)
Viruses 2018 Nov 1;10(11)
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X, Yu J
Nucleic acids research 2018 Jun 1;46(10):5195-5208
Nucleic acids research 2018 Jun 1;46(10):5195-5208
Multifunctional viral protein γ34.5 manipulates nucleolar protein NOP53 for optimal viral replication of HSV-1.
Meng W, Han SC, Li CC, Dong HJ, Wang XJ
Cell death & disease 2018 Jan 24;9(2):103
Cell death & disease 2018 Jan 24;9(2):103
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.
Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X, Ye L
Cancer research 2016 Jan 15;76(2):293-304
Cancer research 2016 Jan 15;76(2):293-304
Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549.
Wu DM, Zhang P, Xu GC, Tong AP, Zhou C, Lang JY, Wang CT
Asian Pacific journal of cancer prevention : APJCP 2015;16(4):1507-13
Asian Pacific journal of cancer prevention : APJCP 2015;16(4):1507-13
Identification of the receptor tyrosine kinases (RTKs)-oriented functional targets of miR-206 by an antibody-based protein array.
Cui Y, Xie S, Luan J, Zhou X, Han J
FEBS letters 2015 Jul 22;589(16):2131-5
FEBS letters 2015 Jul 22;589(16):2131-5
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Zhao L, Teng B, Wen L, Feng Q, Wang H, Li N, Wang Y, Liang Z
International journal of clinical and experimental medicine 2014;7(2):337-47
International journal of clinical and experimental medicine 2014;7(2):337-47
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11149-1-AP(EIF4E antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using EIF4E antibody 11149-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 11149-1-AP(EIF4E antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 11149-1-AP(EIF4E antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue