323602

antibody from BioLegend
Targeting: PDGFRB CD140b, JTK12, PDGFR, PDGFR1
Provider product page for 323602

Antibody data

Product number
323602 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#323602, RRID:AB_756002
Product name
Purified anti-human CD140b (PDGFR‰)
Antibody type
Monoclonal
Antigen
NIH-3T3 cells transfected with human PDGFRbeta
Description
CD140b is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. The identity of the growth factor bound to the receptor determines whether the functional receptor is a homodimer or heterodimer composed of both PDGFR-α and -β. CD140b contains two immunoglobulin-like domains and a tyrosine kinase domain with a predicted molecular weight approximately 124 kD. CD140b is widely expressed on a variety of mesenchymal-derived cells and is preferentially expressed on some tumors such as medulloblastoma. Binding of B-chain containing PDGF molecules can stimulate cell proliferation. CD140b has been shown to interact with a number of kinases (including Raf-1, NCK1, FAK, Fyn, others) as well as adaptor molecules and signaling intermediates (Crk, Grb2, Grb4, RasGAP, SHP2, SHC1, others), and has also been shown to associate with integrin β3 and nexin sorting molecules. CD140b has been implicated in several disease states including atherogenesis and oncogenesis. The PDGFRβ is heavily phosphorylated on numerous tyrosine residues through both autophosphorylation and ligand-dependent processes. 
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
PDGFRB protein structure - 323602 shown in red.