CABT-L1905

antibody from Creative Diagnostics

Targeting: AIM2 PYHIN4

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-L1905

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human AIM2 monoclonal antibdoy, clone 23059

Antibody type

Monoclonal

Description

Absent in melanoma 2 (AIM2) is an interferon-inducible protein containing an amino-terminal pyrin domain and carboxy-terminal HIN-200 domain that functions in innate immunity and tumor progression. Expression of AIM2 can inhibit cell growth and tumor formation. Furthermore, the AIM2 gene has a high frequency of mutations associated with microsatellite-unstable colorectal cancers. AIM2 has a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1ÉÇ and IL-18. Caspase-1 activation is regulated by multi-protein complexes referred to as "inflammasomes". Distinct inflammasome complexes have been described containing NLRP1/NALP1, NLRP3/NALP3, IPAF, and AIM2. The HIN-200 domain of AIM2 is responsible for binding to cytoplasmic double stranded DNA, resulting in caspase-1 activation. This inflammasome complex also involves binding of the pyrin domain of AIM2 to the CARD-domain protein ASC/TMS1, which then interacts directly with caspase-1. As a result, AIM2 has been demonstrated to be an important sensor for a number of different pathogens.

Reactivity

Human, Simian

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

23059

Concentration

Lot specific

Storage

-20°C. Avoid Freeze/Thaw Cycles. Do not aliquot the antibody.