ALX-804-660-C100

antibody from Enzo Life Sciences

Targeting: BCL2L1 Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

ALX-804-660-C100

Provider

Enzo Life Sciences

Proper citation

Enzo Life Sciences Cat#ALX-804-660-C100, RRID:AB_2050814

Product name

Bcl-XL monoclonal antibody (1C2)

Antibody type

Monoclonal

Antigen

Recombinant protein fragment

Description

Protein G-affinity purified.

Reactivity

Human, Mouse

Host

Rat

Isotype

IgG

Antibody clone number

1C2

Vial size

100 μg

Storage

-20°C

Handling

Avoid freeze/thaw cycles.

References

Submitted references

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM
The Journal of cell biology 2007 Apr 23;177(2):277-87

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC
Genes & development 2005 Jun 1;19(11):1294-305