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Learn14-5847-82
antibody from Invitrogen Antibodies
Targeting: FCRLA
FCRL, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRLM1, FCRLX, FREB, MGC4595
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Flow cytometry [1]
- Other assay [2]
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- Product number
- 14-5847-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- FCRLA (FREB) Monoclonal Antibody (N28.1), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The N28.1 monoclonal antibody recognizes the Fc receptor homolog expressed in B cells (FREB), also know as FCRLA or FcRX. FREB is a member of the family of Fc receptors for IgG (FcRg). Unlike FcRg, FREB lacks a transmembrane sequence and has an intracellular localization. FREB has been detected in proliferating and activated B cells, EBV-transformed B cells, germinal center centroblast, follicular lymphoma and the Burkitt's lymphoma cell line Raji. In contrast with published reports, the N28.1 antibody was also able to detect expression of FREB in resting B cells from normal human blood samples.
- Antibody clone number
- N28.1
- Concentration
- 0.5 mg/mL
Submitted references Fc receptor-like molecules.
Variation in gene expression patterns in follicular lymphoma and the response to rituximab.
Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells.
An unusual Fc receptor-related protein expressed in human centroblasts.
FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.
Davis RS
Annual review of immunology 2007;25:525-60
Annual review of immunology 2007;25:525-60
Variation in gene expression patterns in follicular lymphoma and the response to rituximab.
Bohen SP, Troyanskaya OG, Alter O, Warnke R, Botstein D, Brown PO, Levy R
Proceedings of the National Academy of Sciences of the United States of America 2003 Feb 18;100(4):1926-30
Proceedings of the National Academy of Sciences of the United States of America 2003 Feb 18;100(4):1926-30
Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells.
Davis RS, Li H, Chen CC, Wang YH, Cooper MD, Burrows PD
International immunology 2002 Sep;14(9):1075-83
International immunology 2002 Sep;14(9):1075-83
An unusual Fc receptor-related protein expressed in human centroblasts.
Facchetti F, Cella M, Festa S, Fremont DH, Colonna M
Proceedings of the National Academy of Sciences of the United States of America 2002 Mar 19;99(6):3776-81
Proceedings of the National Academy of Sciences of the United States of America 2002 Mar 19;99(6):3776-81
FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.
Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV
European journal of immunology 2002 Jan;32(1):87-96
European journal of immunology 2002 Jan;32(1):87-96
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Normal human peripheral blood cells were stained with 0.015 µg of Mouse IgG1 kappa Isotype Control Purified (Product # 14-4714-82) (left panel) or 0.015 µg of Anti-Human FCRLA (FREB) Purified (Product # 14-5847-82) (right panel) using IC Fixation Buffer (Product # 00-8222-49) followed by F (ab')2 Anti-Mouse IgG PE (Product # 12-4012) and subsequently with Anti-Human CD19 APC (Product # 17-0199-42).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
