DPABH-25094

antibody from Creative Diagnostics

Targeting: CTNNB1 armadillo, beta-catenin, CTNNB

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DPABH-25094

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-25094, RRID:AB_2506244

Product name

Rabbit Anti-Human CTNNB1 Polyclonal antibody

Antibody type

Polyclonal

Description

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Reactivity

Human, Mouse, Rat, Goat, Hamster, Porcine

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 uL