Ab091079

antibody from Aladdin Scientific Corporation

Targeting: CTNNB1 armadillo, beta-catenin, CTNNB

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

Ab091079

Provider

Aladdin Scientific Corporation

Product name

Recombinant beta Catenin Antibody

Antibody type

Recombinant

Description

Rabbit anti Human beta Catenin Antibody, Recombinant (R07-9D5), could be used for WB, ICC/IF and so on.ApplicationWB: 1/500-1/1000ICC/IF: 1/50-1/200Protein FunctionKey dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 663-681


Antibody clone number

R07-9D5

Vial size

100μl,10μl,1ml,50μl

Concentration

0,3 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.