APR00387G

antibody from Leading Biology

Targeting: ABCB1 ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR00387G

Provider

Leading Biology

Product name

P-glycoprotein Antibody

Antibody type

Polyclonal

Description

P-gp, also called MDR1 or ABCB1, is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys, liver, blood–brain barrier and the intestinal epithelium.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.