GTX23364

Onozato D, Yamashita M, Nakanishi A, Akagawa T, Kida Y, Ogawa I, Hashita T, Iwao T, Matsunaga T
Drug metabolism and disposition: the biological fate of chemicals 2018 Nov;46(11):1572-1580

The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus.

Gao F, Gao Y, Meng F, Yang C, Fu J, Li Y
Basic & clinical pharmacology & toxicology 2018 Jul;123(1):14-20

Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions.

Onozato D, Yamashita M, Fukuyama R, Akagawa T, Kida Y, Koeda A, Hashita T, Iwao T, Matsunaga T
Stem cells and development 2018 Aug 1;27(15):1033-1045

Hydralazine is a Suitable Mimetic Agent of Hypoxia to Study the Impact of Hypoxic Stress on In Vitro Blood-Brain Barrier Model.

Chatard M, Puech C, Perek N, Roche F
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(4):1592-1602

(-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways.

Satonaka H, Ishida K, Takai M, Koide R, Shigemasa R, Ueyama J, Ishikawa T, Hayashi K, Goto H, Wakusawa S
Anticancer research 2017 Nov;37(11):6071-6077

Toxicity and accumulation of zinc pyrithione in the liver and kidneys of Carassius auratus gibelio: association with P-glycoprotein expression.

Ren T, Fu GH, Liu TF, Hu K, Li HR, Fang WH, Yang XL
Fish physiology and biochemistry 2017 Feb;43(1):1-9

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

Vellonen KS, Ihalainen J, Boucau MC, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M
Pharmaceutical research 2017 Dec;34(12):2652-2662

Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.

Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T
Biochemical pharmacology 2017 Dec 1;145:192-201

P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride Channel-3.

Deng L, Li Q, Lin G, Huang D, Zeng X, Wang X, Li P, Jin X, Zhang H, Li C, Chen L, Wang L, Huang S, Shao H, Xu B, Mao J
Theranostics 2016;6(2):204-18

Hypoxic Stress Induced by Hydralazine Leads to a Loss of Blood-Brain Barrier Integrity and an Increase in Efflux Transporter Activity.

Chatard M, Puech C, Roche F, Perek N
PloS one 2016;11(6):e0158010

A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.

Kim DG, Bynoe MS
The Journal of clinical investigation 2016 May 2;126(5):1717-33

Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane.

Fantappiè O, Sassoli C, Tani A, Nosi D, Marchetti S, Formigli L, Mazzanti R
Journal of cellular and molecular medicine 2015 Jun;19(6):1410-7

Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter.

Togawa N, Juge N, Miyaji T, Hiasa M, Omote H, Moriyama Y
American journal of physiology. Cell physiology 2015 Jul 15;309(2):C71-80

Induction of apoptotic cell death by betulin in multidrug-resistant human renal carcinoma cells.

Yim NH, Jung YP, Kim A, Kim T, Ma JY
Oncology reports 2015 Aug;34(2):1058-64

Histopathological lesions, P-glycoprotein and PCNA expression in zebrafish (Danio rerio) liver after a single exposure to diethylnitrosamine.

Machado SP, Cunha V, Reis-Henriques MA, Ferreira M
Environmental toxicology and pharmacology 2014 Nov;38(3):720-32

Tissue accumulation and toxicity of isothiazolinone in Ctenopharyngodon idellus (grass carp): association with P-glycoprotein expression and location within tissues.

Hu K, Li HR, Ou RJ, Li CZ, Yang XL
Environmental toxicology and pharmacology 2014 Mar;37(2):529-35

Ursodeoxycholic acid inhibits overexpression of P-glycoprotein induced by doxorubicin in HepG2 cells.

Komori Y, Arisawa S, Takai M, Yokoyama K, Honda M, Hayashi K, Ishigami M, Katano Y, Goto H, Ueyama J, Ishikawa T, Wakusawa S
European journal of pharmacology 2014 Feb 5;724:161-7

Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments.

Yokoi K, Tanei T, Godin B, van de Ven AL, Hanibuchi M, Matsunoki A, Alexander J, Ferrari M
Cancer letters 2014 Apr 1;345(1):48-55

Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

Lee YK, Lin TH, Chang CF, Lo YL
PloS one 2013;8(11):e82478

Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells.

Saint-Pol J, Candela P, Boucau MC, Fenart L, Gosselet F
Brain research 2013 Jun 23;1517:1-15

Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance.

Gong J, Luk F, Jaiswal R, George AM, Grau GE, Bebawy M
European journal of pharmacology 2013 Dec 5;721(1-3):116-25

Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography.

Yamasaki T, Fujinaga M, Kawamura K, Hatori A, Yui J, Nengaki N, Ogawa M, Yoshida Y, Wakizaka H, Yanamoto K, Fukumura T, Zhang MR
Nuclear medicine and biology 2011 Jul;38(5):707-14

Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye.

Pelis RM, Shahidullah M, Ghosh S, Coca-Prados M, Wright SH, Delamere NA
The Journal of pharmacology and experimental therapeutics 2009 May;329(2):479-85

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