Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
Reference
Comment
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- Product number
- 12840-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12840-1-AP, RRID:AB_2135302
- Product name
- LGTN antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LGTN antibody (Cat. #12840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons.
Local translation in nuclear condensate amyloid bodies.
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells.
Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.
Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.
Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I.
Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.
Sonobe Y, Aburas J, Krishnan G, Fleming AC, Ghadge G, Islam P, Warren EC, Gu Y, Kankel MW, Brown AEX, Kiskinis E, Gendron TF, Gao FB, Roos RP, Kratsios P
Nature communications 2021 Oct 15;12(1):6025
Nature communications 2021 Oct 15;12(1):6025
Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons.
Ichihara K, Matsumoto A, Nishida H, Kito Y, Shimizu H, Shichino Y, Iwasaki S, Imami K, Ishihama Y, Nakayama KI
Nucleic acids research 2021 Jul 21;49(13):7298-7317
Nucleic acids research 2021 Jul 21;49(13):7298-7317
Local translation in nuclear condensate amyloid bodies.
Theodoridis PR, Bokros M, Marijan D, Balukoff NC, Wang D, Kirk CC, Budine TD, Goldsmith HD, Wang M, Audas TE, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E
Molecular cell 2020 Dec 3;80(5):876-891.e6
Molecular cell 2020 Dec 3;80(5):876-891.e6
The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells.
González-Almela E, Williams H, Sanz MA, Carrasco L
Frontiers in microbiology 2018;9:207
Frontiers in microbiology 2018;9:207
Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.
Ho JJD, Balukoff NC, Cervantes G, Malcolm PD, Krieger JR, Lee S
Cell reports 2018 Jan 2;22(1):17-26
Cell reports 2018 Jan 2;22(1):17-26
Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.
Sanz MA, González Almela E, Carrasco L
Scientific reports 2017 Feb 27;7:43876
Scientific reports 2017 Feb 27;7:43876
Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I.
Starck SR, Jiang V, Pavon-Eternod M, Prasad S, McCarthy B, Pan T, Shastri N
Science (New York, N.Y.) 2012 Jun 29;336(6089):1719-23
Science (New York, N.Y.) 2012 Jun 29;336(6089):1719-23
Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.
Skabkin MA, Skabkina OV, Dhote V, Komar AA, Hellen CU, Pestova TV
Genes & development 2010 Aug 15;24(16):1787-801
Genes & development 2010 Aug 15;24(16):1787-801
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12840-1-AP(LGTN antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using LGTN antibody 12840-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line