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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [80]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 102-PA32 - Provider product page
- Provider
- ReliaTech GmbH
- Proper citation
- Reliatech Cat#102-PA32, RRID:AB_10013821
- Product name
- Prox-1
- Antibody type
- Polyclonal
- Antigen
- Recombinant human Prox-1
- Description
- antibody Protein-A purified from serum
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
MAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGL
SPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRC
ITSQLIKWFSNFREFYYIQMEKYARQAINDGVTST
EELSITRDCELYRALNMHYNKANDFEVPERFLEVA
QITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSE
VPEIFKSPNCLQELLHE- Antibody clone number
- Rabbit IG
- Vial size
- 200 µl
- Storage
- Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
- Handling
- Restore in sterile water to a concentration of 0.1-1.0 mg/ml. The antibody solution should be gently mixed before use.
Submitted references Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2.
Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy
Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression.
A human initial lymphatic chip reveals distinct mechanisms of primary lymphatic valve dysfunction in acute and chronic inflammation.
Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species.
The lymphatic vascular system: much more than just a sewer.
Expression Profile of CD157 Reveals Functional Heterogeneity of Capillaries in Human Dermal Skin.
Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities.
Transcriptome Analysis of Hypoxic Lymphatic Endothelial Cells Indicates Their Potential to Contribute to Extracellular Matrix Rearrangement.
A Rare Case of Vascular Proliferation in the Mandible of a Juvenile Horse.
High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination.
YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells.
Unraveling human adult hippocampal neurogenesis.
A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development.
The Lymphatic Cell Environment Promotes Kaposi Sarcoma Development by Prox1-Enhanced Productive Lytic Replication of Kaposi Sarcoma Herpes Virus.
Non-canonical WNT-signaling controls differentiation of lymphatics and extension lymphangiogenesis via RAC and JNK signaling.
Podoplanin and PROX1 Expression in Hypercaloric Diet-induced Pancreatic Injuries.
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease.
Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages.
PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
Interleukin-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation
Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats
Time-lapse imaging reveals highly dynamic structural maturation of postnatally born dentate granule cells in organotypic entorhino-hippocampal slice cultures
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms
VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations
Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors
Integration of CD45-positive leukocytes into newly forming lymphatics of adult mice
Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells
Prox1 identifies proliferating neuroblasts and nascent neurons during neurogenesis in sympathetic ganglia
TH2 cells and their cytokines regulate formation and function of lymphatic vessels
Differential Structural Development of Adult-Born Septal Hippocampal Granule Cells in the Thy1-GFP Mouse, Nuclear Size as a New Index of Maturation
Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model
ΔNp63 isoform-mediated β-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma
Fusing VE-Cadherin to -Catenin Impairs Fetal Liver Hematopoiesis and Lymph but Not Blood Vessel Formation
Lymphatic vascular response to acute inflammation.
VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.
PROX1: A Lineage Tracer for Cortical Interneurons Originating in the Lateral/Caudal Ganglionic Eminence and Preoptic Area
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy
Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration
Prox1 suppresses the proliferation of neuroblastoma cells via a dual action in p27-Kip1 and Cdc25A
Lymphatic Reprogramming by Kaposi Sarcoma Herpes Virus Promotes the Oncogenic Activity of the Virus-Encoded G-protein-Coupled Receptor
Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases
Transcriptional Analysis of Gli3 Mutants Identifies Wnt Target Genes in the Developing Hippocampus
Erythropoietin Induces Lymph Node Lymphangiogenesis and Lymph Node Tumor Metastasis
Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse
Aberrant lymphatic development in euploid fetuses with increased nuchal translucency including Noonan syndrome
Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation.
Absence of lymphatic vessels in the dog dental pulp: an immunohistochemical study
miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells
Prox1 Regulates the Notch1-Mediated Inhibition of Neurogenesis
CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche
Homeobox Transcription Factor Prox1 in Sympathetic Ganglia of Vertebrate Embryos: Correlation With Human Stage 4s Neuroblastoma
Kaposin-B Enhances the PROX1 mRNA Stability during Lymphatic Reprogramming of Vascular Endothelial Cells by Kaposi's Sarcoma Herpes Virus
Role of CD11b + Macrophages in Intraperitoneal Lipopolysaccharide-Induced Aberrant Lymphangiogenesis and Lymphatic Function in the Diaphragm
Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade
Endothelial cells from cord blood CD133+CD34+ progenitors share phenotypic, functional and gene expression profile similarities with lymphatics.
Hepatoblast and mesenchymal cell-specific gene-expression in fetal rat liver and in cultured fetal rat liver cells
Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways
Retinal progenitor cells can produce restricted subsets of horizontal cells
Lymph sacs are not required for the initiation of lymph node formation
Altered regulation of Prox1-gene-expression in liver tumors
Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics
Similarities and differences of human and experimental mouse lymphangiomas
Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
Lymphatic development in mouse small intestine
Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1
Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
The Sialomucin CD34 Is a Marker of Lymphatic Endothelial Cells in Human Tumors
Differentiation of Lymphatic Endothelial Cells From Embryonic Stem Cells on OP9 Stromal Cells
Loss of Function of the Candidate Tumor Suppressor prox1 by RNA Mutation in Human Cancer Cells
Tumor Lymphangiogenesis in Inflammatory Breast Carcinoma: A Histomorphometric Study
Generation and Characterization of Telomerase-Transfected Human Lymphatic Endothelial Cells with an Extended Life Span
Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas
Lymphatic regulator PROX1 determines Schlemm canal integrity and identity
Pastor-Alonso O, Syeda Zahra A, Kaske B, García-Moreno F, Tetzlaff F, Bockelmann E, Grunwald V, Martín-Suárez S, Riecken K, Witte OW, Encinas JM, Urbach A
The EMBO journal 2024 Feb;43(3):317-338
The EMBO journal 2024 Feb;43(3):317-338
Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy
Freise L, Behncke R, Allerkamp H, Sandermann T, Chu N, Funk E, Hondrich L, Riedel A, Witzel C, Hansmeier N, Danyel M, Gellhaus A, Dechend R, Hägerling R
Biomolecules 2023;13(6):1009
Biomolecules 2023;13(6):1009
Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression.
Michail A, Gkikas D, Stellas D, Kaltezioti V, Politis PK
Cells 2023 Jul 17;12(14)
Cells 2023 Jul 17;12(14)
A human initial lymphatic chip reveals distinct mechanisms of primary lymphatic valve dysfunction in acute and chronic inflammation.
Kraus S, Lee E
Lab on a chip 2023 Dec 5;23(24):5180-5194
Lab on a chip 2023 Dec 5;23(24):5180-5194
Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species.
Vogel A, Ueberbach T, Wilken-Schmitz A, Hahnefeld L, Franck L, Weyer MP, Jungenitz T, Schmid T, Buchmann G, Freudenberg F, Brandes RP, Gurke R, Schwarzacher SW, Geisslinger G, Mittmann T, Tegeder I
Cell & bioscience 2023 Aug 27;13(1):155
Cell & bioscience 2023 Aug 27;13(1):155
The lymphatic vascular system: much more than just a sewer.
Wilting J, Becker J
Cell & bioscience 2022 Sep 15;12(1):157
Cell & bioscience 2022 Sep 15;12(1):157
Expression Profile of CD157 Reveals Functional Heterogeneity of Capillaries in Human Dermal Skin.
Michalak-Micka K, Rütsche D, Johner L, Moehrlen U, Biedermann T, Klar AS
Biomedicines 2022 Mar 15;10(3)
Biomedicines 2022 Mar 15;10(3)
Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities.
Redder E, Kirschnick N, Bobe S, Hägerling R, Hansmeier NR, Kiefer F
PloS one 2021;16(9):e0249256
PloS one 2021;16(9):e0249256
Transcriptome Analysis of Hypoxic Lymphatic Endothelial Cells Indicates Their Potential to Contribute to Extracellular Matrix Rearrangement.
Becker J, Schwoch S, Zelent C, Sitte M, Salinas G, Wilting J
Cells 2021 Apr 24;10(5)
Cells 2021 Apr 24;10(5)
A Rare Case of Vascular Proliferation in the Mandible of a Juvenile Horse.
Leitzen E, Stumpf S, Zimmermann C, Bienert-Zeit A, Hellige M, Baumgärtner W, Puff C
Frontiers in veterinary science 2020;7:573540
Frontiers in veterinary science 2020;7:573540
High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination.
Arlt A, von Bonin F, Rehberg T, Perez-Rubio P, Engelmann JC, Limm K, Reinke S, Dullin C, Sun X, Specht R, Maulhardt M, Linke F, Bunt G, Klapper W, Vockerodt M, Wilting J, Pukrop T, Dettmer K, Gronwald W, Oefner PJ, Spang R, Kube D
Molecular oncology 2020 Mar;14(3):571-589
Molecular oncology 2020 Mar;14(3):571-589
YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells.
Choi SY, Bae H, Jeong SH, Park I, Cho H, Hong SP, Lee DH, Lee CK, Park JS, Suh SH, Choi J, Yang MJ, Jang JY, Onder L, Moon JH, Jeong HS, Adams RH, Kim JM, Ludewig B, Song JH, Lim DS, Koh GY
Nature communications 2020 Jan 24;11(1):519
Nature communications 2020 Jan 24;11(1):519
Unraveling human adult hippocampal neurogenesis.
Flor-García M, Terreros-Roncal J, Moreno-Jiménez EP, Ávila J, Rábano A, Llorens-Martín M
Nature protocols 2020 Feb;15(2):668-693
Nature protocols 2020 Feb;15(2):668-693
A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development.
Hasenpusch-Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, Abrams SR, Reiter JF, Schneider-Maunoury S, Theil T
eLife 2020 Aug 25;9
eLife 2020 Aug 25;9
The Lymphatic Cell Environment Promotes Kaposi Sarcoma Development by Prox1-Enhanced Productive Lytic Replication of Kaposi Sarcoma Herpes Virus.
Choi D, Park E, Kim KE, Jung E, Seong YJ, Zhao L, Madhavan S, Daghlian G, Lee HH, Daghlian PT, Daghlian S, Bui K, Koh CJ, Wong AK, Cho IT, Hong YK
Cancer research 2020 Aug 1;80(15):3130-3144
Cancer research 2020 Aug 1;80(15):3130-3144
Non-canonical WNT-signaling controls differentiation of lymphatics and extension lymphangiogenesis via RAC and JNK signaling.
Lutze G, Haarmann A, Demanou Toukam JA, Buttler K, Wilting J, Becker J
Scientific reports 2019 Mar 18;9(1):4739
Scientific reports 2019 Mar 18;9(1):4739
Podoplanin and PROX1 Expression in Hypercaloric Diet-induced Pancreatic Injuries.
Taran D, Tarlui VN, Ceausu RA, Cimpean AM, Raica M, Sarb S
In vivo (Athens, Greece) 2019 Jul-Aug;33(4):1157-1163
In vivo (Athens, Greece) 2019 Jul-Aug;33(4):1157-1163
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease.
Moreno-Jiménez EP, Flor-García M, Terreros-Roncal J, Rábano A, Cafini F, Pallas-Bazarra N, Ávila J, Llorens-Martín M
Nature medicine 2019 Apr;25(4):554-560
Nature medicine 2019 Apr;25(4):554-560
Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages.
Suh SH, Choe K, Hong SP, Jeong SH, Mäkinen T, Kim KS, Alitalo K, Surh CD, Koh GY, Song JH
EMBO reports 2019 Apr;20(4)
EMBO reports 2019 Apr;20(4)
PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.
Blesinger H, Kaulfuß S, Aung T, Schwoch S, Prantl L, Rößler J, Wilting J, Becker J
PloS one 2018;13(7):e0200343
PloS one 2018;13(7):e0200343
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
Gauvrit S, Villasenor A, Strilic B, Kitchen P, Collins MM, Marín-Juez R, Guenther S, Maischein HM, Fukuda N, Canham MA, Brickman JM, Bogue CW, Jayaraman PS, Stainier DYR
Nature communications 2018 Jul 13;9(1):2704
Nature communications 2018 Jul 13;9(1):2704
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
Frye M, Taddei A, Dierkes C, Martinez-Corral I, Fielden M, Ortsäter H, Kazenwadel J, Calado D, Ostergaard P, Salminen M, He L, Harvey N, Kiefer F, Mäkinen T
Nature Communications 2018 December;9(1)
Nature Communications 2018 December;9(1)
Interleukin-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation
Park H, Yuk C, Shin K, Lee S
Mucosal Immunology 2017 September
Mucosal Immunology 2017 September
Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats
Radic T, Frieß L, Vijikumar A, Jungenitz T, Deller T, Schwarzacher S
Frontiers in Neuroanatomy 2017 November;11
Frontiers in Neuroanatomy 2017 November;11
Time-lapse imaging reveals highly dynamic structural maturation of postnatally born dentate granule cells in organotypic entorhino-hippocampal slice cultures
Radic T, Jungenitz T, Singer M, Beining M, Cuntz H, Vlachos A, Deller T, Schwarzacher S
Scientific Reports 2017 March;7
Scientific Reports 2017 March;7
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms
Yazdani S, Poosti F, Toro L, Wedel J, Mencke R, Mirković K, de Borst M, Alexander J, Navis G, van Goor H, van den Born J, Hillebrands J
Scientific Reports 2017 March;7
Scientific Reports 2017 March;7
VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations
Hägerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schäfers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer P, Kiefer F
JCI Insight 2017 August;2(16)
JCI Insight 2017 August;2(16)
Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors
Hasselhof V, Sperling A, Buttler K, Ströbel P, Becker J, Aung T, Felmerer G, Wilting J, Dettman R
PLOS ONE 2016 October;11(10)
PLOS ONE 2016 October;11(10)
Integration of CD45-positive leukocytes into newly forming lymphatics of adult mice
Buttler K, Lohrberg M, Gross G, Weich H, Wilting J
Histochemistry and Cell Biology 2016 June;145(6):629-636
Histochemistry and Cell Biology 2016 June;145(6):629-636
Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
Stergiopoulos A, Politis P
Nature Communications 2016 July;7
Nature Communications 2016 July;7
Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells
Choi D, Ramu S, Park E, Jung E, Yang S, Jung W, Choi I, Lee S, Kim K, Seong Y, Hong M, Daghlian G, Kim D, Shin E, Seo J, Khatchadourian V, Zou M, Li W, De Filippo R, Kokorowski P, Chang A, Kim S, Bertoni A, Furlanetto T, Shin S, Li M, Chen Y, Wong A, Koh C, Geliebter J, Hong Y
Cancer Research 2016 January;76(3):582-593
Cancer Research 2016 January;76(3):582-593
Prox1 identifies proliferating neuroblasts and nascent neurons during neurogenesis in sympathetic ganglia
Holzmann J, Hennchen M, Rohrer H
Developmental Neurobiology 2015 December;75(12):1352-1367
Developmental Neurobiology 2015 December;75(12):1352-1367
TH2 cells and their cytokines regulate formation and function of lymphatic vessels
Shin K, Kataru R, Park H, Kwon B, Kim T, Hong Y, Lee S
Nature Communications 2015 December;6(1)
Nature Communications 2015 December;6(1)
Differential Structural Development of Adult-Born Septal Hippocampal Granule Cells in the Thy1-GFP Mouse, Nuclear Size as a New Index of Maturation
Radic T, Al-Qaisi O, Jungenitz T, Beining M, Schwarzacher S, Zheng J
PLOS ONE 2015 August;10(8)
PLOS ONE 2015 August;10(8)
Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model
Quagliata L, Klusmeier S, Cremers N, Pytowski B, Harvey A, Pettis R, Thiele W, Sleeman J
Clinical & Experimental Metastasis 2014 March;31(3):351-365
Clinical & Experimental Metastasis 2014 March;31(3):351-365
ΔNp63 isoform-mediated β-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma
Suarez-Carmona M, Hubert P, Gonzalez A, Duray A, Roncarati P, Erpicum C, Boniver J, Castronovo V, Noel A, Saussez S, Peulen O, Delvenne P, Herfs M
Oncotarget 2014 April;5(7)
Oncotarget 2014 April;5(7)
Fusing VE-Cadherin to -Catenin Impairs Fetal Liver Hematopoiesis and Lymph but Not Blood Vessel Formation
Dartsch N, Schulte D, Hagerling R, Kiefer F, Vestweber D
Molecular and Cellular Biology 2014 April;34(9):1634-1648
Molecular and Cellular Biology 2014 April;34(9):1634-1648
Lymphatic vascular response to acute inflammation.
Lachance PA, Hazen A, Sevick-Muraca EM
PloS one 2013;8(9):e76078
PloS one 2013;8(9):e76078
VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.
Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY
EMBO molecular medicine 2013 Sep;5(9):1415-30
EMBO molecular medicine 2013 Sep;5(9):1415-30
PROX1: A Lineage Tracer for Cortical Interneurons Originating in the Lateral/Caudal Ganglionic Eminence and Preoptic Area
Rubin A, Kessaris N, Henrique D
PLoS ONE 2013 October;8(10)
PLoS ONE 2013 October;8(10)
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy
Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams R, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F
The EMBO Journal 2013 January;32(5):629-644
The EMBO Journal 2013 January;32(5):629-644
Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration
Choi I, Lee Y, Chung H, Choi D, Ecoiffier T, Lee H, Kim K, Lee S, Park E, Maeng Y, Kim N, Ladner R, Petasis N, Koh C, Chen L, Lenz H, Hong Y
Angiogenesis 2013 January;16(1):29-44
Angiogenesis 2013 January;16(1):29-44
Prox1 suppresses the proliferation of neuroblastoma cells via a dual action in p27-Kip1 and Cdc25A
Foskolou I, Stellas D, Rozani I, Lavigne M, Politis P
Oncogene 2013 February;32(8):947-960
Oncogene 2013 February;32(8):947-960
Lymphatic Reprogramming by Kaposi Sarcoma Herpes Virus Promotes the Oncogenic Activity of the Virus-Encoded G-protein-Coupled Receptor
Aguilar B, Choi I, Choi D, Chung H, Lee S, Yoo J, Lee Y, Maeng Y, Lee H, Park E, Kim K, Kim N, Baik J, Jung J, Koh C, Hong Y
Cancer Research 2012 November;72(22):5833-5842
Cancer Research 2012 November;72(22):5833-5842
Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases
Mentzel T, Schildhaus H, Palmedo G, Büttner R, Kutzner H
Modern Pathology 2012 January;25(1):75-85
Modern Pathology 2012 January;25(1):75-85
Transcriptional Analysis of Gli3 Mutants Identifies Wnt Target Genes in the Developing Hippocampus
Hasenpusch-Theil K, Magnani D, Amaniti E, Han L, Armstrong D, Theil T
Cerebral Cortex 2012 December;22(12):2878-2893
Cerebral Cortex 2012 December;22(12):2878-2893
Erythropoietin Induces Lymph Node Lymphangiogenesis and Lymph Node Tumor Metastasis
Lee A, Kim D, Lee J, Jung Y, Kang K, Lee S, Park S, Kwak J, Lee S, Lim S, Sung M, Yoon S, Kim W
Cancer Research 2011 June;71(13):4506-4517
Cancer Research 2011 June;71(13):4506-4517
Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse
Choi I, Chung H, Ramu S, Lee H, Kim K, Lee S, Yoo J, Choi D, Lee Y, Aguilar B, Hong Y
Blood 2011 January;117(1):362-365
Blood 2011 January;117(1):362-365
Aberrant lymphatic development in euploid fetuses with increased nuchal translucency including Noonan syndrome
de Mooij Y, van den Akker N, Bekker M, Bartelings M, van Vugt J, Gittenberger-de Groot A
Prenatal Diagnosis 2011 February;31(2):159-166
Prenatal Diagnosis 2011 February;31(2):159-166
Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation.
Delfortrie S, Pinte S, Mattot V, Samson C, Villain G, Caetano B, Lauridant-Philippin G, Baranzelli MC, Bonneterre J, Trottein F, Faveeuw C, Soncin F
Cancer research 2011 Dec 1;71(23):7176-86
Cancer research 2011 Dec 1;71(23):7176-86
Absence of lymphatic vessels in the dog dental pulp: an immunohistochemical study
Martin A, Gasse H, Staszyk C
Journal of Anatomy 2010 November;217(5):609-615
Journal of Anatomy 2010 November;217(5):609-615
miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo
Leslie Pedrioli D, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin J, Marino D, Kalin R, Leidel S, Cinelli P, Schulte-Merker S, Brandli A, Detmar M
Molecular and Cellular Biology 2010 June;30(14):3620-3634
Molecular and Cellular Biology 2010 June;30(14):3620-3634
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells
Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, Choi I, Otu H, Shin J, Dotto G, Koh C, Detmar M, Hong Y
Blood 2010 July;116(1):140-150
Blood 2010 July;116(1):140-150
Prox1 Regulates the Notch1-Mediated Inhibition of Neurogenesis
Kaltezioti V, Kouroupi G, Oikonomaki M, Mantouvalou E, Stergiopoulos A, Charonis A, Rohrer H, Matsas R, Politis P, Palmer T
PLoS Biology 2010 December;8(12)
PLoS Biology 2010 December;8(12)
CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche
Kim M, Koh Y, Kim K, Koh B, Nam D, Alitalo K, Kim I, Koh G
Cancer Research 2010 December;70(24):10411-10421
Cancer Research 2010 December;70(24):10411-10421
Homeobox Transcription Factor Prox1 in Sympathetic Ganglia of Vertebrate Embryos: Correlation With Human Stage 4s Neuroblastoma
Becker J, Wang B, Pavlakovic H, Buttler K, Wilting J
Pediatric Research 2010 August;68(2):112-117
Pediatric Research 2010 August;68(2):112-117
Kaposin-B Enhances the PROX1 mRNA Stability during Lymphatic Reprogramming of Vascular Endothelial Cells by Kaposi's Sarcoma Herpes Virus
Yoo J, Kang J, Lee H, Aguilar B, Kafka D, Lee S, Choi I, Lee J, Ramu S, Haas J, Koh C, Hong Y, Ganem D
PLoS Pathogens 2010 August;6(8)
PLoS Pathogens 2010 August;6(8)
Role of CD11b + Macrophages in Intraperitoneal Lipopolysaccharide-Induced Aberrant Lymphangiogenesis and Lymphatic Function in the Diaphragm
Kim K, Koh Y, Jeon B, Jang C, Han J, Kataru R, Schwendener R, Kim J, Koh G
The American Journal of Pathology 2009 October;175(4):1733-1745
The American Journal of Pathology 2009 October;175(4):1733-1745
Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade
Spinella F, Garrafa E, Di Castro V, Rosano L, Nicotra M, Caruso A, Natali P, Bagnato A
Cancer Research 2009 March;69(6):2669-2676
Cancer Research 2009 March;69(6):2669-2676
Endothelial cells from cord blood CD133+CD34+ progenitors share phenotypic, functional and gene expression profile similarities with lymphatics.
Nguyen VA, Fürhapter C, Obexer P, Stössel H, Romani N, Sepp N
Journal of cellular and molecular medicine 2009 Mar;13(3):522-34
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Journal of Clinical Investigation
Journal of Clinical Investigation
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Supportive validation
- Submitted by
- ReliaTech GmbH (provider)
- Main image
- Experimental details
- Western analysis with anti-human Prox-1.
Supportive validation
- Submitted by
- ReliaTech GmbH (provider)
- Main image
- Experimental details
- Immunofluorescence with a frozen sections of a mouse embryo at day 13.5 with anti-CD31 [green] and anti-human Prox-1 [red] (RT #102-PA32S). It shows a large lymphatic vessel (lv), blood vessels (arrows) and a sympathetic ganglion (sg) which is also positive for Prox-1 The experiment was performed by PD. Dr. Jörg Wilting, Pädiatrie I, Zentrum für Kinderheilkunde und Jugendmedizin in Göttingen, Germany.
- Sample type
- Mouse embryo
