Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11067-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11067-2-AP, RRID:AB_2268804
- Product name
- PROX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PROX1 antibody (Cat. #11067-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats.
Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts.
The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production.
Native Coronary Collateral Microcirculation Reserve in Rat Hearts.
Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium.
Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid.
Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.
Transplantation of artificial human lymphatic vascular tissues fabricated using a cell-accumulation technique and their engraftment in mouse tissue with vascular remodelling.
Suppression of PROX1-mediated TERT expression in hepatitis B viral hepatocellular carcinoma.
Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum.
Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells.
Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice.
The role of fatty acid β-oxidation in lymphangiogenesis.
Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating interleukin-8 expression.
Mesenchymal status of lymphatic endothelial cell: enlightening treatment of lymphatic malformation.
Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.
The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors.
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
Ton ST, Adamczyk NS, Gerling JP, Vaagenes IC, Wu JY, Hsu K, O'Brien TE, Tsai SY, Kartje GL
Neuroscience insights 2020;15:2633105520968904
Neuroscience insights 2020;15:2633105520968904
Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts.
Ma R, Martínez-Ramírez AS, Borders TL, Gao F, Sosa-Pineda B
eLife 2020 Mar 10;9
eLife 2020 Mar 10;9
The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
Aryal S, Viet J, Weatherbee BAT, Siddam AD, Hernandez FG, Gautier-Courteille C, Paillard L, Lachke SA
Human genetics 2020 Dec;139(12):1541-1554
Human genetics 2020 Dec;139(12):1541-1554
Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production.
Gramolelli S, Elbasani E, Tuohinto K, Nurminen V, Günther T, Kallinen RE, Kaijalainen SP, Diaz R, Grundhoff A, Haglund C, Ziegelbauer JM, Pellinen T, Bower M, Francois M, Ojala PM
Cancer research 2020 Aug 1;80(15):3116-3129
Cancer research 2020 Aug 1;80(15):3116-3129
Native Coronary Collateral Microcirculation Reserve in Rat Hearts.
Liu X, Dong H, Huang B, Miao H, Xu Z, Yuan Y, Qiu F, Chen J, Zhang H, Liu Z, Quan X, Zhu L, Zhang Z
Journal of the American Heart Association 2019 Mar 5;8(5):e011220
Journal of the American Heart Association 2019 Mar 5;8(5):e011220
Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium.
Stone OA, Stainier DYR
Developmental cell 2019 Jul 22;50(2):247-255.e3
Developmental cell 2019 Jul 22;50(2):247-255.e3
Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.
Urner S, Planas-Paz L, Hilger LS, Henning C, Branopolski A, Kelly-Goss M, Stanczuk L, Pitter B, Montanez E, Peirce SM, Mäkinen T, Lammert E
The EMBO journal 2019 Jan 15;38(2)
The EMBO journal 2019 Jan 15;38(2)
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid.
Ahn JH, Cho H, Kim JH, Kim SH, Ham JS, Park I, Suh SH, Hong SP, Song JH, Hong YK, Jeong Y, Park SH, Koh GY
Nature 2019 Aug;572(7767):62-66
Nature 2019 Aug;572(7767):62-66
Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.
Falero-Perez J, Song YS, Zhao Y, Teixeira L, Sorenson CM, Sheibani N
PloS one 2018;13(10):e0206756
PloS one 2018;13(10):e0206756
Transplantation of artificial human lymphatic vascular tissues fabricated using a cell-accumulation technique and their engraftment in mouse tissue with vascular remodelling.
Asano Y, Shimoda H, Matsusaki M, Akashi M
Journal of tissue engineering and regenerative medicine 2018 Mar;12(3):e1501-e1510
Journal of tissue engineering and regenerative medicine 2018 Mar;12(3):e1501-e1510
Suppression of PROX1-mediated TERT expression in hepatitis B viral hepatocellular carcinoma.
Kim YJ, Yoo JE, Jeon Y, Chong JU, Choi GH, Song DG, Jung SH, Oh BK, Park YN
International journal of cancer 2018 Dec 15;143(12):3155-3168
International journal of cancer 2018 Dec 15;143(12):3155-3168
Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum.
Chen CJ, Liao YH, Lin SY, Yu JX, Li ZJ, Lin YC, Chang GJ, Lin CH, Wong AM
American journal of physiology. Regulatory, integrative and comparative physiology 2017 Nov 1;313(5):R601-R607
American journal of physiology. Regulatory, integrative and comparative physiology 2017 Nov 1;313(5):R601-R607
Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells.
Ren JG, Xia HF, Yang JG, Zhu JY, Zhang W, Chen G, Zhao JH, Sun YF, Zhao YF
Human pathology 2017 Jul;65:231-238
Human pathology 2017 Jul;65:231-238
Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice.
Goto T, Elbahrawy A, Furuyama K, Horiguchi M, Hosokawa S, Aoyama Y, Tsuboi K, Sakikubo M, Hirata K, Masui T, Kubo H, Sakai Y, Uemoto S, Kawaguchi Y
FEBS letters 2017 Feb;591(4):624-635
FEBS letters 2017 Feb;591(4):624-635
The role of fatty acid β-oxidation in lymphangiogenesis.
Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P
Nature 2017 Feb 2;542(7639):49-54
Nature 2017 Feb 2;542(7639):49-54
Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating interleukin-8 expression.
Liu Y, Zhang Y, Wang S, Dong QZ, Shen Z, Wang W, Tao S, Gu C, Liu J, Xie Y, Qin LX
Hepatology (Baltimore, Md.) 2017 Dec;66(6):1894-1909
Hepatology (Baltimore, Md.) 2017 Dec;66(6):1894-1909
Mesenchymal status of lymphatic endothelial cell: enlightening treatment of lymphatic malformation.
Cai X, Zhang W, Chen G, Li RF, Sun YF, Zhao YF
International journal of clinical and experimental medicine 2015;8(8):12239-51
International journal of clinical and experimental medicine 2015;8(8):12239-51
Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.
Cho E, Kim DH, Hur YN, Whitcomb DJ, Regan P, Hong JH, Kim H, Ho Suh Y, Cho K, Park M
Scientific reports 2015 Jul 29;5:12624
Scientific reports 2015 Jul 29;5:12624
The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors.
Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G
Genes & development 2014 Oct 1;28(19):2175-87
Genes & development 2014 Oct 1;28(19):2175-87
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 11067-2-AP(PROX1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using PROX1 antibody 11067-2-AP at 1:100 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 11067-2-AP(PROX1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue