BS9192

antibody from Bioworld Technology, Inc

Targeting: CDC42BPA FLJ23347, KIAA0451, MRCK, MRCKA, PK428

Western blot (Data presented on provider website)

Antibody Data

Product number

BS9192

Provider

Bioworld Technology, Inc

Product name

MRCKÏ« (L663) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 634-687 of Human MRCKÏ«.

Description

Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues. Myotonic dystrophy kinase-related Cdc42-binding (DMPK-like) kinases-a and b (MRCK-a, b) contain a cysteine-rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle myosin light chain and influences actin-myosin contractility (3,4). MRCK-a can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/cofilin and to Actin cytoskeletal reorganization. MRCK-a can also influence neurite outgrowth promoted by Cdc42 and Rac.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.