BS7737

antibody from Bioworld Technology, Inc
Targeting: DISC1
Provider product page for BS7737
Western blot
Immunohistochemistry

Antibody data

Product number
BS7737 - Provider product page
Provider
Bioworld Technology, Inc
Product name
DISC1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human DISC1.
Description
The ¡ùDisrupted In Schizophrenia¡ì gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and nudel; proteins which localize receptors to membranes, including a-actinin-2 and spectrin b IV; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain. DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
DISC1 protein structure - BS7737 shown in red.