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- Antigen structure
- References [18]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 10698-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10698-1-AP, RRID:AB_2296744
- Product name
- KMO antibody
- Antibody type
- Polyclonal
- Description
- KMO antibody (Cat. #10698-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression.
Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity.
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.
A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.
Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors.
Fr‑HMGB1 and ds‑HMGB1 activate the kynurenine pathway via different mechanisms in association with depressive‑like behavior.
The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.
Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.
Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.
Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.
Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.
Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).
Itoh G, Takagane K, Fukushi Y, Kuriyama S, Umakoshi M, Goto A, Yanagihara K, Yashiro M, Tanaka M
Molecular oncology 2022 Jan;16(1):166-187
Molecular oncology 2022 Jan;16(1):166-187
Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity.
Morita N, Hoshi M, Hara T, Ninomiya S, Enoki T, Yoneda M, Tsurumi H, Saito K
Oncology letters 2021 Nov;22(5):790
Oncology letters 2021 Nov;22(5):790
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
Liu IL, Chung TF, Huang WH, Hsu CH, Liu CC, Chiu YH, Huang KC, Liao AT, Lin CS
Veterinary and comparative oncology 2021 Mar;19(1):79-91
Veterinary and comparative oncology 2021 Mar;19(1):79-91
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Hoshi M, Kubo H, Ando T, Tashita C, Nakamoto K, Yamamoto Y, Tezuka H, Saito K
ImmunoHorizons 2021 Jun 28;5(6):523-534
ImmunoHorizons 2021 Jun 28;5(6):523-534
Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.
Tan B, Chen J, Qin S, Liao C, Zhang Y, Wang D, Li S, Zhang Z, Zhang P, Xu F
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.
Baumgartner R, Berg M, Matic L, Polyzos KP, Forteza MJ, Hjorth SA, Schwartz TW, Paulsson-Berne G, Hansson GK, Hedin U, Ketelhuth DFJ
Journal of internal medicine 2021 Jan;289(1):53-68
Journal of internal medicine 2021 Jan;289(1):53-68
A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.
Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F
PLoS genetics 2020 Nov;16(11):e1009129
PLoS genetics 2020 Nov;16(11):e1009129
Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors.
Chiu YH, Lei HJ, Huang KC, Chiang YL, Lin CS
Journal of oncology 2019;2019:6201764
Journal of oncology 2019;2019:6201764
Fr‑HMGB1 and ds‑HMGB1 activate the kynurenine pathway via different mechanisms in association with depressive‑like behavior.
Wang B, Lian YJ, Su WJ, Liu LL, Li JM, Jiang CL, Wang YX
Molecular medicine reports 2019 Jul;20(1):359-367
Molecular medicine reports 2019 Jul;20(1):359-367
The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.
Xu G, Liu X, Wang Y
Brain research 2018 Sep 15;1695:53-64
Brain research 2018 Sep 15;1695:53-64
Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.
Hu P, Hunt NH, Arfuso F, Shaw LC, Uddin MN, Zhu M, Devasahayam R, Adamson SJ, Benson VL, Chan-Ling T, Grant MB
Investigative ophthalmology & visual science 2017 Oct 1;58(12):5043-5055
Investigative ophthalmology & visual science 2017 Oct 1;58(12):5043-5055
Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.
Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O'Connor JC, Lee AW, Heijnen CJ, Kavelaars A
Brain, behavior, and immunity 2017 Nov;66:94-102
Brain, behavior, and immunity 2017 Nov;66:94-102
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.
Formisano S, Hornig M, Yaddanapudi K, Vasishtha M, Parsons LH, Briese T, Lipkin WI, Williams BL
Journal of virology 2017 Jul 15;91(14)
Journal of virology 2017 Jul 15;91(14)
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Guastella AR, Michelhaugh SK, Klinger NV, Kupsky WJ, Polin LA, Muzik O, Juhász C, Mittal S
Molecular imaging 2016;15
Molecular imaging 2016;15
Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.
Korstanje R, Deutsch K, Bolanos-Palmieri P, Hanke N, Schroder P, Staggs L, Bräsen JH, Roberts IS, Sheehan S, Savage H, Haller H, Schiffer M
Journal of the American Society of Nephrology : JASN 2016 Nov;27(11):3271-3277
Journal of the American Society of Nephrology : JASN 2016 Nov;27(11):3271-3277
Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.
Rojewska E, Piotrowska A, Makuch W, Przewlocka B, Mika J
Neuropharmacology 2016 Mar;102:80-91
Neuropharmacology 2016 Mar;102:80-91
Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.
Wang Q, Zhang M, Ding Y, Wang Q, Zhang W, Song P, Zou MH
Circulation research 2014 Jan 31;114(3):480-92
Circulation research 2014 Jan 31;114(3):480-92
Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).
Winkler D, Beconi M, Toledo-Sherman LM, Prime M, Ebneth A, Dominguez C, Muñoz-Sanjuan I
Journal of biomolecular screening 2013 Sep;18(8):879-89
Journal of biomolecular screening 2013 Sep;18(8):879-89
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 10698-1-AP(KMO antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Kynurenine 3 monooxygenase antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Kynurenine 3 monooxygenase. This antibody recognizes human,mouse,rat antigen. The Kynurenine 3 monooxygenase antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10698-1-AP(KMO antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10698-1-AP(KMO antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
