CABT-RM102

antibody from Creative Diagnostics

Targeting: MAP1LC3C ATG8J

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-RM102

Provider

Creative Diagnostics

Product name

Rabbit Anti-MAP1LC3C polyclonal antibody

Antibody type

Polyclonal

Description

Microtubule-associated proteins 1A/1B light chain 3C is encoded by the MAP1LC3C gene in human. LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. LC3A is mainly localized to perinuclear and nuclear regions, LC3B is evenly distributed throughout the cytoplasm and is also localized in the nucleolar regions, and LC3C is shown to be located in the cytoplasm and strongly in the nuclei. LC3C is synthesized with a propeptide (aa 127-147), which is removed in the mature form. LC3C is a ubiquitin-like modifier that plays a crucial role in antibacterial autophagy through the selective binding of CALCOCO2. It recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. It is also reported to play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins. LC3C is recruited to damaged mitochondria where it mediates autophagosomal degradation of mitochondrial parts in a piecemeal fashion and is required for maintaining basal mitochondrial network homeostasis. It also mediates autophagosomal degradation of MTX1 protein and cooperates with p62 to deliver MTX1 to lysosomes.

Reactivity

Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

200 _L

Storage

Stable for 1 year at 2-8°C from date of receipt.