CEP170

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Description

Centrosomal protein 170

Tissue specificity

Group enriched (bone marrow, brain, testis)

Subcell location

Centrosome, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (243124428 - 243255348)

Ensembl ID

ENSG00000143702  (ver. 103.38)

Orthologs

Mouse Cep170: ENSMUSG00000057335

UniProt

Q5SW79

neXtProt

NX_Q5SW79

Human splice variants
Mouse splice variants

Protein structure