BS2687

antibody from Bioworld Technology, Inc
Targeting: NF1
Provider product page for BS2687
Western blot
Immunocytochemistry

Antibody data

Product number
BS2687 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS2687, RRID:AB_1662626
Product name
Neurofibromin (R1575) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 1550-1600 of Human Neurofibromin.
Description
Neurofibromatosis type 1 (NF1), or von Reckinghausen neurofibromatosis, is one of the most common autosomal dominant disorders in humans. Early linkage analysis mapped the NF1 gene to chromosome 17. The predicted NF1 transcript encodes a 2818 amino acid protein designated NF1GRP. By sequence analysis, similarity has been demonstrated within a small region of NF1GRP and members of the Ras GAP gene family. Functionally, NF1GRP was shown by biochemical analysis involving RAS-GAP hydrolysis and functional complementation in yeast to further resemble GAP protein. The NF1 protein is expressed at relatively constant levels in a broad range of cell lines and tissues including brain, lung, liver, kidney, spleen, muscle and colon.Although little is known regarding the function of NF1GRP, the homology with the catalytic domain of proteins with GTPase activity suggests that the NF1GRP may also interact in vivo with Ras proteins.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NF1 protein structure - BS2687 shown in red.