BS4358

antibody from Bioworld Technology, Inc

Targeting: RYR2 ARVC2, ARVD2, VTSIP

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS4358

Provider

Bioworld Technology, Inc

Product name

RyR2 (phospho S2808) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human RyR2 around the phosphorylation site of Serine 2808.

Description

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The Ï«1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR Ï«1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR Ï«1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.