Antibody data
- Antibody Data
- Antigen structure
- References [47]
- Comments [0]
- Validations [0]
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- Product number
- A010-30 - Provider product page
- Provider
- Badrilla Ltd
- Proper citation
- Badrilla Cat#A010-30, RRID:AB_2617052
- Product name
- RYR2 Phospho Serine-2808 Anti-Serum
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. Abnormal structure and function of ryanodine receptors has been reported in failing hearts, with Ser-2808 phosphorylation appearing elevated in clinical situations which may contribute to the abnormal Ca2+ handling characteristics of cardiac muscle in these conditions. Ser-2808 can be phosphorylated in vitro by PKA or CaMKII, which is coincident with significant change in RyR2 channel function typified by an increased open probability, the abrogation of the inhibitory effects of CaM, and Mg2+, dissociation of regulatory factors, expression of subconductance states and the expression of channel activity at diastolic Ca2+ concentrations. Serine-2808 in human RyR2 equates to Ser-2809 in rabbit RyR2.
- Reactivity
- Human, Mouse, Rat, Canine, Rabbit
- Host
- Rabbit
- Antigen sequence
YNRTRRIS(PO3H2)QT2810
- Isotype
- IgG
- Vial size
- 50 µl
- Storage
- Lyophilised: 4 °C Reconstituted:-80 °C
- Handling
- Reconstitute lyophilised powder in 50 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
Submitted references Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling.
Effect of metoprolol on sarcoplasmic reticulum Ca2+ leak in a rabbit model of heart failure.
Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.
Reactive oxygen species contribute to the development of arrhythmogenic Ca²⁺ waves during β-adrenergic receptor stimulation in rabbit cardiomyocytes.
Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity.
Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.
Potential role of Hsp25 in calcium-modulated cardiomyocytes.
SUMO1-dependent modulation of SERCA2a in heart failure.
Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.
Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca(2+) cycling.
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.
Myocardial transfection with naked DNA plasmid encoding hepatocyte growth factor prevents the progression of heart failure in dogs.
Sequential alterations in Akt, GSK3β, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.
Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Succinate modulates Ca(2+) transient and cardiomyocyte viability through PKA-dependent pathway.
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.
Defects in ryanodine receptor function are associated with systolic dysfunction in rats subjected to volume overload.
Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.
Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum.
Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice.
Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis.
Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins.
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.
Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells.
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808.
Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release kinetics during beta-adrenergic stimulation.
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.
Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels.
The inotropic adaptation during late preconditioning against myocardial stunning is associated with an increase in FKBP12.6.
Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum.
Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function.
Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.
Modulation of cardiac sarcoplasmic reticulum calcium release by aenosine: a protein kinase C- dependent pathway.
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes.
Calcium dynamics in the failing heart: restoration by beta-adrenergic receptor blockade.
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.
Miyazaki Y, Ikeda Y, Shiraishi K, Fujimoto SN, Aoyama H, Yoshimura K, Inui M, Hoshijima M, Kasahara H, Aoki H, Matsuzaki M
PloS one 2012;7(4):e35875
PloS one 2012;7(4):e35875
Effect of metoprolol on sarcoplasmic reticulum Ca2+ leak in a rabbit model of heart failure.
Zhang SJ, Liu ZH, Zou C, Wang L
Chinese medical journal 2012 Mar;125(5):815-22
Chinese medical journal 2012 Mar;125(5):815-22
Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.
Koch SE, Gao X, Haar L, Jiang M, Lasko VM, Robbins N, Cai W, Brokamp C, Varma P, Tranter M, Liu Y, Ren X, Lorenz JN, Wang HS, Jones WK, Rubinstein J
Journal of molecular and cellular cardiology 2012 Jul;53(1):134-44
Journal of molecular and cellular cardiology 2012 Jul;53(1):134-44
Reactive oxygen species contribute to the development of arrhythmogenic Ca²⁺ waves during β-adrenergic receptor stimulation in rabbit cardiomyocytes.
Bovo E, Lipsius SL, Zima AV
The Journal of physiology 2012 Jul 15;590(Pt 14):3291-304
The Journal of physiology 2012 Jul 15;590(Pt 14):3291-304
Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity.
Thireau J, Karam S, Fauconnier J, Roberge S, Cassan C, Cazorla O, Aimond F, Lacampagne A, Babuty D, Richard S
Cardiovascular research 2012 Jul 1;95(1):59-68
Cardiovascular research 2012 Jul 1;95(1):59-68
Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.
Macdougall DA, Agarwal SR, Stopford EA, Chu H, Collins JA, Longster AL, Colyer J, Harvey RD, Calaghan S
Journal of molecular and cellular cardiology 2012 Feb;52(2):388-400
Journal of molecular and cellular cardiology 2012 Feb;52(2):388-400
Potential role of Hsp25 in calcium-modulated cardiomyocytes.
Das T, Yoo YS, Rhim H, Song EJ
Proteomics 2012 Feb;12(3):411-20
Proteomics 2012 Feb;12(3):411-20
SUMO1-dependent modulation of SERCA2a in heart failure.
Kho C, Lee A, Jeong D, Oh JG, Chaanine AH, Kizana E, Park WJ, Hajjar RJ
Nature 2011 Sep 7;477(7366):601-5
Nature 2011 Sep 7;477(7366):601-5
Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.
André L, Gouzi F, Thireau J, Meyer G, Boissiere J, Delage M, Abdellaoui A, Feillet-Coudray C, Fouret G, Cristol JP, Lacampagne A, Obert P, Reboul C, Fauconnier J, Hayot M, Richard S, Cazorla O
Basic research in cardiology 2011 Nov;106(6):1235-46
Basic research in cardiology 2011 Nov;106(6):1235-46
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K
Circulation 2011 May 24;123(20):2192-203
Circulation 2011 May 24;123(20):2192-203
Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.
Llach A, Molina CE, Prat-Vidal C, Fernandes J, Casadó V, Ciruela F, Lluís C, Franco R, Cinca J, Hove-Madsen L
European heart journal 2011 Mar;32(6):721-9
European heart journal 2011 Mar;32(6):721-9
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.
Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM
Journal of molecular and cellular cardiology 2011 Jan;50(1):230-8
Journal of molecular and cellular cardiology 2011 Jan;50(1):230-8
Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca(2+) cycling.
Aoyama H, Ikeda Y, Miyazaki Y, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M
Cardiovascular research 2011 Jan 1;89(1):79-88
Cardiovascular research 2011 Jan 1;89(1):79-88
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ
Circulation research 2011 Dec 9;109(12):1396-400
Circulation research 2011 Dec 9;109(12):1396-400
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.
Mohamed TM, Oceandy D, Zi M, Prehar S, Alatwi N, Wang Y, Shaheen MA, Abou-Leisa R, Schelcher C, Hegab Z, Baudoin F, Emerson M, Mamas M, Di Benedetto G, Zaccolo M, Lei M, Cartwright EJ, Neyses L
The Journal of biological chemistry 2011 Dec 2;286(48):41520-9
The Journal of biological chemistry 2011 Dec 2;286(48):41520-9
Myocardial transfection with naked DNA plasmid encoding hepatocyte growth factor prevents the progression of heart failure in dogs.
Rastogi S, Guerrero M, Wang M, Ilsar I, Sabbah MS, Gupta RC, Sabbah HN
American journal of physiology. Heart and circulatory physiology 2011 Apr;300(4):H1501-9
American journal of physiology. Heart and circulatory physiology 2011 Apr;300(4):H1501-9
Sequential alterations in Akt, GSK3β, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.
Prévilon M, Pezet M, Dachez C, Mercadier JJ, Rouet-Benzineb P
Canadian journal of physiology and pharmacology 2010 Nov;88(11):1093-101
Canadian journal of physiology and pharmacology 2010 Nov;88(11):1093-101
Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.
Couvreur N, Tissier R, Pons S, Chetboul V, Gouni V, Bruneval P, Mandet C, Pouchelon JL, Berdeaux A, Ghaleh B
European heart journal 2010 Jun;31(12):1529-37
European heart journal 2010 Jun;31(12):1529-37
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Sedej S, Heinzel FR, Walther S, Dybkova N, Wakula P, Groborz J, Gronau P, Maier LS, Vos MA, Lai FA, Napolitano C, Priori SG, Kockskämper J, Pieske B
Cardiovascular research 2010 Jul 1;87(1):50-9
Cardiovascular research 2010 Jul 1;87(1):50-9
Succinate modulates Ca(2+) transient and cardiomyocyte viability through PKA-dependent pathway.
Aguiar CJ, Andrade VL, Gomes ER, Alves MN, Ladeira MS, Pinheiro AC, Gomes DA, Almeida AP, Goes AM, Resende RR, Guatimosim S, Leite MF
Cell calcium 2010 Jan;47(1):37-46
Cell calcium 2010 Jan;47(1):37-46
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.
Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH
Circulation research 2010 Feb 5;106(2):354-62
Circulation research 2010 Feb 5;106(2):354-62
Defects in ryanodine receptor function are associated with systolic dysfunction in rats subjected to volume overload.
Juric D, Yao X, Thandapilly S, Louis X, Cantor E, Chaze B, Wojciechowski P, Vasanji Z, Yang T, Wigle J, Netticadan T
Experimental physiology 2010 Aug;95(8):869-79
Experimental physiology 2010 Aug;95(8):869-79
Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.
Hoyer DP, Grönke S, Frank KF, Addicks K, Wettschureck N, Offermanns S, Erdmann E, Reuter H
Molecular and cellular biochemistry 2010 Aug;341(1-2):235-44
Molecular and cellular biochemistry 2010 Aug;341(1-2):235-44
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.
Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M
Circulation research 2010 Apr 30;106(8):1413-24
Circulation research 2010 Apr 30;106(8):1413-24
Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum.
Sahoo SK, Kim T, Kang GB, Lee JG, Eom SH, Kim do H
The Journal of biological chemistry 2009 Nov 6;284(45):31109-21
The Journal of biological chemistry 2009 Nov 6;284(45):31109-21
Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice.
Yuan Q, Han P, Dong M, Ren X, Zhou X, Chen S, Jones WK, Chu G, Wang HS, Kranias EG
American journal of physiology. Heart and circulatory physiology 2009 May;296(5):H1484-90
American journal of physiology. Heart and circulatory physiology 2009 May;296(5):H1484-90
Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis.
McConnell BK, Popovic Z, Mal N, Lee K, Bautista J, Forudi F, Schwartzman R, Jin JP, Penn M, Bond M
The Journal of biological chemistry 2009 Jan 16;284(3):1583-92
The Journal of biological chemistry 2009 Jan 16;284(3):1583-92
Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins.
Gómez AM, Rueda A, Sainte-Marie Y, Pereira L, Zissimopoulos S, Zhu X, Schaub R, Perrier E, Perrier R, Latouche C, Richard S, Picot MC, Jaisser F, Lai FA, Valdivia HH, Benitah JP
Circulation 2009 Apr 28;119(16):2179-87
Circulation 2009 Apr 28;119(16):2179-87
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Said M, Becerra R, Palomeque J, Rinaldi G, Kaetzel MA, Diaz-Sylvester PL, Copello JA, Dedman JR, Mundiña-Weilenmann C, Vittone L, Mattiazzi A
American journal of physiology. Heart and circulatory physiology 2008 Oct;295(4):H1669-83
American journal of physiology. Heart and circulatory physiology 2008 Oct;295(4):H1669-83
Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.
Medeiros A, Rolim NP, Oliveira RS, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC
Journal of applied physiology (Bethesda, Md. : 1985) 2008 Jan;104(1):103-9
Journal of applied physiology (Bethesda, Md. : 1985) 2008 Jan;104(1):103-9
Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells.
Manni S, Mauban JH, Ward CW, Bond M
The Journal of biological chemistry 2008 Aug 29;283(35):24145-54
The Journal of biological chemistry 2008 Aug 29;283(35):24145-54
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Grote-Wessels S, Baba HA, Boknik P, El-Armouche A, Fabritz L, Gillmann HJ, Kucerova D, Matus M, Müller FU, Neumann J, Schmitz M, Stümpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U
Cardiovascular research 2008 Aug 1;79(3):464-71
Cardiovascular research 2008 Aug 1;79(3):464-71
Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808.
MacDonnell SM, García-Rivas G, Scherman JA, Kubo H, Chen X, Valdivia H, Houser SR
Circulation research 2008 Apr 25;102(8):e65-72
Circulation research 2008 Apr 25;102(8):e65-72
Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release kinetics during beta-adrenergic stimulation.
Ferrero P, Said M, Sánchez G, Vittone L, Valverde C, Donoso P, Mattiazzi A, Mundiña-Weilenmann C
Journal of molecular and cellular cardiology 2007 Sep;43(3):281-91
Journal of molecular and cellular cardiology 2007 Sep;43(3):281-91
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.
Quaile MP, Rossman EI, Berretta RM, Bratinov G, Kubo H, Houser SR, Margulies KB
Journal of molecular and cellular cardiology 2007 Nov;43(5):552-63
Journal of molecular and cellular cardiology 2007 Nov;43(5):552-63
Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels.
An J, Bosnjak ZJ, Jiang MT
Anesthesia and analgesia 2007 Nov;105(5):1207-13, table of contents
Anesthesia and analgesia 2007 Nov;105(5):1207-13, table of contents
The inotropic adaptation during late preconditioning against myocardial stunning is associated with an increase in FKBP12.6.
Lucats L, Vinet L, Bizé A, Monnet X, Morin D, Su JB, Rouet-Benzineb P, Cazorla O, Mercadier JJ, Hittinger L, Berdeaux A, Ghaleh B
Cardiovascular research 2007 Feb 1;73(3):560-7
Cardiovascular research 2007 Feb 1;73(3):560-7
Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum.
Bupha-Intr T, Wattanapermpool J
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1101-8
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1101-8
Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function.
Gregory KN, Ginsburg KS, Bodi I, Hahn H, Marreez YM, Song Q, Padmanabhan PA, Mitton BA, Waggoner JR, Del Monte F, Park WJ, Dorn GW 2nd, Bers DM, Kranias EG
Journal of molecular and cellular cardiology 2006 May;40(5):653-65
Journal of molecular and cellular cardiology 2006 May;40(5):653-65
Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.
Antoons G, Vangheluwe P, Volders PG, Bito V, Holemans P, Ceci M, Wuytack F, Caroni P, Mubagwa K, Sipido KR
Journal of molecular and cellular cardiology 2006 Mar;40(3):350-60
Journal of molecular and cellular cardiology 2006 Mar;40(3):350-60
Modulation of cardiac sarcoplasmic reticulum calcium release by aenosine: a protein kinase C- dependent pathway.
Ghelardoni S, Frascarelli S, Carnicelli V, Ronca-Testoni S, Zucchi R
Molecular and cellular biochemistry 2006 Aug;288(1-2):59-64
Molecular and cellular biochemistry 2006 Aug;288(1-2):59-64
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR Jr, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J Jr, Chen J, Xiao RP, Cheng H, Fu XD
Cell 2005 Jan 14;120(1):59-72
Cell 2005 Jan 14;120(1):59-72
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Wehrens XH, Lehnart SE, Reiken SR, Marks AR
Circulation research 2004 Apr 2;94(6):e61-70
Circulation research 2004 Apr 2;94(6):e61-70
Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes.
Terentyev D, Viatchenko-Karpinski S, Gyorke I, Terentyeva R, Gyorke S
The Journal of physiology 2003 Oct 1;552(Pt 1):109-18
The Journal of physiology 2003 Oct 1;552(Pt 1):109-18
Calcium dynamics in the failing heart: restoration by beta-adrenergic receptor blockade.
Plank DM, Yatani A, Ritsu H, Witt S, Glascock B, Lalli MJ, Periasamy M, Fiset C, Benkusky N, Valdivia HH, Sussman MA
American journal of physiology. Heart and circulatory physiology 2003 Jul;285(1):H305-15
American journal of physiology. Heart and circulatory physiology 2003 Jul;285(1):H305-15
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
Ji Y, Li B, Reed TD, Lorenz JN, Kaetzel MA, Dedman JR
The Journal of biological chemistry 2003 Jul 4;278(27):25063-71
The Journal of biological chemistry 2003 Jul 4;278(27):25063-71
Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.
Stange M, Xu L, Balshaw D, Yamaguchi N, Meissner G
The Journal of biological chemistry 2003 Dec 19;278(51):51693-702
The Journal of biological chemistry 2003 Dec 19;278(51):51693-702
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