Ab123023

antibody from Aladdin Scientific Corporation

Targeting: PSEN1 AD3, FAD, PS1, S182

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

Ab123023

Provider

Aladdin Scientific Corporation

Product name

Recombinant Presenilin 1/PS-1 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human Presenilin 1/PS-1 Antibody, Recombinant (R05-4D4), could be used for WB, IF, ICC and so on.Application:WB: 1/500-1/1000ICC/IF: 1/50-1/200Protein functionProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 346-361


Antibody clone number

R05-4D4

Vial size

100μl,10μl,1ml,50μl

Concentration

0,2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.