Antibody data

Product number
10-1052-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Bcl-2 Antibody
Antibody type
Monoclonal
Description
Bcl-2 (B-cell lymphoma 2), is a member of Bcl-2 family of regulator proteins. These proteins contain a hydrophobic cleft that binds to BH3-only proteins and to the pro-apoptotic Bcl-2 family members Bad, Bak, and Bax to inhibit apoptosis. In the absence of this binding, the proapoptotic Bcl-2 members are recruited to the OMM (Outer Mitochondrial Membrane) at which they oligomerize and cause OMM permeabilization, releasing proapoptotic effectors such as SMAC or cytochrome-c. Bcl-2 also neutralize a group of 'sensor' proteins (such as BIM), which are triggered by cytotoxic stimuli such as chemotherapy. BCL-2 proteins therefore have a central role as guardians against apoptosis, helping cancer cells to evade cell death.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A synthetic peptide corresponding t
o amino acids 41-54 (GAAPAPGIFSSQPG
-Cys), of human Bcl-2 was used as i
mmunogen.
Isotype
IgG
Antibody clone number
BC1
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
BCL2 protein structure - 10-1052-25 shown in red.