Tissue expression
Cell line expression
Protein structure
TNFSF12
TNF superfamily member 12APO3L, DR3LG, TWEAK
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Top validated antibodies |
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Novus Biologicals | NBP1-76695 | 3 references | Polyclonal |
WB
EL
ICC
IHC |
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R&D Systems | AF1090 | 3 references | Polyclonal |
WB
ICC
BN
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LSBio | LS-C19592 | Polyclonal |
WB
EL
ICC
IHC |
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antibodies-online | ABIN501094 | 5 references | Polyclonal |
WB
EL
IHC
|
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Boster Biological Technology | A02009-2 | Polyclonal |
WB
EL
ICC
IHC |
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