301018

antibody from BioLegend

Targeting: CD8A CD8

Immunohistochemistry

Other assay

Antibody data

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Validation data

Product number: 301018 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#301018, RRID:AB_314136
Product name: LEAF™ Purified anti-human CD8a [RPA-T8]
Antibody type: Monoclonal
Antigen: CD8a
Description: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Reactivity: Human, Simian
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 500 µg
Concentration: 1 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.

CD8A protein structure - 301018 shown in red.