Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 14839-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14839-1-AP, RRID:AB_2089323
- Product name
- GEFT-Specific antibody
- Antibody type
- Polyclonal
- Description
- GEFT-Specific antibody (Cat. #14839-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger.
p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
The blocking of angiotensin II type 1 receptor and RhoA/Rho kinase activity in hypertensive patients: Effect of olmesartan medoxomil and implication with cardiovascular-renal remodeling.
Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.
Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients.
Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells.
p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism.
p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.
Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.
Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV
Science signaling 2018 Oct 30;11(554)
Science signaling 2018 Oct 30;11(554)
p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, Lutz S
Journal of molecular and cellular cardiology 2015 Nov;88:39-54
Journal of molecular and cellular cardiology 2015 Nov;88:39-54
The blocking of angiotensin II type 1 receptor and RhoA/Rho kinase activity in hypertensive patients: Effect of olmesartan medoxomil and implication with cardiovascular-renal remodeling.
Ravarotto V, Pagnin E, Maiolino G, Fragasso A, Carraro G, Rossi B, Calò LA
Journal of the renin-angiotensin-aldosterone system : JRAAS 2015 Dec;16(4):1245-50
Journal of the renin-angiotensin-aldosterone system : JRAAS 2015 Dec;16(4):1245-50
Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.
Artamonov MV, Jin L, Franke AS, Momotani K, Ho R, Dong XR, Majesky MW, Somlyo AV
The Journal of biological chemistry 2015 Apr 17;290(16):10353-67
The Journal of biological chemistry 2015 Apr 17;290(16):10353-67
Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients.
Calò LA, Davis PA, Pagnin E, Dal Maso L, Maiolino G, Seccia TM, Pessina AC, Rossi GP
Journal of hypertension 2014 Feb;32(2):331-8
Journal of hypertension 2014 Feb;32(2):331-8
Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV
The Journal of biological chemistry 2013 Nov 22;288(47):34030-34040
The Journal of biological chemistry 2013 Nov 22;288(47):34030-34040
p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells.
Hayashi A, Hiatari R, Tsuji T, Ohashi K, Mizuno K
FEBS letters 2013 Mar 18;587(6):698-705
FEBS letters 2013 Mar 18;587(6):698-705
p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.
Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV
Circulation research 2011 Oct 14;109(9):993-1002
Circulation research 2011 Oct 14;109(9):993-1002
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ
Genes & development 2011 Oct 1;25(19):2069-78
Genes & development 2011 Oct 1;25(19):2069-78
GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism.
Mitchell DC, Bryan BA, Liu L, Hu XH, Huang XQ, Ji WK, Chen PC, Hu WF, Liu JP, Zhang J, Liu M, Li DW
Current molecular medicine 2011 Aug;11(6):465-80
Current molecular medicine 2011 Aug;11(6):465-80
p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.
Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):4865-76
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):4865-76
Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.
Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M
Molecular and cellular biology 2005 Dec;25(24):11089-101
Molecular and cellular biology 2005 Dec;25(24):11089-101
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 14839-1-AP(GEFT-Specific antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GEFT-Specific (IP:14839-1-AP, 4ug; Detection:14839-1-AP 1:1500) with mouse brain tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GEFT-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human GEFT-Specific. This antibody recognizes human,mouse,rat antigen. The GEFT-Specific antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.