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antibody from Invitrogen Antibodies
Targeting: GFAP
FLJ45472
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- Antibody Data
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- References [234]
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- Product number
- 13-0300 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- GFAP Monoclonal Antibody (2.2B10)
- Antibody type
- Monoclonal
- Antigen
- Other
- Reactivity
- Human, Mouse, Rat, Bovine
- Host
- Rat
- Isotype
- IgG
- Antibody clone number
- 2.2B10
- Vial size
- 100 µg
- Concentration
- 0.5 mg/mL
- Storage
- -20°C
Submitted references TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice.
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease.
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.
Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone.
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina.
4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway.
Neuronal-glial communication perturbations in murine SOD1(G93A) spinal cord.
Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development.
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion.
The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma.
Analysing Intercellular Communication in Astrocytic Networks Using "Astral".
Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages.
Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation.
Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice.
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding.
3D spheroids of human placenta-derived mesenchymal stem cells attenuate spinal cord injury in mice.
Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy.
Ndufs4 ablation decreases synaptophysin expression in hippocampus.
The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism.
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
Semaphorin 7A restricts serotonergic innervation and ensures recovery after spinal cord injury.
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models.
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.
Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice.
Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice.
Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1(G93A) murine model of amyotrophic lateral sclerosis in a sex-dependent manner.
Inhibitory control in neuronal networks relies on the extracellular matrix integrity.
Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice.
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains.
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture.
Microglial G(i)-dependent dynamics regulate brain network hyperexcitability.
An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice.
3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics.
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.
Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.
Pemafibrate Prevents Retinal Dysfunction in a Mouse Model of Unilateral Common Carotid Artery Occlusion.
Late-in-life neurodegeneration after chronic sleep loss in young adult mice.
Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury.
Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke.
Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound.
Ferrochelatase regulates retinal neovascularization.
Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory.
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells.
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress.
Depression-like behaviors induced by defective PTPRT activity through dysregulated synaptic functions and neurogenesis.
Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models.
LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
Microglia-organized scar-free spinal cord repair in neonatal mice.
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model.
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.
Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease.
The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome.
Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis.
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.
Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers.
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.
Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice.
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes.
Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.
Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.
Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment.
Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues.
mTORC1 and mTORC2 expression in inner retinal neurons and glial cells.
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice.
Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes.
Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer.
Neuronal vulnerability and multilineage diversity in multiple sclerosis.
Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.
NLRP3 inflammasome activation drives tau pathology.
Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina.
Pannexin 1 Regulates Network Ensembles and Dendritic Spine Development in Cortical Neurons.
Visualization of spatiotemporal dynamics of human glioma stem cell invasion.
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice.
The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury.
Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis.
Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.
Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization.
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Astrocyte-specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity.
Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity.
Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes.
Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.
Blood-brain barrier shuttle peptides enhance AAV transduction in the brain after systemic administration.
Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain.
Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes.
Characterization of the ventricular-subventricular stem cell niche during human brain development.
Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier.
Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development.
Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury.
Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice.
CREB controls cortical circuit plasticity and functional recovery after stroke.
Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria.
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.
Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia.
Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.
Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice.
Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.
Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion.
Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells.
RNA Interference of Human α-Synuclein in Mouse.
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with Complete Spinal Cord Transection.
Defining an Analytic Framework to Evaluate Quantitative MRI Markers of Traumatic Axonal Injury: Preliminary Results in a Mouse Closed Head Injury Model.
Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes.
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration.
Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice.
Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.
Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage.
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.
Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages.
Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.
Neurotoxic reactive astrocytes are induced by activated microglia.
P2Y(12) receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases.
Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.
Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development.
Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats.
Magnetic resonance microdynamic imaging reveals distinct tissue microenvironments.
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
FACS-based Isolation of Neural and Glioma Stem Cell Populations from Fresh Human Tissues Utilizing EGF Ligand.
Regulation of RhoA by STAT3 coordinates glial scar formation.
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters.
Inhibition of neuronal ferroptosis protects hemorrhagic brain.
Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)T(reg) cells.
Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration.
3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.
Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice.
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.
Epigenetic regulation of neural N-glycomics.
Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.
Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors.
CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells.
STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury.
Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.
Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage.
Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina.
Cross-species Analyses Unravel the Complexity of H3K27me3 and H4K20me3 in the Context of Neural Stem Progenitor Cells.
A complement-microglial axis drives synapse loss during virus-induced memory impairment.
The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice.
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.
Isolation and Culture of Adult Neural Stem Cells from the Mouse Subcallosal Zone.
Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia.
Cuprizone demyelination induces a unique inflammatory response in the subventricular zone.
Tumor necrosis factor superfamily member APRIL contributes to fibrotic scar formation after spinal cord injury.
Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration.
Interferon-gamma promotes infection of astrocytes by Trypanosoma cruzi.
Glial Fibrillary Acidic Protein-Expressing Glia in the Mouse Lung.
Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination.
TREM2 regulates microglial cell activation in response to demyelination in vivo.
Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.
Identification of a neurovascular signaling pathway regulating seizures in mice.
Syringe-injectable electronics.
Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling.
The BRAF kinase domain promotes the development of gliomas in vivo.
Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury.
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.
Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor.
Fibronectin Matrix Assembly after Spinal Cord Injury.
Astrocyte overexpression of heme oxygenase-1 improves outcome after intracerebral hemorrhage.
Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling.
The contribution of CXCL12-expressing radial glia cells to neuro-vascular patterning during human cerebral cortex development.
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model.
Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation.
Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.
Neuregulin-1/glial growth factor stimulates Schwann cell migration by inducing α5 β1 integrin-ErbB2-focal adhesion kinase complex formation.
PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.
Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury.
Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait.
Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis.
Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke.
ABCA1 influences neuroinflammation and neuronal death.
Differences in distribution and regulation of astrocytic aquaporin-4 in human and rat hydrocephalic brain.
Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury.
Partial change in EphA4 knockout mouse phenotype: loss of diminished GFAP upregulation following spinal cord injury.
Antiinflammatory treatment ameliorates HPA stress axis dysfunction in a mouse model of stress sensitivity.
p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury.
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice.
Minocycline attenuates photoreceptor degeneration in a mouse model of subretinal hemorrhage microglial: inhibition as a potential therapeutic strategy.
CCAAT/enhancer binding protein-δ expression by dendritic cells regulates CNS autoimmune inflammatory disease.
Factors supporting intrathecal humoral responses following viral encephalomyelitis.
Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain.
Ultrafast resorbing polymers for use as carriers for cortical neural probes.
Comparative characterization of the human and mouse third ventricle germinal zones.
Biohybrid Carbon Nanotube/Agarose Fibers for Neural Tissue Engineering.
The fate of ultrafast degrading polymeric implants in the brain.
Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage.
Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain.
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
Light responses and morphology of bNOS-immunoreactive neurons in the mouse retina.
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.
In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis.
Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice.
Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.
Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.
La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts.
Diverse microglial responses after intrahippocampal administration of lipopolysaccharide.
The cell cycle-apoptosis connection revisited in the adult brain.
Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord.
Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.
Role of the Rap1 GTPase in astrocyte growth regulation.
Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
Recovery from spinal cord injury: a new transection model in the C57Bl/6 mouse.
CNS wound healing is severely depressed in metallothionein I- and II-deficient mice.
Constitutive and heat-inducible expression of HSP105 in neurons and glial cells in culture.
Distribution of integrin-like immunoreactivity on primate brain microvasculature.
Shi CJ, Lian JJ, Zhang BW, Cha JX, Hua QH, Pi XP, Hou YJ, Xie X, Zhang R
Acta pharmacologica Sinica 2023 Jan;44(1):92-104
Acta pharmacologica Sinica 2023 Jan;44(1):92-104
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease.
Dong AQ, Yang YP, Jiang SM, Yao XY, Qi D, Mao CJ, Cheng XY, Wang F, Hu LF, Liu CF
Acta pharmacologica Sinica 2023 Jan;44(1):32-43
Acta pharmacologica Sinica 2023 Jan;44(1):32-43
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.
Hirata T, Kobayashi A, Furuse T, Yamada I, Tamura M, Tomita H, Tokoro Y, Ninomiya A, Fujihara Y, Ikawa M, Maeda Y, Murakami Y, Kizuka Y, Kinoshita T
The Journal of biological chemistry 2022 Mar;298(3):101720
The Journal of biological chemistry 2022 Mar;298(3):101720
Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone.
Norton ES, Whaley LA, Ulloa-Navas MJ, García-Tárraga P, Meneses KM, Lara-Velazquez M, Zarco N, Carrano A, Quiñones-Hinojosa A, García-Verdugo JM, Guerrero-Cázares H
Fluids and barriers of the CNS 2022 Jul 11;19(1):58
Fluids and barriers of the CNS 2022 Jul 11;19(1):58
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina.
Danjo Y, Shinozaki Y, Natsubori A, Kubota Y, Kashiwagi K, Tanaka KF, Koizumi S
Translational vision science & technology 2022 Jan 3;11(1):25
Translational vision science & technology 2022 Jan 3;11(1):25
4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway.
Zhao X, Fisher ES, Wang Y, Zuloaga K, Manley L, Temple S
Stem cell reports 2022 Feb 8;17(2):245-258
Stem cell reports 2022 Feb 8;17(2):245-258
Neuronal-glial communication perturbations in murine SOD1(G93A) spinal cord.
MacLean M, López-Díez R, Vasquez C, Gugger PF, Schmidt AM
Communications biology 2022 Feb 28;5(1):177
Communications biology 2022 Feb 28;5(1):177
Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development.
Gillnäs S, Gallini R, He L, Betsholtz C, Andrae J
Biology open 2022 Aug 15;11(8)
Biology open 2022 Aug 15;11(8)
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
Permanne B, Sand A, Ousson S, Nény M, Hantson J, Schubert R, Wiessner C, Quattropani A, Beher D
ACS chemical neuroscience 2022 Apr 20;13(8):1296-1314
ACS chemical neuroscience 2022 Apr 20;13(8):1296-1314
Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion.
Lee D, Nakai A, Miwa Y, Tomita Y, Serizawa N, Katada Y, Hatanaka Y, Tsubota K, Negishi K, Kurihara T
BioMed research international 2021;2021:7727648
BioMed research international 2021;2021:7727648
The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma.
Kimball E, Schaub J, Quillen S, Keuthan C, Pease ME, Korneva A, Quigley H
PloS one 2021;16(2):e0244123
PloS one 2021;16(2):e0244123
Analysing Intercellular Communication in Astrocytic Networks Using "Astral".
Dzyubenko E, Prazuch W, Pillath-Eilers M, Polanska J, Hermann DM
Frontiers in cellular neuroscience 2021;15:689268
Frontiers in cellular neuroscience 2021;15:689268
Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages.
Zhang M, Zhong L, Han X, Xiong G, Xu D, Zhang S, Cheng H, Chiu K, Xu Y
Frontiers in neuroscience 2021;15:681831
Frontiers in neuroscience 2021;15:681831
Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation.
Linnerbauer M, Lößlein L, Farrenkopf D, Vandrey O, Tsaktanis T, Naumann U, Rothhammer V
Frontiers in immunology 2021;12:800128
Frontiers in immunology 2021;12:800128
Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice.
Pérez-Osorio IN, Espinosa A, Giraldo Velázquez M, Padilla P, Bárcena B, Fragoso G, Jung-Cook H, Besedovsky H, Meneses G, Sciutto Conde EL
The Journal of pharmacology and experimental therapeutics 2021 Sep;378(3):244-250
The Journal of pharmacology and experimental therapeutics 2021 Sep;378(3):244-250
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding.
Han S, Okawa S, Wilkinson GA, Ghazale H, Adnani L, Dixit R, Tavares L, Faisal I, Brooks MJ, Cortay V, Zinyk D, Sivitilli A, Li S, Malik F, Ilnytskyy Y, Angarica VE, Gao J, Chinchalongporn V, Oproescu AM, Vasan L, Touahri Y, David LA, Raharjo E, Kim JW, Wu W, Rahmani W, Chan JA, Kovalchuk I, Attisano L, Kurrasch D, Dehay C, Swaroop A, Castro DS, Biernaskie J, Del Sol A, Schuurmans C
Neuron 2021 Sep 15;109(18):2847-2863.e11
Neuron 2021 Sep 15;109(18):2847-2863.e11
3D spheroids of human placenta-derived mesenchymal stem cells attenuate spinal cord injury in mice.
Deng J, Li M, Meng F, Liu Z, Wang S, Zhang Y, Li M, Li Z, Zhang L, Tang P
Cell death & disease 2021 Nov 22;12(12):1096
Cell death & disease 2021 Nov 22;12(12):1096
Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
Shariq M, Sahasrabuddhe V, Krishna S, Radha S, Nruthyathi, Bellampalli R, Dwivedi A, Cheramangalam R, Reizis B, Hébert J, Ghosh HS
Science advances 2021 May;7(21)
Science advances 2021 May;7(21)
Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy.
Woodburn SC, Bollinger JL, Wohleb ES
Neurobiology of stress 2021 May;14:100312
Neurobiology of stress 2021 May;14:100312
Ndufs4 ablation decreases synaptophysin expression in hippocampus.
Shil SK, Kagawa Y, Umaru BA, Nanto-Hara F, Miyazaki H, Yamamoto Y, Kobayashi S, Suzuki C, Abe T, Owada Y
Scientific reports 2021 May 26;11(1):10969
Scientific reports 2021 May 26;11(1):10969
The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism.
Heiss CN, Mannerås-Holm L, Lee YS, Serrano-Lobo J, Håkansson Gladh A, Seeley RJ, Drucker DJ, Bäckhed F, Olofsson LE
Cell reports 2021 May 25;35(8):109163
Cell reports 2021 May 25;35(8):109163
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Horiuchi H, Cheung DL, Nabekura J, Sugita K, Aihara M, Koizumi S
JCI insight 2021 May 10;6(9)
JCI insight 2021 May 10;6(9)
Semaphorin 7A restricts serotonergic innervation and ensures recovery after spinal cord injury.
Loy K, Fourneau J, Meng N, Denecke C, Locatelli G, Bareyre FM
Cellular and molecular life sciences : CMLS 2021 Mar;78(6):2911-2927
Cellular and molecular life sciences : CMLS 2021 Mar;78(6):2911-2927
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, Pașca SP, Geschwind DH
Nature neuroscience 2021 Mar;24(3):331-342
Nature neuroscience 2021 Mar;24(3):331-342
Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models.
Chen M, Chen Y, Huo Q, Wang L, Tan S, Misrani A, Jiang J, Chen J, Chen S, Zhang J, Tabassum S, Wang J, Chen X, Long C, Yang L
Molecular neurodegeneration 2021 Mar 4;16(1):14
Molecular neurodegeneration 2021 Mar 4;16(1):14
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.
Manganas LN, Durá I, Osenberg S, Semerci F, Tosun M, Mishra R, Parkitny L, Encinas JM, Maletic-Savatic M
Scientific reports 2021 Mar 10;11(1):5546
Scientific reports 2021 Mar 10;11(1):5546
Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice.
Sasaki M, Kamiya Y, Bamba K, Onishi T, Matsuda K, Kohno T, Kurabe M, Furutani K, Yanagimura H
The journal of pain 2021 Jun;22(6):715-729
The journal of pain 2021 Jun;22(6):715-729
Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice.
Gregorius J, Wang C, Stambouli O, Hussner T, Qi Y, Tertel T, Börger V, Mohamud Yusuf A, Hagemann N, Yin D, Dittrich R, Mouloud Y, Mairinger FD, Magraoui FE, Popa-Wagner A, Kleinschnitz C, Doeppner TR, Gunzer M, Meyer HE, Giebel B, Hermann DM
Basic research in cardiology 2021 Jun 8;116(1):40
Basic research in cardiology 2021 Jun 8;116(1):40
Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1(G93A) murine model of amyotrophic lateral sclerosis in a sex-dependent manner.
MacLean M, Juranek J, Cuddapah S, López-Díez R, Ruiz HH, Hu J, Frye L, Li H, Gugger PF, Schmidt AM
Journal of neuroinflammation 2021 Jun 15;18(1):139
Journal of neuroinflammation 2021 Jun 15;18(1):139
Inhibitory control in neuronal networks relies on the extracellular matrix integrity.
Dzyubenko E, Fleischer M, Manrique-Castano D, Borbor M, Kleinschnitz C, Faissner A, Hermann DM
Cellular and molecular life sciences : CMLS 2021 Jul;78(14):5647-5663
Cellular and molecular life sciences : CMLS 2021 Jul;78(14):5647-5663
Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice.
Yang CY, Hung YC, Cheng KH, Ling P, Hsu KS
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):2021-2039
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):2021-2039
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains.
Sharoar MG, Palko S, Ge Y, Saido TC, Yan R
Molecular neurodegeneration 2021 Jul 2;16(1):45
Molecular neurodegeneration 2021 Jul 2;16(1):45
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture.
Lattke M, Goldstone R, Ellis JK, Boeing S, Jurado-Arjona J, Marichal N, MacRae JI, Berninger B, Guillemot F
Nature communications 2021 Jul 15;12(1):4335
Nature communications 2021 Jul 15;12(1):4335
Microglial G(i)-dependent dynamics regulate brain network hyperexcitability.
Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T Jr, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K
Nature neuroscience 2021 Jan;24(1):19-23
Nature neuroscience 2021 Jan;24(1):19-23
An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice.
Nitschke S, Chown EE, Zhao X, Gabrielian S, Petković S, Guisso DR, Perri AM, Wang P, Ahonen S, Nitschke F, Minassian BA
The Journal of biological chemistry 2021 Jan-Jun;296:100150
The Journal of biological chemistry 2021 Jan-Jun;296:100150
3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics.
Shin H, Jeong S, Lee JH, Sun W, Choi N, Cho IJ
Nature communications 2021 Jan 21;12(1):492
Nature communications 2021 Jan 21;12(1):492
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
Li Y, Ritchie EM, Steinke CL, Qi C, Chen L, Zheng B, Jin Y
eLife 2021 Jan 21;10
eLife 2021 Jan 21;10
Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.
Wei H, Wu X, You Y, Duran RC, Zheng Y, Narayanan KL, Hai B, Li X, Tallapragada N, Prajapati TJ, Kim DH, Deneen B, Cao QL, Wu JQ
Cell reports 2021 Feb 2;34(5):108721
Cell reports 2021 Feb 2;34(5):108721
Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.
Olivera GC, Ross EC, Peuckert C, Barragan A
eLife 2021 Dec 8;10
eLife 2021 Dec 8;10
Pemafibrate Prevents Retinal Dysfunction in a Mouse Model of Unilateral Common Carotid Artery Occlusion.
Lee D, Tomita Y, Jeong H, Miwa Y, Tsubota K, Negishi K, Kurihara T
International journal of molecular sciences 2021 Aug 30;22(17)
International journal of molecular sciences 2021 Aug 30;22(17)
Late-in-life neurodegeneration after chronic sleep loss in young adult mice.
Owen JE, Zhu Y, Fenik P, Zhan G, Bell P, Liu C, Veasey S
Sleep 2021 Aug 13;44(8)
Sleep 2021 Aug 13;44(8)
Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury.
Mallah K, Couch C, Alshareef M, Borucki D, Yang X, Alawieh A, Tomlinson S
Acta neuropathologica communications 2021 Apr 20;9(1):72
Acta neuropathologica communications 2021 Apr 20;9(1):72
Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke.
Ge H, Zhang C, Yang Y, Chen W, Zhong J, Fang X, Jiang X, Tan L, Zou Y, Hu R, Chen Y, Feng H
Frontiers in molecular neuroscience 2020;13:596039
Frontiers in molecular neuroscience 2020;13:596039
Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound.
Morse SV, Boltersdorf T, Harriss BI, Chan TG, Baxan N, Jung HS, Pouliopoulos AN, Choi JJ, Long NJ
Theranostics 2020;10(6):2659-2674
Theranostics 2020;10(6):2659-2674
Ferrochelatase regulates retinal neovascularization.
Pran Babu SPS, White D, Corson TW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):12419-12435
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):12419-12435
Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory.
Ouyang X, Ahmad I, Johnson MS, Redmann M, Craver J, Wani WY, Benavides GA, Chacko B, Li P, Young M, Jegga AG, Darley-Usmar V, Zhang J
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1238-1251
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1238-1251
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells.
Kajikawa K, Imaizumi K, Shinozaki M, Shibata S, Shindo T, Kitagawa T, Shibata R, Kamata Y, Kojima K, Nagoshi N, Matsumoto M, Nakamura M, Okano H
Molecular brain 2020 Sep 3;13(1):120
Molecular brain 2020 Sep 3;13(1):120
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.
Butkovich LM, Houser MC, Chalermpalanupap T, Porter-Stransky KA, Iannitelli AF, Boles JS, Lloyd GM, Coomes AS, Eidson LN, De Sousa Rodrigues ME, Oliver DL, Kelly SD, Chang J, Bengoa-Vergniory N, Wade-Martins R, Giasson BI, Joers V, Weinshenker D, Tansey MG
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Sep 23;40(39):7559-7576
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Sep 23;40(39):7559-7576
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
Still KM, Batista SJ, O'Brien CA, Oyesola OO, Früh SP, Webb LM, Smirnov I, Kovacs MA, Cowan MN, Hayes NW, Thompson JA, Tait Wojno ED, Harris TH
PLoS pathogens 2020 Oct;16(10):e1009027
PLoS pathogens 2020 Oct;16(10):e1009027
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, Manis M, Ibrahim A, Deng L, Benitez BA, Cruchaga C, Licastro D, Mihindukulasuriya K, Harari O, Buckland M, Holtzman DM, Rosenthal A, Schwabe T, Tassi I, Piccio L
Acta neuropathologica 2020 Oct;140(4):513-534
Acta neuropathologica 2020 Oct;140(4):513-534
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress.
Kim HR, Lee YJ, Kim TW, Lim RN, Hwang DY, Moffat JJ, Kim S, Seo JW, Ka M
BMC complementary medicine and therapies 2020 Oct 27;20(1):325
BMC complementary medicine and therapies 2020 Oct 27;20(1):325
Depression-like behaviors induced by defective PTPRT activity through dysregulated synaptic functions and neurogenesis.
Lim SH, Shin S, Kim MH, Kim EC, Lee DY, Moon J, Park HY, Ryu YK, Kang YM, Kang YJ, Kim TH, Lee NY, Kim NS, Yu DY, Shim I, Gondo Y, Satake M, Kim E, Kim KS, Min SS, Lee JR
Journal of cell science 2020 Oct 21;133(20)
Journal of cell science 2020 Oct 21;133(20)
Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models.
Doustar J, Rentsendorj A, Torbati T, Regis GC, Fuchs DT, Sheyn J, Mirzaei N, Graham SL, Shah PK, Mastali M, Van Eyk JE, Black KL, Gupta VK, Mirzaei M, Koronyo Y, Koronyo-Hamaoui M
Aging cell 2020 Oct 14;19(11):e13246
Aging cell 2020 Oct 14;19(11):e13246
LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
Jeong D, Lozano Casasbuenas D, Gengatharan A, Edwards K, Saghatelyan A, Kaplan DR, Miller FD, Yuzwa SA
Cell reports 2020 Oct 13;33(2):108257
Cell reports 2020 Oct 13;33(2):108257
Microglia-organized scar-free spinal cord repair in neonatal mice.
Li Y, He X, Kawaguchi R, Zhang Y, Wang Q, Monavarfeshani A, Yang Z, Chen B, Shi Z, Meng H, Zhou S, Zhu J, Jacobi A, Swarup V, Popovich PG, Geschwind DH, He Z
Nature 2020 Nov;587(7835):613-618
Nature 2020 Nov;587(7835):613-618
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
Dodge JC, Jensen EH, Yu J, Sardi SP, Bialas AR, Taksir TV, Bangari DS, Shihabuddin LS
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Nov 18;40(47):9137-9147
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Nov 18;40(47):9137-9147
Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model.
Park YH, Shin SJ, Kim HS, Hong SB, Kim S, Nam Y, Kim JJ, Lim K, Kim JS, Kim JI, Jeon SG, Moon M
International journal of molecular sciences 2020 May 29;21(11)
International journal of molecular sciences 2020 May 29;21(11)
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.
Espinosa-Garcia C, Atif F, Yousuf S, Sayeed I, Neigh GN, Stein DG
International journal of molecular sciences 2020 May 26;21(11)
International journal of molecular sciences 2020 May 26;21(11)
Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease.
Kim S, Nam Y, Kim C, Lee H, Hong S, Kim HS, Shin SJ, Park YH, Mai HN, Oh SM, Kim KS, Yoo DH, Chung WK, Chung H, Moon M
International journal of molecular sciences 2020 May 23;21(10)
International journal of molecular sciences 2020 May 23;21(10)
The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome.
Smith BC, Sinyuk M, Jenkins JE 3rd, Psenicka MW, Williams JL
Journal of neuroinflammation 2020 Jun 12;17(1):184
Journal of neuroinflammation 2020 Jun 12;17(1):184
Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis.
Mòdol-Caballero G, García-Lareu B, Verdés S, Ariza L, Sánchez-Brualla I, Brocard F, Bosch A, Navarro X, Herrando-Grabulosa M
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1048-1060
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1048-1060
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.
Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV
Cell 2020 Jul 23;182(2):388-403.e15
Cell 2020 Jul 23;182(2):388-403.e15
Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers.
Hoffmann D, Dvorakova T, Stroobant V, Bouzin C, Daumerie A, Solvay M, Klaessens S, Letellier MC, Renauld JC, van Baren N, Lelotte J, Marbaix E, Van den Eynde BJ
Cancer immunology research 2020 Jan;8(1):19-31
Cancer immunology research 2020 Jan;8(1):19-31
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.
Koronyo-Hamaoui M, Sheyn J, Hayden EY, Li S, Fuchs DT, Regis GC, Lopes DHJ, Black KL, Bernstein KE, Teplow DB, Fuchs S, Koronyo Y, Rentsendorj A
Brain : a journal of neurology 2020 Jan 1;143(1):336-358
Brain : a journal of neurology 2020 Jan 1;143(1):336-358
Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice.
de Carvalho TS, Sanchez-Mendoza EH, Nascentes Melo LM, Schultz Moreira AR, Sardari M, Dzyubenko E, Kleinschnitz C, Hermann DM
Translational stroke research 2020 Feb;11(1):135-146
Translational stroke research 2020 Feb;11(1):135-146
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes.
Kagawa Y, Umaru BA, Shima H, Ito R, Zama R, Islam A, Kanno SI, Yasui A, Sato S, Jozaki K, Shil SK, Miyazaki H, Kobayashi S, Yamamoto Y, Kogo H, Shimamoto-Mitsuyama C, Sugawara A, Sugino N, Kanamori M, Tominaga T, Yoshikawa T, Fukunaga K, Igarashi K, Owada Y
Molecular neurobiology 2020 Dec;57(12):4891-4910
Molecular neurobiology 2020 Dec;57(12):4891-4910
Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?
Liu AM, Chen BL, Yu LT, Liu T, Shi LL, Yu PP, Qu YB, So KF, Zhou LB
Neural regeneration research 2020 Dec;15(12):2306-2317
Neural regeneration research 2020 Dec;15(12):2306-2317
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.
OʼShea TM, Wollenberg AL, Kim JH, Ao Y, Deming TJ, Sofroniew MV
Nature communications 2020 Dec 4;11(1):6203
Nature communications 2020 Dec 4;11(1):6203
Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.
Chavali M, Ulloa-Navas MJ, Pérez-Borredá P, Garcia-Verdugo JM, McQuillen PS, Huang EJ, Rowitch DH
Neuron 2020 Dec 23;108(6):1130-1145.e5
Neuron 2020 Dec 23;108(6):1130-1145.e5
Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment.
Sigfridsson E, Marangoni M, Hardingham GE, Horsburgh K, Fowler JH
Journal of neuroinflammation 2020 Dec 1;17(1):367
Journal of neuroinflammation 2020 Dec 1;17(1):367
Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues.
Sadick JS, Crawford LA, Cramer HC 3rd, Franck C, Liddelow SA, Darling EM
Annals of biomedical engineering 2020 Aug;48(8):2218-2232
Annals of biomedical engineering 2020 Aug;48(8):2218-2232
mTORC1 and mTORC2 expression in inner retinal neurons and glial cells.
Losiewicz MK, Elghazi L, Fingar DC, Rajala RVS, Lentz SI, Fort PE, Abcouwer SF, Gardner TW
Experimental eye research 2020 Aug;197:108131
Experimental eye research 2020 Aug;197:108131
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR
Cell 2020 Aug 6;182(3):594-608.e11
Cell 2020 Aug 6;182(3):594-608.e11
AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.
Lammert CR, Frost EL, Bellinger CE, Bolte AC, McKee CA, Hurt ME, Paysour MJ, Ennerfelt HE, Lukens JR
Nature 2020 Apr;580(7805):647-652
Nature 2020 Apr;580(7805):647-652
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice.
Early AN, Gorman AA, Van Eldik LJ, Bachstetter AD, Morganti JM
Journal of neuroinflammation 2020 Apr 14;17(1):115
Journal of neuroinflammation 2020 Apr 14;17(1):115
Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes.
Manrique-Castano D, Sardari M, Silva de Carvalho T, Doeppner TR, Popa-Wagner A, Kleinschnitz C, Chan A, Hermann DM
Frontiers in cellular neuroscience 2019;13:412
Frontiers in cellular neuroscience 2019;13:412
Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer.
Gao L, Zhang Z, Lu J, Pei G
Frontiers in cellular neuroscience 2019;13:316
Frontiers in cellular neuroscience 2019;13:316
Neuronal vulnerability and multilineage diversity in multiple sclerosis.
Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH
Nature 2019 Sep;573(7772):75-82
Nature 2019 Sep;573(7772):75-82
Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.
Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ
Cell 2019 Sep 19;179(1):251-267.e24
Cell 2019 Sep 19;179(1):251-267.e24
NLRP3 inflammasome activation drives tau pathology.
Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT
Nature 2019 Nov;575(7784):669-673
Nature 2019 Nov;575(7784):669-673
Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina.
Lee BJ, Jun HO, Kim JH, Kim JH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6045-6054
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6045-6054
Pannexin 1 Regulates Network Ensembles and Dendritic Spine Development in Cortical Neurons.
Sanchez-Arias JC, Liu M, Choi CSW, Ebert SN, Brown CE, Swayne LA
eNeuro 2019 May Jun;6(3)
eNeuro 2019 May Jun;6(3)
Visualization of spatiotemporal dynamics of human glioma stem cell invasion.
Tamura R, Miyoshi H, Sampetrean O, Shinozaki M, Morimoto Y, Iwasawa C, Fukaya R, Mine Y, Masuda H, Maruyama T, Narita M, Saya H, Yoshida K, Okano H, Toda M
Molecular brain 2019 May 6;12(1):45
Molecular brain 2019 May 6;12(1):45
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Kojima K, Miyoshi H, Nagoshi N, Kohyama J, Itakura G, Kawabata S, Ozaki M, Iida T, Sugai K, Ito S, Fukuzawa R, Yasutake K, Renault-Mihara F, Shibata S, Matsumoto M, Nakamura M, Okano H
Stem cells translational medicine 2019 Mar;8(3):260-270
Stem cells translational medicine 2019 Mar;8(3):260-270
Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
Yang CY, Yu TH, Wen WL, Ling P, Hsu KS
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jun 19;39(25):4959-4975
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jun 19;39(25):4959-4975
Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
McLeod VM, Lau CL, Chiam MDF, Rupasinghe TW, Roessner U, Djouma E, Boon WC, Turner BJ
British journal of pharmacology 2019 Jul;176(13):2111-2130
British journal of pharmacology 2019 Jul;176(13):2111-2130
Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice.
Campos-Pires R, Hirnet T, Valeo F, Ong BE, Radyushkin K, Aldhoun J, Saville J, Edge CJ, Franks NP, Thal SC, Dickinson R
British journal of anaesthesia 2019 Jul;123(1):60-73
British journal of anaesthesia 2019 Jul;123(1):60-73
The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury.
Hoshino Y, Nishide K, Nagoshi N, Shibata S, Moritoki N, Kojima K, Tsuji O, Matsumoto M, Kohyama J, Nakamura M, Okano H
Scientific reports 2019 Jul 8;9(1):9844
Scientific reports 2019 Jul 8;9(1):9844
Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis.
Moutal A, Kalinin S, Kowal K, Marangoni N, Dupree J, Lin SX, Lis K, Lisi L, Hensley K, Khanna R, Feinstein DL
ASN neuro 2019 Jan-Dec;11:1759091419892090
ASN neuro 2019 Jan-Dec;11:1759091419892090
Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.
Bellver-Landete V, Bretheau F, Mailhot B, Vallières N, Lessard M, Janelle ME, Vernoux N, Tremblay MÈ, Fuehrmann T, Shoichet MS, Lacroix S
Nature communications 2019 Jan 31;10(1):518
Nature communications 2019 Jan 31;10(1):518
Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization.
Ma W, Silverman SM, Zhao L, Villasmil R, Campos MM, Amaral J, Wong WT
eLife 2019 Jan 22;8
eLife 2019 Jan 22;8
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.
Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, Halle A, Petzold GC
EMBO molecular medicine 2019 Feb;11(2)
EMBO molecular medicine 2019 Feb;11(2)
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Garber C, Soung A, Vollmer LL, Kanmogne M, Last A, Brown J, Klein RS
Nature neuroscience 2019 Aug;22(8):1276-1288
Nature neuroscience 2019 Aug;22(8):1276-1288
Astrocyte-specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity.
Michalovicz LT, Kelly KA, Vashishtha S, Ben-Hamo R, Efroni S, Miller JV, Locker AR, Sullivan K, Broderick G, Miller DB, O'Callaghan JP
Journal of neurochemistry 2019 Aug;150(4):420-440
Journal of neurochemistry 2019 Aug;150(4):420-440
Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity.
Mattapallil MJ, Kielczewski JL, Zárate-Bladés CR, St Leger AJ, Raychaudhuri K, Silver PB, Jittayasothorn Y, Chan CC, Caspi RR
Journal of autoimmunity 2019 Aug;102:65-76
Journal of autoimmunity 2019 Aug;102:65-76
Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.
Moreno-Blas D, Gorostieta-Salas E, Pommer-Alba A, Muciño-Hernández G, Gerónimo-Olvera C, Maciel-Barón LA, Konigsberg M, Massieu L, Castro-Obregón S
Aging 2019 Aug 30;11(16):6175-6198
Aging 2019 Aug 30;11(16):6175-6198
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes.
Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham MC
Nature neuroscience 2018 Sep;21(9):1171-1184
Nature neuroscience 2018 Sep;21(9):1171-1184
Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.
Wollenberg AL, O'Shea TM, Kim JH, Czechanski A, Reinholdt LG, Sofroniew MV, Deming TJ
Biomaterials 2018 Sep;178:527-545
Biomaterials 2018 Sep;178:527-545
Blood-brain barrier shuttle peptides enhance AAV transduction in the brain after systemic administration.
Zhang X, He T, Chai Z, Samulski RJ, Li C
Biomaterials 2018 Sep;176:71-83
Biomaterials 2018 Sep;176:71-83
Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
Schirmer L, Möbius W, Zhao C, Cruz-Herranz A, Ben Haim L, Cordano C, Shiow LR, Kelley KW, Sadowski B, Timmons G, Pröbstel AK, Wright JN, Sin JH, Devereux M, Morrison DE, Chang SM, Sabeur K, Green AJ, Nave KA, Franklin RJ, Rowitch DH
eLife 2018 Sep 11;7
eLife 2018 Sep 11;7
Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain.
Betlazar C, Harrison-Brown M, Middleton RJ, Banati R, Liu GJ
International journal of molecular sciences 2018 Sep 11;19(9)
International journal of molecular sciences 2018 Sep 11;19(9)
Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes.
Hackett AR, Yahn SL, Lyapichev K, Dajnoki A, Lee DH, Rodriguez M, Cammer N, Pak J, Mehta ST, Bodamer O, Lemmon VP, Lee JK
Experimental neurology 2018 Oct;308:72-79
Experimental neurology 2018 Oct;308:72-79
Characterization of the ventricular-subventricular stem cell niche during human brain development.
Coletti AM, Singh D, Kumar S, Shafin TN, Briody PJ, Babbitt BF, Pan D, Norton ES, Brown EC, Kahle KT, Del Bigio MR, Conover JC
Development (Cambridge, England) 2018 Oct 26;145(20)
Development (Cambridge, England) 2018 Oct 26;145(20)
Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier.
Mäe MA, Li T, Bertuzzi G, Raschperger E, Vanlandewijck M, He L, Nahar K, Dalheim A, Hofmann JJ, Laviña B, Keller A, Betsholtz C, Genové G
Scientific reports 2018 Nov 29;8(1):17462
Scientific reports 2018 Nov 29;8(1):17462
Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development.
Storer MA, Gallagher D, Fatt MP, Simonetta JV, Kaplan DR, Miller FD
Stem cell reports 2018 May 8;10(5):1464-1480
Stem cell reports 2018 May 8;10(5):1464-1480
Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury.
Alawieh A, Langley EF, Weber S, Adkins D, Tomlinson S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Mar 7;38(10):2519-2532
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Mar 7;38(10):2519-2532
Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice.
Zukor K, Wang H, Siddharthan V, Julander JG, Morrey JD
Journal of neurovirology 2018 Jun;24(3):273-290
Journal of neurovirology 2018 Jun;24(3):273-290
CREB controls cortical circuit plasticity and functional recovery after stroke.
Caracciolo L, Marosi M, Mazzitelli J, Latifi S, Sano Y, Galvan L, Kawaguchi R, Holley S, Levine MS, Coppola G, Portera-Cailliau C, Silva AJ, Carmichael ST
Nature communications 2018 Jun 8;9(1):2250
Nature communications 2018 Jun 8;9(1):2250
Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria.
Wilson KD, Ochoa LF, Solomon OD, Pal R, Cardona SM, Carpio VH, Keiser PH, Cardona AE, Vargas G, Stephens R
Journal of neuroinflammation 2018 Jun 4;15(1):173
Journal of neuroinflammation 2018 Jun 4;15(1):173
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, Xu L, Ma Z, Dong X, Lin Y, Koenig S, Nait-Oumesmar B, Martin DM, Wu LN, Xin M, Zhou W, Parras C, Lu QR
Developmental cell 2018 Jun 18;45(6):753-768.e8
Developmental cell 2018 Jun 18;45(6):753-768.e8
Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.
McLane VD, Kumar S, Leeming R, Rau S, Willis CL, Cao L
Journal of neuroimmunology 2018 Jun 15;319:117-129
Journal of neuroimmunology 2018 Jun 15;319:117-129
Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia.
Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH
Journal of neurochemistry 2018 Jul;146(2):160-172
Journal of neurochemistry 2018 Jul;146(2):160-172
Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
Chalermpalanupap T, Schroeder JP, Rorabaugh JM, Liles LC, Lah JJ, Levey AI, Weinshenker D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):74-92
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):74-92
Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.
Muthusamy N, Brumm A, Zhang X, Carmichael ST, Ghashghaei HT
Scientific reports 2018 Jan 29;8(1):1766
Scientific reports 2018 Jan 29;8(1):1766
Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice.
Morrey JD, Wang H, Hurst BL, Zukor K, Siddharthan V, Van Wettere AJ, Sinex DG, Tarbet EB
Viruses 2018 Jan 12;10(1)
Viruses 2018 Jan 12;10(1)
Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.
Baruteau J, Perocheau DP, Hanley J, Lorvellec M, Rocha-Ferreira E, Karda R, Ng J, Suff N, Diaz JA, Rahim AA, Hughes MP, Banushi B, Prunty H, Hristova M, Ridout DA, Virasami A, Heales S, Howe SJ, Buckley SMK, Mills PB, Gissen P, Waddington SN
Nature communications 2018 Aug 29;9(1):3505
Nature communications 2018 Aug 29;9(1):3505
Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion.
Sigfridsson E, Marangoni M, Johnson JA, Hardingham GE, Fowler JH, Horsburgh K
Scientific reports 2018 Aug 22;8(1):12552
Scientific reports 2018 Aug 22;8(1):12552
Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells.
Sunamura N, Iwashita S, Enomoto K, Kadoshima T, Isono F
Scientific reports 2018 Aug 2;8(1):11585
Scientific reports 2018 Aug 2;8(1):11585
RNA Interference of Human α-Synuclein in Mouse.
Kim YC, Miller A, Lins LC, Han SW, Keiser MS, Boudreau RL, Davidson BL, Narayanan NS
Frontiers in neurology 2017;8:13
Frontiers in neurology 2017;8:13
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Chami M, Halmer R, Schnoeder L, Anne Becker K, Meier C, Fassbender K, Gulbins E, Walter S
PloS one 2017;12(6):e0178622
PloS one 2017;12(6):e0178622
Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with Complete Spinal Cord Transection.
Ganz J, Shor E, Guo S, Sheinin A, Arie I, Michaelevski I, Pitaru S, Offen D, Levenberg S
Frontiers in neuroscience 2017;11:589
Frontiers in neuroscience 2017;11:589
Defining an Analytic Framework to Evaluate Quantitative MRI Markers of Traumatic Axonal Injury: Preliminary Results in a Mouse Closed Head Injury Model.
Haber M, Hutchinson EB, Sadeghi N, Cheng WH, Namjoshi D, Cripton P, Irfanoglu MO, Wellington C, Diaz-Arrastia R, Pierpaoli C
eNeuro 2017 Sep-Oct;4(5)
eNeuro 2017 Sep-Oct;4(5)
Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes.
Li X, Cao VY, Zhang W, Mastwal SS, Liu Q, Otte S, Wang KH
Journal of neuroscience methods 2017 Nov 1;291:238-248
Journal of neuroscience methods 2017 Nov 1;291:238-248
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP
The Journal of experimental medicine 2017 May 1;214(5):1351-1370
The Journal of experimental medicine 2017 May 1;214(5):1351-1370
Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration.
Wang X, Zhao L, Zhang Y, Ma W, Gonzalez SR, Fan J, Kretschmer F, Badea TC, Qian HH, Wong WT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 22;37(12):3294-3310
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 22;37(12):3294-3310
Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice.
Yungher BJ, Ribeiro M, Park KK
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1743-1750
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1743-1750
Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.
Zhu Y, Lyapichev K, Lee DH, Motti D, Ferraro NM, Zhang Y, Yahn S, Soderblom C, Zha J, Bethea JR, Spiller KL, Lemmon VP, Lee JK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 1;37(9):2362-2376
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 1;37(9):2362-2376
Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage.
Chen-Roetling J, Kamalapathy P, Cao Y, Song W, Schipper HM, Regan RF
Neurobiology of disease 2017 Jun;102:140-146
Neurobiology of disease 2017 Jun;102:140-146
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S
Nature communications 2017 Jun 22;8(1):28
Nature communications 2017 Jun 22;8(1):28
Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.
Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Jun 21;37(25):6132-6148
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Jun 21;37(25):6132-6148
Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages.
Meller J, Chen Z, Dudiki T, Cull RM, Murtazina R, Bal SK, Pluskota E, Stefl S, Plow EF, Trapp BD, Byzova TV
JCI insight 2017 Jun 2;2(11)
JCI insight 2017 Jun 2;2(11)
Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.
Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H
Scientific reports 2017 Jul 28;7(1):6771
Scientific reports 2017 Jul 28;7(1):6771
Neurotoxic reactive astrocytes are induced by activated microglia.
Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA
Nature 2017 Jan 26;541(7638):481-487
Nature 2017 Jan 26;541(7638):481-487
P2Y(12) receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases.
Mildner A, Huang H, Radke J, Stenzel W, Priller J
Glia 2017 Feb;65(2):375-387
Glia 2017 Feb;65(2):375-387
Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.
Menzel L, Kleber L, Friedrich C, Hummel R, Dangel L, Winter J, Schmitz K, Tegeder I, Schäfer MK
Glia 2017 Feb;65(2):278-292
Glia 2017 Feb;65(2):278-292
Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development.
Behm M, Wahlstedt H, Widmark A, Eriksson M, Öhman M
Journal of cell science 2017 Feb 15;130(4):745-753
Journal of cell science 2017 Feb 15;130(4):745-753
Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats.
Park KK, Luo X, Mooney SJ, Yungher BJ, Belin S, Wang C, Holmes MM, He Z
The Journal of comparative neurology 2017 Feb 1;525(2):380-388
The Journal of comparative neurology 2017 Feb 1;525(2):380-388
Magnetic resonance microdynamic imaging reveals distinct tissue microenvironments.
Benjamini D, Basser PJ
NeuroImage 2017 Dec;163:183-196
NeuroImage 2017 Dec;163:183-196
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K
Neuron 2017 Dec 6;96(5):1003-1012.e7
Neuron 2017 Dec 6;96(5):1003-1012.e7
FACS-based Isolation of Neural and Glioma Stem Cell Populations from Fresh Human Tissues Utilizing EGF Ligand.
Tome-Garcia J, Doetsch F, Tsankova NM
Bio-protocol 2017 Dec 20;7(24)
Bio-protocol 2017 Dec 20;7(24)
Regulation of RhoA by STAT3 coordinates glial scar formation.
Renault-Mihara F, Mukaino M, Shinozaki M, Kumamaru H, Kawase S, Baudoux M, Ishibashi T, Kawabata S, Nishiyama Y, Sugai K, Yasutake K, Okada S, Nakamura M, Okano H
The Journal of cell biology 2017 Aug 7;216(8):2533-2550
The Journal of cell biology 2017 Aug 7;216(8):2533-2550
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR
The Journal of clinical investigation 2017 Aug 1;127(8):3136-3151
The Journal of clinical investigation 2017 Aug 1;127(8):3136-3151
Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters.
Zukor K, Wang H, Hurst BL, Siddharthan V, Van Wettere A, Pilowsky PM, Morrey JD
Journal of neurovirology 2017 Apr;23(2):186-204
Journal of neurovirology 2017 Apr;23(2):186-204
Inhibition of neuronal ferroptosis protects hemorrhagic brain.
Li Q, Han X, Lan X, Gao Y, Wan J, Durham F, Cheng T, Yang J, Wang Z, Jiang C, Ying M, Koehler RC, Stockwell BR, Wang J
JCI insight 2017 Apr 6;2(7):e90777
JCI insight 2017 Apr 6;2(7):e90777
Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)T(reg) cells.
Liu Y, Marin A, Ejlerskov P, Rasmussen LM, Prinz M, Issazadeh-Navikas S
Nature communications 2017 Apr 24;8:14709
Nature communications 2017 Apr 24;8:14709
Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration.
Song D, Wilson B, Zhao L, Bhuyan R, Bandyopadhyay M, Lyubarsky A, Yu C, Li Y, Kanu L, Miwa T, Song WC, Finnemann SC, Rohrer B, Dunaief JL
PloS one 2016;11(11):e0166348
PloS one 2016;11(11):e0166348
3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.
Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV
Nature medicine 2016 Sep;22(9):1050-5
Nature medicine 2016 Sep;22(9):1050-5
Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice.
Huang WC, Abraham R, Shim BS, Choe H, Page DT
Scientific reports 2016 Oct 7;6:34793
Scientific reports 2016 Oct 7;6:34793
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.
Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, Ohdo S
Nature communications 2016 Oct 14;7:13102
Nature communications 2016 Oct 14;7:13102
Epigenetic regulation of neural N-glycomics.
Kizuka Y, Nakano M, Miura Y, Taniguchi N
Proteomics 2016 Nov;16(22):2854-2863
Proteomics 2016 Nov;16(22):2854-2863
Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.
Walker WP, Oehler A, Edinger AL, Wagner KU, Gunn TM
Biology of the cell 2016 Nov;108(11):324-337
Biology of the cell 2016 Nov;108(11):324-337
Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors.
Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 9;36(45):11544-11558
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 9;36(45):11544-11558
CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells.
Zhang L, Hua Q, Tang K, Shi C, Xie X, Zhang R
Neuroscience 2016 Nov 19;337:88-97
Neuroscience 2016 Nov 19;337:88-97
STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury.
Hackett AR, Lee DH, Dawood A, Rodriguez M, Funk L, Tsoulfas P, Lee JK
Neurobiology of disease 2016 May;89:10-22
Neurobiology of disease 2016 May;89:10-22
Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.
Jara JH, Stanford MJ, Zhu Y, Tu M, Hauswirth WW, Bohn MC, DeVries SH, Özdinler PH
Gene therapy 2016 Mar;23(3):272-82
Gene therapy 2016 Mar;23(3):272-82
Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage.
Hristova M, Rocha-Ferreira E, Fontana X, Thei L, Buckle R, Christou M, Hompoonsup S, Gostelow N, Raivich G, Peebles D
Journal of neurochemistry 2016 Mar;136(5):981-94
Journal of neurochemistry 2016 Mar;136(5):981-94
Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina.
Wang X, Zhao L, Zhang J, Fariss RN, Ma W, Kretschmer F, Wang M, Qian HH, Badea TC, Diamond JS, Gan WB, Roger JE, Wong WT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Mar 2;36(9):2827-42
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Mar 2;36(9):2827-42
Cross-species Analyses Unravel the Complexity of H3K27me3 and H4K20me3 in the Context of Neural Stem Progenitor Cells.
Rhodes CT, Sandstrom RS, Huang SA, Wang Y, Schotta G, Berger MS, Lin CA
Neuroepigenetics 2016 Jun;6:10-25
Neuroepigenetics 2016 Jun;6:10-25
A complement-microglial axis drives synapse loss during virus-induced memory impairment.
Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS
Nature 2016 Jun 23;534(7608):538-43
Nature 2016 Jun 23;534(7608):538-43
The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice.
Smeester BA, O'Brien EE, Michlitsch KS, Lee JH, Beitz AJ
Neuroscience 2016 Jun 2;324:344-54
Neuroscience 2016 Jun 2;324:344-54
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.
Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N
The Biochemical journal 2016 Jan 1;473(1):21-30
The Biochemical journal 2016 Jan 1;473(1):21-30
Isolation and Culture of Adult Neural Stem Cells from the Mouse Subcallosal Zone.
Kim JY, Lee JH, Sun W
Journal of visualized experiments : JoVE 2016 Dec 15;(118)
Journal of visualized experiments : JoVE 2016 Dec 15;(118)
Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia.
Saggu R, Schumacher T, Gerich F, Rakers C, Tai K, Delekate A, Petzold GC
Acta neuropathologica communications 2016 Aug 4;4(1):76
Acta neuropathologica communications 2016 Aug 4;4(1):76
Cuprizone demyelination induces a unique inflammatory response in the subventricular zone.
Hillis JM, Davies J, Mundim MV, Al-Dalahmah O, Szele FG
Journal of neuroinflammation 2016 Aug 22;13(1):190
Journal of neuroinflammation 2016 Aug 22;13(1):190
Tumor necrosis factor superfamily member APRIL contributes to fibrotic scar formation after spinal cord injury.
Funk LH, Hackett AR, Bunge MB, Lee JK
Journal of neuroinflammation 2016 Apr 20;13(1):87
Journal of neuroinflammation 2016 Apr 20;13(1):87
Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration.
Gómez-López S, Martínez-Silva AV, Montiel T, Osorio-Gómez D, Bermúdez-Rattoni F, Massieu L, Escalante-Alcalde D
Scientific reports 2016 Apr 11;6:24028
Scientific reports 2016 Apr 11;6:24028
Interferon-gamma promotes infection of astrocytes by Trypanosoma cruzi.
Silva RR, Mariante RM, Silva AA, dos Santos AL, Roffê E, Santiago H, Gazzinelli RT, Lannes-Vieira J
PloS one 2015;10(2):e0118600
PloS one 2015;10(2):e0118600
Glial Fibrillary Acidic Protein-Expressing Glia in the Mouse Lung.
Suarez-Mier GB, Buckwalter MS
ASN neuro 2015 Sep-Oct;7(5)
ASN neuro 2015 Sep-Oct;7(5)
Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination.
Puntambekar SS, Hinton DR, Yin X, Savarin C, Bergmann CC, Trapp BD, Stohlman SA
Glia 2015 Nov;63(11):2106-2120
Glia 2015 Nov;63(11):2106-2120
TREM2 regulates microglial cell activation in response to demyelination in vivo.
Cantoni C, Bollman B, Licastro D, Xie M, Mikesell R, Schmidt R, Yuede CM, Galimberti D, Olivecrona G, Klein RS, Cross AH, Otero K, Piccio L
Acta neuropathologica 2015 Mar;129(3):429-47
Acta neuropathologica 2015 Mar;129(3):429-47
Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.
Crouch EE, Liu C, Silva-Vargas V, Doetsch F
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Mar 18;35(11):4528-39
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Mar 18;35(11):4528-39
Identification of a neurovascular signaling pathway regulating seizures in mice.
Fredriksson L, Stevenson TK, Su EJ, Ragsdale M, Moore S, Craciun S, Schielke GP, Murphy GG, Lawrence DA
Annals of clinical and translational neurology 2015 Jul;2(7):722-38
Annals of clinical and translational neurology 2015 Jul;2(7):722-38
Syringe-injectable electronics.
Liu J, Fu TM, Cheng Z, Hong G, Zhou T, Jin L, Duvvuri M, Jiang Z, Kruskal P, Xie C, Suo Z, Fang Y, Lieber CM
Nature nanotechnology 2015 Jul;10(7):629-636
Nature nanotechnology 2015 Jul;10(7):629-636
Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling.
Chen Y, Huang WC, Séjourné J, Clipperton-Allen AE, Page DT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jul 15;35(28):10252-67
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jul 15;35(28):10252-67
The BRAF kinase domain promotes the development of gliomas in vivo.
Shin CH, Grossmann AH, Holmen SL, Robinson JP
Genes & cancer 2015 Jan;6(1-2):9-18
Genes & cancer 2015 Jan;6(1-2):9-18
Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury.
Zhu Y, Soderblom C, Krishnan V, Ashbaugh J, Bethea JR, Lee JK
Neurobiology of disease 2015 Feb;74:114-25
Neurobiology of disease 2015 Feb;74:114-25
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N
EMBO molecular medicine 2015 Feb;7(2):175-89
EMBO molecular medicine 2015 Feb;7(2):175-89
Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.
Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K
Nature neuroscience 2015 Aug;18(8):1077-80
Nature neuroscience 2015 Aug;18(8):1077-80
Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor.
O'Brien EE, Smeester BA, Michlitsch KS, Lee JH, Beitz AJ
Neuroscience 2015 Aug 20;301:235-45
Neuroscience 2015 Aug 20;301:235-45
Fibronectin Matrix Assembly after Spinal Cord Injury.
Zhu Y, Soderblom C, Trojanowsky M, Lee DH, Lee JK
Journal of neurotrauma 2015 Aug 1;32(15):1158-67
Journal of neurotrauma 2015 Aug 1;32(15):1158-67
Astrocyte overexpression of heme oxygenase-1 improves outcome after intracerebral hemorrhage.
Chen-Roetling J, Song W, Schipper HM, Regan CS, Regan RF
Stroke 2015 Apr;46(4):1093-8
Stroke 2015 Apr;46(4):1093-8
Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling.
Wu CH, Hung TH, Chen CC, Ke CH, Lee CY, Wang PY, Chen SF
PloS one 2014;9(11):e113397
PloS one 2014;9(11):e113397
The contribution of CXCL12-expressing radial glia cells to neuro-vascular patterning during human cerebral cortex development.
Errede M, Girolamo F, Rizzi M, Bertossi M, Roncali L, Virgintino D
Frontiers in neuroscience 2014;8:324
Frontiers in neuroscience 2014;8:324
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.
Kawase S, Kuwako K, Imai T, Renault-Mihara F, Yaguchi K, Itohara S, Okano H
Stem cells and development 2014 Sep 15;23(18):2250-61
Stem cells and development 2014 Sep 15;23(18):2250-61
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model.
Delekate A, Füchtemeier M, Schumacher T, Ulbrich C, Foddis M, Petzold GC
Nature communications 2014 Nov 19;5:5422
Nature communications 2014 Nov 19;5:5422
Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation.
Howerton AR, Roland AV, Bale TL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 21;34(21):7113-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 21;34(21):7113-23
Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.
Cekanaviciute E, Dietrich HK, Axtell RC, Williams AM, Egusquiza R, Wai KM, Koshy AA, Buckwalter MS
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):139-49
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):139-49
Neuregulin-1/glial growth factor stimulates Schwann cell migration by inducing α5 β1 integrin-ErbB2-focal adhesion kinase complex formation.
Wakatsuki S, Araki T, Sehara-Fujisawa A
Genes to cells : devoted to molecular & cellular mechanisms 2014 Jan;19(1):66-77
Genes to cells : devoted to molecular & cellular mechanisms 2014 Jan;19(1):66-77
PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.
Puttagunta R, Tedeschi A, Sória MG, Hervera A, Lindner R, Rathore KI, Gaub P, Joshi Y, Nguyen T, Schmandke A, Laskowski CJ, Boutillier AL, Bradke F, Di Giovanni S
Nature communications 2014 Apr 1;5:3527
Nature communications 2014 Apr 1;5:3527
Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury.
Zukor K, Belin S, Wang C, Keelan N, Wang X, He Z
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sep 25;33(39):15350-61
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sep 25;33(39):15350-61
Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait.
Cops EJ, Sashindranath M, Daglas M, Short KM, da Fonseca Pereira C, Pang TY, Lijnen RH, Smyth IM, Hannan AJ, Samson AL, Medcalf RL
Experimental neurology 2013 Nov;249:8-19
Experimental neurology 2013 Nov;249:8-19
Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis.
Phares TW, Stohlman SA, Hinton DR, Bergmann CC
Journal of virology 2013 Mar;87(6):3382-92
Journal of virology 2013 Mar;87(6):3382-92
Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke.
Young CC, van der Harg JM, Lewis NJ, Brooks KJ, Buchan AM, Szele FG
Cerebral cortex (New York, N.Y. : 1991) 2013 Mar;23(3):647-59
Cerebral cortex (New York, N.Y. : 1991) 2013 Mar;23(3):647-59
ABCA1 influences neuroinflammation and neuronal death.
Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR
Neurobiology of disease 2013 Jun;54:445-55
Neurobiology of disease 2013 Jun;54:445-55
Differences in distribution and regulation of astrocytic aquaporin-4 in human and rat hydrocephalic brain.
Skjolding AD, Holst AV, Broholm H, Laursen H, Juhler M
Neuropathology and applied neurobiology 2013 Feb;39(2):179-91
Neuropathology and applied neurobiology 2013 Feb;39(2):179-91
Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury.
Chen SF, Tsai HJ, Hung TH, Chen CC, Lee CY, Wu CH, Wang PY, Liao NC
PloS one 2012;7(9):e45763
PloS one 2012;7(9):e45763
Partial change in EphA4 knockout mouse phenotype: loss of diminished GFAP upregulation following spinal cord injury.
Dixon KJ, Munro KM, Boyd AW, Bartlett PF, Turnley AM
Neuroscience letters 2012 Sep 6;525(1):66-71
Neuroscience letters 2012 Sep 6;525(1):66-71
Antiinflammatory treatment ameliorates HPA stress axis dysfunction in a mouse model of stress sensitivity.
Gerber AR, Bale TL
Endocrinology 2012 Oct;153(10):4830-7
Endocrinology 2012 Oct;153(10):4830-7
p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury.
Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, Kigerl KA, Popovich PG, Di Giovanni S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Oct 3;32(40):13956-70
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Oct 3;32(40):13956-70
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD
The Journal of clinical investigation 2012 Jul;122(7):2601-12
The Journal of clinical investigation 2012 Jul;122(7):2601-12
Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice.
Lutz SE, Raine CS, Brosnan CF
Journal of neuroimmunology 2012 Apr;245(1-2):8-14
Journal of neuroimmunology 2012 Apr;245(1-2):8-14
Minocycline attenuates photoreceptor degeneration in a mouse model of subretinal hemorrhage microglial: inhibition as a potential therapeutic strategy.
Zhao L, Ma W, Fariss RN, Wong WT
The American journal of pathology 2011 Sep;179(3):1265-77
The American journal of pathology 2011 Sep;179(3):1265-77
CCAAT/enhancer binding protein-δ expression by dendritic cells regulates CNS autoimmune inflammatory disease.
Tsai VW, Mohammad MG, Tolhurst O, Breit SN, Sawchenko PE, Brown DA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Nov 30;31(48):17612-21
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Nov 30;31(48):17612-21
Factors supporting intrathecal humoral responses following viral encephalomyelitis.
Phares TW, Marques CP, Stohlman SA, Hinton DR, Bergmann CC
Journal of virology 2011 Mar;85(6):2589-98
Journal of virology 2011 Mar;85(6):2589-98
Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain.
Wu T, Wu H, Wang J, Wang J
Journal of neuroinflammation 2011 Mar 8;8:22
Journal of neuroinflammation 2011 Mar 8;8:22
Ultrafast resorbing polymers for use as carriers for cortical neural probes.
Lewitus D, Smith KL, Shain W, Kohn J
Acta biomaterialia 2011 Jun;7(6):2483-91
Acta biomaterialia 2011 Jun;7(6):2483-91
Comparative characterization of the human and mouse third ventricle germinal zones.
Dahiya S, Lee DY, Gutmann DH
Journal of neuropathology and experimental neurology 2011 Jul;70(7):622-33
Journal of neuropathology and experimental neurology 2011 Jul;70(7):622-33
Biohybrid Carbon Nanotube/Agarose Fibers for Neural Tissue Engineering.
Lewitus DY, Landers J, Branch J, Smith KL, Callegari G, Kohn J, Neimark AV
Advanced functional materials 2011 Jul 22;21(14):2624-2632
Advanced functional materials 2011 Jul 22;21(14):2624-2632
The fate of ultrafast degrading polymeric implants in the brain.
Lewitus DY, Smith KL, Shain W, Bolikal D, Kohn J
Biomaterials 2011 Aug;32(24):5543-50
Biomaterials 2011 Aug;32(24):5543-50
Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage.
Chang CF, Chen SF, Lee TS, Lee HF, Chen SF, Shyue SK
The American journal of pathology 2011 Apr;178(4):1749-61
The American journal of pathology 2011 Apr;178(4):1749-61
Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain.
Skjolding AD, Rowland IJ, Søgaard LV, Praetorius J, Penkowa M, Juhler M
Cerebrospinal fluid research 2010 Nov 5;7:20
Cerebrospinal fluid research 2010 Nov 5;7:20
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
Yang H, Zhuo JM, Chu J, Chinnici C, Praticò D
Biological psychiatry 2010 Nov 15;68(10):922-9
Biological psychiatry 2010 Nov 15;68(10):922-9
Light responses and morphology of bNOS-immunoreactive neurons in the mouse retina.
Pang JJ, Gao F, Wu SM
The Journal of comparative neurology 2010 Jul 1;518(13):2456-74
The Journal of comparative neurology 2010 Jul 1;518(13):2456-74
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.
Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ
Proceedings of the National Academy of Sciences of the United States of America 2010 Dec 14;107(50):21795-800
Proceedings of the National Academy of Sciences of the United States of America 2010 Dec 14;107(50):21795-800
In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis.
DellaValle B, Hempel C, Kurtzhals JA, Penkowa M
Glia 2010 Aug;58(10):1220-7
Glia 2010 Aug;58(10):1220-7
Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice.
VanBrocklin MW, Robinson JP, Lastwika KJ, Khoury JD, Holmen SL
Pigment cell & melanoma research 2010 Aug;23(4):531-41
Pigment cell & melanoma research 2010 Aug;23(4):531-41
Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.
Ariyannur PS, Moffett JR, Madhavarao CN, Arun P, Vishnu N, Jacobowitz DM, Hallows WC, Denu JM, Namboodiri AM
The Journal of comparative neurology 2010 Aug 1;518(15):2952-77
The Journal of comparative neurology 2010 Aug 1;518(15):2952-77
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, Zhang MR, Suzuki K, Ando K, Staufenbiel M, Trojanowski JQ, Lee VM, Higuchi M, Suhara T
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nov 19;28(47):12255-67
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nov 19;28(47):12255-67
Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.
Chaudhry UA, Zhuang H, Crain BJ, Doré S
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008 Jan;4(1):6-13
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008 Jan;4(1):6-13
Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.
Hoff S, Zeller F, von Weyhern CW, Wegner M, Schemann M, Michel K, Rühl A
The Journal of comparative neurology 2008 Aug 1;509(4):356-71
The Journal of comparative neurology 2008 Aug 1;509(4):356-71
La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts.
Blakqori G, Delhaye S, Habjan M, Blair CD, Sánchez-Vargas I, Olson KE, Attarzadeh-Yazdi G, Fragkoudis R, Kohl A, Kalinke U, Weiss S, Michiels T, Staeheli P, Weber F
Journal of virology 2007 May;81(10):4991-9
Journal of virology 2007 May;81(10):4991-9
Diverse microglial responses after intrahippocampal administration of lipopolysaccharide.
Herber DL, Maloney JL, Roth LM, Freeman MJ, Morgan D, Gordon MN
Glia 2006 Mar;53(4):382-91
Glia 2006 Mar;53(4):382-91
The cell cycle-apoptosis connection revisited in the adult brain.
Bauer S, Patterson PH
The Journal of cell biology 2005 Nov 21;171(4):641-50
The Journal of cell biology 2005 Nov 21;171(4):641-50
Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord.
Wicher G, Larsson M, Rask L, Aldskogius H
The Journal of comparative neurology 2005 Nov 14;492(2):123-31
The Journal of comparative neurology 2005 Nov 14;492(2):123-31
Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.
Takeuchi T, Fujinami K, Goto H, Fujita A, Taketo MM, Manabe T, Matsui M, Hata F
Journal of neurophysiology 2005 May;93(5):2841-8
Journal of neurophysiology 2005 May;93(5):2841-8
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.
Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 May 4;25(18):4649-58
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 May 4;25(18):4649-58
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Dasgupta B, Li W, Perry A, Gutmann DH
Cancer research 2005 Jan 1;65(1):236-45
Cancer research 2005 Jan 1;65(1):236-45
Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.
Herber DL, Roth LM, Wilson D, Wilson N, Mason JE, Morgan D, Gordon MN
Experimental neurology 2004 Nov;190(1):245-53
Experimental neurology 2004 Nov;190(1):245-53
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Apicelli AJ, Uhlmann EJ, Baldwin RL, Ding H, Nagy A, Guha A, Gutmann DH
Glia 2003 May;42(3):225-34
Glia 2003 May;42(3):225-34
Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
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Oncogene 2002 Jun 6;21(25):4050-9
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Journal of neuroscience research 2002 Feb 1;67(3):337-45
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The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Apr 1;19(7):2535-45
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Apr 1;19(7):2535-45
Constitutive and heat-inducible expression of HSP105 in neurons and glial cells in culture.
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Neuroreport 1998 Sep 14;9(13):2977-83
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Journal of neuropathology and experimental neurology 1996 Feb;55(2):236-45
Journal of neuropathology and experimental neurology 1996 Feb;55(2):236-45
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of beta-3 Tubulin (green) and GFAP (red) in human iPSC-derived forebrain organoids derived at Day 84. The organoids were fixed with 4% PFA for 1 hour at room temperature, followed by incubation with 30% sucrose solution overnight at 4°C. The organoids were then embedded in OCT and cryosectioned at 5 µm, permeabilized with 0.2% Triton X-100 for 20 min, and blocked with 10% donkey serum in PBS for 30 min at room temperature. Organoid slices were stained with a Mouse beta-3 Tubulin monoclonal antibody (green; Product # MA1-118) at a dilution of 1:500, and a Rat GFAP monoclonal antibody (red; Product # 13-0300) at a dilution of 1:500 in blocking buffer overnight at 4°C, and then incubated with Donkey anti-Mouse Alexa Fluor 488 (Product # R37114) and Donkey anti-Rat Alexa Fluor 568 (Product # A11077) at a dilution of 1:1,000 as well as DAPI (blue; 1:25,000) in blocking solution at room temperature for 1 hour. Images were taken at 20X magnification. Data courtesy of Dr. Zhexing Wen at Emory University.
Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of astrocytoma tissue using Rt anti-GFAP (Product # 13-0300).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 4. Regions with altered DTI metrics exhibit histologic abnormalities consistent with injury. Representative photomicrographs of sham ( A-E ) and 0.65J CHIMERA-injured ( F-J ) optic tract. Sections were stained with silver stain ( A , F ), APP ( B , G ), GFAP ( C , H ), IBA-1 ( D , I ), MBP ( E , J ), and NF ( K , L ). Scale bar = 100 mum. Retraction bulbs and axonal varicosities are prominent in magnified photomicrographs of the 0.65J tissue ( M , N ). Scale bar = 10 mum.
