60048.1

GFAP antibody from STEMCELL Technologies Inc
FLJ45472
Immunocytochemistry
Recommended by provider
Immunohistochemistry
Recommended by provider
Flow cytometry
Recommended by provider

Antibody data

Product number
60048.1
Provider
STEMCELL Technologies Inc
Product name
Anti-GFAP Antibody, Clone 2E1.E9
Provider product page
STEMCELL Technologies Inc - 60048.1
Antibody type
Monoclonal
Description
The 2E1.E9 antibody reacts with glial fibrillary acidic protein (GFAP), an ~49 kDa type III intermediate filament (IF) protein that, within the central nervous system, is expressed primarily by astrocytes, though found at high levels in some glial-derived tumors. GFAP is thought to contribute to the structural architecture and strength of the cytoskeleton. The 2E1.E9 antibody does not cross-react with other IF proteins and can be used to distinguish astrocytes from other glial cells. GFAP has also been identified in Leydig cells, keratinocytes, chondrocytes and osteocytes. The GFAP polypeptide comprises an N-terminal head, a central rod, and a C-terminal tail domain, and assembles as dimers by a process dependent on phosphorylation and dephosphorylation of the N-terminal domain. Several splice variants have been identified, encoding three distinct isoforms. Many mutations in the GFAP gene (>50) have been associated with Alexander disease, a progressive leukoencephalopathy characterized by cytoplasmic inclusions and dysfunctional myelination. This antibody clone has been verified for labeling neural stem and progenitor cells grown in NeuroCult™ NS-A Proliferation Kit (Human; Catalog #05751) and NeuroCult™ Proliferation Kit (Mouse; Catalog #05702).
Reactivity
Human, Mouse, Rat
Isotype
IgG
Vial size
25 µg
Storage
2 - 8°C
Provider Type Product Number
- No reagents -