311902

TNFRSF13B antibody from BioLegend
CD267, IGAD2, TACI

Antibody data

Product number
311902
Provider
BioLegend
Proper citation
BioLegend Cat#311902, RRID:AB_528979
Product name
Purified anti-human CD267 (TACI)
Provider product page
BioLegend - 311902
Antibody type
Monoclonal
Antigen
TACI-transfected RBL cells
Description
TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs). Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins (BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-κ B and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.
Reactivity
Human
Host
Rat
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
Provider Type Product Number
- No reagents -