22225-1-AP

antibody from Proteintech Group

Targeting: MPO

Provider product page for 22225-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [32]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 22225-1-AP - Provider product page
Provider: Proteintech Group
Product name: MPO antibody
Antibody type: Polyclonal
Description: MPO antibody (Cat. #22225-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MPO protein structure - 22225-1-AP shown in red.

Submitted references ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.

Li S, Ma Y, Ye S, Hu D, Xiao F
Journal of hazardous materials 2022 Jan 5;421:126758

Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats.

Cheng N, Shi JH, Jin Y, Shi YB, Liu XD, Zhang HP, Cao SL, Yang H, Guo WZ, Zhang SJ
Frontiers in surgery 2021;8:665260

Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.

Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839

NETs Lead to Sympathetic Hyperactivity After Traumatic Brain Injury Through the LL37-Hippo/MST1 Pathway.

Zhu K, Zhu Y, Hou X, Chen W, Qu X, Zhang Y, Li Z, Wang C, Chen J, Lv L, Wang J, Zhang D, Hou L
Frontiers in neuroscience 2021;15:621477

Quantitative Proteomic Analysis of Mouse Sciatic Nerve Reveals Post-injury Upregulation of ADP-Dependent Glucokinase Promoting Macrophage Phagocytosis.

Zhang K, Wang Q, Liang Y, Yan Y, Wang H, Cao X, Shan B, Zhang Y, Li A, Fang Y
Frontiers in molecular neuroscience 2021;14:777621

Neutrophil extracellular traps induce thrombogenicity in severe carotid stenosis.

Zhang S, Guo M, Liu Q, Liu J, Cui Y
Immunity, inflammation and disease 2021 Sep;9(3):1025-1036

Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.

Ma Y, Li S, Ye S, Tang S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2021 Oct 15;223:112614

Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.

Kong L, Ma Y, Wang Z, Liu N, Ma G, Liu C, Shi R, Du G
International immunopharmacology 2021 May;94:107507

Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

Zhang Z, Xue Z, Yang H, Zhao F, Liu C, Chen J, Lu S, Zou Z, Zhou Y, Zhang X
Food & function 2021 Mar 1;12(4):1803-1817

Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps.

Dong W, Liu D, Zhang T, You Q, Huang F, Wu J
Ecotoxicology and environmental safety 2021 Jun 1;215:112161

Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.

Liu N, Liu C, Yang Y, Ma G, Wei G, Liu S, Kong L, Du G
Pharmacological research 2021 Jul;169:105650

Indole-3-carbinol ameliorates necroptosis and inflammation of intestinal epithelial cells in mice with ulcerative colitis by activating aryl hydrocarbon receptor.

Peng C, Wu C, Xu X, Pan L, Lou Z, Zhao Y, Jiang H, He Z, Ruan B
Experimental cell research 2021 Jul 15;404(2):112638

Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.

Ye S, Li S, Ma Y, Hu D, Xiao F
Ecotoxicology and environmental safety 2021 Dec 1;225:112779

Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.

Gelfand CA, Sakurai R, Wang Y, Liu Y, Segal R, Rehan VK
American journal of physiology. Lung cellular and molecular physiology 2020 Sep 1;319(3):L576-L584

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- κ B and NF- κ B-mediated cellular FLICE-inhibitory protein.

Yuan Z, Yuan Z, Hasnat M, Zhang H, Liang P, Sun L, Jiang Z, Zhang L
Acta pharmaceutica Sinica. B 2020 May;10(5):861-877

Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats.

Fang D, Lin Q, Wang C, Zheng C, Li Y, Huang T, Ni F, Wu Z, Chen B, Sun L
International immunopharmacology 2020 Mar;80:106151

Normothermic Machine Perfusion Combined with Bone Marrow Mesenchymal Stem Cells Improves the Oxidative Stress Response and Mitochondrial Function in Rat Donation After Circulatory Death Livers.

Yang L, Cao H, Sun D, Lin L, Zheng WP, Shen ZY, Song HL
Stem cells and development 2020 Jul 1;29(13):835-852

Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis.

Zha C, Meng X, Li L, Mi S, Qian D, Li Z, Wu P, Hu S, Zhao S, Cai J, Liu Y
Cancer biology & medicine 2020 Feb 15;17(1):154-168

Heatstroke-induced hepatocyte exosomes promote liver injury by activating the NOD-like receptor signaling pathway in mice.

Li Y, Zhu X, Zhang M, Tong H, Su L
PeerJ 2019;7:e8216

Dysregulated Tgfbr2/ERK-Smad4/SOX2 Signaling Promotes Lung Squamous Cell Carcinoma Formation.

Wang Y, Tan X, Tang Y, Zhang C, Xu J, Zhou J, Cheng X, Hou N, Liu W, Yang G, Teng Y, Yang X
Cancer research 2019 Sep 1;79(17):4466-4479

The role of inflammasome activation in Triptolide-induced acute liver toxicity.

Yuan Z, Hasnat M, Liang P, Yuan Z, Zhang H, Sun L, Zhang L, Jiang Z
International immunopharmacology 2019 Oct;75:105754

Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.

Hou C, Zhu X, Shi C, Peng Y, Huang D, Li Q, Miao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455

Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.

Zhang Q, Tao X, Xia S, Qu J, Song H, Liu J, Li H, Shang D
Oncology reports 2019 Jan;41(1):270-278

Proteomic Profiling of LPS-Induced Macrophage-Derived Exosomes Indicates Their Involvement in Acute Liver Injury.

Wang G, Jin S, Ling X, Li Y, Hu Y, Zhang Y, Huang Y, Chen T, Lin J, Ning Z, Meng Y, Li X
Proteomics 2019 Feb;19(3):e1800274

A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.

Yuan Z, Zhang H, Hasnat M, Ding J, Chen X, Liang P, Sun L, Zhang L, Jiang Z
Toxicology 2019 Feb 15;414:45-56

Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.

Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R
Toxicology and applied pharmacology 2018 May 1;346:28-36

α7-nAChR Activation Has an Opposite Effect on Healing of Covered and Uncovered Wounds.

Li JY, Jiang SK, Wang LL, Zhang MZ, Wang S, Jiang ZF, Liu YL, Cheng H, Zhang M, Zhao R, Guan DW
Inflammation 2018 Mar;41(2):474-484

A severe mouse model of spinal muscular atrophy develops early systemic inflammation.

Wan B, Feng P, Guan Z, Sheng L, Liu Z, Hua Y
Human molecular genetics 2018 Dec 1;27(23):4061-4076

Chronic Low-Dose Cadmium Exposure Impairs Cutaneous Wound Healing With Defective Early Inflammatory Responses After Skin Injury.

Mei H, Yao P, Wang S, Li N, Zhu T, Chen X, Yang M, Zhuo S, Chen S, Wang JM, Wang H, Xie D, Wu Y, Le Y
Toxicological sciences : an official journal of the Society of Toxicology 2017 Oct 1;159(2):327-338

Regulation of Postoperative Ileus by Lentivirus-Mediated HuR RNA Interference via the p38/MK2 Signaling Pathway.

Xiong YD, Rong LX, Pan C
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2017 Feb;21(2):389-397

Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction.

Xiang H, Wang G, Qu J, Xia S, Tao X, Qi B, Zhang Q, Shang D
Frontiers in pharmacology 2016;7:378

Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation.

Fu H, Ma Y, Yang M, Zhang C, Huang H, Xia Y, Lu L, Jin W, Cui D
Scientific reports 2016 Jul 14;6:29762

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 22225-1-AP(MPO antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver using 22225-1-AP(MPO antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MPO antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human MPO. This antibody recognizes human antigen. The MPO antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 22225-1-AP.pdf

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