CLDN12

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Sep 2011]

Description

Claudin 12

Tissue specificity

Low tissue specificity

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

7 (90383721 - 90513402)

Ensembl ID

ENSG00000157224  (ver. 103.38)

Orthologs

Mouse Cldn12: ENSMUSG00000046798

UniProt

P56749

neXtProt

NX_P56749

Human splice variants
Mouse splice variants

Protein structure