Antibody data
- Antibody Data
- Antigen structure
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- Product number
- APR03642G - Provider product page
- Provider
- Leading Biology
- Product name
- WT1 Antibody (Center E361)
- Antibody type
- Polyclonal
- Description
- This gene encodes a transcription factor that containsfour zinc-finger motifs at the C-terminus and aproline/glutamine-rich DNA-binding domain at the N-terminus. It hasan essential role in the normal development of the urogenitalsystem, and it is mutated in a small subset of patients with Wilm'stumors. This gene exhibits complex tissue-specific and polymorphicimprinting pattern, with biallelic, and monoallelic expression fromthe maternal and paternal alleles in different tissues. Multipletranscript variants have been described. In several variants, thereis evidence for the use of a non-AUG (CUG) translation initiationsite upstream of and in-frame with the first AUG. Authors ofPMID:7926762 also provide evidence that WT1 mRNA undergoes RNAediting in human and rat, and that this process istissue-restricted and developmentally regulated. [provided byRefSeq].
- Reactivity
- Human
- Host
- Rabbit
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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