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- Antibody Data
- Antigen structure
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- Immunoprecipitation [1]
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- Product number
- 10442-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10442-1-AP, RRID:AB_2206609
- Product name
- P53 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated P53 antibody (Cat. #10442-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Utilizing network pharmacology and molecular docking to explore the underlying mechanism of Guizhi Fuling Wan in treating endometriosis.
p53-GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways.
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.
p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides.
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Decipering the Molecular Mechanism of ACE2 Regulating A549 Cells.
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance.
Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis.
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
Targeting Mutated p53 Dependency in Triple-Negative Breast Cancer Cells Through CDK7 Inhibition.
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1.
Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.
A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.
Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis.
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation.
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer.
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Protective Effects of L-Theanine on IPEC-J2 Cells Growth Inhibition Induced by Dextran Sulfate Sodium via p53 Signaling Pathway.
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
Protective Effect of Manganese on Apoptosis and Mitochondrial Function of Heat-Stressed Primary Chick Embryonic Myocardial Cells.
miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer.
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins.
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis.
Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster.
Sodium hydrosulfide alleviates dexamethasone-induced cell senescence and dysfunction through targeting the miR-22/sirt1 pathway in osteoblastic MC3T3-E1 cells.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice.
Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53.
The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity.
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling.
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.
The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.
Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis.
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
miRNA-146a-5p mitigates stress-induced premature senescence of D-galactose-induced primary thymic stromal cells.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53.
Protective effect of thioredoxin reductase 1 in Parkinson's disease.
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Effects of redox interference on the pancreatic mitochondria and the abnormal blood glucose.
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
TRPV1 Activation Promotes β-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus:Implications for p53 Regulation and Neurite Outgrowth.
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction.
Simiao Qingwen Baidu decoction inhibits Epstein-Barr virus-induced B lymphoproliferative disease and lytic viral replication.
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment.
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis.
Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway.
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway.
MicroRNA-22 contributes to dexamethasone-induced osteoblast differentiation inhibition and dysfunction through targeting caveolin-3 expression in osteoblastic cells.
A novel amphibian-derived peptide alleviated ultraviolet B-induced photodamage in mice.
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma.
Polychlorinated biphenyl quinone regulates MLKL phosphorylation that stimulates exosome biogenesis and secretion via a short negative feedback loop.
PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis.
Piperlongumine Attenuates High Calcium/Phosphate-Induced Arterial Calcification by Preserving P53/PTEN Signaling.
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury.
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium.
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Kidney and lung tissue modifications after BDL-induced liver injury in mice are associated with increased expression of IGFBPrP1 and activation of the NF-κB inflammation pathway.
GCNT4 is Associated with Prognosis and Suppress Cell Proliferation in Gastric Cancer.
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Fibroblast Activation Protein (FAP) Overexpression Induces Epithelial-Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma by Down-Regulating Dipeptidyl Peptidase 9 (DPP9).
Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation.
Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma.
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Abnormal expression of homeobox c6 in the atherosclerotic aorta and its effect on proliferation and migration of rat vascular smooth muscle cells.
lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer.
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Targeting DNA to the endoplasmic reticulum efficiently enhances gene delivery and therapy.
MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways.
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle.
Loss of RAD6B induces degeneration of the cochlea in mice.
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11.
Functionalized graphene oxide against U251 glioma cells and its molecular mechanism.
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury.
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.
Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction.
ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells.
Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice.
G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system.
Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription.
10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.
Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis.
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Curcumin-enhanced antitumor effects of sorafenib via regulating the metabolism and tumor microenvironment.
The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways.
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p.
Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells.
Liver changes induced by cadmium poisoning distinguished by confocal Raman imaging.
Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress.
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway.
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
miR-106a Regulates Cell Proliferation and Autophagy by Targeting LKB1 in HPV-16-Associated Cervical Cancer.
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma.
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Synergistic effects of tanshinone IIA and andrographolide on the apoptosis of cancer cells via crosstalk between p53 and reactive oxygen species pathways.
COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence.
N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation.
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.
A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine.
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines.
MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma.
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
6-Bromoindirubin-3'-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver.
Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts.
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway.
RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21.
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity.
Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling.
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung.
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
RNA sequencing analysis of the CAL-27 cell response to over-expressed ZNF750 gene revealed an extensive regulation on cell cycle.
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
CD105 Is Expressed in Ovarian Cancer Precursor Lesions and Is Required for Metastasis to the Ovary.
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
Establishment and characterization of a radiation-induced dermatitis rat model.
miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer.
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth.
Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study.
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.
SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride.
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction.
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K.
Effects of palmatine hydrochloride mediated photodynamic therapy on oral squamous cell carcinoma.
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis.
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel.
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Estrogen receptor variant ER-α36 promotes tamoxifen agonist activity in glioblastoma cells.
Intracellular NO-Generator Based on Enzyme Trigger for Localized Tumor-Cytoplasm Rapid Drug Release and Synergetic Cancer Therapy.
Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo.
Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA.
MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop.
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2.
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis.
Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.
Interferon regulatory factor-1 reverses chemoresistance by downregulating the expression of P-glycoprotein in gastric cancer.
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy.
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway.
Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.
SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury.
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.
S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53.
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Protective effect and mechanism of rat recombinant S100 calcium-binding protein A4 on oxidative stress injury of rat vascular endothelial cells.
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
UVB-inhibited H19 activates melanogenesis by paracrine effects.
Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.
Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels.
Study on the expression of p53 and MMP-2 in patients with lung cancer after interventional therapy.
The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways.
Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.
A biobank of patient-derived pediatric brain tumor models.
Inhibin B suppresses anoikis resistance and migration through the transforming growth factor-β signaling pathway in nasopharyngeal carcinoma.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Radiation-induced premature cellular senescence involved in glomerular diseases in rats.
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16.
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Oxidative stress-mediated p53/p21WAF1/CIP1 pathway may be involved in microcystin-LR-induced cytotoxicity in HepG2 cells.
Potent hydrazone derivatives targeting esophageal cancer cells.
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis.
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62.
N‑cadherin attenuates nucleus pulposus cell senescence under high‑magnitude compression.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway.
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu.
Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling.
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway.
Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression.
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells.
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.
Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer.
H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing.
Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α.
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway.
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Inhibition effect of tacrolimus and platelet-derived growth factor-BB on restenosis after vascular intimal injury.
High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G2/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer.
Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.
HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells.
TRPC5 channel modulates endothelial cells senescence.
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis.
Y14 governs p53 expression and modulates DNA damage sensitivity.
Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change.
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis.
Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis.
Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency.
Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines.
Molecular characterization of breast cancer cell lines through multiple omic approaches.
0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop.
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).
Hypoxia-inducible factor-2α promotes hepatocyte apoptosis during cholestasis.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
ISG15 inhibits cancer cell growth and promotes apoptosis.
S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53.
The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway.
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage.
Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents.
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells.
Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.
Role of Epithelial Cell Transforming Sequence 2 (ECT2) in Predicting Prognosis of Osteosarcoma.
Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53.
Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro.
Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica.
Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability.
Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis.
Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Expression of Hedgehog Signals and Growth Inhibition by Itraconazole in Endometrial Cancer.
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
Inhibitory effect of diosgenin on experimentally induced benign prostatic hyperplasia in rats.
H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway.
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Paper-based microreactor array for rapid screening of cell signaling cascades.
Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis.
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells.
Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells.
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells.
Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.
Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways.
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1.
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.
Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis.
HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53.
The effect of mesenchymal stem cells on the p53 methylation in irradiation-induced thymoma in C57BL/6 mice.
Identification of nestin as a urinary biomarker for acute kidney injury.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Elevated p53 expression levels correlate with tumor progression and poor prognosis in patients exhibiting esophageal squamous cell carcinoma.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Protective effects of dioscin against alcohol-induced liver injury.
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
DDX3X regulates cell survival and cell cycle during mouse early embryonic development.
MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression.
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
Bisphenol A induces oxidative stress-associated DNA damage in INS-1 cells.
Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Differential effects of p53 on bystander phenotypes induced by gamma ray and high LET heavy ion radiation.
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
High level of COP1 expression is associated with poor prognosis in primary gastric cancer.
Alantolactone induces activation of apoptosis in human hepatoma cells.
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Sensitive detection of intracellular sumoylation via SNAP tag-mediated translation and RNA polymerase-based amplification.
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway.
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network.
Wang H, Zhou G, Zhuang M, Wang W, Fu X
PeerJ 2021;9:e11087
PeerJ 2021;9:e11087
p53-GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival.
Wang Y, Peng J, Mi X, Yang M
Frontiers in molecular biosciences 2021;8:697457
Frontiers in molecular biosciences 2021;8:697457
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Cai Y, Du Q, Deng TH, Shen BB, Peng YM, Zeng PH, Yu SR
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Zhang S, Zhang R, Qiao P, Ma X, Lu R, Wang F, Li C, E L, Liu H
Stem cells international 2021;2021:6616240
Stem cells international 2021;2021:6616240
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y, Tian H
Oxidative medicine and cellular longevity 2021;2021:4714649
Oxidative medicine and cellular longevity 2021;2021:4714649
Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways.
Che X, Zhan J, Zhao F, Zhong Z, Chen M, Han R, Wang Y
BioMed research international 2021;2021:4340950
BioMed research international 2021;2021:4340950
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
Chen G, Liu B, Chen S, Li H, Liu J, Mai Z, Chen E, Zhou C, Sun G, Guo Z, Lei L, Huang S, Zhang L, Li M, Tan N, Li H, Liao Y, Liu J, Chen J, Liu Y
International journal of biological sciences 2021;17(3):882-896
International journal of biological sciences 2021;17(3):882-896
CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.
Zhao S, Zhang Y, Lu X, Ding H, Han B, Song X, Miao H, Cui X, Wei S, Liu W, Chen S, Wang J
International journal of biological sciences 2021;17(13):3608-3621
International journal of biological sciences 2021;17(13):3608-3621
p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides.
Zhang Y, Xia M, Zhou Z, Hu X, Wang J, Zhang M, Li Y, Sun L, Chen F, Yu H
International journal of nanomedicine 2021;16:283-296
International journal of nanomedicine 2021;16:283-296
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Chen YQ, Zhu WT, Lin CY, Yuan ZW, Li ZH, Yan PK
International journal of nanomedicine 2021;16:269-281
International journal of nanomedicine 2021;16:269-281
Decipering the Molecular Mechanism of ACE2 Regulating A549 Cells.
Xiao K, Song L, Bai Y, Liu P, Liu Y, Xie F, Xie L
Frontiers in genetics 2021;12:653725
Frontiers in genetics 2021;12:653725
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306
Frontiers in pharmacology 2021;12:653306
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
Yang M, Li WY, Xie J, Wang ZL, Wen YL, Zhao CC, Tao L, Li LF, Tian Y, Sheng J
Frontiers in pharmacology 2021;12:639256
Frontiers in pharmacology 2021;12:639256
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Du JK, Yu Q, Liu YJ, Du SF, Huang LY, Xu DH, Ni X, Zhu XY
Theranostics 2021;11(9):4207-4231
Theranostics 2021;11(9):4207-4231
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance.
Zhao M, Wang Y, Li L, Liu S, Wang C, Yuan Y, Yang G, Chen Y, Cheng J, Lu Y, Liu J
Theranostics 2021;11(4):1845-1863
Theranostics 2021;11(4):1845-1863
Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis.
Cheng T, Ding S, Liu S, Li Y, Sun L
Theranostics 2021;11(2):893-905
Theranostics 2021;11(2):893-905
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
Wu D, Yu HQ, Xiong HJ, Zhang YJ, Lin XT, Zhang J, Wu W, Wang T, Liu XY, Xie CM
Frontiers in oncology 2021;11:743824
Frontiers in oncology 2021;11:743824
Targeting Mutated p53 Dependency in Triple-Negative Breast Cancer Cells Through CDK7 Inhibition.
Peng J, Yang M, Bi R, Wang Y, Wang C, Wei X, Zhang Z, Xie X, Wei W
Frontiers in oncology 2021;11:664848
Frontiers in oncology 2021;11:664848
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1.
Zhang L, Zheng J, Tie X, Lin T, Yang W, Li Z, Zou Y, Guan G, Liu P, Luo W, Li Z
Canadian journal of physiology and pharmacology 2021 Sep;99(9):900-909
Canadian journal of physiology and pharmacology 2021 Sep;99(9):900-909
Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.
Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, Zhao X, Zhuang S, Pan Q, Sun F, Shang W, Barasch J, Qiu A
Free radical biology & medicine 2021 Sep;173:81-96
Free radical biology & medicine 2021 Sep;173:81-96
A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.
Zhou L, Chen J, Sun Y, Chai K, Zhu Z, Wang C, Chen M, Han W, Hu X, Li R, Yao T, Li H, Dong C, Shi S
Journal of nanobiotechnology 2021 Sep 4;19(1):261
Journal of nanobiotechnology 2021 Sep 4;19(1):261
Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis.
Kuang H, Wang T, Liu L, Tang C, Li T, Liu M, Wang T, Zhong W, Wang Y
Neuroscience letters 2021 Sep 25;762:136134
Neuroscience letters 2021 Sep 25;762:136134
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes.
Chang ACY, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL, Blau HM
Stem cell reports 2021 Sep 14;16(9):2169-2181
Stem cell reports 2021 Sep 14;16(9):2169-2181
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation.
Zou ZL, Sun MH, Yin WF, Yang L, Kong LY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153657
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153657
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
Nie Z, Zhang L, Chen W, Zhang Y, Wang W, Hua R, Zhang T, Zhao C, Gong M, Wu H
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.
Xiong L, Ye X, Chen Z, Fu H, Li S, Xu P, Yu J, Wen L, Gao R, Fu Y, Qi H, Kilby MD, Saffery R, Baker PN, Tong C
Aging cell 2021 Oct;20(10):e13491
Aging cell 2021 Oct;20(10):e13491
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y
Bioorganic chemistry 2021 Oct;115:105239
Bioorganic chemistry 2021 Oct;115:105239
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Li S, Liu J, Liu S, Jiao W, Wang X
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2021 Oct 21;
Andrology 2021 Oct 21;
The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer.
Yi L, Wang H, Li W, Ye K, Xiong W, Yu H, Jin X
Cell death & disease 2021 Oct 14;12(10):944
Cell death & disease 2021 Oct 14;12(10):944
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Wang S, Xu X, Che D, Fan R, Gao M, Cao Y, Ge C, Feng Y, Li J, Xie S, Wang C, Dai F, Gao L, Wang Y
International journal of molecular sciences 2021 Oct 12;22(20)
International journal of molecular sciences 2021 Oct 12;22(20)
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Wang D, Wei X, Chen X, Wang Q, Zhang J, Kalvakolanu DV, Guo B, Zhang L
Experimental cell research 2021 Oct 1;407(1):112799
Experimental cell research 2021 Oct 1;407(1):112799
Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.
Xie Y, Zhi K, Meng X
Molecular neurobiology 2021 Nov;58(11):5756-5771
Molecular neurobiology 2021 Nov;58(11):5756-5771
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Wang L, Bao S, Liu X, Wang F, Zhang J, Dang P, Wang F, Li B, Lin Y
Ecotoxicology and environmental safety 2021 Nov;224:112703
Ecotoxicology and environmental safety 2021 Nov;224:112703
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Lv Y, Ma P, Wang J, Xu Q, Fan J, Yan L, Ma P, Zhou R
European journal of pharmacology 2021 Nov 5;910:174311
European journal of pharmacology 2021 Nov 5;910:174311
Protective Effects of L-Theanine on IPEC-J2 Cells Growth Inhibition Induced by Dextran Sulfate Sodium via p53 Signaling Pathway.
Zhang L, Ma M, Li Z, Zhang H, He X, Song Z
Molecules (Basel, Switzerland) 2021 Nov 19;26(22)
Molecules (Basel, Switzerland) 2021 Nov 19;26(22)
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY
iScience 2021 Nov 19;24(11):103368
iScience 2021 Nov 19;24(11):103368
Protective Effect of Manganese on Apoptosis and Mitochondrial Function of Heat-Stressed Primary Chick Embryonic Myocardial Cells.
Wang R, Shi Z, Li J, Tang D, Qin S, Guo Y
Biological trace element research 2021 Nov 15;
Biological trace element research 2021 Nov 15;
miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer.
Liu H, Xiang Y, Zong QB, Zhang XY, Wang ZW, Fang SQ, Zhang TC, Liao XH
Aging 2021 Nov 14;13(21):24402-24416
Aging 2021 Nov 14;13(21):24402-24416
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Xu JJ, Cui J, Lin Q, Chen XY, Zhang J, Gao EH, Wei B, Zhao W
International journal of cardiology 2021 Nov 1;342:82-93
International journal of cardiology 2021 Nov 1;342:82-93
Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins.
Zhen X, Zhang S, Xie F, Zhou M, Hu Z, Zhu F, Nie J
Kidney diseases (Basel, Switzerland) 2021 May;7(3):186-199
Kidney diseases (Basel, Switzerland) 2021 May;7(3):186-199
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, Zhang H, Guan H, Guo D, Zeng C, Zhang R, Bai X, Zhang H, Cai D
Cell death & disease 2021 May 25;12(6):533
Cell death & disease 2021 May 25;12(6):533
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H
Cell death & disease 2021 May 18;12(6):510
Cell death & disease 2021 May 18;12(6):510
AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis.
Ding L, Fang Y, Li Y, Hu Q, Ai M, Deng K, Huang X, Xin H
Journal of cellular and molecular medicine 2021 Mar;25(6):3019-3030
Journal of cellular and molecular medicine 2021 Mar;25(6):3019-3030
Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster.
Ji G, Zhou W, Li X, Du J, Li X, Hao H
Molecular medicine reports 2021 Mar;23(3)
Molecular medicine reports 2021 Mar;23(3)
Sodium hydrosulfide alleviates dexamethasone-induced cell senescence and dysfunction through targeting the miR-22/sirt1 pathway in osteoblastic MC3T3-E1 cells.
Li P, Mao WW, Zhang S, Zhang L, Chen ZR, Lu ZD
Experimental and therapeutic medicine 2021 Mar;21(3):238
Experimental and therapeutic medicine 2021 Mar;21(3):238
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS.
Bai L, Wang W, Xiang Y, Wang S, Wan S, Zhu Y
Molecular therapy. Nucleic acids 2021 Mar 5;23:294-309
Molecular therapy. Nucleic acids 2021 Mar 5;23:294-309
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Shao Y, Zhao C, Pan J, Zeng C, Zhang H, Liu L, Fan K, Liu X, Luo B, Fang H, Bai X, Zhang H, Cai D
Aging 2021 Mar 19;13(7):9646-9664
Aging 2021 Mar 19;13(7):9646-9664
Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice.
Luan Z, Wei Y, Huo X, Sun X, Zhang C, Ming W, Luo Z, Du C, Li Y, Xu H, Lu H, Zheng F, Guan Y, Zhang X
Biochimica et biophysica acta. Molecular basis of disease 2021 Mar 1;1867(3):165996
Biochimica et biophysica acta. Molecular basis of disease 2021 Mar 1;1867(3):165996
Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53.
Huang S, Lu Y, Li S, Zhou T, Wang J, Xia J, Zhang X, Zhou Z
Environmental toxicology 2021 Jun;36(6):1181-1194
Environmental toxicology 2021 Jun;36(6):1181-1194
The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Hsieh YH, Chao AC, Lin YC, Chen SD, Yang DI
Free radical biology & medicine 2021 Jun;169:36-61
Free radical biology & medicine 2021 Jun;169:36-61
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Jia R, Yang F, Yan P, Ma L, Yang L, Li L
Free radical biology & medicine 2021 Jun;169:158-168
Free radical biology & medicine 2021 Jun;169:158-168
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity.
Ellison V, Annor GK, Freedman C, Xiao G, Lundine D, Freulich E, Prives C, Bargonetti J
Oncotarget 2021 Jun 8;12(12):1128-1146
Oncotarget 2021 Jun 8;12(12):1128-1146
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling.
Yao JY, Xu S, Sun YN, Xu Y, Guo QL, Wei LB
Acta pharmacologica Sinica 2021 Jun 29;
Acta pharmacologica Sinica 2021 Jun 29;
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Wang W, Wei J, Zhang H, Zheng X, Zhou H, Luo Y, Yang J, Deng Q, Huang S, Fu Z
Cell death & disease 2021 Jun 11;12(6):605
Cell death & disease 2021 Jun 11;12(6):605
Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.
Guan R, Li Z, Dai X, Zou W, Yu X, Liu H, Chen Q, Teng W, Liu P, Liu X, Dong S
Molecular medicine reports 2021 Jul;24(1)
Molecular medicine reports 2021 Jul;24(1)
The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.
Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Yang Z, Zhang YY, Wang YD, Tian FM, Zhang L
Orthopaedic surgery 2021 Jul;13(5):1662-1672
Orthopaedic surgery 2021 Jul;13(5):1662-1672
Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.
Hou X, Qiao L, Liu R, Han X, Zhang W
Biomolecules 2021 Jul 6;11(7)
Biomolecules 2021 Jul 6;11(7)
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Liu J, He J, Ge L, Xiao H, Huang Y, Zeng L, Jiang Z, Lu M, Hu Z
Stem cell research & therapy 2021 Jul 22;12(1):413
Stem cell research & therapy 2021 Jul 22;12(1):413
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RA
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis.
He Z, Liao W, Song Q, Li B, Liu J, Xiong Y, Song C, Yang S
International journal of molecular medicine 2021 Jan;47(1):289-301
International journal of molecular medicine 2021 Jan;47(1):289-301
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Liu JY, Fu WQ, Zheng XJ, Li W, Ren LW, Wang JH, Yang C, Du GH
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Wang P, Wang C, Liu C
Oncology letters 2021 Jan;21(1):59
Oncology letters 2021 Jan;21(1):59
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
Tang LJ, Zhou YJ, Xiong XM, Li NS, Zhang JJ, Luo XJ, Peng J
Free radical biology & medicine 2021 Jan;162:339-352
Free radical biology & medicine 2021 Jan;162:339-352
miRNA-146a-5p mitigates stress-induced premature senescence of D-galactose-induced primary thymic stromal cells.
Du H, Wang Y, Liu X, Wang S, Wu S, Yuan Z, Zhu X
Cytokine 2021 Jan;137:155314
Cytokine 2021 Jan;137:155314
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538
ACS nano 2021 Jan 26;15(1):1519-1538
Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53.
Wang J, Liu D, Sun Z, Ye T, Li J, Zeng B, Zhao Q, Rosie Xing H
Cell death & disease 2021 Jan 19;12(1):98
Cell death & disease 2021 Jan 19;12(1):98
Protective effect of thioredoxin reductase 1 in Parkinson's disease.
Liu Z, Ye Q, Wang F, Guo Y, Cui R, Wang J, Wang D
Neuroscience letters 2021 Jan 10;741:135457
Neuroscience letters 2021 Jan 10;741:135457
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Wang X, Liu K, Gong H, Li D, Chu W, Zhao D, Wang X, Xu D
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Effects of redox interference on the pancreatic mitochondria and the abnormal blood glucose.
Xie F, Wu M, Lai B, Halim M, Liu S, Shi D
Free radical research 2021 Feb;55(2):119-130
Free radical research 2021 Feb;55(2):119-130
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Ke W, Wang B, Hua W, Song Y, Lu S, Luo R, Li G, Wang K, Liao Z, Xiang Q, Li S, Wu X, Zhang Y, Yang C
Cell proliferation 2021 Feb;54(2):e12987
Cell proliferation 2021 Feb;54(2):e12987
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Wang X, Cheng G, Miao Y, Qiu F, Bai L, Gao Z, Huang Y, Dong L, Niu X, Wang X, Li Y, Tang H, Xu Y, Song X
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q
Experimental and molecular pathology 2021 Feb;118:104571
Experimental and molecular pathology 2021 Feb;118:104571
TRPV1 Activation Promotes β-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus:Implications for p53 Regulation and Neurite Outgrowth.
Hassan A, Iftinca M, Young D, Flynn R, Agosti F, Abdullah N, Defaye M, Scott MGH, Dufour A, Altier C
International journal of molecular sciences 2021 Feb 25;22(5)
International journal of molecular sciences 2021 Feb 25;22(5)
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Peng X, Hao M, Zhao Y, Cai Y, Chen X, Chen H, Zhang Y, Dong L, Liu X, Ding C, Liu W, Yang M, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction.
Zhou Q, Deng J, Yao J, Song J, Meng D, Zhu Y, Xu M, Liang Y, Xu J, Sluijter JP, Xiao J
EBioMedicine 2021 Dec;74:103713
EBioMedicine 2021 Dec;74:103713
Simiao Qingwen Baidu decoction inhibits Epstein-Barr virus-induced B lymphoproliferative disease and lytic viral replication.
Yang X, Liu L, Zhang H, Sun X, Yan Y, Ran R
Pharmaceutical biology 2021 Dec;59(1):741-747
Pharmaceutical biology 2021 Dec;59(1):741-747
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
Li P, Jiang H, Peng H, Zeng W, Zhong Y, He M, Xie L, Chen J, Guo D, Wu J, Li CM
Virologica Sinica 2021 Dec;36(6):1411-1420
Virologica Sinica 2021 Dec;36(6):1411-1420
Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment.
Xie Y, Song A, Zhu Y, Jiang A, Peng W, Zhang C, Meng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112266
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112266
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
Huang L, Liu Q, Zhou T, Zhang J, Tian Q, Zhang Q, Wei W, Wu H
International immunopharmacology 2021 Dec;101(Pt A):108281
International immunopharmacology 2021 Dec;101(Pt A):108281
IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis.
Dang W, Cao P, Yan Q, Yang L, Wang Y, Yang J, Xin S, Zhang J, Li J, Long S, Zhang W, Zhang S, Lu J
Cancer letters 2021 Dec 28;523:135-147
Cancer letters 2021 Dec 28;523:135-147
Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway.
Zhang L, Yao X, Ma M, Ding Y, Zhang H, He X, Song Z
Journal of agricultural and food chemistry 2021 Dec 1;69(47):14192-14203
Journal of agricultural and food chemistry 2021 Dec 1;69(47):14192-14203
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
Zeng L, Zhang F, Zhang Z, Xu M, Xu Y, Liu Y, Xu H, Sun X, Sang M, Luo H
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22822
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22822
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Cheng Y, Hu Y, Wang H, Zhao Z, Jiang X, Zhang Y, Zhang J, Tong Y, Qiu X
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway.
Wang Z, Liu L, Dai H, Si X, Zhang L, Li E, Yang Z, Chao G, Zheng J, Ke Y, Lihong S, Zhang Q, Liu H
Bioorganic & medicinal chemistry 2021 Aug 1;43:116265
Bioorganic & medicinal chemistry 2021 Aug 1;43:116265
MicroRNA-22 contributes to dexamethasone-induced osteoblast differentiation inhibition and dysfunction through targeting caveolin-3 expression in osteoblastic cells.
Li P, Mao W, Zhang S, Zhang L, Chen Z, Lu Z
Experimental and therapeutic medicine 2021 Apr;21(4):336
Experimental and therapeutic medicine 2021 Apr;21(4):336
A novel amphibian-derived peptide alleviated ultraviolet B-induced photodamage in mice.
Zhang X, Feng C, Wang S, Wang Y, Fu Z, Zhang Y, Sun H, Xie C, Fu Y, Tao J, Luo M, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111258
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111258
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Chen CC, Chen J, Wang WL, Xie L, Shao CQ, Zhang YX
Orthopaedic surgery 2021 Apr;13(2):583-591
Orthopaedic surgery 2021 Apr;13(2):583-591
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723
Aging 2021 Apr 6;13(7):10703-10723
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
Cai Y, Gu WT, Cheng K, Jia PF, Li F, Wang M, Zhang WF, Qiu JT, Wu ZB, Zhao WG
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
Yang Y, Xiang K, Sun D, Zheng M, Song Z, Li M, Wang X, Li H, Chen L
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma.
Sheng J, He X, Yu W, Chen Y, Long Y, Wang K, Zhu S, Liu Q
Cancer letters 2021 Apr 10;503:54-68
Cancer letters 2021 Apr 10;503:54-68
Polychlorinated biphenyl quinone regulates MLKL phosphorylation that stimulates exosome biogenesis and secretion via a short negative feedback loop.
Peng L, Wang Y, Yang B, Qin Q, Song E, Song Y
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:115606
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:115606
PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis.
Guo Q, Ke XX, Fang SX, Gao WL, Song YX, Chen C, Lu HL, Xu G
Frontiers in cell and developmental biology 2020;8:581919
Frontiers in cell and developmental biology 2020;8:581919
Piperlongumine Attenuates High Calcium/Phosphate-Induced Arterial Calcification by Preserving P53/PTEN Signaling.
Shi W, Lu J, Li J, Qiu M, Lu Y, Gu J, Kong X, Sun W
Frontiers in cardiovascular medicine 2020;7:625215
Frontiers in cardiovascular medicine 2020;7:625215
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
Karakurt S, AbuŞoĞlu G, Arituluk ZC
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury.
Zhu LY, Yu LM, Zhang WH, Deng JJ, Liu SF, Huang W, Zhang MH, Lu YQ, Han XX, Liu YH
Stem cells international 2020;2020:8412598
Stem cells international 2020;2020:8412598
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium.
Zhu L, Xu Y, Chen X, Qin J, Niu T, Zhu Y, Jiang Y, Zhao S, Liu K, Lu J, Jin G, Ma J, Dong Z, Zhao J
BioMed research international 2020;2020:4534289
BioMed research international 2020;2020:4534289
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548
Oxidative medicine and cellular longevity 2020;2020:4196548
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
Mao Y, Li W, Hua B, Gu X, Pan W, Chen Q, Xu B, Wang Z, Lu C
BioMed research international 2020;2020:2406159
BioMed research international 2020;2020:2406159
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Peng S, Sun Y, Luo Y, Ma S, Sun W, Tang G, Li S, Zhang N, Ren J, Xiao Y, Liu X, Zhang J, Gong Y, Xie C
International journal of biological sciences 2020;16(12):2145-2158
International journal of biological sciences 2020;16(12):2145-2158
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Lin L, Wang D, Qu S, Zhao H, Lin Y
Drug design, development and therapy 2020;14:1127-1141
Drug design, development and therapy 2020;14:1127-1141
Kidney and lung tissue modifications after BDL-induced liver injury in mice are associated with increased expression of IGFBPrP1 and activation of the NF-κB inflammation pathway.
Hu ZH, Kong YY, Ren JJ, Huang TJ, Wang YQ, Liu LX
International journal of clinical and experimental pathology 2020;13(2):192-202
International journal of clinical and experimental pathology 2020;13(2):192-202
GCNT4 is Associated with Prognosis and Suppress Cell Proliferation in Gastric Cancer.
Sun H, Chang J, Ye M, Weng W, Zhang M, Ni S, Tan C, Huang D, Wang L, Du X, Xu MD, Sheng W
OncoTargets and therapy 2020;13:8601-8613
OncoTargets and therapy 2020;13:8601-8613
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, Liu H, Zhang Y, Zhang J, Gui R, Nie X
OncoTargets and therapy 2020;13:473-486
OncoTargets and therapy 2020;13:473-486
Fibroblast Activation Protein (FAP) Overexpression Induces Epithelial-Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma by Down-Regulating Dipeptidyl Peptidase 9 (DPP9).
Wu QQ, Zhao M, Huang GZ, Zheng ZN, Chen Y, Zeng WS, Lv XZ
OncoTargets and therapy 2020;13:2599-2611
OncoTargets and therapy 2020;13:2599-2611
Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation.
Wang S, Wang T, Wang L, Zhong L, Li K
OncoTargets and therapy 2020;13:10917-10929
OncoTargets and therapy 2020;13:10917-10929
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
Liu Y, Feng Y, Li Y, Hu Y, Zhang Q, Huang Y, Shi K, Ran C, Hou J, Zhou G, Wang X
Frontiers in pharmacology 2020;11:867
Frontiers in pharmacology 2020;11:867
STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation.
Hu S, Chen X, Xu X, Zheng C, Huang W, Zhou Y, Akuetteh PDP, Yang H, Shi K, Chen B, Zhang Q
Frontiers in oncology 2020;10:594224
Frontiers in oncology 2020;10:594224
Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer.
Shen Z, Chen Y, Li L, Liu L, Peng M, Chen X, Wu X, Sferra TJ, Wu M, Lin X, Cheng Y, Chu J, Shen A, Peng J
Frontiers in oncology 2020;10:1035
Frontiers in oncology 2020;10:1035
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
Zhou L, Sheng W, Jia C, Shi X, Cao R, Wang G, Lin Y, Zhu F, Dong Q, Dong M
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma.
Xu J, Zhang M, Lin X, Wang Y, He X
Steroids 2020 Sep;161:108672
Steroids 2020 Sep;161:108672
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Wu Q, Song Y, Liu R, Wang R, Mei W, Chen W, Yang H, Wang X
Bioorganic chemistry 2020 Sep;102:104074
Bioorganic chemistry 2020 Sep;102:104074
Abnormal expression of homeobox c6 in the atherosclerotic aorta and its effect on proliferation and migration of rat vascular smooth muscle cells.
Long X, You G, Wu Q, Zhou Y, Yu F, Xiao Y, Deng S, Song F, Huang J, Tian M
Acta biochimica et biophysica Sinica 2020 Sep 8;52(9):935-943
Acta biochimica et biophysica Sinica 2020 Sep 8;52(9):935-943
lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer.
Na H, Li X, Zhang X, Xu Y, Sun Y, Cui J, Chen Z, Shi X, Ren S, Zuo Y
Molecular therapy. Nucleic acids 2020 Sep 4;21:480-491
Molecular therapy. Nucleic acids 2020 Sep 4;21:480-491
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Chen DB, Xie XW, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Fei R, Qin WY, Wang JH, Wu X, Shao QX, Wei L, Chen HS
Scientific reports 2020 Sep 3;10(1):14538
Scientific reports 2020 Sep 3;10(1):14538
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Jiang TY, Pan YF, Wan ZH, Lin YK, Zhu B, Yuan ZG, Ma YH, Shi YY, Zeng TM, Dong LW, Tan YX, Wang HY
Science translational medicine 2020 Sep 23;12(562)
Science translational medicine 2020 Sep 23;12(562)
Targeting DNA to the endoplasmic reticulum efficiently enhances gene delivery and therapy.
Qin B, Yuan X, Jiang M, Yin H, Luo Z, Zhang J, Zhu C, Li X, Shi Y, Luo L, Du Y, You J
Nanoscale 2020 Sep 21;12(35):18249-18262
Nanoscale 2020 Sep 21;12(35):18249-18262
MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
Wan X, Yao B, Ma Y, Liu Y, Tang Y, Hu J, Li M, Fu S, Zheng X, Yin D
Biochemical and biophysical research communications 2020 Sep 10;530(1):314-321
Biochemical and biophysical research communications 2020 Sep 10;530(1):314-321
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, Kong W, Kong W
Experimental cell research 2020 Sep 1;394(1):112093
Experimental cell research 2020 Sep 1;394(1):112093
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
Matic S, D'Souza DH, Wu T, Pangloli P, Dia VP
Immunological investigations 2020 Oct;49(7):711-725
Immunological investigations 2020 Oct;49(7):711-725
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
Liu N, Yang Y, Chen J, Jia H, Zhang Y, Jiang D, Wu G, Wu Z
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Zhu MJ, Liu BY, Shi L, Wang X, Wang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Yu X, Li H, Zhu M, Hu P, Liu X, Qing Y, Wang X, Wang H, Wang Z, Xu J, Tan R, Guo Q, Hui H
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways.
Shen Z, Shen A, Chen X, Wu X, Chu J, Cheng Y, Peng M, Chen Y, Weygant N, Wu M, Lin X, Peng J, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110618
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Wu Z, Zhan Y, Wang L, Tong J, Zhang L, Lin M, Jin X, Jiang L, Lou Y, Qiu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
Jin Y, Qin X
The international journal of biochemistry & cell biology 2020 Oct;127:105846
The international journal of biochemistry & cell biology 2020 Oct;127:105846
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle.
Miao ZF, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun JX, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang ZN, Mills JC
Developmental cell 2020 Oct 26;55(2):178-194.e7
Developmental cell 2020 Oct 26;55(2):178-194.e7
Loss of RAD6B induces degeneration of the cochlea in mice.
Ma Y, Song Y, Shen R, Li P, Ding H, Guo Z, Liu X, Wang D
Biochemical and biophysical research communications 2020 Oct 20;531(3):402-408
Biochemical and biophysical research communications 2020 Oct 20;531(3):402-408
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Deng H, Yu B, Yu Y, Tian G, Yang L
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
Lin J, Xu R, Shen X, Jiang H, Du S
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11.
Song Z, Guo Q, Wang H, Gao L, Wang S, Liu D, Liu J, Qi Y, Lin B
Pathology, research and practice 2020 Nov;216(11):153148
Pathology, research and practice 2020 Nov;216(11):153148
Functionalized graphene oxide against U251 glioma cells and its molecular mechanism.
Wang P, Wang X, Tang Q, Chen H, Zhang Q, Jiang H, Wang Z
Materials science & engineering. C, Materials for biological applications 2020 Nov;116:111187
Materials science & engineering. C, Materials for biological applications 2020 Nov;116:111187
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
Kong Z, Zhou C, Kang J, Tan Z
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Wei M, Xie M, Zhang Z, Wei Y, Zhang J, Pan H, Li B, Wang J, Song Y, Chong C, Zhao R, Wang J, Yu L, Yang G, Yang C
European journal of medicinal chemistry 2020 Nov 15;206:112677
European journal of medicinal chemistry 2020 Nov 15;206:112677
Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury.
Wang SJ, Chen H, Tang LJ, Tu H, Liu B, Li NS, Luo XJ, Peng J
Canadian journal of physiology and pharmacology 2020 May;98(5):259-266
Canadian journal of physiology and pharmacology 2020 May;98(5):259-266
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Wang L, Tan Z, Zhang Y, Kady Keita N, Liu H, Zhang Y
International journal of oncology 2020 May;56(5):1162-1174
International journal of oncology 2020 May;56(5):1162-1174
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933
Biochemical pharmacology 2020 May;175:113933
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.
Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V
Nature communications 2020 May 12;11(1):2376
Nature communications 2020 May 12;11(1):2376
Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction.
Zhang H, Ma Y, Wang M, Elsabagh M, Loor JJ, Wang H
Food & function 2020 May 1;11(5):4456-4470
Food & function 2020 May 1;11(5):4456-4470
ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells.
Lu W, Ma YY, Shao QQ, Liang J, Qi TT, Huang Y, Wang QJ
Molecular medicine reports 2020 Mar;21(3):1208-1216
Molecular medicine reports 2020 Mar;21(3):1208-1216
Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.
Zhang Y, Cui N, Zheng G
Oncology letters 2020 Mar;19(3):1975-1984
Oncology letters 2020 Mar;19(3):1975-1984
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB
PLoS pathogens 2020 Mar;16(3):e1008429
PLoS pathogens 2020 Mar;16(3):e1008429
Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice.
Liu L, Liu Y, Li N, Huang R, Zheng X, Huang L, Hou S, Yuan Q
Brain research bulletin 2020 Mar;156:86-104
Brain research bulletin 2020 Mar;156:86-104
G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.
Lai S, Fu X, Yang S, Zhang S, Lin Q, Zhang M, Chen H
Journal of diabetes 2020 Mar;12(3):247-258
Journal of diabetes 2020 Mar;12(3):247-258
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Fan Z, Chen X, Liu L, Zhu C, Xu J, Yin X, Sheng Y, Zhu Z, Wen L, Zuo X, Zheng X, Zhang Y, Xu J, Huang H, Zhou F, Sun L, Luo J, Zhang D, Chen X, Cui Y, Hao Y, Cui Y, Zhang X, Chen R
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.
Wang J, Zhang ZQ, Li FQ, Chen JN, Gong X, Cao BB, Wang W
Oncology reports 2020 Jun;43(6):1863-1874
Oncology reports 2020 Jun;43(6):1863-1874
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
Dou Y, Huang D, Zeng X, Zhou Y, Jiang X, Yue C, He J, Xiao S
Biotechnology letters 2020 Jun;42(6):1051-1060
Biotechnology letters 2020 Jun;42(6):1051-1060
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system.
Chen Y, Jiang H, Wang T, He D, Tian R, Cui Z, Tian X, Gao Q, Ma X, Yang J, Wu J, Tan S, Xu H, Tang X, Wang Y, Yu Z, Han H, Das BC, Severinov K, Hitzeroth II, Debata PR, Xu W, Fan W, Jin Z, Cao C, Yu M, Xie W, Huang Z, Hu Z, You Z
Antiviral research 2020 Jun;178:104794
Antiviral research 2020 Jun;178:104794
Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma.
Huang X, He C, Hua X, Kan A, Mao Y, Sun S, Duan F, Wang J, Huang P, Li S
Clinical and translational medicine 2020 Jun;10(2):e41
Clinical and translational medicine 2020 Jun;10(2):e41
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, Peng S, Luo M, Liu D, Zhang L, Mei Q, Long G, Hu G, Hu G
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
Liu H, Zhang W, Fang Y, Yang H, Tian L, Li K, Lai W, Bian L, Lin B, Liu X, Xi Z
Journal of hazardous materials 2020 Jun 15;392:122312
Journal of hazardous materials 2020 Jun 15;392:122312
MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription.
Tong D, Zhang J, Wang X, Li Q, Liu LY, Yang J, Guo B, Ni L, Zhao L, Huang C
Oncogenesis 2020 Jun 1;9(5):56
Oncogenesis 2020 Jun 1;9(5):56
10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.
You M, Miao Z, Sienkiewicz O, Jiang X, Zhao X, Hu F
International immunopharmacology 2020 Jul;84:106501
International immunopharmacology 2020 Jul;84:106501
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
Li Y, Shi H, Yuan J, Qiao L, Dong L, Wang Y
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1291-1300
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1291-1300
Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.
Zhu L, Dai L, Yang N, Liu M, Ma S, Li C, Shen J, Lin T, Wang D, Pan W, Li X
Cell biochemistry and function 2020 Jul;38(5):621-629
Cell biochemistry and function 2020 Jul;38(5):621-629
Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis.
Wang H, Wen C, Chen S, Wang F, He L, Li W, Zhou Q, Yu WK, Huang L, Chen J, Liu R, Li W, Yang X, Liu H
Biochemical pharmacology 2020 Jul;177:114014
Biochemical pharmacology 2020 Jul;177:114014
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
Zhang S, Wang C, Ma B, Xu M, Xu S, Liu J, Tian Y, Fu Y, Luo Y
Cell reports 2020 Jul 7;32(1):107879
Cell reports 2020 Jul 7;32(1):107879
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, Zhou Z, Zhang L, Liang B, He J, Chen Z, Yan C, Yang Z, Xian S, Wang L
Cell death & disease 2020 Jul 24;11(7):574
Cell death & disease 2020 Jul 24;11(7):574
Curcumin-enhanced antitumor effects of sorafenib via regulating the metabolism and tumor microenvironment.
Man S, Yao J, Lv P, Liu Y, Yang L, Ma L
Food & function 2020 Jul 22;11(7):6422-6432
Food & function 2020 Jul 22;11(7):6422-6432
The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.
Saez I, Gerbracht JV, Koyuncu S, Lee HJ, Horn M, Kroef V, Denzel MS, Dieterich C, Gehring NH, Vilchez D
FEBS letters 2020 Jan;594(1):175-188
FEBS letters 2020 Jan;594(1):175-188
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Liu L, Wang F, Tong Y, Li LF, Liu Y, Gao WQ
Cell proliferation 2020 Jan;53(1):e12718
Cell proliferation 2020 Jan;53(1):e12718
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways.
Li Y, Chen F, Chen J, Chan S, He Y, Liu W, Zhang G
Cancers 2020 Jan 6;12(1)
Cancers 2020 Jan 6;12(1)
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Wang G, Sheng W, Tang J, Li X, Zhou J, Dong M
Bioscience reports 2020 Jan 31;40(1)
Bioscience reports 2020 Jan 31;40(1)
Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p.
Cheng Y, Li J, Wang C, Yang H, Wang Y, Zhan T, Guo S, Liang J, Bai Y, Yu J, Liu G
Experimental animals 2020 Jan 29;69(1):34-44
Experimental animals 2020 Jan 29;69(1):34-44
Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells.
Li DY, Song JD, Liang ZY, Oskouei K, Xiao XQ, Hou WZ, Li JT, Yang YS, Wang ML, Murbach M
International journal of environmental research and public health 2020 Jan 28;17(3)
International journal of environmental research and public health 2020 Jan 28;17(3)
Liver changes induced by cadmium poisoning distinguished by confocal Raman imaging.
Li Y, Shen R, Wu H, Yu L, Wang Z, Wang D
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2020 Jan 15;225:117483
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2020 Jan 15;225:117483
Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Guo SS, Liu R, Wen YF, Liu LT, Yuan L, Li YX, Li Y, Hao WW, Peng JY, Chen DN, Tang QN, Sun XS, Guo L, Mo HY, Qian CN, Zeng MS, Bei JX, Sun SY, Chen QY, Tang LQ, Mai HQ
Cancer letters 2020 Jan 1;468:27-40
Cancer letters 2020 Jan 1;468:27-40
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
Tseng SH, Park ST, Lam B, Tsai YC, Cheng MA, Farmer E, Xing D, Hung CF
Journal for immunotherapy of cancer 2020 Feb;8(1)
Journal for immunotherapy of cancer 2020 Feb;8(1)
NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress.
Yu A, Zhou R, Xia B, Dang W, Yang Z, Chen X
Cellular signalling 2020 Feb;66:109496
Cellular signalling 2020 Feb;66:109496
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Hou B, Li W, Li J, Ma J, Xia P, Liu Z, Zeng Q, Zhang X, Chang D
Oncology reports 2020 Feb;43(2):536-548
Oncology reports 2020 Feb;43(2):536-548
GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway.
Wang Q, Ren H, Xu Y, Jiang J, Wudu M, Liu Z, Su H, Jiang X, Zhang Y, Zhang B, Qiu X
Experimental cell research 2020 Feb 15;387(2):111806
Experimental cell research 2020 Feb 15;387(2):111806
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
Nordgren KKS, Wallace KB
Cardiovascular toxicology 2020 Dec;20(6):557-570
Cardiovascular toxicology 2020 Dec;20(6):557-570
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Ma Y, Yan R, Wan Q, Lv B, Yang Y, Lv T, Xin W
Journal of physiology and biochemistry 2020 Aug;76(3):373-382
Journal of physiology and biochemistry 2020 Aug;76(3):373-382
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
Hao Y, Huang Y, Chen J, Li J, Yuan Y, Wang M, Han L, Xin X, Wang H, Lin D, Peng F, Yu F, Zheng C, Shen C
Cell proliferation 2020 Aug;53(8):e12869
Cell proliferation 2020 Aug;53(8):e12869
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
miR-106a Regulates Cell Proliferation and Autophagy by Targeting LKB1 in HPV-16-Associated Cervical Cancer.
Cui X, Wang X, Zhou X, Jia J, Chen H, Zhao W
Molecular cancer research : MCR 2020 Aug;18(8):1129-1141
Molecular cancer research : MCR 2020 Aug;18(8):1129-1141
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Deng X, Zhao J, Qu L, Duan Z, Fu R, Zhu C, Fan D
Biochemical pharmacology 2020 Aug;178:114038
Biochemical pharmacology 2020 Aug;178:114038
BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma.
Wang F, Wang J, Wang J, Zhang L, Fu H, Li J, Tian T, Zuo J, Lv W, Ma X
Biochemical and biophysical research communications 2020 Aug 27;529(3):685-691
Biochemical and biophysical research communications 2020 Aug 27;529(3):685-691
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Liu JR, Cai GY, Ning YC, Wang JC, Lv Y, Guo YN, Fu B, Hong Q, Sun XF, Chen XM
Aging 2020 Aug 27;12(18):18052-18072
Aging 2020 Aug 27;12(18):18052-18072
Synergistic effects of tanshinone IIA and andrographolide on the apoptosis of cancer cells via crosstalk between p53 and reactive oxygen species pathways.
Li Y, Jiang B, Wang R, Wang J, Li Y, Bao Y
Pharmacological reports : PR 2020 Apr;72(2):400-417
Pharmacological reports : PR 2020 Apr;72(2):400-417
COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence.
Zhang CY, Duan JX, Yang HH, Sun CC, Zhong WJ, Tao JH, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX
The FEBS journal 2020 Apr;287(8):1666-1680
The FEBS journal 2020 Apr;287(8):1666-1680
N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation.
Zhao T, Sun D, Zhao M, Lai Y, Liu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2020 Apr;259:113908
Environmental pollution (Barking, Essex : 1987) 2020 Apr;259:113908
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Shi L, Duan Y, Yao X, Song R, Ren Y
Animal reproduction science 2020 Apr;215:106330
Animal reproduction science 2020 Apr;215:106330
Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.
Li X, Yao Z, Yang D, Jiang X, Sun J, Tian L, Hu J, Wu B, Bai W
Journal of hazardous materials 2020 Apr 5;387:121706
Journal of hazardous materials 2020 Apr 5;387:121706
A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine.
Li R, Yan L, Sun X, Zheng W
Bioorganic & medicinal chemistry 2020 Apr 1;28(7):115356
Bioorganic & medicinal chemistry 2020 Apr 1;28(7):115356
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
Feng Y, Chen X, Ding W, Ma J, Zhang B, Li X
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.
Zhao WS, Yan WP, Chen DB, Dai L, Yang YB, Kang XZ, Fu H, Chen P, Deng KJ, Wang XY, Xie XW, Chen HS, Chen KN
American journal of cancer research 2019;9(6):1183-1200
American journal of cancer research 2019;9(6):1183-1200
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, Chen H, Xu F, Li Q, Zhao G
Theranostics 2019;9(16):4795-4810
Theranostics 2019;9(16):4795-4810
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Guo S, Jian L, Tao K, Chen C, Yu H, Liu S
Frontiers in oncology 2019;9:1325
Frontiers in oncology 2019;9:1325
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Wu Z, Chen D, Wang K, Cao C, Xu X
Frontiers in oncology 2019;9:1260
Frontiers in oncology 2019;9:1260
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.
Feng X, Yan N, Sun W, Zheng S, Jiang S, Wang J, Guo C, Hao L, Tian Y, Liu S, Sun MZ
Cell death discovery 2019;5:89
Cell death discovery 2019;5:89
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines.
Zheng D, Chang X, Liu Y, Xu J, Gou W, Li Z, Zuo D, Zhang W, Wu Y
Cancer biology & therapy 2019;20(4):513-523
Cancer biology & therapy 2019;20(4):513-523
MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma.
Fan X, Wang Y, Song J, Wu H, Yang M, Lu L, Weng X, Liu L, Nie G
Cancer biology & therapy 2019;20(10):1328-1336
Cancer biology & therapy 2019;20(10):1328-1336
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L
International journal of medical sciences 2019;16(12):1573-1582
International journal of medical sciences 2019;16(12):1573-1582
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Liu H, Zhao J, Fu R, Zhu C, Fan D
PloS one 2019;14(5):e0216759
PloS one 2019;14(5):e0216759
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G
International journal of nanomedicine 2019;14:3753-3771
International journal of nanomedicine 2019;14:3753-3771
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
Guo Z, Tian Y, Guo Y, Li B, Liu X, Xie K, Song Y, Wang D
Frontiers in cellular neuroscience 2019;13:392
Frontiers in cellular neuroscience 2019;13:392
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
Hu YH, Ma S, Zhang XN, Zhang ZY, Zhu HF, Ji YH, Li J, Qian XL, Wang YX
OncoTargets and therapy 2019;12:8105-8115
OncoTargets and therapy 2019;12:8105-8115
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
Yu W, Yang Z, Huang R, Min Z, Ye M
OncoTargets and therapy 2019;12:2861-2868
OncoTargets and therapy 2019;12:2861-2868
6-Bromoindirubin-3'-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver.
Guo D, Shen Y, Li W, Li Q, Zhao Y, Pan C, Chen B, Zhong Y, Miao Y
Frontiers in pharmacology 2019;10:320
Frontiers in pharmacology 2019;10:320
Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation.
Li S, Hong X, Wei Z, Xie M, Li W, Liu G, Guo H, Yang J, Wei W, Zhang S
Frontiers in microbiology 2019;10:2483
Frontiers in microbiology 2019;10:2483
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
Wu G, Chen Z, Wang P, Zhao M, Fujino M, Zhang C, Zhou W, Hirano SI, Li XK, Zhao L
Experimental biology and medicine (Maywood, N.J.) 2019 Sep;244(12):1017-1027
Experimental biology and medicine (Maywood, N.J.) 2019 Sep;244(12):1017-1027
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, Wang J, Bao Y
Pharmacological research 2019 Sep;147:104387
Pharmacological research 2019 Sep;147:104387
Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts.
Ren Y, Li Y, Lv J, Guo X, Zhang J, Zhou D, Zhang Z, Xue Z, Yang G, Xi Q, Liu H, Liu Z, Zhang L, Zhang Q, Yao Z, Zhang R, Da Y
Journal of cellular biochemistry 2019 Sep;120(9):15695-15708
Journal of cellular biochemistry 2019 Sep;120(9):15695-15708
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang L, Lei H
Nucleic acids research 2019 Sep 5;47(15):8239-8254
Nucleic acids research 2019 Sep 5;47(15):8239-8254
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway.
Zhan S, Wang K, Song Y, Li S, Yin H, Luo R, Liao Z, Wu X, Zhang Y, Yang C
Arthritis research & therapy 2019 Sep 3;21(1):201
Arthritis research & therapy 2019 Sep 3;21(1):201
RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21.
Liu G, Zhang Q, Xia L, Shi M, Cai J, Zhang H, Li J, Lin G, Xie W, Zhang Y, Xu N
Cell death & disease 2019 Sep 18;10(10):688
Cell death & disease 2019 Sep 18;10(10):688
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y
European journal of medicinal chemistry 2019 Sep 15;178:177-194
European journal of medicinal chemistry 2019 Sep 15;178:177-194
miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity.
Pan JA, Tang Y, Yu JY, Zhang H, Zhang JF, Wang CQ, Gu J
Cell death & disease 2019 Sep 11;10(9):668
Cell death & disease 2019 Sep 11;10(9):668
Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling.
Gao Y, Yin H, Zhang Y, Dong Y, Yang F, Wu X, Liu H
Life sciences 2019 Sep 1;232:116611
Life sciences 2019 Sep 1;232:116611
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung.
Yang J, Yu F, Guan J, Wang T, Liu C, Wang Y, Liu G, Zhu S
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Oct;97(5):589-599
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Oct;97(5):589-599
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
Gao X, Zhang Y, Zhang R, Zhao Z, Zhang H, Wu J, Shen W, Zhong M
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Yang J, Zeng Z, Qiao L, Jiang X, Ma J, Wang J, Ye S, Ma Q, Wei J, Wu M, Huang X, Ma D, Gao Q
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
RNA sequencing analysis of the CAL-27 cell response to over-expressed ZNF750 gene revealed an extensive regulation on cell cycle.
Liu X, Yang Y, Xu C, Yang H, Chen S, Chen H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109377
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109377
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
Liu XY, Liu D, Lin GP, Wu YJ, Gao LY, Ai C, Huang YF, Wang MF, El-Seedi HR, Chen XH, Zhao C
International journal of biological macromolecules 2019 Oct 15;139:342-351
International journal of biological macromolecules 2019 Oct 15;139:342-351
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Xu J, Sheng Z, Li F, Wang S, Yuan Y, Wang M, Yu Z
Experimental cell research 2019 Oct 1;383(1):111505
Experimental cell research 2019 Oct 1;383(1):111505
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H, Luo YQ
Oncology reports 2019 Nov;42(5):1725-1734
Oncology reports 2019 Nov;42(5):1725-1734
Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Tang S, Wang J, Liu J, Huang Y, Zhou Y, Yang S, Zhang W, Yang M, Zhang H
Renal failure 2019 Nov;41(1):455-466
Renal failure 2019 Nov;41(1):455-466
Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity.
Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, Qi Y, Shi J, Qi S, Bao Y, Nie G
ACS nano 2019 Nov 26;13(11):13445-13455
ACS nano 2019 Nov 26;13(11):13445-13455
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G
Aging 2019 Nov 22;11(22):10356-10373
Aging 2019 Nov 22;11(22):10356-10373
CD105 Is Expressed in Ovarian Cancer Precursor Lesions and Is Required for Metastasis to the Ovary.
Bai S, Zhu W, Coffman L, Vlad A, Schwartz LE, Elishaev E, Drapkin R, Buckanovich RJ
Cancers 2019 Nov 2;11(11)
Cancers 2019 Nov 2;11(11)
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
Wang G, Sheng W, Shi X, Li X, Zhou J, Dong M
The FEBS journal 2019 May;286(9):1668-1682
The FEBS journal 2019 May;286(9):1668-1682
Establishment and characterization of a radiation-induced dermatitis rat model.
Sheng X, Zhou Y, Wang H, Shen Y, Liao Q, Rao Z, Deng F, Xie L, Yao C, Mao H, Liu Z, Peng M, Long Y, Zeng Y, Xue L, Gao N, Kong Y, Zhou X
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer.
Huang Z, Li Q, Luo K, Zhang Q, Geng J, Zhou X, Xu Y, Qian M, Zhang JA, Ji L, Wu J
Cell death & disease 2019 May 8;10(5):372
Cell death & disease 2019 May 8;10(5):372
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S
Cell death & disease 2019 May 28;10(6):404
Cell death & disease 2019 May 28;10(6):404
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Wang Y, Zhang J, Li J, Gui R, Nie X, Huang R
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth.
Fu R, Yang P, Sajid A, Li Z
Journal of agricultural and food chemistry 2019 May 1;67(17):4808-4816
Journal of agricultural and food chemistry 2019 May 1;67(17):4808-4816
Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study.
Negi H, Merugu SB, Mangukiya HB, Li Z, Zhou B, Sehar Q, Kamle S, Yunus FU, Mashausi DS, Wu Z, Li D
Cancer letters 2019 May 1;449:125-134
Cancer letters 2019 May 1;449:125-134
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, Liu Y, Fan S, Li Z, Xiong W, Li X, Ren C, Tan M, Li G, Zhou M
Cancer science 2019 Mar;110(3):939-949
Cancer science 2019 Mar;110(3):939-949
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.
Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW
Journal of translational medicine 2019 Mar 7;17(1):72
Journal of translational medicine 2019 Mar 7;17(1):72
SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride.
Gu X, Wang Z, Gao J, Han D, Zhang L, Chen P, Luo G, Han B
Toxicology in vitro : an international journal published in association with BIBRA 2019 Jun;57:28-38
Toxicology in vitro : an international journal published in association with BIBRA 2019 Jun;57:28-38
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
Liu R, Xu X, Liang C, Chen X, Yu X, Zhong H, Xu W, Cheng Y, Wang W, Wu Y, Yu L, Hu X
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Xu S, Wu W, Huang H, Huang R, Xie L, Su A, Liu S, Zheng R, Yuan Y, Zheng HL, Sun X, Xiong XD, Liu X
Aging cell 2019 Jun;18(3):e12918
Aging cell 2019 Jun;18(3):e12918
Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction.
Luo X, Jiang X, Li J, Bai Y, Li Z, Wei P, Sun S, Liang Y, Han S, Li X, Zhang B
Cell death & disease 2019 Jun 6;10(6):451
Cell death & disease 2019 Jun 6;10(6):451
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Gao J, Wang Y, Yang J, Zhang W, Meng K, Sun Y, Li Y, He QY
Cancers 2019 Jun 18;11(6)
Cancers 2019 Jun 18;11(6)
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
Dong S, Ji J, Hu L, Wang H
Life sciences 2019 Jun 15;227:20-29
Life sciences 2019 Jun 15;227:20-29
2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K.
Li ED, Lin Q, Meng YQ, Zhang LY, Song PP, Li N, Xin JC, Yang P, Bao CN, Zhang DQ, Zhang Y, Wang JK, Zhang QR, Liu HM
European journal of medicinal chemistry 2019 Jun 15;172:36-47
European journal of medicinal chemistry 2019 Jun 15;172:36-47
Effects of palmatine hydrochloride mediated photodynamic therapy on oral squamous cell carcinoma.
Qi F, Sun Y, Lv M, Qin F, Cao W, Bi L
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2019 Jun 12;18(6):1596-1605
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2019 Jun 12;18(6):1596-1605
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
Lin Y, Liu B, Deng T, Zhong J, Feng Z, Zeng Q, Huang G, Chen Z
Stem cell research 2019 Jul;38:101464
Stem cell research 2019 Jul;38:101464
NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.
Khanal T, Leung YK, Jiang W, Timchenko N, Ho SM, Kim K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8335-8348
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8335-8348
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Wang SY, Wang WJ, Liu JQ, Song YH, Li P, Sun XF, Cai GY, Chen XM
Cell cycle (Georgetown, Tex.) 2019 Jul;18(14):1573-1587
Cell cycle (Georgetown, Tex.) 2019 Jul;18(14):1573-1587
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis.
Chen DB, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Cong X, Fei R, Wu X, Shao QX, Wei L, Xie XW, Chen HS
Chinese medical journal 2019 Jul 5;132(13):1572-1581
Chinese medical journal 2019 Jul 5;132(13):1572-1581
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, Guo Y, Jin T, Shan H, Zhao X, Yang R, Shan H, Liang H
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Li XY, Zhang TJ, Kamara MO, Lu GQ, Xu HL, Wang DP, Meng FH
Cell death & disease 2019 Jul 11;10(7):532
Cell death & disease 2019 Jul 11;10(7):532
ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel.
Li S, Zhao X, Chang S, Li Y, Guo M, Guan Y
International journal of oncology 2019 Jan;54(1):249-260
International journal of oncology 2019 Jan;54(1):249-260
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q, Shen DY
Oncology reports 2019 Jan;41(1):213-223
Oncology reports 2019 Jan;41(1):213-223
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Shan H, Li T, Zhang L, Yang R, Li Y, Zhang M, Dong Y, Zhou Y, Xu C, Yang B, Liang H, Gao X, Shan H
EBioMedicine 2019 Jan;39:59-68
EBioMedicine 2019 Jan;39:59-68
Estrogen receptor variant ER-α36 promotes tamoxifen agonist activity in glioblastoma cells.
Qu C, Ma J, Zhang Y, Han C, Huang L, Shen L, Li H, Wang X, Liu J, Zou W
Cancer science 2019 Jan;110(1):221-234
Cancer science 2019 Jan;110(1):221-234
Intracellular NO-Generator Based on Enzyme Trigger for Localized Tumor-Cytoplasm Rapid Drug Release and Synergetic Cancer Therapy.
Hou L, Zhang Y, Yang X, Tian C, Yan Y, Zhang H, Shi J, Zhang H, Zhang Z
ACS applied materials & interfaces 2019 Jan 9;11(1):255-268
ACS applied materials & interfaces 2019 Jan 9;11(1):255-268
Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.
Xu J, Liu H, Yang Y, Wang X, Liu P, Li Y, Meyers C, Banerjee NS, Wang HK, Cam M, Lu W, Chow LT, Xie X, Zhu J, Zheng ZM
mBio 2019 Jan 29;10(1)
mBio 2019 Jan 29;10(1)
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
Liu HM, Wu Q, Cao JQ, Wang X, Song Y, Mei WJ, Wang XC
European journal of pharmacology 2019 Jan 15;843:285-291
European journal of pharmacology 2019 Jan 15;843:285-291
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Liu C, Wang X, Zhang Y
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao Q
EBioMedicine 2019 Feb;40:92-105
EBioMedicine 2019 Feb;40:92-105
PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):135-144
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):135-144
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo.
Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C, Huang Z, Yin XM, Liu P, Li M
Autophagy 2019 Feb;15(2):295-311
Autophagy 2019 Feb;15(2):295-311
Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA.
Xie Z, Guo Z, Lei J, Yu J
European journal of pharmacology 2019 Feb 5;844:9-16
European journal of pharmacology 2019 Feb 5;844:9-16
MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop.
Luo P, Wang Q, Ye Y, Zhang J, Lu D, Cheng L, Zhou H, Xie M, Wang B
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):74
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):74
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, Wang Q, Su H, Jiang X, Dao R, Qiu X
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2.
Chen X, Zeng K, Xu M, Liu X, Hu X, Xu T, He B, Pan Y, Sun H, Wang S
Cell death & disease 2019 Feb 12;10(2):131
Cell death & disease 2019 Feb 12;10(2):131
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Sha J, Zhang H, Zhao Y, Feng X, Hu X, Wang C, Song M, Fan H
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
Guo J, Tang Q, Wang Q, Sun W, Pu Z, Wang J, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Liu B, Jin J, Zhang Z, Zuo L, Jiang M, Xie C
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Wu XT, Ansari AR, Pang XX, Li HZ, Zhang ZW, Luo Y, Arshad M, Song H
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C
Oncogene 2019 Aug;38(33):6142-6157
Oncogene 2019 Aug;38(33):6142-6157
Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis.
Li E, Sun Y, Lv G, Li Y, Zhang Z, Hu Z, Cao W
The international journal of biochemistry & cell biology 2019 Aug;113:104-114
The international journal of biochemistry & cell biology 2019 Aug;113:104-114
Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.
Que Z, Zhou Z, Luo B, Dong C, Jiang Y, Li H, Tian J
BMC complementary and alternative medicine 2019 Aug 7;19(1):204
BMC complementary and alternative medicine 2019 Aug 7;19(1):204
Interferon regulatory factor-1 reverses chemoresistance by downregulating the expression of P-glycoprotein in gastric cancer.
Yuan J, Yin Z, Tan L, Zhu W, Tao K, Wang G, Shi W, Gao J
Cancer letters 2019 Aug 10;457:28-39
Cancer letters 2019 Aug 10;457:28-39
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Pan JH, Zhou H, Zhu SB, Huang JL, Zhao XX, Ding H, Qin L, Pan YL
Journal of cellular physiology 2019 Apr;234(4):4385-4395
Journal of cellular physiology 2019 Apr;234(4):4385-4395
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Sun Y, Liu W, Wang C, Meng Q, Liu Z, Huo X, Yang X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, Peng W, Han D, Zhou X, Wu J, He H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy.
Sun CY, Nie J, Zheng ZL, Zhao J, Wu LM, Zhu Y, Su ZQ, Zheng GJ, Feng B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108647
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108647
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.
Lin F, Xie YJ, Zhang XK, Huang TJ, Xu HF, Mei Y, Liang H, Hu H, Lin ST, Luo FF, Lang YH, Peng LX, Qian CN, Huang BJ
Journal of experimental & clinical cancer research : CR 2019 Apr 8;38(1):152
Journal of experimental & clinical cancer research : CR 2019 Apr 8;38(1):152
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, Zhang C, Zheng X, Xu X, Xue S, Hui L, Ji H, Wei B, Wang H
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
Daicheng H, Shiwen X, Huaping Z, Yong L, Qianqian Z, Changxia H
Translational neuroscience 2018;9:117-122
Translational neuroscience 2018;9:117-122
N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway.
Hou G, Zhao H, Teng H, Li P, Xu W, Zhang J, Lv L, Guo Z, Wei L, Yao H, Xu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):257-265
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):257-265
Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.
Gao M, Chen M, Li C, Xu M, Liu Y, Cong M, Sang N, Liu S
Cell discovery 2018;4:5
Cell discovery 2018;4:5
SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury.
Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, Zhou M
Oxidative medicine and cellular longevity 2018;2018:4783602
Oxidative medicine and cellular longevity 2018;2018:4783602
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Zhang Y, Wang C, Jin Y, Yang Q, Meng Q, Liu Q, Dai Y, Cai L, Liu Z, Liu K, Sun H
Oxidative medicine and cellular longevity 2018;2018:2876350
Oxidative medicine and cellular longevity 2018;2018:2876350
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
Ding W, Ji T, Xiong W, Li T, Pu D, Liu R
Drug design, development and therapy 2018;12:3459-3469
Drug design, development and therapy 2018;12:3459-3469
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
Fang J, Zhu Y, Wang H, Cao B, Fei M, Niu W, Zhou Y, Wang X, Li X, Zhou M
Frontiers in neuroscience 2018;12:1006
Frontiers in neuroscience 2018;12:1006
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
Liu X, Zhao Y, Zhang W, Gao Y, Huo M, Liu M, Xiao Z, Liang S, Xu N, Zhu H
OncoTargets and therapy 2018;11:3087-3100
OncoTargets and therapy 2018;11:3087-3100
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.
Ling Z, Guan H, You Z, Wang C, Hu L, Zhang L, Wang Y, Chen S, Xu B, Chen M
OncoTargets and therapy 2018;11:2735-2743
OncoTargets and therapy 2018;11:2735-2743
S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53.
Yang T, Cheng J, You J, Yan B, Liu H, Li F
Oncology reports 2018 Sep;40(3):1574-1582
Oncology reports 2018 Sep;40(3):1574-1582
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Li S, Wang C
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Protective effect and mechanism of rat recombinant S100 calcium-binding protein A4 on oxidative stress injury of rat vascular endothelial cells.
Meng X, Gao X, Zhang Z, Zhou X, Wu L, Yang M, Wang K, Ren H, Sun B, Wang T
Oncology letters 2018 Sep;16(3):3614-3622
Oncology letters 2018 Sep;16(3):3614-3622
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Song XQ, Liu YH, Shao J, Zhang ZL, Xie CZ, Qiao X, Bao WG, Xu JY
European journal of medicinal chemistry 2018 Sep 5;157:188-197
European journal of medicinal chemistry 2018 Sep 5;157:188-197
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, Du Y, Song D, Yang M, Li S, Han B, Zhao G, Zhang H, Fan Z, Miao QR
Breast cancer research : BCR 2018 Sep 12;20(1):112
Breast cancer research : BCR 2018 Sep 12;20(1):112
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
Li Y, Peng Z, Wang C, Li L, Leng Y, Chen R, Yuan H, Zhou S, Zhang Z, Chen AF
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
UVB-inhibited H19 activates melanogenesis by paracrine effects.
Pei S, Huang J, Chen J, Hu S, Lei L, Fu C, Jiang L, Ding Y, Leng Y, Huang L, Xiang H, Zeng Q
Experimental dermatology 2018 Oct;27(10):1120-1125
Experimental dermatology 2018 Oct;27(10):1120-1125
Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.
Cui Q, Kong D, Li Z, Ahiable P, Wang K, Wu K, Wu G
Clinical breast cancer 2018 Oct;18(5):e875-e882
Clinical breast cancer 2018 Oct;18(5):e875-e882
Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels.
Ma S, Lei Y, Zhang L, Wang J
Oncology letters 2018 Oct;16(4):4379-4383
Oncology letters 2018 Oct;16(4):4379-4383
Study on the expression of p53 and MMP-2 in patients with lung cancer after interventional therapy.
Zhang XS, Wang KY, Gao JQ, Li RJ, Guan QB, Song L
Oncology letters 2018 Oct;16(4):4291-4296
Oncology letters 2018 Oct;16(4):4291-4296
The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways.
Li H, Wang Z, Jiang M, Fang RP, Shi H, Shen Y, Cai XL, Liu Q, Ye K, Fan SJ, Zhang WY, Ye LH
Acta pharmacologica Sinica 2018 Nov;39(11):1787-1796
Acta pharmacologica Sinica 2018 Nov;39(11):1787-1796
Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
Xie Z, Guo Z, Wang Y, Lei J, Yu J
Phytotherapy research : PTR 2018 Nov;32(11):2256-2263
Phytotherapy research : PTR 2018 Nov;32(11):2256-2263
Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.
Ma J, Li X
Environmental pollution (Barking, Essex : 1987) 2018 Nov;242(Pt B):1337-1345
Environmental pollution (Barking, Essex : 1987) 2018 Nov;242(Pt B):1337-1345
A biobank of patient-derived pediatric brain tumor models.
Brabetz S, Leary SES, Gröbner SN, Nakamoto MW, Şeker-Cin H, Girard EJ, Cole B, Strand AD, Bloom KL, Hovestadt V, Mack NL, Pakiam F, Schwalm B, Korshunov A, Balasubramanian GP, Northcott PA, Pedro KD, Dey J, Hansen S, Ditzler S, Lichter P, Chavez L, Jones DTW, Koster J, Pfister SM, Kool M, Olson JM
Nature medicine 2018 Nov;24(11):1752-1761
Nature medicine 2018 Nov;24(11):1752-1761
Inhibin B suppresses anoikis resistance and migration through the transforming growth factor-β signaling pathway in nasopharyngeal carcinoma.
Zou G, Ren B, Liu Y, Fu Y, Chen P, Li X, Luo S, He J, Gao G, Zeng Z, Xiong W, Li G, Huang Y, Xu K, Zhang W
Cancer science 2018 Nov;109(11):3416-3427
Cancer science 2018 Nov;109(11):3416-3427
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Radiation-induced premature cellular senescence involved in glomerular diseases in rats.
Aratani S, Tagawa M, Nagasaka S, Sakai Y, Shimizu A, Tsuruoka S
Scientific reports 2018 Nov 14;8(1):16812
Scientific reports 2018 Nov 14;8(1):16812
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Wang H, Zhong Q, Yang T, Qi Y, Fu M, Yang X, Qiao L, Ling Q, Liu S, Zhao Y
Molecular medicine reports 2018 May;17(5):6551-6559
Molecular medicine reports 2018 May;17(5):6551-6559
Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.
Wang ZL, Chen LB, Qiu Z, Chen XB, Liu Y, Li J, Wang L, Wang YP
Molecular medicine reports 2018 May;17(5):6269-6276
Molecular medicine reports 2018 May;17(5):6269-6276
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
Chen L, Yan F, Chen W, Zhao L, Zhang J, Lu Q, Liu R
Chemico-biological interactions 2018 May 25;288:12-23
Chemico-biological interactions 2018 May 25;288:12-23
Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16.
Hao B, Xiao Y, Song F, Long X, Huang J, Tian M, Deng S, Wu Q
International journal of molecular medicine 2018 Mar;41(3):1365-1376
International journal of molecular medicine 2018 Mar;41(3):1365-1376
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K
Oncogene 2018 Mar;37(11):1503-1518
Oncogene 2018 Mar;37(11):1503-1518
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Oxidative stress-mediated p53/p21WAF1/CIP1 pathway may be involved in microcystin-LR-induced cytotoxicity in HepG2 cells.
Ma J, Li Y, Wu M, Li X
Chemosphere 2018 Mar;194:773-783
Chemosphere 2018 Mar;194:773-783
Potent hydrazone derivatives targeting esophageal cancer cells.
Li LY, Peng JD, Zhou W, Qiao H, Deng X, Li ZH, Li JD, Fu YD, Li S, Sun K, Liu HM, Zhao W
European journal of medicinal chemistry 2018 Mar 25;148:359-371
European journal of medicinal chemistry 2018 Mar 25;148:359-371
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Tang X, Liu B, Wang X, Yu Q, Fang R
International journal of molecular sciences 2018 Mar 14;19(3)
International journal of molecular sciences 2018 Mar 14;19(3)
Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.
Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, Liu X, Zhong M, Xie D, Huang W, Jia W, Li S, Liu X, Zuo X, Cheng D, Dai J, Ren C
International journal of oncology 2018 Jun;52(6):1787-1800
International journal of oncology 2018 Jun;52(6):1787-1800
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T, Du G
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, Liu Z, Guo Z, Chen X, He P, Li Z, Li F, Jiang J, Liu P, Li Z
Aging 2018 Jul 24;10(7):1722-1744
Aging 2018 Jul 24;10(7):1722-1744
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.
Guo P, Qiu Y, Ma X, Li T, Ma X, Zhu L, Lin Y, Han L
Experimental cell research 2018 Jul 1;368(1):59-66
Experimental cell research 2018 Jul 1;368(1):59-66
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
Wang W, Cai G, Chen X
Experimental gerontology 2018 Jul 1;107:4-10
Experimental gerontology 2018 Jul 1;107:4-10
Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis.
Zhu X, Wang K, Yao Y, Zhang K, Zhou F, Zhu L
Journal of biochemical and molecular toxicology 2018 Jan;32(1)
Journal of biochemical and molecular toxicology 2018 Jan;32(1)
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
Liu L, Zhang L, Wang J, Zhao X, Xu Q, Lu Y, Zuo Y, Chen L, Du J, Lian Y, Zhang Q
Molecular medicine reports 2018 Jan;17(1):835-842
Molecular medicine reports 2018 Jan;17(1):835-842
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Zhang JJ, Zhang YZ, Peng JJ, Li NS, Xiong XM, Ma QL, Luo XJ, Liu B, Peng J
Mechanisms of ageing and development 2018 Jan;169:10-18
Mechanisms of ageing and development 2018 Jan;169:10-18
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Zhang J, Yuan JP, Wang Q, Shao LH, Liu SP, Firestone RA, Hong YP, Li JG, Xin YC, Li Y
Oncotarget 2018 Jan 5;9(2):1957-1968
Oncotarget 2018 Jan 5;9(2):1957-1968
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y
European journal of medicinal chemistry 2018 Jan 20;144:817-842
European journal of medicinal chemistry 2018 Jan 20;144:817-842
The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.
Zhang W, Yao F, Zhang H, Li N, Zou X, Sui L, Hou L
International journal of molecular sciences 2018 Jan 2;19(1)
International journal of molecular sciences 2018 Jan 2;19(1)
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Zhang ZF, Zhang HR, Zhang QY, Lai SY, Feng YZ, Zhou Y, Zheng SR, Shi R, Zhou JY
Journal of translational medicine 2018 Jan 19;16(1):9
Journal of translational medicine 2018 Jan 19;16(1):9
Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62.
Ai TJ, Sun JY, Du LJ, Shi C, Li C, Sun XN, Liu Y, Li L, Xia Z, Jia L, Liu J, Duan SZ
Cell death and differentiation 2018 Feb;25(2):319-329
Cell death and differentiation 2018 Feb;25(2):319-329
N‑cadherin attenuates nucleus pulposus cell senescence under high‑magnitude compression.
Niu M, Ma F, Qian J, Li J, Wang T, Gao Y, Jin J
Molecular medicine reports 2018 Feb;17(2):2879-2884
Molecular medicine reports 2018 Feb;17(2):2879-2884
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Xiong Y, Wang L, Wang S, Wang M, Zhao J, Zhang Z, Li X, Jia L, Han Y
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.
Ma D, Chen X, Zhang PY, Zhang H, Wei LJ, Hu S, Tang JZ, Zhou MT, Xie C, Ou R, Xu Y, Tang KF
Oncogene 2018 Feb 22;37(8):1041-1048
Oncogene 2018 Feb 22;37(8):1041-1048
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
Li CF, Sun JX, Gao Y, Shi F, Pan YK, Wang YC, Sun XQ
Cell death & disease 2018 Feb 2;9(2):147
Cell death & disease 2018 Feb 2;9(2):147
NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.
Lin C, Zhang J, Lu Y, Li X, Zhang W, Zhang W, Lin W, Zheng L, Li X
Cell death & disease 2018 Feb 15;9(3):263
Cell death & disease 2018 Feb 15;9(3):263
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Journal of experimental & clinical cancer research : CR 2018 Feb 13;37(1):28
Journal of experimental & clinical cancer research : CR 2018 Feb 13;37(1):28
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway.
Yang HW, Hong HL, Luo WW, Dai CM, Chen XY, Wang LP, Li Q, Li ZQ, Liu PQ, Li ZM
Acta pharmacologica Sinica 2018 Dec;39(12):1837-1846
Acta pharmacologica Sinica 2018 Dec;39(12):1837-1846
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.
Yang X, Qu S, Wang L, Zhang H, Yang Z, Wang J, Dai B, Tao K, Shang R, Liu Z, Li X, Zhang Z, Xia C, Ma B, Liu W, Li H, Dou K
Oncogene 2018 Dec;37(50):6399-6413
Oncogene 2018 Dec;37(50):6399-6413
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773
Cancer science 2018 Dec;109(12):3762-3773
Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu.
Li Q, Pang P, Zheng K, Sun L, Wang J, Chen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:201-207
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:201-207
Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling.
Sui Y, Han Y, Zhao X, Li D, Li G
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):36-42
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):36-42
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Hu M, Liu L, Yao W
Gene 2018 Dec 15;678:261-269
Gene 2018 Dec 15;678:261-269
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, Huang T, Wang X, Yang GL, Yang B, Ma S, Guan F
Cell and tissue research 2018 Aug;373(2):379-393
Cell and tissue research 2018 Aug;373(2):379-393
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854
Cell research 2018 Aug;28(8):833-854
A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway.
Liu S, Gao X, Zhang L, Qin S, Wei M, Liu N, Zhao R, Li B, Meng Y, Lin G, Lu C, Liu X, Xie M, Liu T, Zhou H, Qi M, Yang G, Yang C
European journal of medicinal chemistry 2018 Aug 5;156:21-42
European journal of medicinal chemistry 2018 Aug 5;156:21-42
Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression.
Jiang Y, Dong G, Song Y
Bioscience reports 2018 Aug 31;38(4)
Bioscience reports 2018 Aug 31;38(4)
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Wang N, Zou C, Zhao S, Wang Y, Han C, Zheng Z
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
Wang X, Su GY, Zhao C, Qu FZ, Wang P, Zhao YQ
Journal of ginseng research 2018 Apr;42(2):133-143
Journal of ginseng research 2018 Apr;42(2):133-143
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
Sun Y, Wang C, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2018 Apr;233(4):3066-3079
Journal of cellular physiology 2018 Apr;233(4):3066-3079
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
Liu DZ, Cheng Y, Cai RQ, Wang Bd WW, Cui H, Liu M, Zhang BL, Mei QB, Zhou SY
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells.
Ruan W, Zhao F, Zhao S, Zhang L, Shi L, Pang T
Gene 2018 Apr 5;649:32-39
Gene 2018 Apr 5;649:32-39
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, Chen H, Liu D, Liu X, Zhai X, Jiang C
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.
Jin Y, Hu W, Liu T, Rana U, Aguilera-Barrantes I, Kong A, Kumar SN, Wang B, Gao P, Wang X, Duan Y, Shi A, Song D, Yang M, Li S, Han B, Zhao G, Fan Z, Miao QR
Cancer letters 2018 Apr 10;419:233-244
Cancer letters 2018 Apr 10;419:233-244
Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer.
Pan Y, Zhang F, Zhao Y, Shao D, Zheng X, Chen Y, He K, Li J, Chen L
Journal of Cancer 2017;8(9):1679-1689
Journal of Cancer 2017;8(9):1679-1689
H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing.
Wu W, Hou CL, Mu XP, Sun C, Zhu YC, Wang MJ, Lv QZ
Oxidative medicine and cellular longevity 2017;2017:5707830
Oxidative medicine and cellular longevity 2017;2017:5707830
Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α.
Pan Y, Shao D, Zhao Y, Zhang F, Zheng X, Tan Y, He K, Li J, Chen L
International journal of biological sciences 2017;13(6):794-803
International journal of biological sciences 2017;13(6):794-803
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X
International journal of biological sciences 2017;13(3):327-338
International journal of biological sciences 2017;13(3):327-338
17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway.
Li P, Gan Y, Xu Y, Wang L, Ouyang B, Zhang C, Luo L, Zhao C, Zhou Q
International journal of biological sciences 2017;13(2):145-156
International journal of biological sciences 2017;13(2):145-156
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420
Frontiers in cellular neuroscience 2017;11:420
Inhibition effect of tacrolimus and platelet-derived growth factor-BB on restenosis after vascular intimal injury.
Ma X, Jiang C, Li Y, Feng L, Liu J, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Sep;93:180-189
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Sep;93:180-189
High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.
Zhai Y, Wu R, Kuick R, Sessine MS, Schulman S, Green M, Fearon ER, Cho KR
The Journal of pathology 2017 Sep;243(1):16-25
The Journal of pathology 2017 Sep;243(1):16-25
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Lei CT, Tang H, Ye C, You CQ, Zhang J, Zhang CY, Xiong W, Su H, Zhang C
Scientific reports 2017 Sep 4;7(1):10393
Scientific reports 2017 Sep 4;7(1):10393
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G2/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W
Oncotarget 2017 Sep 22;8(37):61846-61860
Oncotarget 2017 Sep 22;8(37):61846-61860
ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer.
Drosos Y, Escobar D, Chiang MY, Roys K, Valentine V, Valentine MB, Rehg JE, Sahai V, Begley LA, Ye J, Paul L, McKinnon PJ, Sosa-Pineda B
Scientific reports 2017 Sep 11;7(1):11144
Scientific reports 2017 Sep 11;7(1):11144
Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.
Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, Peluso G, Giordano A, Galderisi U
Neoplasia (New York, N.Y.) 2017 Oct;19(10):781-790
Neoplasia (New York, N.Y.) 2017 Oct;19(10):781-790
HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.
Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S, Yu S, Lu Z, Han S, Hu X, Qu Z, Liu X, Assefa Yimer T, Yang L, Tang Z, Li DW, Liu M
Cell death & disease 2017 Oct 5;8(10):e3082
Cell death & disease 2017 Oct 5;8(10):e3082
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y
Scientific reports 2017 Oct 19;7(1):13554
Scientific reports 2017 Oct 19;7(1):13554
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Zhao W, Lu D, Liu L, Cai J, Zhou Y, Yang Y, Zhang Y, Zhang J
Oncotarget 2017 Nov 7;8(55):93672-93687
Oncotarget 2017 Nov 7;8(55):93672-93687
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Ye J, Wei X, Shang Y, Pan Q, Yang M, Tian Y, He Y, Peng Z, Chen L, Chen W, Wang R
Oncogene 2017 Nov 16;36(46):6391-6407
Oncogene 2017 Nov 16;36(46):6391-6407
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F
European journal of pharmacology 2017 Nov 15;815:282-289
European journal of pharmacology 2017 Nov 15;815:282-289
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells.
Ren G, Hu J, Shang Y, Zhong Y, Yu Z, An J
Toxicology research 2017 Nov 1;6(6):902-911
Toxicology research 2017 Nov 1;6(6):902-911
TRPC5 channel modulates endothelial cells senescence.
Li Z, Guo G, Wang H, Si X, Zhou G, Xiong Y, Li S, Dai R, Yang C
European journal of pharmacology 2017 May 5;802:27-35
European journal of pharmacology 2017 May 5;802:27-35
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Yin Y, Zhou Z, Liu W, Chang Q, Sun G, Dai Y
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
Ye Q, Pang S, Zhang W, Guo X, Wang J, Zhang Y, Liu Y, Wu X, Jiang F
Arteriosclerosis, thrombosis, and vascular biology 2017 Mar;37(3):476-484
Arteriosclerosis, thrombosis, and vascular biology 2017 Mar;37(3):476-484
12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis.
Wang X, Sun YY, Zhao C, Qu FZ, Zhao YQ
European journal of pharmacology 2017 Mar 5;798:49-56
European journal of pharmacology 2017 Mar 5;798:49-56
Y14 governs p53 expression and modulates DNA damage sensitivity.
Lu CC, Lee CC, Tseng CT, Tarn WY
Scientific reports 2017 Mar 31;7:45558
Scientific reports 2017 Mar 31;7:45558
Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change.
Hu T, Yang C, Fu M, Yang J, Du R, Ran X, Yin T, Wang G
Regenerative biomaterials 2017 Jun;4(3):167-178
Regenerative biomaterials 2017 Jun;4(3):167-178
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Zhang JJ, Liu WQ, Peng JJ, Ma QL, Peng J, Luo XJ
Mechanisms of ageing and development 2017 Jun;164:8-19
Mechanisms of ageing and development 2017 Jun;164:8-19
Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis.
Lu Q, Zhuang J, Guo H
Oncology letters 2017 Jun;13(6):4521-4525
Oncology letters 2017 Jun;13(6):4521-4525
Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis.
Ren Y, Li Y, Yan J, Ma M, Zhou D, Xue Z, Zhang Z, Liu H, Yang H, Jia L, Zhang L, Zhang Q, Mu S, Zhang R, Da Y
Scientific reports 2017 Jun 9;7(1):3209
Scientific reports 2017 Jun 9;7(1):3209
Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency.
Jiang H, Guo S, Xiao D, Bian X, Wang J, Wang Y, Zhou H, Cai J, Zheng Z
Oncotarget 2017 Jun 6;8(23):37694-37704
Oncotarget 2017 Jun 6;8(23):37694-37704
Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines.
Wang Q, Ding W, Ding Y, Ma J, Qian Z, Shao J, Li Y
Oncotarget 2017 Jun 6;8(23):37594-37604
Oncotarget 2017 Jun 6;8(23):37594-37604
Molecular characterization of breast cancer cell lines through multiple omic approaches.
Smith SE, Mellor P, Ward AK, Kendall S, McDonald M, Vizeacoumar FS, Vizeacoumar FJ, Napper S, Anderson DH
Breast cancer research : BCR 2017 Jun 5;19(1):65
Breast cancer research : BCR 2017 Jun 5;19(1):65
0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop.
Xia C, Shui L, Lou G, Ye B, Zhu W, Wang J, Wu S, Xu X, Mao L, Xu W, Chen Z, Liu Y, Zheng M
Scientific reports 2017 Jun 30;7(1):4396
Scientific reports 2017 Jun 30;7(1):4396
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Liu L, Liu Y, Chen X, Wang M, Zhou Y, Zhou P, Li W, Zhu F
Oncotarget 2017 Jul 4;8(27):43990-44003
Oncotarget 2017 Jul 4;8(27):43990-44003
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
Su WC, Lin YF, Yu XP, Wang YX, Lin XD, Su QZ, Shen DY, Chen QX
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).
Zu G, Yao J, Ji A, Ning S, Luo F, Li Z, Feng D, Rui Y, Li Y, Wang G, Tian X
Journal of molecular medicine (Berlin, Germany) 2017 Jan;95(1):83-95
Journal of molecular medicine (Berlin, Germany) 2017 Jan;95(1):83-95
Hypoxia-inducible factor-2α promotes hepatocyte apoptosis during cholestasis.
Hua X, Lu T, Zhang J, Miao Q, Bian Z, Zhang H, Huang S, Lin W, Xi Z, Zhang M, Chen Q, Ma X, Zhang J, Xia Q
Hepatology research : the official journal of the Japan Society of Hepatology 2017 Jan;47(1):95-102
Hepatology research : the official journal of the Japan Society of Hepatology 2017 Jan;47(1):95-102
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, Wu M, Ye S, Huang X, Ma D, Liu R, Gao Q
Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P
Cell death & disease 2017 Jan 12;8(1):e2546
Cell death & disease 2017 Jan 12;8(1):e2546
ISG15 inhibits cancer cell growth and promotes apoptosis.
Zhou MJ, Chen FZ, Chen HC, Wan XX, Zhou X, Fang Q, Zhang DZ
International journal of molecular medicine 2017 Feb;39(2):446-452
International journal of molecular medicine 2017 Feb;39(2):446-452
S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53.
Yang T, Cheng J, Yang Y, Qi W, Zhao Y, Long H, Xie R, Zhu B
Stem cells (Dayton, Ohio) 2017 Feb;35(2):325-336
Stem cells (Dayton, Ohio) 2017 Feb;35(2):325-336
The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway.
Li P, Gan Y, Xu Y, Song L, Wang L, Ouyang B, Zhang C, Zhou Q
Scientific reports 2017 Feb 17;7:42938
Scientific reports 2017 Feb 17;7:42938
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M
Chemosphere 2017 Dec;189:489-497
Chemosphere 2017 Dec;189:489-497
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Liu L, Zhang P, Guo H, Tang X, Liu L, Li J, Guo R, Cai Y, Liu Y, Li Y
Molecular medicine reports 2017 Dec;16(6):9137-9142
Molecular medicine reports 2017 Dec;16(6):9137-9142
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Duan H, Wang R, Yan X, Liu H, Zhang Y, Mu D, Han J, Li X
Oncology letters 2017 Dec;14(6):6763-6768
Oncology letters 2017 Dec;14(6):6763-6768
Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage.
Ding ZM, Jiao XF, Wu D, Zhang JY, Chen F, Wang YS, Huang CJ, Zhang SX, Li X, Huo LJ
Chemico-biological interactions 2017 Dec 25;278:222-229
Chemico-biological interactions 2017 Dec 25;278:222-229
Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents.
Zhang M, Liang YR, Li H, Liu MM, Wang Y
Bioorganic & medicinal chemistry 2017 Dec 15;25(24):6623-6634
Bioorganic & medicinal chemistry 2017 Dec 15;25(24):6623-6634
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z
Scientific reports 2017 Aug 8;7(1):7599
Scientific reports 2017 Aug 8;7(1):7599
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells.
Wang X, Zhang X, Wang G, Wang L, Lin Y, Sun F
Gene 2017 Aug 30;626:344-353
Gene 2017 Aug 30;626:344-353
Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.
Cai X, Cao C, Li J, Chen F, Zhang S, Liu B, Zhang W, Zhang X, Ye L
Oncotarget 2017 Aug 29;8(35):58338-58352
Oncotarget 2017 Aug 29;8(35):58338-58352
Role of Epithelial Cell Transforming Sequence 2 (ECT2) in Predicting Prognosis of Osteosarcoma.
Chen Z, Liu J, Zhang Y
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 10;23:3861-3868
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 10;23:3861-3868
Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
Zhou Z, Yin Y, Chang Q, Sun G, Lin J, Dai Y
Cell proliferation 2017 Apr;50(2)
Cell proliferation 2017 Apr;50(2)
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.
Wang Y, Xiao H, Wu H, Yao C, He H, Wang C, Li W
Oncology reports 2017 Apr;37(4):1998-2006
Oncology reports 2017 Apr;37(4):1998-2006
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
Shen Y, Liu S, Fan J, Jin Y, Tian B, Zheng X, Fu H
EMBO reports 2017 Apr;18(4):536-548
EMBO reports 2017 Apr;18(4):536-548
Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53.
Yao C, Cao X, Fu Z, Tian J, Dong W, Xu J, An K, Zhai L, Yu J
Medical science monitor : international medical journal of experimental and clinical research 2017 Apr 29;23:2059-2064
Medical science monitor : international medical journal of experimental and clinical research 2017 Apr 29;23:2059-2064
Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro.
Shi L, Song R, Yao X, Ren Y
Theriogenology 2017 Apr 15;93:24-32
Theriogenology 2017 Apr 15;93:24-32
Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica.
Zhang M, Yao F, Qin T, Hou L, Zou X
Gene 2017 Apr 15;608:28-40
Gene 2017 Apr 15;608:28-40
Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.
Ren X, Liu H, Zhang M, Wang M, Ma S
Molecular medicine reports 2016 Sep;14(3):2431-8
Molecular medicine reports 2016 Sep;14(3):2431-8
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Wang Y, Zhang XN, Xie WH, Zheng YX, Cao JP, Cao PR, Chen QJ, Li X, Sun CD
Nutrients 2016 Sep 27;8(10)
Nutrients 2016 Sep 27;8(10)
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
Gamallat Y, Meyiah A, Kuugbee ED, Hago AM, Chiwala G, Awadasseid A, Bamba D, Zhang X, Shang X, Luo F, Xin Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Chen L, Lv D, Wang D, Chen X, Zhu Z, Cao Y, Chai Y
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, Shen L, Luo A, Wang S
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability.
Wu H, Yang P, Hu W, Wang Y, Lu Y, Zhang L, Fan Y, Xiao H, Li Z
Oncotarget 2016 Nov 22;7(47):78069-78082
Oncotarget 2016 Nov 22;7(47):78069-78082
Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis.
Zhu X, Wang K, Zhang K, Zhang T, Yin Y, Xu F
International journal of molecular sciences 2016 Nov 22;17(11)
International journal of molecular sciences 2016 Nov 22;17(11)
Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.
Hu K, Tian Y, Du Y, Huang L, Chen J, Li N, Liu W, Liang Z, Zhao L
International journal of oncology 2016 May;48(5):2166-74
International journal of oncology 2016 May;48(5):2166-74
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, Xu Y, Wang C, Peng J
European journal of pharmacology 2016 Mar 5;774:105-17
European journal of pharmacology 2016 Mar 5;774:105-17
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y, Tian X
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function.
Du JK, Cong BH, Yu Q, Wang H, Wang L, Wang CN, Tang XL, Lu JQ, Zhu XY, Ni X
Free radical biology & medicine 2016 Jul;96:406-17
Free radical biology & medicine 2016 Jul;96:406-17
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Zhang XF, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Wang DD, Jiang SS, Zheng HX, Lv L, Chen CL, Zhang HX, Xia JC
Molecular carcinogenesis 2016 Jan;55(1):64-76
Molecular carcinogenesis 2016 Jan;55(1):64-76
Expression of Hedgehog Signals and Growth Inhibition by Itraconazole in Endometrial Cancer.
Inoue K, Tsubamoto H, Sakata K, Sakane R, Hao H, Hirota S, Sonoda T, Shibahara H
Anticancer research 2016 Jan;36(1):149-53
Anticancer research 2016 Jan;36(1):149-53
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
Dong C, Zhao B, Long F, Liu Y, Liu Z, Li S, Yang X, Sun D, Wang H, Liu Q, Liang R, Li Y, Gao Z, Shao S, Miao QR, Wang L
Oncotarget 2016 Feb 23;7(8):8850-65
Oncotarget 2016 Feb 23;7(8):8850-65
Inhibitory effect of diosgenin on experimentally induced benign prostatic hyperplasia in rats.
Chen J, Zhang HF, Xiong CM, Ruan JL
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2016 Dec;36(6):806-810
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2016 Dec;36(6):806-810
H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway.
Zhao S, Li L, Wang S, Yu C, Xiao B, Lin L, Cong W, Cheng J, Yang W, Sun W, Cui S
Oncotarget 2016 Dec 20;7(51):84839-84850
Oncotarget 2016 Dec 20;7(51):84839-84850
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Tang Q, Ji F, Sun W, Wang J, Guo J, Guo L, Li Y, Bao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin.
Tang Q, Ji F, Guo J, Wang J, Li Y, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:693-703
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:693-703
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research 2016 Aug;57(8):1398-411
Journal of lipid research 2016 Aug;57(8):1398-411
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis.
Lu Y, Wen J, Chen D, Wu L, Li Q, Xie Y, Wu D, Liu X, Chen X
Clinical and experimental nephrology 2016 Apr;20(2):178-86
Clinical and experimental nephrology 2016 Apr;20(2):178-86
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells.
Lu Y, Wang J, Dapeng C, Wu D, Cai G, Chen X
BMC nephrology 2016 Apr 1;17:39
BMC nephrology 2016 Apr 1;17:39
Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells.
Yu L, Wang X, Zhu D, Ding W, Wang L, Zhang C, Jiang X, Shen H, Liao S, Ma D, Hu Z, Wang H
OncoTargets and therapy 2015;8:37-44
OncoTargets and therapy 2015;8:37-44
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.
Zhan W, Han T, Zhang C, Xie C, Gan M, Deng K, Fu M, Wang JB
PloS one 2015;10(11):e0142596
PloS one 2015;10(11):e0142596
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
Hao L, Zhou X, Liu S, Sun M, Song Y, Du S, Sun B, Guo C, Gong L, Hu J, Guan H, Shao S
Proteomics 2015 Sep;15(17):3087-100
Proteomics 2015 Sep;15(17):3087-100
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells.
Li P, Zhao M, Parris AB, Feng X, Yang X
Biochemical and biophysical research communications 2015 Sep 4;464(4):1267-1274
Biochemical and biophysical research communications 2015 Sep 4;464(4):1267-1274
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L
Oncotarget 2015 Sep 29;6(29):27199-213
Oncotarget 2015 Sep 29;6(29):27199-213
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X, Ye L
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
Wang X, Han L, Zhang J, Xia Q
Digestive diseases and sciences 2015 Oct;60(10):3011-8
Digestive diseases and sciences 2015 Oct;60(10):3011-8
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Zhang HX, Jiang SS, Zhang XF, Zhou ZQ, Pan QZ, Chen CL, Zhao JJ, Tang Y, Xia JC, Weng DS
Oncotarget 2015 Oct 27;6(33):34800-17
Oncotarget 2015 Oct 27;6(33):34800-17
Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells.
Yang Y, Jiang L, She Y, Chen M, Li Q, Yang G, Geng C, Tang L, Zhong L, Jiang L, Liu X
Environmental toxicology and pharmacology 2015 Nov;40(3):792-9
Environmental toxicology and pharmacology 2015 Nov;40(3):792-9
Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.
Yu J, Ren P, Zhong T, Wang Y, Yan M, Xue B, Li R, Dai C, Liu C, Chen G, Yu XF
Molecular medicine reports 2015 Nov;12(5):7195-202
Molecular medicine reports 2015 Nov;12(5):7195-202
Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways.
Yuan H, Wang J, Wang F, Zhang N, Li Q, Xie F, Chen T, Zhai R, Wang F, Guo Y, Ni W, Tai G
Molecular medicine reports 2015 Nov;12(5):6782-8
Molecular medicine reports 2015 Nov;12(5):6782-8
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1.
Ying Q, Ansong E, Diamond AM, Yang W
International journal of molecular sciences 2015 Nov 18;16(11):27599-608
International journal of molecular sciences 2015 Nov 18;16(11):27599-608
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Song X, Li L, Shi Q, Lehmler HJ, Fu J, Su C, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Jin Y, Cao B, Zhang M, Zhan Q, Herman JG, Yu M, Guo M
Genes & cancer 2015 May;6(5-6):231-40
Genes & cancer 2015 May;6(5-6):231-40
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W
British journal of pharmacology 2015 May;172(9):2232-45
British journal of pharmacology 2015 May;172(9):2232-45
Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
Gu Y, He Y, Zhang X, Shi Y, Yang Q, Yu L, Sun Z, Zhang H, Wang J, Gao X, Wang J
Molecular reproduction and development 2015 Jun;82(6):475-88
Molecular reproduction and development 2015 Jun;82(6):475-88
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells.
Dan J, Sun X, Li W, Zhang Y, Li X, Xu H, Li Z, Tian Z, Guo S, Yao J, Gao W, Tian Y
Ultrasound in medicine & biology 2015 Jun;41(6):1681-9
Ultrasound in medicine & biology 2015 Jun;41(6):1681-9
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, Wang L, Zhu B, Zeng L, Feng X, Zhang C, Chen H, Jia W, Zhang L, Xia X, Chen Y
Scientific reports 2015 Jul 24;5:11614
Scientific reports 2015 Jul 24;5:11614
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.
Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X
International journal of oncology 2015 Jan;46(1):360-8
International journal of oncology 2015 Jan;46(1):360-8
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.
Hu Z, Ding W, Zhu D, Yu L, Jiang X, Wang X, Zhang C, Wang L, Ji T, Liu D, He D, Xia X, Zhu T, Wei J, Wu P, Wang C, Xi L, Gao Q, Chen G, Liu R, Li K, Li S, Wang S, Zhou J, Ma D, Wang H
The Journal of clinical investigation 2015 Jan;125(1):425-36
The Journal of clinical investigation 2015 Jan;125(1):425-36
Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.
Zhu DW, Yuan YX, Qiao JK, Yu C, Yang X, Wang LZ, Zhang ZY, Zhong LP
Cancer letters 2015 Jan 28;356(2 Pt B):773-80
Cancer letters 2015 Jan 28;356(2 Pt B):773-80
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
Li X, Liu X, Xu Y, He Y, Liu J, Xie M
International journal of oncology 2015 Feb;46(2):677-84
International journal of oncology 2015 Feb;46(2):677-84
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
Sun S, Cheng B, Sun PG, Wu XH, Wu QQ, He P
Experimental biology and medicine (Maywood, N.J.) 2015 Dec;240(12):1606-13
Experimental biology and medicine (Maywood, N.J.) 2015 Dec;240(12):1606-13
5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis.
Hu Z, Fan H, Lv G, Zhou Q, Yang B, Zheng J, Cao W
Journal of dermatological science 2015 Aug;79(2):155-62
Journal of dermatological science 2015 Aug;79(2):155-62
HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53.
Huang M, Li D, Huang Y, Cui X, Liao S, Wang J, Liu F, Li C, Gao M, Chen J, Tang Z, Li DW, Liu M
Biochimica et biophysica acta 2015 Aug;1853(8):1808-17
Biochimica et biophysica acta 2015 Aug;1853(8):1808-17
The effect of mesenchymal stem cells on the p53 methylation in irradiation-induced thymoma in C57BL/6 mice.
Zheng HB, Fu YT, Pan ZX, Yang TW, Sun LH, Chen YB, Tong T
Journal of cancer research and therapeutics 2015 Apr-Jun;11(2):403-8
Journal of cancer research and therapeutics 2015 Apr-Jun;11(2):403-8
Identification of nestin as a urinary biomarker for acute kidney injury.
Zhang W, Zhang L, Chen YX, Xie YY, Zou YF, Zhang MJ, Gao YH, Liu Y, Zhao Q, Huang QH, Chen N
American journal of nephrology 2014;39(2):110-21
American journal of nephrology 2014;39(2):110-21
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
Transplantation 2014 Sep 27;98(6):604-11
Elevated p53 expression levels correlate with tumor progression and poor prognosis in patients exhibiting esophageal squamous cell carcinoma.
Huang K, Chen L, Zhang J, Wu Z, Lan L, Wang L, Lu B, Liu Y
Oncology letters 2014 Oct;8(4):1441-1446
Oncology letters 2014 Oct;8(4):1441-1446
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Protective effects of dioscin against alcohol-induced liver injury.
Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53
Archives of toxicology 2014 Mar;88(3):739-53
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Yang CF, Peng LX, Huang TJ, Yang GD, Chu QQ, Liang YY, Cao X, Xie P, Zheng LS, Huang HB, Cai MD, Huang JL, Liu RY, Zhu ZY, Qian CN, Huang BJ
Cancer letters 2014 Mar 28;344(2):260-71
Cancer letters 2014 Mar 28;344(2):260-71
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
Annani-Akollor ME, Wang S, Fan J, Liu L, Padhiar AA, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 Jul;68(6):785-90
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 Jul;68(6):785-90
DDX3X regulates cell survival and cell cycle during mouse early embryonic development.
Li Q, Zhang P, Zhang C, Wang Y, Wan R, Yang Y, Guo X, Huo R, Lin M, Zhou Z, Sha J
Journal of biomedical research 2014 Jul;28(4):282-91
Journal of biomedical research 2014 Jul;28(4):282-91
MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression.
Tang W, Jiang Y, Mu X, Xu L, Cheng W, Wang X
Cellular signalling 2014 Jul;26(7):1420-6
Cellular signalling 2014 Jul;26(7):1420-6
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
Fu HL, Ma Y, Lu LG, Hou P, Li BJ, Jin WL, Cui DX
Journal of biomedical nanotechnology 2014 Jul;10(7):1217-30
Journal of biomedical nanotechnology 2014 Jul;10(7):1217-30
Bisphenol A induces oxidative stress-associated DNA damage in INS-1 cells.
Xin F, Jiang L, Liu X, Geng C, Wang W, Zhong L, Yang G, Chen M
Mutation research. Genetic toxicology and environmental mutagenesis 2014 Jul 15;769:29-33
Mutation research. Genetic toxicology and environmental mutagenesis 2014 Jul 15;769:29-33
Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
Li M, Lu Y, Hu Y, Zhai X, Xu W, Jing H, Tian X, Lin Y, Gao D, Yao J
Toxicology letters 2014 Jul 15;228(2):67-74
Toxicology letters 2014 Jul 15;228(2):67-74
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Wang XM, Yao M, Liu SX, Hao J, Liu QJ, Gao F
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Differential effects of p53 on bystander phenotypes induced by gamma ray and high LET heavy ion radiation.
He M, Dong C, Konishi T, Tu W, Liu W, Shiomi N, Kobayashi A, Uchihori Y, Furusawa Y, Hei TK, Dang B, Shao C
Life sciences in space research 2014 Apr;1:53-9
Life sciences in space research 2014 Apr;1:53-9
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Ye J, Liu Z, Wei J, Lu L, Huang Y, Luo L, Xie H
Neuroscience letters 2013 Oct 11;553:72-7
Neuroscience letters 2013 Oct 11;553:72-7
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Zhang S, Qi Y, Xu Y, Han X, Peng J, Liu K, Sun CK
Neurochemistry international 2013 Nov;63(5):522-32
Neurochemistry international 2013 Nov;63(5):522-32
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
Gao F, Yao M, Shi Y, Hao J, Ren Y, Liu Q, Wang X, Duan H
Journal of cellular biochemistry 2013 May;114(5):1029-38
Journal of cellular biochemistry 2013 May;114(5):1029-38
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Zhang J, Sun Q, Zhang Z, Ge S, Han ZG, Chen WT
Oncogene 2013 Jan 3;32(1):61-9
Oncogene 2013 Jan 3;32(1):61-9
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Dong D, Zhang S, Yin L, Tang X, Xu Y, Han X, Qi Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
High level of COP1 expression is associated with poor prognosis in primary gastric cancer.
Li YF, Wang DD, Zhao BW, Wang W, Huang CY, Chen YM, Zheng Y, Keshari RP, Xia JC, Zhou ZW
International journal of biological sciences 2012;8(8):1168-77
International journal of biological sciences 2012;8(8):1168-77
Alantolactone induces activation of apoptosis in human hepatoma cells.
Lei JC, Yu JQ, Yin Y, Liu YW, Zou GL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Jia Y, Ji L, Zhang S, Xu L, Yin L, Li L, Zhao Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Sensitive detection of intracellular sumoylation via SNAP tag-mediated translation and RNA polymerase-based amplification.
Yang Y, Zhang CY
Analytical chemistry 2012 Feb 7;84(3):1229-34
Analytical chemistry 2012 Feb 7;84(3):1229-34
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Yin Y, Chen W, Tang C, Ding H, Jang J, Weng M, Cai Y, Zou G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway.
Li L, Qi Z, Qian J, Bi F, Lv J, Xu L, Zhang L, Chen H, Jia R
Molecular and cellular biochemistry 2010 Sep;342(1-2):125-31
Molecular and cellular biochemistry 2010 Sep;342(1-2):125-31
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
Chen W, Hou J, Yin Y, Jang J, Zheng Z, Fan H, Zou G
Biochemical pharmacology 2010 Jul 15;80(2):247-54
Biochemical pharmacology 2010 Jul 15;80(2):247-54
MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network.
Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, Chen W
Molecular cancer 2010 Aug 6;9:211
Molecular cancer 2010 Aug 6;9:211
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 10442-1-AP(P53 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-P53 (IP:10442-1-AP, 4ug; Detection:10442-1-AP 1:1000) with A431 cells lysate 3000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human endometrial cancer using 10442-1-AP(P53 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The P53 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human P53. This antibody recognizes human, rat, mouse antigen. The P53 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
