Antibody data
- Antibody Data
- Antigen structure
- References [329]
- Comments [0]
- Validations
- Western blot [4]
- Immunocytochemistry [5]
- Immunohistochemistry [3]
- Other assay [46]
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Validation data
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- Product number
- MA5-11869 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Actin Monoclonal Antibody (ACTN05 (C4))
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- MA5-11869 reacts with all six known vertebrate isoforms of actin (MW ~42kDa), and with two cytoplasmic actins (beta and gamma), which are highly homologous to each other but differ from the muscle actins by ~25 amino acid residues. This product is highly recommended for monitoring total protein load on Western blots.
- Antibody clone number
- ACTN05 (C4)
- Concentration
- 0.2 mg/mL
Submitted references Characterization of dengue virus 3'UTR RNA binding proteins in mosquitoes reveals that AeStaufen reduces subgenomic flaviviral RNA in saliva.
Autophagy Induction and Accumulation of Phosphorylated Tau in the Hippocampus and Prefrontal Cortex of Adult C57BL/6 Mice Subjected to Adolescent Fluoxetine Treatment.
CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent Manner.
Centromeric transcription maintains centromeric cohesion in human cells.
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.
Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor.
MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Shigella OspC3 suppresses murine cytosolic LPS sensing.
Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.
MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.
Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts.
Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients.
18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress.
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.
Antifungal itraconazole ameliorates experimental autoimmune encephalomyelitis through a novel mechanism of action.
Epstein-Barr virus-positive gastric cancer involves enhancer activation through activating transcription factor 3.
In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring.
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice.
Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells.
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons.
Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation.
An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome.
Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer.
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats.
Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.
The Non-ureogenic Stinging Catfish, Heteropneustes fossilis, Actively Excretes Ammonia With the Help of Na(+)/K(+)-ATPase When Exposed to Environmental Ammonia.
Profilin and formin constitute a pacemaker system for robust actin filament growth.
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.
Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine.
Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth.
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.
Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes.
Early redox activities modulate Xenopus tail regeneration.
In Vitro Transformation of Human Bronchial Epithelial Cells by Diesel Exhaust Particles: Gene Expression Profiling and Early Toxic Responses.
Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins.
C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.
Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor.
Synthesis and anti-glioblastoma effects of artemisinin-isothiocyanate derivatives.
Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis.
The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells.
Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.
Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer.
Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133(+) cells.
Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells.
Adaptive response activated by dietary cis9, trans11 conjugated linoleic acid prevents distinct signs of gliadin-induced enteropathy in mice.
Increased caveolin-1 in intervertebral disc degeneration facilitates repair.
The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC.
Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.
Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.
Anti-fatigue effect of Myelophil in a chronic forced exercise mouse model.
Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms.
The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.
Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts.
CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence.
Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression.
Hematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils.
Altered migratory behavior of interneurons in a model of cortical dysplasia: the influence of elevated GABAA activity.
The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70.
Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.
Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice.
WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition.
Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier.
Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model.
A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.
eRapa restores a normal life span in a FAP mouse model.
Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virus.
Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells.
The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.
Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth.
A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.
A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia.
Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.
Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process.
High brain ammonia tolerance and down-regulation of Na+:K+:2Cl(-) Cotransporter 1b mRNA and protein expression in the brain of the Swamp Eel, Monopterus albus, exposed to environmental ammonia or terrestrial conditions.
Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis.
Tanshinone IIA increases the bystander effect of herpes simplex virus thymidine kinase/ganciclovir gene therapy via enhanced gap junctional intercellular communication.
Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations.
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion.
Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.
The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10,c12-conjugated linoleic acid isomer on A375 melanoma cells.
Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization.
Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis.
Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: implications for cardiorenal syndrome.
Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.
Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains.
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.
Preference toward a polylysine enantiomer in inhibiting prions.
The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis.
Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status.
Galectin-7 and actin are components of amyloid deposit of localized cutaneous amyloidosis.
Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion.
Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies.
Senescent human periodontal ligament fibroblasts after replicative exhaustion or ionizing radiation have a decreased capacity towards osteoblastic differentiation.
Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.
Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate.
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice.
Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation.
Caloric restriction reduced 1, 2-dimethylhydrazine-induced aberrant crypt foci and induces the expression of Sirtuins in colonic mucosa of F344 rats.
Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells.
Advanced glycation end-products induce calpain-mediated degradation of ezrin.
Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Effect of different durations of overdistention on rat bladder function and morphology.
Quantification of dystrophin immunofluorescence in dystrophinopathy muscle specimens.
CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach.
Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer.
Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma.
Heat stress induces epithelial plasticity and cell migration independent of heat shock factor 1.
MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells.
Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome.
Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: application to corneal disease.
PER1 modulates SGLT1 transcription in vitro independent of E-box status.
Induction of apoptosis in Eμ-myc lymphoma cells in vitro and in vivo through calpain inhibition.
Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model.
The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
Involvement of Rho kinase (ROCK) in sepsis-induced acute lung injury.
Strategic combination therapy overcomes tyrosine kinase coactivation in adrenocortical carcinoma.
Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism.
Cell movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus.
Influence of conformationally restricted pyrimidines on the activity of 10-23 DNAzymes.
Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model.
Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis.
Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer.
Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells.
TNF-α-decreased thrombomodulin expression in monocytes is inhibited by propofol through regulation of tristetraprolin and human antigen R activities.
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone.
c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M.
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer.
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia.
Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Overexpression of HSP70 inhibits cofilin phosphorylation and promotes lymphocyte migration in heat-stressed cells.
CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.
Effects of EpCAM overexpression on human breast cancer cell lines.
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.
Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli.
A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development.
ABC50 modulates sensitivity of HL60 leukemic cells to endoplasmic reticulum (ER) stress-induced cell death.
Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage.
Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.
Identification of tetranectin as a potential biomarker for metastatic oral cancer.
Increased cellular apoptosis susceptibility (CSE1L/CAS) protein expression promotes protrusion extension and enhances migration of MCF-7 breast cancer cells.
Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.
Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines.
Fibroblast nemosis induces angiogenic responses of endothelial cells.
Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation.
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.
Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation.
Plasminogen stimulates propagation of protease-resistant prion protein in vitro.
Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2.
Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells.
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain.
Melatonin reprogrammes proteomic profile in light-exposed retina in vivo.
Maternal deprivation induces a rapid decline in circulating leptin levels and sexually dimorphic modifications in hypothalamic trophic factors and cell turnover.
Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer.
Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats.
Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria.
IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas.
Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients.
Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.
Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils.
Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model.
Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice.
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori.
Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration.
Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis.
Higher prevalence of secretory CSE1L/CAS in sera of patients with metastatic cancer.
Intracellular adaptation of Brucella abortus.
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.
Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors.
Identification of AML1-ETO modulators by chemical genomics.
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion.
Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
SDF-1 alpha expression during wound healing in the aged is HIF dependent.
Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells.
EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.
Autophagy: a new target for advanced papillary thyroid cancer therapy.
Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.
Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress.
Classic and desmoplastic medulloblastoma: complete case reports and characterizations of two new cell lines.
p53-dependent antiproliferative and antitumor effect of novel alkyl series of diorganotin(IV) compounds.
Diminished intracellular invariant chain expression after vaccinia virus infection.
Expression of apoptotic tumour necrosis factor receptor-associated factor, caspase recruitment domain and cell death-inducing DFF-45 effector genes in therapy-treated renal cell carcinoma.
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
Epidermal growth factor receptor/beta-catenin/T-cell factor 4/matrix metalloproteinase 1: a new pathway for regulating keratinocyte invasiveness after UVA irradiation.
Short and long-term tumor cell responses to Aurora kinase inhibitors.
Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathway.
Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization.
Effect of hemodialysis on hepatic cytochrome P450 functional expression.
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
NBS1 regulates a novel apoptotic pathway through Bax activation.
Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin(IV) compounds.
CRBL cells: establishment, characterization and susceptibility to prion infection.
Estrogen induces rapid translocation of estrogen receptor beta, but not estrogen receptor alpha, to the neuronal plasma membrane.
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Mitogen-stimulated and rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells.
Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance.
Lithium treatment decreases activities of tau kinases in a murine model of senescence.
Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose cotransporter (SGLT1).
Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot study.
Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA--role of MAPK and NF-kappaB.
Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells.
Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine.
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.
Nemosis of fibroblasts is inhibited by benign HaCaT keratinocytes but promoted by malignant HaCaT cells.
Oocyte selection is concurrent with meiosis resumption in the coenocystic oogenesis of Oikopleura.
Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.
(-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells.
Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control.
Hepatocyte growth factor improves viability after H2O2-induced toxicity in bile duct epithelial cells.
Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment.
Influence of warm ischemia time on peripheral-type benzodiazepine receptor: a new aspect of the role of mitochondria.
Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling.
Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysis.
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Sodium butyrate-induced death-associated protein kinase expression promote Raji cell morphological change and apoptosis by reducing FAK protein levels.
Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis.
Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells.
The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.
Effect of huanglian jiedu decoction ) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats.
UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma.
Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8+ cells and prolongs cardiac allograft survival.
Analysis of mitotic phosphorylation of borealin.
Prolactin stimulates prostate cell proliferation by increasing endoplasmic reticulum content due to SERCA 2b over-expression.
Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance.
Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.
Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.
Heavy ion beams induce survivin expression in human hepatoma SMMC-7721 cells more effectively than X-rays.
P53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury.
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.
Inhibition of NAD(P)H oxidase reduces fibronectin expression in stroke-prone renovascular hypertensive rat brain.
Morphologic, phenotypic and functional characteristics of endothelial cells derived from human hepatic cavernous hemangioma.
A comparison of enhanced green fluorescent protein expression induced by immediate-early cytomegalovirus (IE-CMV) and gG pseudorabies virus (gG-PRV) promoters, using pseudorabies virus amplicons as vectors.
Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma.
Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemia.
ERK contributes to the effects of Smad signaling on oxidized LDL-induced PAI-1 expression in human mesangial cells.
Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells.
Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability.
Role of parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure.
Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin.
Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/Fas ligand cytotoxic pathway.
Cyclopedic protein expression analysis of cultured canine mammary gland adenocarcinoma cells from six tumours.
Stellettin A induces oxidative stress and apoptosis in HL-60 human leukemia and LNCaP prostate cancer cell lines.
Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell.
Effect of cobalt and chromium ions on human MG-63 osteoblasts in vitro: morphology, cytotoxicity, and oxidative stress.
Introduction of the MASH1 gene into mouse embryonic stem cells leads to differentiation of motoneuron precursors lacking Nogo receptor expression that can be applicable for transplantation to spinal cord injury.
Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.
Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.
The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?
Stress response in mesoangioblast stem cells.
Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir.
Improved surgical mesh integration into the rat abdominal wall with arginine administration.
Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils.
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation.
Cobalt and chromium ions induce nitration of proteins in human U937 macrophages in vitro.
Lineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors.
Proteomic analysis of Caco-2 cells treated with monacolin K.
N-glycosylation affects the molecular organization and stability of E-cadherin junctions.
Overexpression of EIF3S3 promotes cancer cell growth.
Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy.
TFAR19 gene changes the biophysical properties of murine erythroleukemia cells.
The effect of isoforms of the cell polarity protein, human ASIP, on the cell cycle and Fas/FasL-mediated apoptosis in human hepatoma cells.
Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis.
Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor.
Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinases.
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo.
Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.
Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast cancer cells transfected with progesterone receptor.
Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.
RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance.
HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion.
Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.
Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages.
Effect of glycine on recovery of bladder smooth muscle contractility after acute urinary retention in rats.
Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment.
EphA2 as a glioma-associated antigen: a novel target for glioma vaccines.
Histone H4 post-translational modifications in chordate mitotic and endoreduplicative cell cycles.
Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter.
Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication.
Proteolytic processing of TGFalpha redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine.
Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism.
Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax.
Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer.
The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein.
Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2.
Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes.
Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells.
CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells.
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells.
Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line.
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness.
Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation.
Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury.
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities.
Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes.
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Measles virus-induced modulation of host-cell gene expression.
Yeh SC, Diosa-Toro M, Tan WL, Rachenne F, Hain A, Yeo CPX, Bribes I, Xiang BWW, Sathiamoorthy Kannan G, Manuel MC, Missé D, Mok YK, Pompon J
PLoS pathogens 2022 Sep;18(9):e1010427
PLoS pathogens 2022 Sep;18(9):e1010427
Autophagy Induction and Accumulation of Phosphorylated Tau in the Hippocampus and Prefrontal Cortex of Adult C57BL/6 Mice Subjected to Adolescent Fluoxetine Treatment.
Sierra-Fonseca JA, Rodriguez M, Themann A, Lira O, Flores-Ramirez FJ, Vargas-Medrano J, Gadad BS, Iñiguez SD
Journal of Alzheimer's disease : JAD 2021;83(4):1691-1702
Journal of Alzheimer's disease : JAD 2021;83(4):1691-1702
CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent Manner.
Alcedo KP, Rouse MA, Jung GS, Fu D, Minor M, Willcockson HH, Greene KG, Snider NT
Cellular and molecular gastroenterology and hepatology 2021;12(1):141-157
Cellular and molecular gastroenterology and hepatology 2021;12(1):141-157
Centromeric transcription maintains centromeric cohesion in human cells.
Chen Y, Zhang Q, Teng Z, Liu H
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.
Han S, Zhao F, Hsia J, Ma X, Liu Y, Torres S, Fujioka H, Zhu X
Journal of cell science 2021 Jul 1;134(13)
Journal of cell science 2021 Jul 1;134(13)
Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor.
Bergamin LS, Penolazzi L, Lambertini E, Falzoni S, Sarti AC, Molle CM, Gendron FP, De Bonis P, Di Virgilio F, Piva R
Journal of cellular physiology 2021 Jan;236(1):641-652
Journal of cellular physiology 2021 Jan;236(1):641-652
MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Bamunuarachchi G, Yang X, Huang C, Liang Y, Guo Y, Liu L
Cellular microbiology 2021 Feb;23(2):e13281
Cellular microbiology 2021 Feb;23(2):e13281
Shigella OspC3 suppresses murine cytosolic LPS sensing.
Oh C, Verma A, Hafeez M, Hogland B, Aachoui Y
iScience 2021 Aug 20;24(8):102910
iScience 2021 Aug 20;24(8):102910
Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.
Abedin MR, Powers K, Aiardo R, Barua D, Barua S
Scientific reports 2021 Apr 1;11(1):7347
Scientific reports 2021 Apr 1;11(1):7347
MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.
Chen A, Santana AL, Doudican N, Roudiani N, Laursen K, Therrien JP, Lee J, Felsen D, Carucci JA
PloS one 2020;15(11):e0241551
PloS one 2020;15(11):e0241551
Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts.
Purde V, Kudryashova E, Heisler DB, Shakya R, Kudryashov DS
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 8;117(36):22090-22100
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 8;117(36):22090-22100
Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients.
Ravera S, Ghiotto F, Tenca C, Gugiatti E, Santamaria S, Ledda B, Ibatici A, Cutrona G, Mazzarello AN, Bagnara D, Cardillo M, Zarcone D, Darzynkiewicz Z, Ciccone E, Fais F, Bruno S
Scientific reports 2020 Oct 5;10(1):16519
Scientific reports 2020 Oct 5;10(1):16519
18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress.
Miceli A, Cossu V, Marini C, Castellani P, Raffa S, Donegani MI, Bruno S, Ravera S, Emionite L, Orengo AM, Grillo F, Nobili F, Morbelli S, Uccelli A, Sambuceti G, Bauckneht M
International journal of molecular sciences 2020 Oct 31;21(21)
International journal of molecular sciences 2020 Oct 31;21(21)
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature 2020 Nov;587(7835):673-677
Nature 2020 Nov;587(7835):673-677
Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.
Gómez-Escribano AP, Bono-Yagüe J, García-Gimeno MA, Sequedo MD, Hervás D, Fornés-Ferrer V, Torres-Sánchez SC, Millán JM, Sanz P, Vázquez-Manrique RP
Pharmacological research 2020 Nov;161:105105
Pharmacological research 2020 Nov;161:105105
Antifungal itraconazole ameliorates experimental autoimmune encephalomyelitis through a novel mechanism of action.
Huang H, Tian X, Peng X, Huang L, Mei L, Zhan Y, Chen S, Wu H, Wei G, Cai X
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2020 May;29(5):535-545
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2020 May;29(5):535-545
Epstein-Barr virus-positive gastric cancer involves enhancer activation through activating transcription factor 3.
Asakawa Y, Okabe A, Fukuyo M, Li W, Ikeda E, Mano Y, Funata S, Namba H, Fujii T, Kita K, Matsusaka K, Kaneda A
Cancer science 2020 May;111(5):1818-1828
Cancer science 2020 May;111(5):1818-1828
In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring.
Palanisamy A, Giri T, Jiang J, Bice A, Quirk JD, Conyers SB, Maloney SE, Raghuraman N, Bauer AQ, Garbow JR, Wozniak DF
JCI insight 2020 May 21;5(10)
JCI insight 2020 May 21;5(10)
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice.
Dong Y, Li S, Lu Y, Li X, Liao Y, Peng Z, Li Y, Hou L, Yuan Z, Cheng J
Journal of neuroinflammation 2020 Jul 7;17(1):205
Journal of neuroinflammation 2020 Jul 7;17(1):205
Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells.
Lee JS, Jeon YJ, Kang JY, Lee SK, Lee HD, Son CG
International journal of molecular sciences 2020 Jul 30;21(15)
International journal of molecular sciences 2020 Jul 30;21(15)
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
Kovacs SB, Oh C, Maltez VI, McGlaughon BD, Verma A, Miao EA, Aachoui Y
Cell reports 2020 Jul 28;32(4):107967
Cell reports 2020 Jul 28;32(4):107967
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons.
Vellani V, Sabatini C, Milia C, Caselli G, Lanza M, Letari O, Rovati LC, Giacomoni C
British journal of pharmacology 2020 Jan;177(1):48-64
British journal of pharmacology 2020 Jan;177(1):48-64
Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation.
Matthew-Onabanjo AN, Janusis J, Mercado-Matos J, Carlisle AE, Kim D, Levine F, Cruz-Gordillo P, Richards R, Lee MJ, Shaw LM
Cancer research 2020 Jan 15;80(2):249-262
Cancer research 2020 Jan 15;80(2):249-262
An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome.
Lee JS, Jeon YJ, Park SY, Son CG
Biomolecules 2020 Jan 1;10(1)
Biomolecules 2020 Jan 1;10(1)
Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer.
Kvorjak M, Ahmed Y, Miller ML, Sriram R, Coronnello C, Hashash JG, Hartman DJ, Telmer CA, Miskov-Zivanov N, Finn OJ, Cascio S
Cancer immunology research 2020 Feb;8(2):167-178
Cancer immunology research 2020 Feb;8(2):167-178
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY
Nature 2020 Dec;588(7839):693-698
Nature 2020 Dec;588(7839):693-698
Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats.
Eassawy MMT, Salem AA, Ismail AFM
Environmental toxicology 2020 Dec 17;
Environmental toxicology 2020 Dec 17;
Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.
Zhang Q, Hu L, Chen Y, Tian W, Liu H
Molecular biology of the cell 2020 Aug 1;31(17):1892-1903
Molecular biology of the cell 2020 Aug 1;31(17):1892-1903
The Non-ureogenic Stinging Catfish, Heteropneustes fossilis, Actively Excretes Ammonia With the Help of Na(+)/K(+)-ATPase When Exposed to Environmental Ammonia.
Chew SF, Tan SZL, Ip SCY, Pang CZ, Hiong KC, Ip YK
Frontiers in physiology 2019;10:1615
Frontiers in physiology 2019;10:1615
Profilin and formin constitute a pacemaker system for robust actin filament growth.
Funk J, Merino F, Venkova L, Heydenreich L, Kierfeld J, Vargas P, Raunser S, Piel M, Bieling P
eLife 2019 Oct 24;8
eLife 2019 Oct 24;8
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P
Nature 2019 May;569(7758):718-722
Nature 2019 May;569(7758):718-722
High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.
Satoh M, Nomura S, Harada M, Yamaguchi T, Ko T, Sumida T, Toko H, Naito AT, Takeda N, Tobita T, Fujita T, Ito M, Fujita K, Ishizuka M, Kariya T, Akazawa H, Kobayashi Y, Morita H, Takimoto E, Aburatani H, Komuro I
Journal of molecular and cellular cardiology 2019 Mar;128:77-89
Journal of molecular and cellular cardiology 2019 Mar;128:77-89
Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine.
Kimble JB, Malherbe DC, Meyer M, Gunn BM, Karim MM, Ilinykh PA, Iampietro M, Mohamed KS, Negi S, Gilchuk P, Huang K, Wolf YI, Braun W, Crowe JE, Alter G, Bukreyev A
Journal of virology 2019 Feb 15;93(4)
Journal of virology 2019 Feb 15;93(4)
Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth.
Bergamin LS, Capece M, Salaro E, Sarti AC, Falzoni S, Pereira MSL, De Bastiani MA, Scholl JN, Battastini AMO, Di Virgilio F
Oncotarget 2019 Aug 6;10(47):4840-4856
Oncotarget 2019 Aug 6;10(47):4840-4856
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS
Nature communications 2019 Aug 22;10(1):3790
Nature communications 2019 Aug 22;10(1):3790
HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.
Sheu JR, Hsieh CY, Jayakumar T, Lin GY, Lee HN, Huang SW, Yang CH
Journal of biomedical science 2019 Apr 18;26(1):27
Journal of biomedical science 2019 Apr 18;26(1):27
Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes.
Middleton RC, Rogers RG, De Couto G, Tseliou E, Luther K, Holewinski R, Soetkamp D, Van Eyk JE, Antes TJ, Marbán E
Journal of extracellular vesicles 2018;7(1):1456888
Journal of extracellular vesicles 2018;7(1):1456888
Early redox activities modulate Xenopus tail regeneration.
Ferreira F, Raghunathan V, Luxardi G, Zhu K, Zhao M
Nature communications 2018 Oct 16;9(1):4296
Nature communications 2018 Oct 16;9(1):4296
In Vitro Transformation of Human Bronchial Epithelial Cells by Diesel Exhaust Particles: Gene Expression Profiling and Early Toxic Responses.
Rynning I, Neca J, Vrbova K, Libalova H, Rossner P Jr, Holme JA, Gützkow KB, Afanou AKJ, Arnoldussen YJ, Hruba E, Skare Ø, Haugen A, Topinka J, Machala M, Mollerup S
Toxicological sciences : an official journal of the Society of Toxicology 2018 Nov 1;166(1):51-64
Toxicological sciences : an official journal of the Society of Toxicology 2018 Nov 1;166(1):51-64
Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins.
Kudryashova E, Heisler DB, Williams B, Harker AJ, Shafer K, Quinlan ME, Kovar DR, Vavylonis D, Kudryashov DS
Current biology : CB 2018 May 21;28(10):1536-1547.e9
Current biology : CB 2018 May 21;28(10):1536-1547.e9
C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.
Ambrose RL, Liu YC, Adams TE, Bean AGD, Stewart CR
The Journal of biological chemistry 2018 Jul 6;293(27):10561-10573
The Journal of biological chemistry 2018 Jul 6;293(27):10561-10573
Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor.
Kays J, Zhang YH, Khorodova A, Strichartz G, Nicol GD
Neuroscience 2018 Feb 10;371:420-432
Neuroscience 2018 Feb 10;371:420-432
Synthesis and anti-glioblastoma effects of artemisinin-isothiocyanate derivatives.
Nyein CM, Zhong X, Lu J, Luo H, Wang J, Rapposelli S, Li M, Ou-Yang Y, Pi R, He X
RSC advances 2018 Dec 4;8(71):40974-40983
RSC advances 2018 Dec 4;8(71):40974-40983
Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis.
Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ
Scientific reports 2017 Oct 2;7(1):12480
Scientific reports 2017 Oct 2;7(1):12480
The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells.
Horvathova I, Voigt F, Kotrys AV, Zhan Y, Artus-Revel CG, Eglinger J, Stadler MB, Giorgetti L, Chao JA
Molecular cell 2017 Nov 2;68(3):615-625.e9
Molecular cell 2017 Nov 2;68(3):615-625.e9
Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.
Zhang Q, Sivakumar S, Chen Y, Gao H, Yang L, Yuan Z, Yu H, Liu H
Current biology : CB 2017 May 22;27(10):1477-1484.e4
Current biology : CB 2017 May 22;27(10):1477-1484.e4
Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.
Matos ML, Lapyckyj L, Rosso M, Besso MJ, Mencucci MV, Briggiler CI, Giustina S, Furlong LI, Vazquez-Levin MH
Journal of cellular physiology 2017 Jun;232(6):1368-1386
Journal of cellular physiology 2017 Jun;232(6):1368-1386
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
Mayrhofer M, Gourain V, Reischl M, Affaticati P, Jenett A, Joly JS, Benelli M, Demichelis F, Poliani PL, Sieger D, Mione M
Disease models & mechanisms 2017 Jan 1;10(1):15-28
Disease models & mechanisms 2017 Jan 1;10(1):15-28
TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer.
Chen Z, Tang C, Zhu Y, Xie M, He D, Pan Q, Zhang P, Hua D, Wang T, Jin L, Qi X, Zhu Y, Yao X, Jin J, Ma X
Clinical science (London, England : 1979) 2017 Feb 1;131(3):227-237
Clinical science (London, England : 1979) 2017 Feb 1;131(3):227-237
Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133(+) cells.
Sousa AM, Rei M, Freitas R, Ricardo S, Caffrey T, David L, Almeida R, Hollingsworth MA, Santos-Silva F
Oncology letters 2016 Sep;12(3):1811-1817
Oncology letters 2016 Sep;12(3):1811-1817
Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells.
Das SK, Rehman I, Ghosh A, Sengupta S, Majumdar P, Jana B, Das BB
Nucleic acids research 2016 Sep 30;44(17):8363-75
Nucleic acids research 2016 Sep 30;44(17):8363-75
Adaptive response activated by dietary cis9, trans11 conjugated linoleic acid prevents distinct signs of gliadin-induced enteropathy in mice.
Bergamo P, Palmieri G, Cocca E, Ferrandino I, Gogliettino M, Monaco A, Maurano F, Rossi M
European journal of nutrition 2016 Mar;55(2):729-740
European journal of nutrition 2016 Mar;55(2):729-740
Increased caveolin-1 in intervertebral disc degeneration facilitates repair.
Bach FC, Zhang Y, Miranda-Bedate A, Verdonschot LC, Bergknut N, Creemers LB, Ito K, Sakai D, Chan D, Meij BP, Tryfonidou MA
Arthritis research & therapy 2016 Mar 3;18:59
Arthritis research & therapy 2016 Mar 3;18:59
The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC.
Strickland SW, Vande Pol S
Journal of virology 2016 Jun 15;90(12):5611-5621
Journal of virology 2016 Jun 15;90(12):5611-5621
Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.
Passalacqua KD, Charbonneau ME, Donato NJ, Showalter HD, Sun D, Wen B, He M, Sun H, O'Riordan MX, Wobus CE
Antimicrobial agents and chemotherapy 2016 Jul;60(7):4183-96
Antimicrobial agents and chemotherapy 2016 Jul;60(7):4183-96
Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.
Walia MK, Ho PM, Taylor S, Ng AJ, Gupte A, Chalk AM, Zannettino AC, Martin TJ, Walkley CR
eLife 2016 Apr 12;5
eLife 2016 Apr 12;5
Anti-fatigue effect of Myelophil in a chronic forced exercise mouse model.
Lee JS, Kim HG, Han JM, Kim YA, Son CG
European journal of pharmacology 2015 Oct 5;764:100-108
European journal of pharmacology 2015 Oct 5;764:100-108
Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms.
Zhang W, Pelicano H, Yin R, Zeng J, Wen T, Ding L, Huang R
Molecular medicine reports 2015 Nov;12(5):7374-88
Molecular medicine reports 2015 Nov;12(5):7374-88
The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.
Hong SS, Lee JY, Lee JS, Lee HW, Kim HG, Lee SK, Park BK, Son CG
Journal of ethnopharmacology 2015 Jun 20;168:268-78
Journal of ethnopharmacology 2015 Jun 20;168:268-78
Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts.
Lee WR, Shen SC, Shih YH, Chou CL, Tseng JT, Chin SY, Liu KH, Chen YC, Jiang MC
Journal of translational medicine 2015 Jun 13;13:191
Journal of translational medicine 2015 Jun 13;13:191
CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
Xie XJ, Hsu FN, Gao X, Xu W, Ni JQ, Xing Y, Huang L, Hsiao HC, Zheng H, Wang C, Zheng Y, Xiaoli AM, Yang F, Bondos SE, Ji JY
PLoS biology 2015 Jul;13(7):e1002207
PLoS biology 2015 Jul;13(7):e1002207
ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
Heisler DB, Kudryashova E, Grinevich DO, Suarez C, Winkelman JD, Birukov KG, Kotha SR, Parinandi NL, Vavylonis D, Kovar DR, Kudryashov DS
Science (New York, N.Y.) 2015 Jul 31;349(6247):535-9
Science (New York, N.Y.) 2015 Jul 31;349(6247):535-9
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Farhang Ghahremani M, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Canté-Barrett K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JP, Soulier J, Van Vlierberghe P, Haigh JJ
Nature communications 2015 Jan 7;6:5794
Nature communications 2015 Jan 7;6:5794
Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence.
Morancho B, Martínez-Barriocanal Á, Villanueva J, Arribas J
Breast cancer research : BCR 2015 Aug 12;17(1):106
Breast cancer research : BCR 2015 Aug 12;17(1):106
Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression.
Gracanin A, Timmermans-Sprang EP, van Wolferen ME, Rao NA, Grizelj J, Vince S, Hellmen E, Mol JA
PloS one 2014;9(6):e98698
PloS one 2014;9(6):e98698
Hematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils.
Du Roure C, Versavel A, Doll T, Cao C, Pillonel V, Matthias G, Kaller M, Spetz JF, Kopp P, Kohler H, Müller M, Matthias P
PloS one 2014;9(4):e92836
PloS one 2014;9(4):e92836
Altered migratory behavior of interneurons in a model of cortical dysplasia: the influence of elevated GABAA activity.
Abbah J, Juliano SL
Cerebral cortex (New York, N.Y. : 1991) 2014 Sep;24(9):2297-308
Cerebral cortex (New York, N.Y. : 1991) 2014 Sep;24(9):2297-308
The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70.
Roufayel R, Johnston DS, Mosser DD
Cell death & disease 2014 Nov 27;5(11):e1546
Cell death & disease 2014 Nov 27;5(11):e1546
Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.
Hessel S, Gottschalk C, Schumann D, These A, Preiss-Weigert A, Lampen A
Molecular nutrition & food research 2014 May;58(5):995-1004
Molecular nutrition & food research 2014 May;58(5):995-1004
Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice.
Ceci C, Mela V, Macrì S, Marco EM, Viveros MP, Laviola G
Psychopharmacology 2014 May;231(10):2131-44
Psychopharmacology 2014 May;231(10):2131-44
WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition.
Hamilton DH, Huang B, Fernando RI, Tsang KY, Palena C
Cancer research 2014 May 1;74(9):2510-9
Cancer research 2014 May 1;74(9):2510-9
Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier.
Ehlers A, These A, Hessel S, Preiss-Weigert A, Lampen A
Toxicology letters 2014 Mar 3;225(2):311-7
Toxicology letters 2014 Mar 3;225(2):311-7
Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model.
Groeneweg JW, Hall TR, Zhang L, Kim M, Byron VF, Tambouret R, Sathayanrayanan S, Foster R, Rueda BR, Growdon WB
Gynecologic oncology 2014 Jun;133(3):607-15
Gynecologic oncology 2014 Jun;133(3):607-15
A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.
Yuan B, Wan P, Chu D, Nie J, Cao Y, Luo W, Lu S, Chen J, Yang Z
The American journal of pathology 2014 Jul;184(7):1967-80
The American journal of pathology 2014 Jul;184(7):1967-80
eRapa restores a normal life span in a FAP mouse model.
Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD
Cancer prevention research (Philadelphia, Pa.) 2014 Jan;7(1):169-78
Cancer prevention research (Philadelphia, Pa.) 2014 Jan;7(1):169-78
Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virus.
Schmid S, Sachs D, tenOever BR
The Journal of biological chemistry 2014 Jan 3;289(1):299-311
The Journal of biological chemistry 2014 Jan 3;289(1):299-311
Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells.
McPherson LA, Shen Y, Ford JM
Cancer letters 2014 Feb 28;343(2):217-23
Cancer letters 2014 Feb 28;343(2):217-23
The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.
Bach FC, Rutten K, Hendriks K, Riemers FM, Cornelissen P, de Bruin A, Arkesteijn GJ, Wubbolts R, Horton WA, Penning LC, Tryfonidou MA
Journal of cellular physiology 2014 Dec;229(12):1999-2014
Journal of cellular physiology 2014 Dec;229(12):1999-2014
Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth.
Izzo F, Mercogliano F, Venturutti L, Tkach M, Inurrigarro G, Schillaci R, Cerchietti L, Elizalde PV, Proietti CJ
Breast cancer research : BCR 2014 Dec 6;16(6):491
Breast cancer research : BCR 2014 Dec 6;16(6):491
A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.
Zheng Y, Hsu FN, Xu W, Xie XJ, Ren X, Gao X, Ni JQ, Ji JY
Mechanisms of development 2014 Aug;133:36-53
Mechanisms of development 2014 Aug;133:36-53
A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia.
Deangelo DJ, Neuberg D, Amrein PC, Berchuck J, Wadleigh M, Sirulnik LA, Galinsky I, Golub T, Stegmaier K, Stone RM
Leukemia research 2014 Apr;38(4):430-4
Leukemia research 2014 Apr;38(4):430-4
Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.
Walline CC, Deffit SN, Wang N, Guindon LM, Crotzer VL, Liu J, Hollister K, Eisenlohr LC, Brutkiewicz RR, Kaplan MH, Blum JS
Immunology 2014 Apr;141(4):531-9
Immunology 2014 Apr;141(4):531-9
Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process.
Ardiani A, Gameiro SR, Palena C, Hamilton DH, Kwilas A, King TH, Schlom J, Hodge JW
Cancer research 2014 Apr 1;74(7):1945-57
Cancer research 2014 Apr 1;74(7):1945-57
High brain ammonia tolerance and down-regulation of Na+:K+:2Cl(-) Cotransporter 1b mRNA and protein expression in the brain of the Swamp Eel, Monopterus albus, exposed to environmental ammonia or terrestrial conditions.
Ip YK, Hou Z, Chen XL, Ong JL, Chng YR, Ching B, Hiong KC, Chew SF
PloS one 2013;8(9):e69512
PloS one 2013;8(9):e69512
Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis.
Wang SC, Yu CF, Hong JH, Tsai CS, Chiang CS
PloS one 2013;8(8):e69182
PloS one 2013;8(8):e69182
Tanshinone IIA increases the bystander effect of herpes simplex virus thymidine kinase/ganciclovir gene therapy via enhanced gap junctional intercellular communication.
Xiao J, Zhang G, Qiu P, Liu X, Wu Y, Du B, Li J, Zhou J, Li J, Tan Y
PloS one 2013;8(7):e67662
PloS one 2013;8(7):e67662
Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations.
Laviolette LA, Wilson J, Koller J, Neil C, Hulick P, Rejtar T, Karger B, Teh BT, Iliopoulos O
PloS one 2013;8(7):e66775
PloS one 2013;8(7):e66775
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
Leko V, Park GJ, Lao U, Simon JA, Bedalov A
PloS one 2013;8(6):e66283
PloS one 2013;8(6):e66283
Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion.
Gagnon H, Refaie S, Gagnon S, Desjardins R, Salzet M, Day R
PloS one 2013;8(4):e61557
PloS one 2013;8(4):e61557
Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.
Chen XL, Wee NL, Hiong KC, Ong JL, Chng YR, Ching B, Wong WP, Chew SF, Ip YK
PloS one 2013;8(12):e84298
PloS one 2013;8(12):e84298
The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
Lekawanvijit S, Kumfu S, Wang BH, Manabe M, Nishijima F, Kelly DJ, Krum H, Kompa AR
PloS one 2013;8(12):e83687
PloS one 2013;8(12):e83687
RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10,c12-conjugated linoleic acid isomer on A375 melanoma cells.
Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
PloS one 2013;8(11):e80900
PloS one 2013;8(11):e80900
Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization.
Smith NL, Abi Abdallah DS, Butcher BA, Denkers EY, Baird B, Holowka D
Frontiers in microbiology 2013;4:179
Frontiers in microbiology 2013;4:179
Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis.
Bronner DN, O'Riordan MX, He Y
Frontiers in cellular and infection microbiology 2013;3:83
Frontiers in cellular and infection microbiology 2013;3:83
Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: implications for cardiorenal syndrome.
Liu S, Kompa AR, Kumfu S, Nishijima F, Kelly DJ, Krum H, Wang BH
International journal of cardiology 2013 Oct 3;168(3):1866-80
International journal of cardiology 2013 Oct 3;168(3):1866-80
Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.
Park ES, Woods DC, Tilly JL
Fertility and sterility 2013 Nov;100(5):1468-75
Fertility and sterility 2013 Nov;100(5):1468-75
Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains.
Kumari R, Castillo C, Francesconi A
The Journal of biological chemistry 2013 Nov 1;288(44):32004-19
The Journal of biological chemistry 2013 Nov 1;288(44):32004-19
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
Cipriano R, Miskimen KL, Bryson BL, Foy CR, Bartel CA, Jackson MW
Oncotarget 2013 May;4(5):729-38
Oncotarget 2013 May;4(5):729-38
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.
Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G
The Journal of biological chemistry 2013 May 3;288(18):12967-77
The Journal of biological chemistry 2013 May 3;288(18):12967-77
Preference toward a polylysine enantiomer in inhibiting prions.
Jackson KS, Yeom J, Han Y, Bae Y, Ryou C
Amino acids 2013 Mar;44(3):993-1000
Amino acids 2013 Mar;44(3):993-1000
The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis.
Kashyap A, Zimmerman T, Ergül N, Bosserhoff A, Hartman U, Alla V, Bataille F, Galle PR, Strand S, Strand D
Oncogene 2013 Mar 14;32(11):1396-407
Oncogene 2013 Mar 14;32(11):1396-407
Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status.
Nguyen CH, Lang BJ, Chai RC, Vieusseux JL, Kouspou MM, Price JT
The Biochemical journal 2013 Jun 1;452(2):321-9
The Biochemical journal 2013 Jun 1;452(2):321-9
Galectin-7 and actin are components of amyloid deposit of localized cutaneous amyloidosis.
Miura Y, Harumiya S, Ono K, Fujimoto E, Akiyama M, Fujii N, Kawano H, Wachi H, Tajima S
Experimental dermatology 2013 Jan;22(1):36-40
Experimental dermatology 2013 Jan;22(1):36-40
Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion.
Sengupta PK, Bouchie MP, Nita-Lazar M, Yang HY, Kukuruzinska MA
Journal of cell science 2013 Jan 15;126(Pt 2):484-96
Journal of cell science 2013 Jan 15;126(Pt 2):484-96
Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.
Hessel S, John A, Seidel A, Lampen A
Archives of toxicology 2013 Feb;87(2):269-80
Archives of toxicology 2013 Feb;87(2):269-80
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies.
Morin-Brureau M, De Bock F, Lerner-Natoli M
Fluids and barriers of the CNS 2013 Feb 7;10(1):11
Fluids and barriers of the CNS 2013 Feb 7;10(1):11
Senescent human periodontal ligament fibroblasts after replicative exhaustion or ionizing radiation have a decreased capacity towards osteoblastic differentiation.
Konstantonis D, Papadopoulou A, Makou M, Eliades T, Basdra EK, Kletsas D
Biogerontology 2013 Dec;14(6):741-51
Biogerontology 2013 Dec;14(6):741-51
Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.
Iwaya T, Fukagawa T, Suzuki Y, Takahashi Y, Sawada G, Ishibashi M, Kurashige J, Sudo T, Tanaka F, Shibata K, Endo F, Katagiri H, Ishida K, Kume K, Nishizuka S, Iinuma H, Wakabayashi G, Mori M, Sasako M, Mimori K
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Dec 1;19(23):6438-49
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Dec 1;19(23):6438-49
Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate.
Lekawanvijit S, Kompa AR, Manabe M, Wang BH, Langham RG, Nishijima F, Kelly DJ, Krum H
PloS one 2012;7(7):e41281
PloS one 2012;7(7):e41281
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice.
Fukada M, Hanai A, Nakayama A, Suzuki T, Miyata N, Rodriguiz RM, Wetsel WC, Yao TP, Kawaguchi Y
PloS one 2012;7(2):e30924
PloS one 2012;7(2):e30924
Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation.
Yuan L, Hu J, Luo Y, Liu Q, Li T, Parish CR, Freeman C, Zhu X, Ma W, Hu X, Yu H, Tang S
Molecular vision 2012;18:1684-95
Molecular vision 2012;18:1684-95
Caloric restriction reduced 1, 2-dimethylhydrazine-induced aberrant crypt foci and induces the expression of Sirtuins in colonic mucosa of F344 rats.
Tomita M
Journal of carcinogenesis 2012;11:10
Journal of carcinogenesis 2012;11:10
Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells.
Le Chalony C, Hoffschir F, Gauthier LR, Gross J, Biard DS, Boussin FD, Pennaneach V
Cellular and molecular life sciences : CMLS 2012 Sep;69(17):2933-49
Cellular and molecular life sciences : CMLS 2012 Sep;69(17):2933-49
Advanced glycation end-products induce calpain-mediated degradation of ezrin.
McRobert EA, Young AN, Bach LA
The FEBS journal 2012 Sep;279(17):3240-50
The FEBS journal 2012 Sep;279(17):3240-50
Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Biswas K, Das R, Eggington JM, Qiao H, North SL, Stauffer S, Burkett SS, Martin BK, Southon E, Sizemore SC, Pruss D, Bowles KR, Roa BB, Hunter N, Tessarollo L, Wenstrup RJ, Byrd RA, Sharan SK
Human molecular genetics 2012 Sep 15;21(18):3993-4006
Human molecular genetics 2012 Sep 15;21(18):3993-4006
Effect of different durations of overdistention on rat bladder function and morphology.
Jin XD, Cao M, Zhou XL, Yin HP, Chen ZD, Xu N, Jiang H
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2012 Oct;45(10):921-8
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2012 Oct;45(10):921-8
Quantification of dystrophin immunofluorescence in dystrophinopathy muscle specimens.
Taylor LE, Kaminoh YJ, Rodesch CK, Flanigan KM
Neuropathology and applied neurobiology 2012 Oct;38(6):591-601
Neuropathology and applied neurobiology 2012 Oct;38(6):591-601
CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach.
Duckworth CA, Clyde D, Pritchard DM
American journal of physiology. Gastrointestinal and liver physiology 2012 Oct 15;303(8):G915-26
American journal of physiology. Gastrointestinal and liver physiology 2012 Oct 15;303(8):G915-26
Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer.
Jalava SE, Urbanucci A, Latonen L, Waltering KK, Sahu B, Jänne OA, Seppälä J, Lähdesmäki H, Tammela TL, Visakorpi T
Oncogene 2012 Oct 11;31(41):4460-71
Oncogene 2012 Oct 11;31(41):4460-71
Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma.
Kang Y, Yin M, Jiang W, Zhang H, Xia B, Xue Y, Huang Y
American journal of surgery 2012 Nov;204(5):677-83
American journal of surgery 2012 Nov;204(5):677-83
Heat stress induces epithelial plasticity and cell migration independent of heat shock factor 1.
Lang BJ, Nguyen L, Nguyen HC, Vieusseux JL, Chai RC, Christophi C, Fifis T, Kouspou MM, Price JT
Cell stress & chaperones 2012 Nov;17(6):765-78
Cell stress & chaperones 2012 Nov;17(6):765-78
MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells.
Tomita M, Tanaka Y, Mori N
International journal of cancer 2012 May 15;130(10):2300-9
International journal of cancer 2012 May 15;130(10):2300-9
Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome.
Lekawanvijit S, Kompa AR, Zhang Y, Wang BH, Kelly DJ, Krum H
American journal of physiology. Heart and circulatory physiology 2012 May 1;302(9):H1884-93
American journal of physiology. Heart and circulatory physiology 2012 May 1;302(9):H1884-93
Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: application to corneal disease.
You J, Hodge C, Wen L, McAvoy JW, Madigan MC, Sutton G
Experimental eye research 2012 Jun;99:55-62
Experimental eye research 2012 Jun;99:55-62
PER1 modulates SGLT1 transcription in vitro independent of E-box status.
Balakrishnan A, Stearns AT, Ashley SW, Rhoads DB, Tavakkolizadeh A
Digestive diseases and sciences 2012 Jun;57(6):1525-36
Digestive diseases and sciences 2012 Jun;57(6):1525-36
Induction of apoptosis in Eμ-myc lymphoma cells in vitro and in vivo through calpain inhibition.
Li H, Nepal RM, Martin A, Berger SA
Experimental hematology 2012 Jul;40(7):548-563.e2
Experimental hematology 2012 Jul;40(7):548-563.e2
Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model.
Wang SC, Hong JH, Hsueh C, Chiang CS
Laboratory investigation; a journal of technical methods and pathology 2012 Jan;92(1):151-62
Laboratory investigation; a journal of technical methods and pathology 2012 Jan;92(1):151-62
The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
Morandell D, Kaiser A, Herold S, Rostek U, Lechner S, Mitterberger MC, Jansen-Dürr P, Eilers M, Zwerschke W
Virology 2012 Jan 20;422(2):242-53
Virology 2012 Jan 20;422(2):242-53
Involvement of Rho kinase (ROCK) in sepsis-induced acute lung injury.
Cinel I, Ark M, Dellinger P, Karabacak T, Tamer L, Cinel L, Michael P, Hussein S, Parrillo JE, Kumar A, Kumar A
Journal of thoracic disease 2012 Feb;4(1):30-9
Journal of thoracic disease 2012 Feb;4(1):30-9
Strategic combination therapy overcomes tyrosine kinase coactivation in adrenocortical carcinoma.
Lin CI, Whang EE, Moalem J, Ruan DT
Surgery 2012 Dec;152(6):1045-50
Surgery 2012 Dec;152(6):1045-50
Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism.
Backes S, Shapiro JS, Sabin LR, Pham AM, Reyes I, Moss B, Cherry S, tenOever BR
Cell host & microbe 2012 Aug 16;12(2):200-10
Cell host & microbe 2012 Aug 16;12(2):200-10
Cell movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus.
Morita H, Kajiura-Kobayashi H, Takagi C, Yamamoto TS, Nonaka S, Ueno N
Development (Cambridge, England) 2012 Apr;139(8):1417-26
Development (Cambridge, England) 2012 Apr;139(8):1417-26
Influence of conformationally restricted pyrimidines on the activity of 10-23 DNAzymes.
Robaldo L, Izzo F, Dellafiore M, Proietti C, Elizalde PV, Montserrat JM, Iribarren AM
Bioorganic & medicinal chemistry 2012 Apr 15;20(8):2581-6
Bioorganic & medicinal chemistry 2012 Apr 15;20(8):2581-6
Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model.
Shen Y, Herde R, Doxey BW, Xu C, Gray PD, Kuwada SK
International journal of cancer 2012 Apr 1;130(7):1494-503
International journal of cancer 2012 Apr 1;130(7):1494-503
Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis.
Cheng L, Smith DJ, Anderson RL, Nagley P
PloS one 2011;6(9):e24473
PloS one 2011;6(9):e24473
Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer.
Yoffou PH, Edjekouane L, Meunier L, Tremblay A, Provencher DM, Mes-Masson AM, Carmona E
PloS one 2011;6(6):e20705
PloS one 2011;6(6):e20705
Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells.
Siltanen S, Wahlfors T, Schindler M, Saramäki OR, Mpindi JP, Latonen L, Vessella RL, Tammela TL, Kallioniemi O, Visakorpi T, Schleutker J
PloS one 2011;6(10):e26595
PloS one 2011;6(10):e26595
TNF-α-decreased thrombomodulin expression in monocytes is inhibited by propofol through regulation of tristetraprolin and human antigen R activities.
Lin FY, Tsai YT, Lee CY, Lin CY, Lin YW, Li CY, Shih CM, Huang CY, Chang NC, Tsai JC, Chen TL, Tsai CS
Shock (Augusta, Ga.) 2011 Sep;36(3):279-88
Shock (Augusta, Ga.) 2011 Sep;36(3):279-88
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
Biswas K, Das R, Alter BP, Kuznetsov SG, Stauffer S, North SL, Burkett S, Brody LC, Meyer S, Byrd RA, Sharan SK
Blood 2011 Sep 1;118(9):2430-42
Blood 2011 Sep 1;118(9):2430-42
Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone.
Leung JC, Chan LY, Tang SC, Lam MF, Chow CW, Lim AI, Lai KN
Journal of translational medicine 2011 Oct 6;9:169
Journal of translational medicine 2011 Oct 6;9:169
c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M.
Kan CE, Cipriano R, Jackson MW
Cancer research 2011 Nov 15;71(22):6930-9
Cancer research 2011 Nov 15;71(22):6930-9
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Simard N, Konforte D, Tran AH, Esufali J, Leonard WJ, Paige CJ
Journal of immunology (Baltimore, Md. : 1950) 2011 May 1;186(9):5244-53
Journal of immunology (Baltimore, Md. : 1950) 2011 May 1;186(9):5244-53
Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer.
Lin CI, Du J, Shen WT, Whang EE, Donner DB, Griff N, He F, Moore FD Jr, Clark OH, Ruan DT
The Journal of clinical endocrinology and metabolism 2011 Mar;96(3):E554-65
The Journal of clinical endocrinology and metabolism 2011 Mar;96(3):E554-65
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
Kubota Y, O'Grady P, Saito H, Takekawa M
Nature cell biology 2011 Mar;13(3):282-91
Nature cell biology 2011 Mar;13(3):282-91
Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia.
Tsumuraya T, Ishikawa C, Machijima Y, Nakachi S, Senba M, Tanaka J, Mori N
Biochemical pharmacology 2011 Mar 15;81(6):713-22
Biochemical pharmacology 2011 Mar 15;81(6):713-22
Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.
Separovic D, Joseph N, Breen P, Bielawski J, Pierce JS, Buren EV, Bhatti G, Saad ZH, Bai A, Bielawska A
Biochemical and biophysical research communications 2011 Jun 10;409(3):372-7
Biochemical and biophysical research communications 2011 Jun 10;409(3):372-7
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, Salles B, Muller C
Journal of cell science 2011 Jun 1;124(Pt 11):1943-51
Journal of cell science 2011 Jun 1;124(Pt 11):1943-51
Overexpression of HSP70 inhibits cofilin phosphorylation and promotes lymphocyte migration in heat-stressed cells.
Simard JP, Reynolds DN, Kraguljac AP, Smith GS, Mosser DD
Journal of cell science 2011 Jul 15;124(Pt 14):2367-74
Journal of cell science 2011 Jul 15;124(Pt 14):2367-74
CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.
Pfeiffer JR, McAvoy BL, Fecteau RE, Deleault KM, Brooks SA
Molecular and cellular biology 2011 Jan;31(2):277-86
Molecular and cellular biology 2011 Jan;31(2):277-86
Effects of EpCAM overexpression on human breast cancer cell lines.
Gostner JM, Fong D, Wrulich OA, Lehne F, Zitt M, Hermann M, Krobitsch S, Martowicz A, Gastl G, Spizzo G
BMC cancer 2011 Jan 31;11:45
BMC cancer 2011 Jan 31;11:45
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.
Habtezion A, Toivola DM, Asghar MN, Kronmal GS, Brooks JD, Butcher EC, Omary MB
Proceedings of the National Academy of Sciences of the United States of America 2011 Jan 25;108(4):1445-50
Proceedings of the National Academy of Sciences of the United States of America 2011 Jan 25;108(4):1445-50
Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli.
Flynn AN, Wang A, McKay DM, Buret AG
Canadian journal of physiology and pharmacology 2011 Feb;89(2):143-8
Canadian journal of physiology and pharmacology 2011 Feb;89(2):143-8
A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development.
Araki T, Kusakabe M, Nishida E
The Journal of biological chemistry 2011 Feb 25;286(8):6760-8
The Journal of biological chemistry 2011 Feb 25;286(8):6760-8
ABC50 modulates sensitivity of HL60 leukemic cells to endoplasmic reticulum (ER) stress-induced cell death.
Yu Y, Zhang Y, Zhu Z, Berger SA
Biochemical pharmacology 2011 Feb 15;81(4):488-97
Biochemical pharmacology 2011 Feb 15;81(4):488-97
Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage.
Weerasinghe SV, Moons DS, Altshuler PJ, Shah YM, Omary MB
Hepatology (Baltimore, Md.) 2011 Apr;53(4):1323-32
Hepatology (Baltimore, Md.) 2011 Apr;53(4):1323-32
Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.
Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD Jr, Ruan DT
Molecular cancer research : MCR 2010 Sep;8(9):1217-26
Molecular cancer research : MCR 2010 Sep;8(9):1217-26
Identification of tetranectin as a potential biomarker for metastatic oral cancer.
Arellano-Garcia ME, Li R, Liu X, Xie Y, Yan X, Loo JA, Hu S
International journal of molecular sciences 2010 Sep 2;11(9):3106-21
International journal of molecular sciences 2010 Sep 2;11(9):3106-21
Increased cellular apoptosis susceptibility (CSE1L/CAS) protein expression promotes protrusion extension and enhances migration of MCF-7 breast cancer cells.
Tai CJ, Shen SC, Lee WR, Liao CF, Deng WP, Chiou HY, Hsieh CI, Tung JN, Chen CS, Chiou JF, Li LT, Lin CY, Hsu CH, Jiang MC
Experimental cell research 2010 Oct 15;316(17):2969-81
Experimental cell research 2010 Oct 15;316(17):2969-81
Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.
Polo ML, Arnoni MV, Riggio M, Wargon V, Lanari C, Novaro V
PloS one 2010 May 26;5(5):e10786
PloS one 2010 May 26;5(5):e10786
Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines.
Olszewski U, Hlozek M, Hamilton G
Biochemical and biophysical research communications 2010 Mar 12;393(3):414-9
Biochemical and biophysical research communications 2010 Mar 12;393(3):414-9
Fibroblast nemosis induces angiogenic responses of endothelial cells.
Enzerink A, Rantanen V, Vaheri A
Experimental cell research 2010 Mar 10;316(5):826-35
Experimental cell research 2010 Mar 10;316(5):826-35
Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation.
Cho NL, Lin CI, Whang EE, Carothers AM, Moore FD Jr, Ruan DT
Thyroid : official journal of the American Thyroid Association 2010 Jun;20(6):615-22
Thyroid : official journal of the American Thyroid Association 2010 Jun;20(6):615-22
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.
Feng Q, Baird D, Yoo S, Antonyak M, Cerione RA
The Journal of biological chemistry 2010 Jun 11;285(24):18806-16
The Journal of biological chemistry 2010 Jun 11;285(24):18806-16
Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation.
Rivas MA, Tkach M, Beguelin W, Proietti CJ, Rosemblit C, Charreau EH, Elizalde PV, Schillaci R
Breast cancer research and treatment 2010 Jul;122(1):111-24
Breast cancer research and treatment 2010 Jul;122(1):111-24
Plasminogen stimulates propagation of protease-resistant prion protein in vitro.
Mays CE, Ryou C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):5102-12
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):5102-12
Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2.
Ark M, Ozdemir A, Polat B
Apoptosis : an international journal on programmed cell death 2010 Dec;15(12):1494-506
Apoptosis : an international journal on programmed cell death 2010 Dec;15(12):1494-506
Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells.
Tkaczyk C, Huk OL, Mwale F, Antoniou J, Zukor DJ, Petit A, Tabrizian M
Journal of biomedical materials research. Part A 2010 Aug;94(2):419-25
Journal of biomedical materials research. Part A 2010 Aug;94(2):419-25
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
Deisenroth C, Thorner AR, Enomoto T, Perou CM, Zhang Y
Molecular and cellular biology 2010 Aug;30(16):3981-93
Molecular and cellular biology 2010 Aug;30(16):3981-93
Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain.
Pichon X, Wattiez AS, Becamel C, Ehrlich I, Bockaert J, Eschalier A, Marin P, Courteix C
Molecular therapy : the journal of the American Society of Gene Therapy 2010 Aug;18(8):1462-70
Molecular therapy : the journal of the American Society of Gene Therapy 2010 Aug;18(8):1462-70
Melatonin reprogrammes proteomic profile in light-exposed retina in vivo.
Zhang R, Hrushesky WJ, Wood PA, Lee SH, Hunt RC, Jahng WJ
International journal of biological macromolecules 2010 Aug 1;47(2):255-60
International journal of biological macromolecules 2010 Aug 1;47(2):255-60
Maternal deprivation induces a rapid decline in circulating leptin levels and sexually dimorphic modifications in hypothalamic trophic factors and cell turnover.
Viveros MP, Díaz F, Mateos B, Rodríguez N, Chowen JA
Hormones and behavior 2010 Apr;57(4-5):405-14
Hormones and behavior 2010 Apr;57(4-5):405-14
Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer.
Stella Tsai CS, Chen HC, Tung JN, Tsou SS, Tsao TY, Liao CF, Chen YC, Yeh CY, Yeh KT, Jiang MC
The American journal of pathology 2010 Apr;176(4):1619-28
The American journal of pathology 2010 Apr;176(4):1619-28
Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats.
Markusic DM, de Waart DR, Seppen J
PloS one 2010 Apr 1;5(4):e9974
PloS one 2010 Apr 1;5(4):e9974
Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria.
Rodriguez ME, Zhang P, Azizuddin K, Delos Santos GB, Chiu SM, Xue LY, Berlin JC, Peng X, Wu H, Lam M, Nieminen AL, Kenney ME, Oleinick NL
Photochemistry and photobiology 2009 Sep-Oct;85(5):1189-200
Photochemistry and photobiology 2009 Sep-Oct;85(5):1189-200
IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas.
Moore LM, Holmes KM, Smith SM, Wu Y, Tchougounova E, Uhrbom L, Sawaya R, Bruner JM, Fuller GN, Zhang W
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 29;106(39):16675-9
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 29;106(39):16675-9
Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients.
Quaedackers ME, Mol W, Korevaar SS, van Gurp EA, van Ijcken WF, Chan G, Weimar W, Baan CC
Transplantation 2009 Oct 27;88(8):1002-9
Transplantation 2009 Oct 27;88(8):1002-9
Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.
Waltering KK, Helenius MA, Sahu B, Manni V, Linja MJ, Jänne OA, Visakorpi T
Cancer research 2009 Oct 15;69(20):8141-9
Cancer research 2009 Oct 15;69(20):8141-9
Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils.
Toyoda T, Tsukamoto T, Takasu S, Shi L, Hirano N, Ban H, Kumagai T, Tatematsu M
International journal of cancer 2009 Oct 15;125(8):1786-95
International journal of cancer 2009 Oct 15;125(8):1786-95
Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model.
Guo H, Leung JC, Cheung JS, Chan LY, Wu EX, Lai KN
The British journal of surgery 2009 Nov;96(11):1323-35
The British journal of surgery 2009 Nov;96(11):1323-35
Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice.
Peluso JJ, Gawkowska A, Liu X, Shioda T, Pru JK
Endocrinology 2009 Nov;150(11):4846-54
Endocrinology 2009 Nov;150(11):4846-54
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori.
Nossa CW, Jain P, Tamilselvam B, Gupta VR, Chen LF, Schreiber V, Desnoyers S, Blanke SR
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 24;106(47):19998-20003
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 24;106(47):19998-20003
Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration.
Enzerink A, Salmenperä P, Kankuri E, Vaheri A
Molecular immunology 2009 May;46(8-9):1787-95
Molecular immunology 2009 May;46(8-9):1787-95
Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis.
Leung JC, Lam MF, Tang SC, Chan LY, Tam KY, Yip TP, Lai KN
Journal of clinical immunology 2009 May;29(3):365-78
Journal of clinical immunology 2009 May;29(3):365-78
Higher prevalence of secretory CSE1L/CAS in sera of patients with metastatic cancer.
Tung MC, Tsai CS, Tung JN, Tsao TY, Chen HC, Yeh KT, Liao CF, Jiang MC
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 May;18(5):1570-7
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 May;18(5):1570-7
Intracellular adaptation of Brucella abortus.
Lamontagne J, Forest A, Marazzo E, Denis F, Butler H, Michaud JF, Boucher L, Pedro I, Villeneuve A, Sitnikov D, Trudel K, Nassif N, Boudjelti D, Tomaki F, Chaves-Olarte E, Guzmán-Verri C, Brunet S, Côté-Martin A, Hunter J, Moreno E, Paramithiotis E
Journal of proteome research 2009 Mar;8(3):1594-609
Journal of proteome research 2009 Mar;8(3):1594-609
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.
Proietti CJ, Rosemblit C, Beguelin W, Rivas MA, Díaz Flaqué MC, Charreau EH, Schillaci R, Elizalde PV
Molecular and cellular biology 2009 Mar;29(5):1249-65
Molecular and cellular biology 2009 Mar;29(5):1249-65
Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors.
Stearns AT, Balakrishnan A, Rhoads DB, Ashley SW, Tavakkolizadeh A
Surgery 2009 Mar;145(3):294-302
Surgery 2009 Mar;145(3):294-302
Identification of AML1-ETO modulators by chemical genomics.
Corsello SM, Roti G, Ross KN, Chow KT, Galinsky I, DeAngelo DJ, Stone RM, Kung AL, Golub TR, Stegmaier K
Blood 2009 Jun 11;113(24):6193-205
Blood 2009 Jun 11;113(24):6193-205
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.
Vaseva AV, Marchenko ND, Moll UM
Cell cycle (Georgetown, Tex.) 2009 Jun 1;8(11):1711-9
Cell cycle (Georgetown, Tex.) 2009 Jun 1;8(11):1711-9
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion.
Antonyak MA, Li B, Regan AD, Feng Q, Dusaban SS, Cerione RA
The Journal of biological chemistry 2009 Jul 3;284(27):17914-25
The Journal of biological chemistry 2009 Jul 3;284(27):17914-25
Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
Lin YJ, Hou YC, Lin CH, Hsu YA, Sheu JJ, Lai CH, Chen BH, Lee Chao PD, Wan L, Tsai FJ
Biochemical and biophysical research communications 2009 Jan 23;378(4):683-8
Biochemical and biophysical research communications 2009 Jan 23;378(4):683-8
SDF-1 alpha expression during wound healing in the aged is HIF dependent.
Loh SA, Chang EI, Galvez MG, Thangarajah H, El-Ftesi S, Vial IN, Lin DA, Gurtner GC
Plastic and reconstructive surgery 2009 Feb;123(2 Suppl):65S-75S
Plastic and reconstructive surgery 2009 Feb;123(2 Suppl):65S-75S
Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells.
Lin CI, Whang EE, Abramson MA, Donner DB, Bertagnolli MM, Moore FD Jr, Ruan DT
Biochemical and biophysical research communications 2009 Feb 6;379(2):626-31
Biochemical and biophysical research communications 2009 Feb 6;379(2):626-31
EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.
Naslavsky N, McKenzie J, Altan-Bonnet N, Sheff D, Caplan S
Journal of cell science 2009 Feb 1;122(Pt 3):389-400
Journal of cell science 2009 Feb 1;122(Pt 3):389-400
Autophagy: a new target for advanced papillary thyroid cancer therapy.
Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, Moore FD Jr, Ruan DT
Surgery 2009 Dec;146(6):1208-14
Surgery 2009 Dec;146(6):1208-14
Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.
Tate CM, Fishel ML, Holleran JL, Egorin MJ, Skalnik DG
DNA repair 2009 Dec 3;8(12):1411-23
DNA repair 2009 Dec 3;8(12):1411-23
Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress.
Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M
Carcinogenesis 2009 Aug;30(8):1288-97
Carcinogenesis 2009 Aug;30(8):1288-97
Classic and desmoplastic medulloblastoma: complete case reports and characterizations of two new cell lines.
Holthouse DJ, Dallas PB, Ford J, Fabian V, Murch AR, Watson M, Wong G, Bertram C, Egli S, Baker DL, Kees UR
Neuropathology : official journal of the Japanese Society of Neuropathology 2009 Aug;29(4):398-409
Neuropathology : official journal of the Japanese Society of Neuropathology 2009 Aug;29(4):398-409
p53-dependent antiproliferative and antitumor effect of novel alkyl series of diorganotin(IV) compounds.
Koch B, Basu Baul TS, Chatterjee A
Investigational new drugs 2009 Aug;27(4):319-26
Investigational new drugs 2009 Aug;27(4):319-26
Diminished intracellular invariant chain expression after vaccinia virus infection.
Wang N, Weber E, Blum JS
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1542-50
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1542-50
Expression of apoptotic tumour necrosis factor receptor-associated factor, caspase recruitment domain and cell death-inducing DFF-45 effector genes in therapy-treated renal cell carcinoma.
Rajandram R, Pat BK, Li J, Johnson DW, Gobe GC
Nephrology (Carlton, Vic.) 2009 Apr;14(2):205-12
Nephrology (Carlton, Vic.) 2009 Apr;14(2):205-12
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
Cummings CM, Bentley CA, Perdue SA, Baas PW, Singer JD
The Journal of biological chemistry 2009 Apr 24;284(17):11663-75
The Journal of biological chemistry 2009 Apr 24;284(17):11663-75
Epidermal growth factor receptor/beta-catenin/T-cell factor 4/matrix metalloproteinase 1: a new pathway for regulating keratinocyte invasiveness after UVA irradiation.
Jean C, Blanc A, Prade-Houdellier N, Ysebaert L, Hernandez-Pigeon H, Al Saati T, Haure MJ, Coluccia AM, Charveron M, Delabesse E, Laurent G
Cancer research 2009 Apr 15;69(8):3291-9
Cancer research 2009 Apr 15;69(8):3291-9
Short and long-term tumor cell responses to Aurora kinase inhibitors.
Dreier MR, Grabovich AZ, Katusin JD, Taylor WR
Experimental cell research 2009 Apr 15;315(7):1085-99
Experimental cell research 2009 Apr 15;315(7):1085-99
Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Meulle A, Salles B, Daviaud D, Valet P, Muller C
PloS one 2008;3(10):e3345
PloS one 2008;3(10):e3345
Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathway.
Horie T, Tatebayashi K, Yamada R, Saito H
Molecular and cellular biology 2008 Sep;28(17):5172-83
Molecular and cellular biology 2008 Sep;28(17):5172-83
Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization.
Marín-Briggiler CI, Veiga MF, Matos ML, Echeverría MF, Furlong LI, Vazquez-Levin MH
Molecular human reproduction 2008 Oct;14(10):561-71
Molecular human reproduction 2008 Oct;14(10):561-71
Effect of hemodialysis on hepatic cytochrome P450 functional expression.
Michaud J, Nolin TD, Naud J, Dani M, Lafrance JP, Leblond FA, Himmelfarb J, Pichette V
Journal of pharmacological sciences 2008 Oct;108(2):157-63
Journal of pharmacological sciences 2008 Oct;108(2):157-63
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Surucu B, Bozulic L, Hynx D, Parcellier A, Hemmings BA
The Journal of biological chemistry 2008 Oct 31;283(44):30025-33
The Journal of biological chemistry 2008 Oct 31;283(44):30025-33
Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV
The Journal of biological chemistry 2008 Oct 24;283(43):29532-44
The Journal of biological chemistry 2008 Oct 24;283(43):29532-44
NBS1 regulates a novel apoptotic pathway through Bax activation.
Iijima K, Muranaka C, Kobayashi J, Sakamoto S, Komatsu K, Matsuura S, Kubota N, Tauchi H
DNA repair 2008 Oct 1;7(10):1705-16
DNA repair 2008 Oct 1;7(10):1705-16
Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
Orimoto AM, Dumaresq-Doiron K, Jiang JY, Tanphaichitr N, Tsang BK, Carmona E
Endocrinology 2008 Nov;149(11):5835-47
Endocrinology 2008 Nov;149(11):5835-47
Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin(IV) compounds.
Koch B, Baul TS, Chatterjee A
Journal of applied toxicology : JAT 2008 May;28(4):430-8
Journal of applied toxicology : JAT 2008 May;28(4):430-8
CRBL cells: establishment, characterization and susceptibility to prion infection.
Mays CE, Kang HE, Kim Y, Shim SH, Bang JE, Woo HJ, Cho YH, Kim JB, Ryou C
Brain research 2008 May 7;1208:170-80
Brain research 2008 May 7;1208:170-80
Estrogen induces rapid translocation of estrogen receptor beta, but not estrogen receptor alpha, to the neuronal plasma membrane.
Sheldahl LC, Shapiro RA, Bryant DN, Koerner IP, Dorsa DM
Neuroscience 2008 May 15;153(3):751-61
Neuroscience 2008 May 15;153(3):751-61
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P
Molecular and cellular biology 2008 Mar;28(5):1688-701
Molecular and cellular biology 2008 Mar;28(5):1688-701
Mitogen-stimulated and rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells.
Wilson-O'Brien AL, Dehaan CL, Rogers S
Endocrinology 2008 Mar;149(3):917-24
Endocrinology 2008 Mar;149(3):917-24
Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance.
Venojärvi M, Aunola S, Puhke R, Marniemi J, Hämäläinen H, Halonen JP, Lindström J, Rastas M, Hällsten K, Nuutila P, Hänninen O, Atalay M
BMC endocrine disorders 2008 Mar 27;8:3
BMC endocrine disorders 2008 Mar 27;8:3
Lithium treatment decreases activities of tau kinases in a murine model of senescence.
Tajes M, Gutierrez-Cuesta J, Folch J, Ferrer I, Caballero B, Smith MA, Casadesus G, Camins A, Pallás M
Journal of neuropathology and experimental neurology 2008 Jun;67(6):612-23
Journal of neuropathology and experimental neurology 2008 Jun;67(6):612-23
Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose cotransporter (SGLT1).
Balakrishnan A, Stearns AT, Rounds J, Irani J, Giuffrida M, Rhoads DB, Ashley SW, Tavakkolizadeh A
Surgery 2008 Jun;143(6):813-8
Surgery 2008 Jun;143(6):813-8
Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot study.
Kralova A, Svetlikova M, Madar J, Ulcova-Gallova Z, Bukovsky A, Peknicova J
Reproductive biology and endocrinology : RB&E 2008 Jul 2;6:27
Reproductive biology and endocrinology : RB&E 2008 Jul 2;6:27
Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA--role of MAPK and NF-kappaB.
Leung JC, Tang SC, Chan LY, Chan WL, Lai KN
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Jan;23(1):72-81
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Jan;23(1):72-81
Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells.
Tian Z, Shen J, Moseman AP, Yang Q, Yang J, Xiao P, Wu E, Kohane IS
International journal of cancer 2008 Jan 1;122(1):31-8
International journal of cancer 2008 Jan 1;122(1):31-8
Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine.
Subramanian S, Rhodes JM, Hart CA, Tam B, Roberts CL, Smith SL, Corkill JE, Winstanley C, Virji M, Campbell BJ
Inflammatory bowel diseases 2008 Feb;14(2):162-75
Inflammatory bowel diseases 2008 Feb;14(2):162-75
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.
Fishel ML, He Y, Reed AM, Chin-Sinex H, Hutchins GD, Mendonca MS, Kelley MR
DNA repair 2008 Feb 1;7(2):177-86
DNA repair 2008 Feb 1;7(2):177-86
Nemosis of fibroblasts is inhibited by benign HaCaT keratinocytes but promoted by malignant HaCaT cells.
Räsänen K, Salmenperä P, Baumann M, Virtanen I, Vaheri A
Molecular oncology 2008 Dec;2(4):340-8
Molecular oncology 2008 Dec;2(4):340-8
Oocyte selection is concurrent with meiosis resumption in the coenocystic oogenesis of Oikopleura.
Ganot P, Moosmann-Schulmeister A, Thompson EM
Developmental biology 2008 Dec 15;324(2):266-76
Developmental biology 2008 Dec 15;324(2):266-76
Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.
Ishikawa C, Tafuku S, Kadekaru T, Sawada S, Tomita M, Okudaira T, Nakazato T, Toda T, Uchihara JN, Taira N, Ohshiro K, Yasumoto T, Ohta T, Mori N
International journal of cancer 2008 Dec 1;123(11):2702-12
International journal of cancer 2008 Dec 1;123(11):2702-12
(-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells.
Chen CY, Liu TZ, Tseng WC, Lu FJ, Hung RP, Chen CH, Chen CH
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008 Aug;46(8):2694-702
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008 Aug;46(8):2694-702
Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control.
Langham RG, Kelly DJ, Gow RM, Zhang Y, Cox AJ, Qi W, Thai K, Pollock CA, Christensen PK, Parving HH, Gilbert RE
Diabetologia 2008 Apr;51(4):668-74
Diabetologia 2008 Apr;51(4):668-74
Hepatocyte growth factor improves viability after H2O2-induced toxicity in bile duct epithelial cells.
Arends B, Slump E, Spee B, Rothuizen J, Penning LC
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2008 Apr;147(3):324-30
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2008 Apr;147(3):324-30
Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment.
Montero Girard G, Vanzulli SI, Cerliani JP, Bottino MC, Bolado J, Vela J, Becu-Villalobos D, Benavides F, Gutkind S, Patel V, Molinolo A, Lanari C
Breast cancer research : BCR 2007;9(2):R22
Breast cancer research : BCR 2007;9(2):R22
Influence of warm ischemia time on peripheral-type benzodiazepine receptor: a new aspect of the role of mitochondria.
Doucet C, Zhang K, Desurmont T, Hebrard W, Scepi M, Nadeau C, Cau J, Leyre P, Febrer G, Carretier M, Richer JP, Papadopoulos V, Hauet T, Burucoa C, Goujon JM
Nephron. Experimental nephrology 2007;107(1):e1-11
Nephron. Experimental nephrology 2007;107(1):e1-11
Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling.
Hall KJ, Jones ML, Poole AW
The Biochemical journal 2007 Sep 15;406(3):501-9
The Biochemical journal 2007 Sep 15;406(3):501-9
Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysis.
Guo H, Leung JC, Lam MF, Chan LY, Tsang AW, Lan HY, Lai KN
Journal of the American Society of Nephrology : JASN 2007 Oct;18(10):2689-703
Journal of the American Society of Nephrology : JASN 2007 Oct;18(10):2689-703
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Takami T, Kaposi-Novak P, Uchida K, Gomez-Quiroz LE, Conner EA, Factor VM, Thorgeirsson SS
Cancer research 2007 Oct 15;67(20):9844-51
Cancer research 2007 Oct 15;67(20):9844-51
Sodium butyrate-induced death-associated protein kinase expression promote Raji cell morphological change and apoptosis by reducing FAK protein levels.
Zhang HT, Feng ZL, Wu J, Wang YJ, Guo X, Liang NC, Zhu ZY, Ma JQ
Acta pharmacologica Sinica 2007 Nov;28(11):1783-90
Acta pharmacologica Sinica 2007 Nov;28(11):1783-90
Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis.
Tian Z, Pan R, Chang Q, Si J, Xiao P, Wu E
Journal of ethnopharmacology 2007 Nov 1;114(2):227-33
Journal of ethnopharmacology 2007 Nov 1;114(2):227-33
Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells.
Ray S, Chatterjee A
International journal of radiation biology 2007 May;83(5):347-54
International journal of radiation biology 2007 May;83(5):347-54
The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.
Parikh N, Koshy C, Dhayabaran V, Perumalsamy LR, Sowdhamini R, Sarin A
BMC cell biology 2007 May 23;8:16
BMC cell biology 2007 May 23;8:16
Effect of huanglian jiedu decoction ) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats.
Chen G, Lu FE, Jin D, Xu LJ, Wang KF
Chinese journal of integrative medicine 2007 Mar;13(1):41-5
Chinese journal of integrative medicine 2007 Mar;13(1):41-5
UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.
Hernandez-Pigeon H, Jean C, Charruyer A, Haure MJ, Baudouin C, Charveron M, Quillet-Mary A, Laurent G
The Journal of biological chemistry 2007 Mar 16;282(11):8157-64
The Journal of biological chemistry 2007 Mar 16;282(11):8157-64
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE
The Journal of biological chemistry 2007 Mar 16;282(11):7825-32
The Journal of biological chemistry 2007 Mar 16;282(11):7825-32
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma.
Frederick BA, Helfrich BA, Coldren CD, Zheng D, Chan D, Bunn PA Jr, Raben D
Molecular cancer therapeutics 2007 Jun;6(6):1683-91
Molecular cancer therapeutics 2007 Jun;6(6):1683-91
Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.
Carnevale RP, Proietti CJ, Salatino M, Urtreger A, Peluffo G, Edwards DP, Boonyaratanakornkit V, Charreau EH, Bal de Kier Joffé E, Schillaci R, Elizalde PV
Molecular endocrinology (Baltimore, Md.) 2007 Jun;21(6):1335-58
Molecular endocrinology (Baltimore, Md.) 2007 Jun;21(6):1335-58
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
Rigau V, Morin M, Rousset MC, de Bock F, Lebrun A, Coubes P, Picot MC, Baldy-Moulinier M, Bockaert J, Crespel A, Lerner-Natoli M
Brain : a journal of neurology 2007 Jul;130(Pt 7):1942-56
Brain : a journal of neurology 2007 Jul;130(Pt 7):1942-56
Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8+ cells and prolongs cardiac allograft survival.
Oshima K, Cui G, Tung T, Okotie O, Laks H, Sen L
American journal of physiology. Heart and circulatory physiology 2007 Jan;292(1):H277-84
American journal of physiology. Heart and circulatory physiology 2007 Jan;292(1):H277-84
Analysis of mitotic phosphorylation of borealin.
Kaur H, Stiff AC, Date DA, Taylor WR
BMC cell biology 2007 Jan 22;8:5
BMC cell biology 2007 Jan 22;8:5
Prolactin stimulates prostate cell proliferation by increasing endoplasmic reticulum content due to SERCA 2b over-expression.
Crépin A, Bidaux G, Vanden-Abeele F, Dewailly E, Goffin V, Prevarskaya N, Slomianny C
The Biochemical journal 2007 Jan 1;401(1):49-55
The Biochemical journal 2007 Jan 1;401(1):49-55
Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance.
Hsu CW, Yeh CT, Chang ML, Liaw YF
Gastroenterology 2007 Feb;132(2):543-50
Gastroenterology 2007 Feb;132(2):543-50
Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.
Zhong B, Strnad P, Toivola DM, Tao GZ, Ji X, Greenberg HB, Omary MB
Molecular biology of the cell 2007 Dec;18(12):4969-78
Molecular biology of the cell 2007 Dec;18(12):4969-78
Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.
Wu TC, Chen YH, Leu HB, Chen YL, Lin FY, Lin SJ, Chen JW
Free radical biology & medicine 2007 Dec 1;43(11):1508-22
Free radical biology & medicine 2007 Dec 1;43(11):1508-22
Heavy ion beams induce survivin expression in human hepatoma SMMC-7721 cells more effectively than X-rays.
Gong L, Jin X, Li Q, Liu J, An L
Acta biochimica et biophysica Sinica 2007 Aug;39(8):575-82
Acta biochimica et biophysica Sinica 2007 Aug;39(8):575-82
P53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury.
Kailong L, Du X, Yani H, Lin Z, Jvrong Y, Ruihua S, Lin C
Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 2007 Aug;31(2):213-23
Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 2007 Aug;31(2):213-23
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.
Stegmaier K, Wong JS, Ross KN, Chow KT, Peck D, Wright RD, Lessnick SL, Kung AL, Golub TR
PLoS medicine 2007 Apr;4(4):e122
PLoS medicine 2007 Apr;4(4):e122
Inhibition of NAD(P)H oxidase reduces fibronectin expression in stroke-prone renovascular hypertensive rat brain.
Cui C, Chen AF, Jiang Z, Wu Q, Lin J, Wen H, Zeng J
Clinical and experimental pharmacology & physiology 2007 Apr;34(4):304-9
Clinical and experimental pharmacology & physiology 2007 Apr;34(4):304-9
Morphologic, phenotypic and functional characteristics of endothelial cells derived from human hepatic cavernous hemangioma.
Zhang WJ, Ye LY, Wu LQ, Xin YL, Gu F, Niu JX, Yang ZH, Zhu GJ, Grau GE, Lou JN
Journal of vascular research 2006;43(6):522-32
Journal of vascular research 2006;43(6):522-32
A comparison of enhanced green fluorescent protein expression induced by immediate-early cytomegalovirus (IE-CMV) and gG pseudorabies virus (gG-PRV) promoters, using pseudorabies virus amplicons as vectors.
Muñoz AL, Prieto C, Tabarés E
Journal of virological methods 2006 Sep;136(1-2):257-60
Journal of virological methods 2006 Sep;136(1-2):257-60
Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.
Drouet J, Frit P, Delteil C, de Villartay JP, Salles B, Calsou P
The Journal of biological chemistry 2006 Sep 22;281(38):27784-93
The Journal of biological chemistry 2006 Sep 22;281(38):27784-93
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma.
Rudelius M, Pittaluga S, Nishizuka S, Pham TH, Fend F, Jaffe ES, Quintanilla-Martinez L, Raffeld M
Blood 2006 Sep 1;108(5):1668-76
Blood 2006 Sep 1;108(5):1668-76
Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemia.
Boag JM, Beesley AH, Firth MJ, Freitas JR, Ford J, Hoffmann K, Cummings AJ, de Klerk NH, Kees UR
Leukemia 2006 Oct;20(10):1731-7
Leukemia 2006 Oct;20(10):1731-7
ERK contributes to the effects of Smad signaling on oxidized LDL-induced PAI-1 expression in human mesangial cells.
Hong HK, Song CY, Kim BC, Lee HS
Translational research : the journal of laboratory and clinical medicine 2006 Oct;148(4):171-9
Translational research : the journal of laboratory and clinical medicine 2006 Oct;148(4):171-9
Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells.
Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):5041-50
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):5041-50
Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability.
Gavarini S, Bécamel C, Altier C, Lory P, Poncet J, Wijnholds J, Bockaert J, Marin P
Molecular biology of the cell 2006 Nov;17(11):4619-31
Molecular biology of the cell 2006 Nov;17(11):4619-31
Role of parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure.
Michaud J, Naud J, Chouinard J, Désy F, Leblond FA, Desbiens K, Bonnardeaux A, Pichette V
Journal of the American Society of Nephrology : JASN 2006 Nov;17(11):3041-8
Journal of the American Society of Nephrology : JASN 2006 Nov;17(11):3041-8
Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin.
Hernandez-Pigeon H, Jean C, Charruyer A, Haure MJ, Titeux M, Tonasso L, Quillet-Mary A, Baudouin C, Charveron M, Laurent G
The Journal of biological chemistry 2006 May 12;281(19):13525-13532
The Journal of biological chemistry 2006 May 12;281(19):13525-13532
Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/Fas ligand cytotoxic pathway.
Schillaci R, Salatino M, Cassataro J, Proietti CJ, Giambartolomei GH, Rivas MA, Carnevale RP, Charreau EH, Elizalde PV
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3426-37
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3426-37
Cyclopedic protein expression analysis of cultured canine mammary gland adenocarcinoma cells from six tumours.
Nakagawa T, Watanabe M, Ohashi E, Uyama R, Takauji S, Mochizuki M, Nishimura R, Ogawa H, Sugano S, Sasaki N
Research in veterinary science 2006 Jun;80(3):317-23
Research in veterinary science 2006 Jun;80(3):317-23
Stellettin A induces oxidative stress and apoptosis in HL-60 human leukemia and LNCaP prostate cancer cell lines.
Liu WK, Cheung FW, Che CT
Journal of natural products 2006 Jun;69(6):934-7
Journal of natural products 2006 Jun;69(6):934-7
Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell.
Leung JC, Chan LY, Tang SC, Chu KM, Lai KN
Kidney international 2006 Jun;69(11):2078-86
Kidney international 2006 Jun;69(11):2078-86
Effect of cobalt and chromium ions on human MG-63 osteoblasts in vitro: morphology, cytotoxicity, and oxidative stress.
Fleury C, Petit A, Mwale F, Antoniou J, Zukor DJ, Tabrizian M, Huk OL
Biomaterials 2006 Jun;27(18):3351-60
Biomaterials 2006 Jun;27(18):3351-60
Introduction of the MASH1 gene into mouse embryonic stem cells leads to differentiation of motoneuron precursors lacking Nogo receptor expression that can be applicable for transplantation to spinal cord injury.
Hamada M, Yoshikawa H, Ueda Y, Kurokawa MS, Watanabe K, Sakakibara M, Tadokoro M, Akashi K, Aoki H, Suzuki N
Neurobiology of disease 2006 Jun;22(3):509-22
Neurobiology of disease 2006 Jun;22(3):509-22
Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.
Zhang M, Haapasalo A, Kim DY, Ingano LA, Pettingell WH, Kovacs DM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jun;20(8):1176-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jun;20(8):1176-8
Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.
Foglietti C, Filocamo G, Cundari E, De Rinaldis E, Lahm A, Cortese R, Steinkühler C
The Journal of biological chemistry 2006 Jun 30;281(26):17968-76
The Journal of biological chemistry 2006 Jun 30;281(26):17968-76
The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?
Barker CR, Hamlett J, Pennington SR, Burrows F, Lundgren K, Lough R, Watson AJ, Jenkins JR
International journal of cancer 2006 Jun 1;118(11):2685-93
International journal of cancer 2006 Jun 1;118(11):2685-93
Stress response in mesoangioblast stem cells.
Geraci F, Turturici G, Galli D, Cossu G, Giudice G, Sconzo G
Cell death and differentiation 2006 Jul;13(7):1057-63
Cell death and differentiation 2006 Jul;13(7):1057-63
Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir.
Dewan MZ, Uchihara JN, Terashima K, Honda M, Sata T, Ito M, Fujii N, Uozumi K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N
Blood 2006 Jan 15;107(2):716-24
Blood 2006 Jan 15;107(2):716-24
Improved surgical mesh integration into the rat abdominal wall with arginine administration.
Arbos MA, Ferrando JM, Quiles MT, Vidal J, López-Cano M, Gil J, Manero JM, Peña J, Huguet P, Schwartz-Riera S, Reventós J, Armengol M
Biomaterials 2006 Feb;27(5):758-68
Biomaterials 2006 Feb;27(5):758-68
Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils.
El Kebir D, József L, Khreiss T, Filep JG
Cellular signalling 2006 Dec;18(12):2302-13
Cellular signalling 2006 Dec;18(12):2302-13
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation.
Salatino M, Beguelin W, Peters MG, Carnevale R, Proietti CJ, Galigniana MD, Vedoy CG, Schillaci R, Charreau EH, Sogayar MC, Elizalde PV
Oncogene 2006 Dec 14;25(59):7723-39
Oncogene 2006 Dec 14;25(59):7723-39
Cobalt and chromium ions induce nitration of proteins in human U937 macrophages in vitro.
Petit A, Mwale F, Tkaczyk C, Antoniou J, Zukor DJ, Huk OL
Journal of biomedical materials research. Part A 2006 Dec 1;79(3):599-605
Journal of biomedical materials research. Part A 2006 Dec 1;79(3):599-605
Lineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors.
Bottardi S, Ross J, Pierre-Charles N, Blank V, Milot E
The EMBO journal 2006 Aug 9;25(15):3586-95
The EMBO journal 2006 Aug 9;25(15):3586-95
Proteomic analysis of Caco-2 cells treated with monacolin K.
Lin WY, Song CY, Pan TM
Journal of agricultural and food chemistry 2006 Aug 23;54(17):6192-200
Journal of agricultural and food chemistry 2006 Aug 23;54(17):6192-200
N-glycosylation affects the molecular organization and stability of E-cadherin junctions.
Liwosz A, Lei T, Kukuruzinska MA
The Journal of biological chemistry 2006 Aug 11;281(32):23138-49
The Journal of biological chemistry 2006 Aug 11;281(32):23138-49
Overexpression of EIF3S3 promotes cancer cell growth.
Savinainen KJ, Helenius MA, Lehtonen HJ, Visakorpi T
The Prostate 2006 Aug 1;66(11):1144-50
The Prostate 2006 Aug 1;66(11):1144-50
Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy.
Blehm KN, Spiess PE, Bondaruk JE, Dujka ME, Villares GJ, Zhao YJ, Bogler O, Aldape KD, Grossman HB, Adam L, McConkey DJ, Czerniak BA, Dinney CP, Bar-Eli M
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Aug 1;12(15):4671-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Aug 1;12(15):4671-7
TFAR19 gene changes the biophysical properties of murine erythroleukemia cells.
Gu L, Jiang Y, Wang Y, Yao W, Sun D, Ka W, Tang Z, Xu X, Wen Z, Chien S
Cell biochemistry and biophysics 2005;43(3):355-63
Cell biochemistry and biophysics 2005;43(3):355-63
The effect of isoforms of the cell polarity protein, human ASIP, on the cell cycle and Fas/FasL-mediated apoptosis in human hepatoma cells.
Hu Y, Fang C, Xu Y
Cellular and molecular life sciences : CMLS 2005 Sep;62(17):1974-83
Cellular and molecular life sciences : CMLS 2005 Sep;62(17):1974-83
Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis.
Leroy I, de Thonel A, Laurent G, Quillet-Mary A
Cellular signalling 2005 Sep;17(9):1149-57
Cellular signalling 2005 Sep;17(9):1149-57
Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor.
Hamdi HK, Castellon R
Biochemical and biophysical research communications 2005 Sep 2;334(3):769-78
Biochemical and biophysical research communications 2005 Sep 2;334(3):769-78
Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinases.
Luo L, Petit A, Antoniou J, Zukor DJ, Huk OL, Liu RC, Winnik FM, Mwale F
Biomaterials 2005 Oct;26(28):5587-93
Biomaterials 2005 Oct;26(28):5587-93
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y
Molecular and cellular biology 2005 Oct;25(20):8925-37
Molecular and cellular biology 2005 Oct;25(20):8925-37
Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
Usubütün A, Karaman N, Ayhan A, Küçükali T
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2005 Oct;24(4):352-4
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2005 Oct;24(4):352-4
Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo.
Howard BA, Furumai R, Campa MJ, Rabbani ZN, Vujaskovic Z, Wang XF, Patz EF Jr
Cancer research 2005 Oct 1;65(19):8853-60
Cancer research 2005 Oct 1;65(19):8853-60
Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.
Thebault S, Lemonnier L, Bidaux G, Flourakis M, Bavencoffe A, Gordienko D, Roudbaraki M, Delcourt P, Panchin Y, Shuba Y, Skryma R, Prevarskaya N
The Journal of biological chemistry 2005 Nov 25;280(47):39423-35
The Journal of biological chemistry 2005 Nov 25;280(47):39423-35
Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast cancer cells transfected with progesterone receptor.
Leo JC, Wang SM, Guo CH, Aw SE, Zhao Y, Li JM, Hui KM, Lin VC
International journal of cancer 2005 Nov 20;117(4):561-8
International journal of cancer 2005 Nov 20;117(4):561-8
Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.
Stankiewicz AR, Lachapelle G, Foo CP, Radicioni SM, Mosser DD
The Journal of biological chemistry 2005 Nov 18;280(46):38729-39
The Journal of biological chemistry 2005 Nov 18;280(46):38729-39
RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance.
Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 May 1;11(9):3433-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 May 1;11(9):3433-8
HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion.
Lokeshwar VB, Cerwinka WH, Lokeshwar BL
Cancer research 2005 Mar 15;65(6):2243-50
Cancer research 2005 Mar 15;65(6):2243-50
Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.
Bidaux G, Roudbaraki M, Merle C, Crépin A, Delcourt P, Slomianny C, Thebault S, Bonnal JL, Benahmed M, Cabon F, Mauroy B, Prevarskaya N
Endocrine-related cancer 2005 Jun;12(2):367-82
Endocrine-related cancer 2005 Jun;12(2):367-82
Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages.
Petit A, Mwale F, Tkaczyk C, Antoniou J, Zukor DJ, Huk OL
Biomaterials 2005 Jul;26(21):4416-22
Biomaterials 2005 Jul;26(21):4416-22
Effect of glycine on recovery of bladder smooth muscle contractility after acute urinary retention in rats.
Hong SK, Son H, Kim SW, Oh SJ, Choi H
BJU international 2005 Dec;96(9):1403-8
BJU international 2005 Dec;96(9):1403-8
Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment.
Spee B, Penning LC, van den Ingh TS, Arends B, Ijzer J, van Sluijs FJ, Rothuizen J
Comparative hepatology 2005 Dec 7;4:7
Comparative hepatology 2005 Dec 7;4:7
EphA2 as a glioma-associated antigen: a novel target for glioma vaccines.
Hatano M, Eguchi J, Tatsumi T, Kuwashima N, Dusak JE, Kinch MS, Pollack IF, Hamilton RL, Storkus WJ, Okada H
Neoplasia (New York, N.Y.) 2005 Aug;7(8):717-22
Neoplasia (New York, N.Y.) 2005 Aug;7(8):717-22
Histone H4 post-translational modifications in chordate mitotic and endoreduplicative cell cycles.
Spada F, Chioda M, Thompson EM
Journal of cellular biochemistry 2005 Aug 1;95(5):885-901
Journal of cellular biochemistry 2005 Aug 1;95(5):885-901
Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter.
Markusic D, Oude-Elferink R, Das AT, Berkhout B, Seppen J
Nucleic acids research 2005 Apr 4;33(6):e63
Nucleic acids research 2005 Apr 4;33(6):e63
Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication.
Domitrovich AM, Diebel KW, Ali N, Sarker S, Siddiqui A
Virology 2005 Apr 25;335(1):72-86
Virology 2005 Apr 25;335(1):72-86
Proteolytic processing of TGFalpha redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine.
Roh M, Paterson AJ, Liu K, McAndrew J, Chin E, Kudlow JE
Biochimica et biophysica acta 2005 Apr 15;1743(3):231-42
Biochimica et biophysica acta 2005 Apr 15;1743(3):231-42
Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism.
Sainz RM, Mayo JC, Tan DX, León J, Manchester L, Reiter RJ
The Prostate 2005 Apr 1;63(1):29-43
The Prostate 2005 Apr 1;63(1):29-43
Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax.
Mori N, Krensky AM, Ohshima K, Tomita M, Matsuda T, Ohta T, Yamada Y, Tomonaga M, Ikeda S, Yamamoto N
International journal of cancer 2004 Sep 10;111(4):548-57
International journal of cancer 2004 Sep 10;111(4):548-57
Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer.
Duxbury MS, Matros E, Ito H, Zinner MJ, Ashley SW, Whang EE
Annals of surgery 2004 Oct;240(4):667-74; discussion 675-6
Annals of surgery 2004 Oct;240(4):667-74; discussion 675-6
The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein.
Tomita M, Choe J, Tsukazaki T, Mori N
Oncogene 2004 Oct 28;23(50):8272-81
Oncogene 2004 Oct 28;23(50):8272-81
Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2.
Ito H, Duxbury M, Benoit E, Clancy TE, Zinner MJ, Ashley SW, Whang EE
Cancer research 2004 Oct 15;64(20):7439-46
Cancer research 2004 Oct 15;64(20):7439-46
Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes.
Wang Y, Thuillier R, Culty M
Biology of reproduction 2004 Nov;71(5):1652-64
Biology of reproduction 2004 Nov;71(5):1652-64
Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells.
Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE
Surgery 2004 May;135(5):555-62
Surgery 2004 May;135(5):555-62
CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells.
Duxbury MS, Ito H, Ashley SW, Whang EE
The Journal of biological chemistry 2004 May 28;279(22):23176-82
The Journal of biological chemistry 2004 May 28;279(22):23176-82
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
Bukczynska P, Klingler-Hoffmann M, Mitchelhill KI, Lam MH, Ciccomancini M, Tonks NK, Sarcevic B, Kemp BE, Tiganis T
The Biochemical journal 2004 Jun 15;380(Pt 3):939-49
The Biochemical journal 2004 Jun 15;380(Pt 3):939-49
CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells.
Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE
Oncogene 2004 Jan 15;23(2):465-73
Oncogene 2004 Jan 15;23(2):465-73
Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line.
Guan J, Chen XP, Zhu H, Luo SF, Cao B, Ding L
World journal of gastroenterology 2004 Dec 1;10(23):3522-7
World journal of gastroenterology 2004 Dec 1;10(23):3522-7
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Rinne M, Caldwell D, Kelley MR
Molecular cancer therapeutics 2004 Aug;3(8):955-67
Molecular cancer therapeutics 2004 Aug;3(8):955-67
Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness.
Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE
Biochemical and biophysical research communications 2004 Aug 6;320(4):1096-102
Biochemical and biophysical research communications 2004 Aug 6;320(4):1096-102
Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation.
Zhong B, Zhou Q, Toivola DM, Tao GZ, Resurreccion EZ, Omary MB
Journal of cell science 2004 Apr 1;117(Pt 9):1709-19
Journal of cell science 2004 Apr 1;117(Pt 9):1709-19
Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury.
Tao GZ, Toivola DM, Zhong B, Michie SA, Resurreccion EZ, Tamai Y, Taketo MM, Omary MB
Journal of cell science 2003 Nov 15;116(Pt 22):4629-38
Journal of cell science 2003 Nov 15;116(Pt 22):4629-38
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Onclercq-Delic R, Calsou P, Delteil C, Salles B, Papadopoulo D, Amor-Guéret M
Nucleic acids research 2003 Nov 1;31(21):6272-82
Nucleic acids research 2003 Nov 1;31(21):6272-82
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Zayed H, Izsvák Z, Khare D, Heinemann U, Ivics Z
Nucleic acids research 2003 May 1;31(9):2313-22
Nucleic acids research 2003 May 1;31(9):2313-22
Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities.
Morita N, Yasumori T, Nakayama K
Biochemical pharmacology 2003 Jun 1;65(11):1843-52
Biochemical pharmacology 2003 Jun 1;65(11):1843-52
Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes.
Ericson KK, Krull D, Slomiany P, Grossel MJ
Molecular cancer research : MCR 2003 Jul;1(9):654-64
Molecular cancer research : MCR 2003 Jul;1(9):654-64
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Calsou P, Delteil C, Frit P, Drouet J, Salles B
Journal of molecular biology 2003 Feb 7;326(1):93-103
Journal of molecular biology 2003 Feb 7;326(1):93-103
Measles virus-induced modulation of host-cell gene expression.
Bolt G, Berg K, Blixenkrone-Møller M
The Journal of general virology 2002 May;83(Pt 5):1157-1165
The Journal of general virology 2002 May;83(Pt 5):1157-1165
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- Western blot analysis of actin was performed by loading 25 µg of various whole cell lysates and 10 µL of PageRuler Plus Prestained Protein Ladder (Product # 26619) per well onto a 4-20% Tris-HCl polyacrylamide gel. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for at least 1 hour. The membrane was probed with a pan actin monoclonal antibody (Product # MA5-11869) at a dilution of 1:3200 overnight at 4°C on a rocking platform, washed in TBS-0.1%Tween-20, and probed with HRP-conjugated goat anti-mouse IgG secondary antibody (Product # 31430) at a dilution of 1:40,000 for at least 1 hour. Chemiluminescent detection was performed using SuperSignal West Pico (Product # 34080).
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- Western blot of Actin pan using Actin pan Monoclonal Antibody (Product # MA5-11869) on HeLa Cells.
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- Western blot analysis of actin was performed by loading 25 µg of various whole cell lysates and 10 µL of PageRuler Plus Prestained Protein Ladder (Product # 26619) per well onto a 4-20% Tris-HCl polyacrylamide gel. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for at least 1 hour. The membrane was probed with a pan actin monoclonal antibody (Product # MA5-11869) at a dilution of 1:3200 overnight at 4°C on a rocking platform, washed in TBS-0.1%Tween-20, and probed with HRP-conjugated goat anti-mouse IgG secondary antibody (Product # 31430) at a dilution of 1:40,000 for at least 1 hour. Chemiluminescent detection was performed using SuperSignal West Pico (Product # 34080).
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- Western blot analysis of Actin in differentiated THP-1 macrophage lysates. The cell lysates were subjected to 12% SDS-PAGE and proteins were then transferred to PDVF membrane. The membrane was incubated with Pan-Actin monoclonal antibody (Product # MA5-11869) at 1:1000 dilution with 5% skim milk in PBST (0.1% Tween) overnight at 4 degree and then 2 h at RT with HRP-conjugated Goat anti-mouse antibody. Signal was detected by incubation of membrane with HRP substrate (Product # 34579). Data courtesy of Antibody Data Exchange Program.
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- Immunofluorescent analysis of Actin pan (green) showing staining in the cytoplasm of Hela cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with an Actin pan monoclonal antibody (Product # MA5-11869) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4 ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a fluorescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.
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- Immunofluorescent analysis of Actin pan (green) showing staining in the cytoplasm of NIH-3T3 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with an Actin pan monoclonal antibody (Product # MA5-11869) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4 ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a fluorescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.
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- Immunofluorescent analysis of Actin pan (green) showing staining in the cytoplasm of T-47D cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with an Actin pan monoclonal antibody (Product # MA5-11869) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4 ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a fluorescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.
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- Immunofluorescent analysis of actin (green) in COS7 cells. Cells were fixed and permeabilized with ice-cold methanol for 10 minutes at room temperature, and blocked with 0.3% BSA in PBS for 1 hour at room temperature. Cells were probed with a pan actin monoclonal antibody (Product # MA5-11869) at a dilution of 1:100 (right panel) or incubated in blocking buffer as a negative control (left panel) overnight at 4°C, washed with PBS, and incubated with DyLight 488 goat anti-mouse IgG secondary antibody (Product # 35502) at a dilution of 1:250 for 1 hour at room temperature. Nuclei (blue) were stained with DAPI (Product # 46190). Images were taken on a Thermo Scientific ToxInsight Instrument at 20X magnification.
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- Immunofluorescent analysis of actin (green) in COS7 cells. Cells were fixed and permeabilized with ice-cold methanol for 10 minutes at room temperature, and blocked with 0.3% BSA in PBS for 1 hour at room temperature. Cells were probed with a pan actin monoclonal antibody (Product # MA5-11869) at a dilution of 1:100 (right panel) or incubated in blocking buffer as a negative control (left panel) overnight at 4°C, washed with PBS, and incubated with DyLight 488 goat anti-mouse IgG secondary antibody (Product # 35502) at a dilution of 1:250 for 1 hour at room temperature. Nuclei (blue) were stained with DAPI (Product # 46190). Images were taken on a Thermo Scientific ToxInsight Instrument at 20X magnification.
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- Immunohistochemistry analysis of Actin pan showing positive staining in the cytoplasm of paraffin-treated Human prostate carcinoma (right) compared with a negative control in the absence of primary antibody (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Actin pan monoclonal antibody (Product # MA5-11869) diluted by 3% BSA-PBS at a dilution of 1:200 overnight at 4°C in a humidified chamber. Tissues were washed extensively PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
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- Immunohistochemistry analysis of Actin pan showing positive staining in the cytoplasm of paraffin-treated Human skeletal muscle (right) compared with a negative control in the absence of primary antibody (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Actin pan monoclonal antibody (Product # MA5-11869) diluted by 3% BSA-PBS at a dilution of 1:200 overnight at 4°C in a humidified chamber. Tissues were washed extensively PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
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- Immunohistochemistry analysis of Actin pan showing positive staining in the cytoplasm of paraffin-treated Mouse skeletal muscle (right) compared with a negative control in the absence of primary antibody (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Actin pan monoclonal antibody (Product # MA5-11869) diluted by 3% BSA-PBS at a dilution of 1:200 overnight at 4°C in a humidified chamber. Tissues were washed extensively PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
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- Immunoprecipitation of Actin pan using Actin pan Monoclonal Antibody (Product # MA5-11869) on denatured Human HeLa Cells.
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- Figure 4 Analysis of autophagy and mitochondrial dynamics in MEFs and hepatocytes in WT and Rev1 -/- cells. ( a) Analysis of autophagy by immunoblot and ( b) quantification of LC3B-II/Actin ratio in the liver of WT and Rev1 -/- 5 months old mice (females, n = 3; males n = 2). ( c) Immunoblot analysis of total and phosphorylated DRP1 (Ser616) in the liver of WT and Rev1 -/- 5 months old mice (male and females together, n = 5). ( d ) Quantification of total and phosphorylated DRP1 (Ser616) from panel ( c ). ( e ) Immunoblot with WT and Rev1 -/- MEF cells, treated with rotenone (0 muM, 2 uM and 4 uM) for 12 hrs (n = 3; df = 2). ( f) The LC3B-II/Actin ratio in untreated and treated MEF cells after 12 hrs (0 uM: t = 1, 2 uM: t = 2.2, 4 uM: t = 14). ( g , h) Analysis of total DRP1 (0 uM: t = 0.56; 2 uM: t = 5.1; 4 uM: t = 7.36) and phosphorylated DRP1 (Ser616) (0 uM: t = 3.96; 2 uM: t = 21.93; 4 uM: t = 14.14) in untreated and treated MEFs. ( i , j) Analysis of total AMPKalpha (0 uM: t = 2.09; 2 uM: t = 0.56; 4 uM: 81.52) and phospho- AMPKalpha (Thr172) (0 uM: t = 64.37; 2 uM: t = 21.2; 4 uM: t = 4.67) in untreated and treated MEFs. n = sample number; t = t value; df = degree of freedom; *p < 0.05. **p < 0.01. ***p < 0.001. ****p < 0.0001. Data presented are mean +- M.S.E. Dark bars: WT and gray bars: Rev1 -/- .
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- Fig 7 CDK8-CycC may couple nutrient intake, lipid biosynthesis, and developmental timing. (A) Model for the CDK8-SREBP/EcR regulatory network: In response to nutrient intake, CDK8-CycC may coordinately regulate lipogenesis by directly inhibiting SREBP-activated gene expression and developmental timing by activating EcR-activated gene expression during the larval-pupal transition. Arrows represent activation, and blunt arrows represent inhibition. (B) The protein levels of CDK8, CycC, SREBP, EcR-B1 and USP (upper band is the 54 kDa full-length USP) in wild-type larvae from L3 (92 hr AEL) to the WPP stage (120 hr AEL). For SREBP, the lower band (approximately 49 kDa, arrow) is the mature nuclear form, while the upper band (53-54 kDa) is the N-terminal fragment of SREBP after cleavage by the S1P (see S5B and S5C Fig for detailed analyses of these SREBP isoforms). (C-K) The mRNA levels of cdk8 , cycC , EcR , usp , E75 , E78 , SREBP , dFAS , and dACS from L3 (92 hr AEL) to the WPP stage (120 hr AEL). The black bars represent the wandering stage, while the white bars represent the WPP stage. The x -axis represents the number of hours AEL. * p < 0.05; ** p < 0.01 based on t -tests. Underlying numerical data and statistical analysis for Fig 7C, 7D, 7E, 7F, 7G, 7H, 7I, 7J, and 7K can be found in S1 Data .
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- Figure 3. Morphology, and migratory and invasive potential. Light microscopy images (x10 magnification) of HBEC3 (A) and T2-HBEC3 (B). C, E-cadherin and vimentin protein levels were analyzed in HBEC3 and T2-HBEC3 by immunoblotting. beta-actin was used as loading control. Migration and invasion were measured in a scratch wound closure assay. D, HBEC3 (*) and T2-HBEC3 (*) display significantly different migration curves. Data display wound density (percent) +- SE, n = 3. p < 0.05 (non-linear mixed effects model). E, Invasive potential of T2-HBEC3 analyzed by live cell imaging. Black lines display the original scratch wound made in the cell layer at 0 h and the white lines display the invading front of cells after 48 h.
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- Fig 4 The levels and subcellular distribution of EcR and USP in cdk8 and cycC mutants in the third instar larvae and pupae. (A) Western blot of EcR and USP in wild-type animals in early L3 (84 hr AEL), L3 wandering (112 hr AEL), white prepupal (120 hr AEL), and pupal stages (72 hr APF). (B and C) Western blot analyses of the protein levels of EcR, USP, CDK8, and CycC in cdk8 and cycC mutants at the L3 wandering stage (B) and the white prepupal stage (C). The arrows in USP blots mark the 54 kDa full-length USP, and the arrows in EcR blots indicate the EcR-B1 isoform. (D) Western blot of EcR and USP in the nuclear and cytoplasmic fractions from early third instar larvae (L3) to white prepupal stages in cdk8 or cycC mutants.
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- Fig 6 Biochemical interactions between CDK8-CycC and EcR-USP. (A) EcR-B1 co-immunoprecipitates with CDK8 in white prepupae; USP serves as the positive control. (B) USP co-immunoprecipitates with CDK8 in white prepupae; EcR serves as the positive control. (C) Mediator subunits that can co-immunoprecipitate with EcR or USP are identified by LC-MS/MS analysis. Subunits of the CDK8 submodule are shown in color. The results were combined from two biological replicates. (D) Immunoprecipitation of EcR by using anti-USP (guinea pig) antibody in white prepupae of w 1118 , cdk8 K185 , and cycC Y5 mutants, and the input is shown in (D'). (E) CDK8 has a LXXLL motif that is highly conserved from yeast to human. The LXXLL motif is highlighted in red. (F) The LXXLL motif in Med14 is conserved from Drosophila to humans, but it is not present in Caenorhabditis elegans . (G) Schematic diagram of the EcR-B1 and USP protein depicting the two activating domains (AF1 and AF2), DNA-binding domain (DBD) and the ligand-binding domains (LBD). (H) Yeast two-hybrid analyses show that EcR-AF1, but not EcR-AF2 or USP-AF1/2, can directly bind to CDK8 and Med14. Underlying numerical data and statistical analysis for Fig 6H can be found in S1 Data .
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- Fig 8 The effects of starvation on the CDK8-SREBP/EcR regulatory network and timing for the larval-pupal transition. (A) The protein levels of CDK8, CycC, mature SREBP (arrow), EcR-B1 (arrow), and USP (arrow, full-length USP) in feeding versus starved larvae from 84 hr to 100 hr AEL. (B-G) The mRNA levels of cdk8 , EcR , E74 , SREBP , dFAS , and dACS in feeding versus starved larvae from 84 hr to 100 hr AEL. The x -axis represents the number of hours AEL. * p < 0.05; ** p < 0.01 based on t -tests. (H) The effect of starvation and refeeding on the timing of the larval-pupal transition in wild-type ( w 1118 ) larvae. The larvae enter into L3 at 72 hr AEL and reach critical weight between 80 and 82 hr AEL. The larvae were starved starting 84 hr AEL and the timing of pupariation was analyzed once every two hours. For the refeeding experiments, the larvae were put back on normal food after 10 hr of starvation (94 hr AEL). Underlying numerical data and statistical analysis for Fig 8B, 8C, 8D, 8E, 8F, 8G, and 8H can be found in S1 Data .
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- Fig 9 The effects of refeeding of starved larvae on the CDK8-SREBP/EcR regulatory network. (A) The experimental scheme for the refeeding treatment. Briefly, the wild-type larvae were starved for 10 hr (from 84 hr AEL to 94 hr AEL), and they were then transferred back onto normal food. Samples were collected after 1, 2, 3, 6, 9 hr after refeeding for further analyses. (B) The protein levels of CDK8, CycC, SREBP, EcR-B1 and USP in starved versus refed larvae after 1, 2, 3 hr of refeeding. (C) The protein levels of CDK8, EcR-B1, and USP in starved versus refed larvae after 3, 6, 9 hr of refeeding. The control (anti-actin) is the same as the S12A Fig (D-H) The mRNA levels of cdk8 , EcR , SREBP , dFAS , and dACS in starved versus refed larvae after 1, 2, 3 hr of refeeding. The x -axis represents the number of hours for refeeding. * p < 0.05; ** p < 0.01 based on t -tests. Underlying numerical data and statistical analysis for Fig 9D, 9E, 9F, 9G, and 9H can be found in S1 Data .
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- Figure 3 Prostaglandin E 2 (PGE 2 ) production and inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in BV2 cells. Cell supernatant PGE 2 levels ( A ), protein expression of iNOS and COX-2 ( B ), and gene expression of iNOS and COX-2 relative to that of GAPDH ( C ) were determined using ELISA ( n = 6), Western blot ( n = 3), or real-time PCR ( n = 3) methods. Semiquantification of protein expression was performed with normalization to beta-actin ( D ). The data are expressed as the mean +- SD. # p < 0.05 and ## p < 0.01 compared with the vehicle-treated cells; * p < 0.05 and ** p < 0.01 compared with the LPS-treated BV2 cells.
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- Figure 1 BRB affects CLL cell viability. ( A ) Left: Flow cytometric dot plots of Propidium Iodide (PI) fluorescence versus Forward Light Scatter (FSC) for the determination of live (intact plasma membrane, PI negative) and dead (disrupted plasma membrane, PI positive) cells, from one CLL patient harboring 17p13 deletion. The cells were either quiescent or stimulated by CpG/ODN2006 + IL-15 and treated with BRB 10 and 20 muM for 48 h. Drug treatment of activated cells started simultaneously with stimulation. Note that the increase of FSC (i.e. cell size) after stimulation was inhibited by the presence of BRB. Right: Cell viability by the PI exclusion test is summarized for leukemic samples from 20 CLL patients, either untreated or treated with BRB at the indicated concentrations, for 48 h. Cell activation was achieved either with CD40L-NIH-3T3 + IL-4 or CpG/ODN2006 + IL-15, as indicated. BRB treatment started at stimulation time (T0), or 48 h after stimulation (T48h). Statistical significance of differences evaluated by a two- sided Wilcoxon signed rank test. ** P
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- Figure 2 Generation of liver-specific CD73-LKO mice. ( A ) PCR analysis of Nt5e generated a 349-bp fragment from the Cre-targeted allele in the CD73-LKO mouse liver. Nt5e (wt/wt) , Nt5e (fl/wt) , and Nt5e (fl/fl) mice are controls. Representative immunoblots of CD73 in ( B ) primary hepatocytes, and ( C ) in total liver lysates from male and female WT and CD73-LKO mice. Actin and tissue nonspecific alkaline phosphatase (TNAP) immunoblots serve as controls. ( D ) Semiquantitative analysis of CD73 protein expression based on immunoblot band intensities in panel C . ** P < .01, *** P < .001, 2-way analysis of variance. Error bars represent SD. ( E ) Immunofluorescence staining for CD73 (green), tight junction protein zonula occludens 1 (ZO1) (red), and 4'',6-diamidino-2-phenylindole (DAPI)-stained DNA (blue) on frozen liver tissue sections from WT ( top ) and CD73-LKO ( bottom ) mice. Scale bar : 20 mum. ( F ) AMPase activity in WT and CD73-LKO mice using formalin-fixed liver tissue sections. The brown deposits indicate ecto-AMPase activity in the presence of AMP. Stars indicate the central vein. Scale bar : 400 mum.
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- 8 FIGURE Curcumin up-regulates the relative protein expression ratio of Nuclear factor erythroid-related factor-2 (Nrf2), and Hemeoxygenase-1 (HO-1) to beta-actin, determined by Western blot analysis in liver tissues of intoxicated rats. The results are demonstrated as mean +- SE, n = 10 rats/group. C, control untreated group; CUR, curcumin-pretreated rats; APAP, acetaminophen treated rats; R, gamma-irradiated rats; R/APAP, animals exposed to gamma-irradiation then intoxicated with APAP; CUR/APAP, Curcumin pretreated rats intoxicated with APAP; CUR/R, Curcumin pretreated rats then exposed to gamma-irradiation; CUR/R/APAP, Curcumin pretreated rats, exposed to gamma-irradiation and intoxicated with APAP; a: significant to the untreated control, b: significant to APAP, c: significant to R, and d: significant to R/APAP, ( p
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- 1 FIGURE Influenza virus induces TNKS2 expression in vitro and in vivo. (a, b) A549 cells were infected with A/PR/8/34 at an MOI of 0.01 and samples were collected at 0, 24, 48 and 72 hpi. Viral NP and TNKS2 protein levels were determined by western blot and normalised to beta-actin ( N = 6). The results for TNKS2 and NP were expressed as a ratio to 0 and 24 hpi, respectively. (c, d) A549 cells were infected with A/PR/8/34 at an MOI of 0.01 for 0, 24, 48 and 72 hr and different MOI for 24 hr. Relative mRNA expression levels of TNKS2 were measured by real-time PCR and normalised to beta-actin ( N = 3). (e) A549 cells infected with different strains of IAV, including A/PR/8/34, A/WSN/33, pdm/Ok/09, and H3N2 A/OK/309/06, at MOI 0.01 for 48 hpi. Relative mRNA expression levels of TNKS2 were measured by real-time PCR and normalised to beta-actin ( N = 3). (f, g) TNKS2 protein expression in the lungs of mice infected with A/PR/8/34 (250 Pfu) at 3 and 7 days post-infection (dpi) was measured by western blot and expressed as a ratio to 0 dpi ( N = 6). All results are displayed as the mean +- SE . * p < .05, ** p < .01 vs 0 hpi, MOI 0 or Mock. One-way ANOVA followed by dunnett ' s pairwise comparison
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- 3 FIGURE miR-206 inhibits IAV replication. (a) A549 cells were co-transfected with pmirGLO-firefly-TNKS2-3'-UTR reporter plasmid and a miRNA expression plasmid or a miRNA control vector (miR-Con) for 24 hr and luciferase activities were measured. Relative firefly luciferase activities were normalised to Renilla luciferase activities and expressed as a percent of miR-Con. (b-g) HEK293 cells were transfected with a miRNA expression vector (miR-206, miR-106b) or a miRNA control vector (miR-Con) for 24 hr. The cells were then infected with A/PR/8/34 virus (MOI = 0.01) for 48 hr. (b) GPF images. (c) Real-time PCR analysis of miRNA expression normalised to U6. (d, e) Viral NP and NS1 protein expression was determined by western blot and normalised to beta-actin. (f) mRNA expression of viral genes (NP, NS1, and PB1) was determined by real-time PCR, normalised to beta-actin and expressed as a ratio to miR-Con. (g) Virus titers in the culture media were determined by TCID 50 assay. (h) HEK293 cells were transfected with a miR-206 or miR-Con plasmid (100 ng), the IAV firefly luciferase reporter plasmid vNP-luc/pHH21 (20 ng) and pRL-TK Renilla plasmid (5 ng) for 24 hr. The cells were then infected with different strains of IAV for 48 hr, including A/PR/8/34, A/WSN/33, pdm/Ok/09, and H3N2 A/OK/309/06, at MOI 0.01, 0.05, 0.005 and 0.01, respectively. Firefly luciferase activities were normalised to Renilla luciferase activity. The results of three independent experiments are displayed as
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- 6 FIGURE Adenovirus expressing miR-206 suppresses IAV infection in vivo and increases survival of IAV-infected mice. (a-h) Two days before IAV infection (-2 dpi), adenovirus expressing miR-206 (Ad-miR-206) or miR-Con (Ad-miR-Con) was delivered intratracheally into the lungs of mice. The mice were then infected intranasally with a sub-lethal dose (250 PFU/mouse) of A/PR/8/34 on day 0. Lung tissue samples were collected at 3, 7 dpi. (a) miR-206 levels were measured using real-time PCR and normalised to U6 snRNA. (b) The virus titre was determined by TCID 50 assay. (c-e) Viral NP, NS1 protein levels were determined by western blot, normalised to beta-actin. (f, g) Viral replication at 7 dpi in the alveolar regions was determined by immunofluorescent staining for NP. For each section, five pictures were taken randomly from each region with x20 magnification. Total cells and NP positive cells were counted to determine the percentage of NP positive cells. (h) The mRNA levels of viral NS1 and PB1 mRNA were determined by real-time PCR and normalised to beta-actin. The results of six animals are displayed as the mean +- SE . * p < .05, ** p < .01, (a, b, d, e, h) Two-way ANOVA followed by sidak ' s multiple comparisons , (g) Student t test . (i, j) Two days after Ad-miR-206 or Ad-miR-con delivery, mice ( N = 12 per group, female) were infected with 1x MLD50 of A/PR/8/34 in 50 mul intranasally. (i) Kaplan-Meier survival analysis of mice. (j) Clinical scores was measured daily. The resu
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- Fig. 6 Aberrant nuclear translocation of HDAC6 after stroke causes hyper-acetylation of alpha-tubulin. ( a ) Representative western blot images of the acetylated-alpha-tubulin at Lys40, alpha-tubulin and beta-actin levels at different time points after MCAO surgery. ( b ) Quantification of the acetylated-alpha-tubulin that normalized to beta-actin after MCAO surgery. n = 4 biological replicates, * p < 0.05 compared to sham operated control. ( c ) Representative western blot images of the HDAC6 distributed between cytosolic or nuclear fractions at different time points after MCAO surgery. alpha-tubulin and Lamin B1 act as the internal control for either cytosolic or nuclear fraction. ( d ) Quantification of the cytoplasmic (top) or nuclear (bottom) protein levels of HDAC6 that normalized to its internal controls at different time points after MCAO. Data are presented as mean +- SEM. n = 5, * p < 0.05 compared to sham operated control. ( e ) A cartoon model illustrates the aberrant nuclear translocation of HDAC6 after stroke that causes hyper-acetylation alpha-tubulin
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- Fig. 8 Requirement of HDAC6 in rehabilitation therapy induced functional recovery. ( a ) Schematic illustration the procedure for studying HDAC6 in rehabilitation therapy induced reversal of dendritic phenotypes. ( b ) Schematic illustration the procedure for studying HDAC6 in rehabilitation therapy induced long term functional recovery after MCAO. ( c ) Representative western blot images and quantification of the acetylated-alpha-tubulin that normalized to beta-actin from different experimental groups. n = 5 biological replicates, * p < 0.05. ( d ) Representative images of the newly generated neurons for their dendritic elaboration at 14 dpi. ""Rehab"" indicates the rehabilitation therapy for the mice. The scale bar is 25 mum. ( e ) Quantification of total dendritic length and the number of dendritic branches of individual newborn neurons at 14 dpi from different groups. Data are presented as mean +- SEM. n = 20 to 40 cells from four mice, one-way ANOVA with Bonferroni's post hoc analysis. * p < 0.05. ( f ) Behavioral performance of adhesive removal task. Two-way ANOVA analysis showed significant difference between the treatments ( p < 0.001) and Bonferroni's post hoc: p < 0.05 for the time points of 28 days for the MCAO+Rehab vs. MCAO+Rehab+ACY-738. ( g ) Object location memory test before or days after MCAO. Two-way ANOVA analysis showed significance between the treatments ( p < 0.01) and Bonferroni's post hoc: p < 0.05 for the time points of 28 days for the MCAO+Rehab vs.
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- Fig. 4. PCSK9 promotes lysosome-mediated degradation of MHC I in tumor cells. a. Quantitative estimates of SIINFEKL-H-2Kb levels in B16F10-OVA cells with or without IFNgamma treatment in control and PCSK9KO B16F10 cells. n=4,4,6,5 biologically independent samples, respectively. b-c . Flow cytometry estimates of H-2Kb/Db levels on the surface of subcutaneously grown control and PCSK9-deficient B16F10 cells. n=3 tumors per group. d . Quantitative estimate of MHC I levels on the surface of in tissue cultured control and PCSK9-deficient 4T1 cells treated with or without IFNgamma. n=5 biologically independent samples. e . The effect of PCSK9 deficiency on HLA-A2 expression on the surface of control and PCSK9KO MDA-MB-231 cells. n=3 biologically independent samples. f . The effect of exogenous PCSK9 protein on HLA-A2 degradation on the surface of MDA-MB-231 PCSK9KO cells. n=4 biologically independent samples. g . Interaction of mouse PCSK9 and H2-K1 in 293T cells were transduced with FLAG-tag labeled H2-K1 gene in combination with HA-tag labeled full-length or various deleted PCSK9 genes. h . PCSK9-promoted H2-K1 migration into the lysosome. Representative fluorescence confocal images of MHC I (H2-K1Flag) distribution in PCSK9 (PCSK9-HA) over-expressing (top panels) or PCSK9 KO (lower panels) B16 F10 cells. Scale bar: 10 mum. Insets showed magnified areas with additional details of co-localization. i-j. Western blot quantification of H2-K1-Flag in the lysosome (i) and plasma membra
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- Extended Data Fig. 3. The influence of tumor or host cell LDLR and host cholesterol levels on tumor growth from control or PCSK9KO tumor cells in immunocompetent hosts. a . Western blot analysis of CRISPR-Cas9 mediated knockdown (KD) of LDLR in B16F10 cells. The analysis was done once. b . Tumor growth from vector control and LDLR KD B16F10 cells in C57BL/6 mice. n=5 tumors per group. Error bars, mean +- S.E.M. P value calculated by two-way ANOVA. c . Kaplan Meier survival curve of mice (from b) bearing control and LDLR KD B16F10 tumors. n=5 mice per group. P value calculated by log-rank test. d . Tumor growth from vector control and PCSK9 knockout B16F10 cells in WT and LDLR-/- mice fed with high-fat diet. n=12, 12, 5, and 5 tumors in C57BL/6 mice inoculated with control and PCSK9KO tumor cells, and LDLR -/- mice inoculated with control and PCSK9 KO tumor cells. Error bars, mean +- S.E.M. P values calculated by two-way ANOVA with multiple comparisons. e. Kapan-Meier survival curve of wild type and LDLR-/- mice (from d) bearing vector control and PCSK9 knockout tumors. P value calculated by log-rank test.
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- Figure 7 Western blot analysis: The cell signaling protein expressions of ( a ) BT-474 and ( b ) MDA-MB-231 cells using PBS, PTX alone, TTZ alone, and PTXNR-TTX treatments. The relative intensity of XIAP, actin, cleaved caspase-9, caspase 3, cleaved caspase 3, and cytochrome C is analyzed after 48 h of treatment in ( c ) BT-474 and ( d ) MDA-MB-231 cells using ImageJ/ Fiji. For each protein expression the experiment was replicated at least n = 2-4 times and the average data is presented as mean +- standard deviation. The relative protein expressions are normalized to the untreated control cells and to the housekeeping GAPDH protein expression (hypothesized expression mean, u = 1). The p values for overexpression or downregulation of cytochrome-C, cleaved caspase-3, and XIAP in BT-474 are 0.039, 0.003, and 0.000049, respectively. The p value for the overexpression of cytochrome-C in MDA-MB-231 is 0.047. ***Represents p < 0.05 (for detailed p value calculations, please see SI Table 6 ).
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- Figure S2. Treament of transcriptional inhibitors does not change CENP-A levels at centromeres and expression of CENP-B DB does not alter Bub1 levels at centromeres. (A) RNA extracted from HeLa Tet-On cells with mock treatment or treated with THZ1 was subjected to real-time PCR analysis with the indicated primers. The average and standard error were calculated based on three independent experiments. (B) Lysates of HeLa Tet-On cells treated with DMSO, alpha-amanitin (Aman), triptolide (Trip), flavopiridol (Flav), or THZ1 were subjected to Western blots with the indicated antibodies. L, light exposure; H, heavy exposure. (C) Nocodazole-arrested HeLa Tet-On cells treated with DMSO, alpha-amanitin (Aman), or triptolide (Trip) were subjected to chromosome spread and stained with the indicated antibodies. The scale bars in the left and right panels represent 5 um and 1 um, respectively. (D) Quantification for relative CENP-A intensity (CENP-A/DNA) at centromeres in C. Quantification details are recorded in the Materials and methods. The experiment was repeated twice, and the results are highly reproducible. Quantification was performed based on the results from a single experiment. The average and standard deviation are shown here. At least 90 centromeres (six per cell) were scored for each condition. (E) Thymidine-arrested HeLa Tet-On cells were released into fresh medium containing DMSO or THZ1 and incubated for 12 h with the treatment with nocodazole in the last 2 h. Mitotic cel
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- Fig. 6 5b induces apoptosis by regulating caspase family proteins and Bcl2 family proteins in human GBM cells. Cells were treated with the indicated concentrations of 5b and DHA for 16 h. The proteins were collected for western blot assay and beta-actin was used as protein loading control. The result was obtained by three different independent experiments.
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- Fig. 7 5b induces autophagy in human GBM cells. Cells were treated with the indicated concentrations of 5b and DHA for 16 h. The proteins were collected for western blot assay with LC3B, p62 and beta-actin antibodies. The result was obtained by three different independent experiments.
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- Figure 4. Protein analyses of AKT signalling. (a) Representative Western blot images for protein phospholylation (p-) states and total AKT expression levels across time points including 15-min, 1-, 6- or 12-h post-treatment are shown for untreated, A1-CM, A1-CM (GW4869) and insulin-treated (1 uM) NRVMs. (b) Graphical representations of the quantitation for p-AKT (S473) to total AKT ratio (top graph) and total AKT levels (lower graph). Experiments were performed in triplicate, total AKT band intensities were calibrated to beta- actin as the loading control and expression values normalized to untreated controls. Statistical significance differences between untreated NRVMs and treatment groups are indicated by * ( p < 0.01), and # indicates statistically significant changes between A1-CM and A1-CM (GW) treatments ( p < 0.01).
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- Figure 1--figure supplement 1. Quantification of profilin-actin levels and purification of mammalian profilin-actin. ( A ) Profilin-actin concentration determination in mammalian cells. Left to right: name of cell type and origin, histograms of the single cell volume from fluorescence eXclusion measurements, quantitative western blot analysis of cellular actin, profilin1 and profilin-2 amount (left: titration of cell number, right: standard curve of recombinant proteins), calculated mean protein concentration [muM] per cell with experimental error (SD, N = 3 independent experiments, see Materials and methods). ( B ) Purification of mammalian cytoplasmic actin from two sources. Top: Schematic workflow of cytoplasmic actin purification. Left: native purification of beta,gamma-actin by gelsolin affinity chromatography. Right: Isolation of beta-actin from recombinant expression of beta-actin-linker-thymosin beta 4 -10xhis and purification via IMAC followed by chymotrypsin cleavage (^). For both strategies, finally released monomers were polymerized and separated from contaminants. Both purification protocols result in very pure and high yields of protein (see last pellet fraction). ( C ) Barbed end polymerization rate of cytoplasmic native mammalian (beta,gamma)-actin as a function of the actin monomer concentration. The mean values +- SD were fitted with a linear function. ( D ) Binding of profilin1 and 2 to ATP-bound cytoplasmic actin monomers measured by fluorescence anisotrop
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- Figure 1--figure supplement 2. Western blots and graphical summary of profilin-actin levels per cell. Determination of protein-levels in different cell types by quantitative western blot analysis. For each cell type (HT1080, B16F10, BMDC, neutrophils, HT1080/B16F10 overexpressing profilin1 and beta-actin) the amount of total profilin1/2 and actin was detected by monoclonal antibodies and calculated with in vitro protein controls in multiple experiments (see Materials and methods). The amount of profilin2 control is equal to the amount of profilin1 unless otherwise indicated. Right: Calculated profilin1/2 and actin concentrations per cell for individual experiments, errors indicate the SD. Last: Western blots from wt HT1080 cells and HT1080 overexpressing profilin1 and beta-actin from a polyclonal integrated construct (+one to +4) after sorting them by their mScarletI fluorescence intensity (see also Figure 6--figure supplement 2B ). For each sample, 250.000 cells were applied.
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- Figure 1. Filament assembly at physiological profilin-actin concentrations. ( A ) Scheme of barbed end elongation from profilin-actin alone (top) or with formins (bottom). ( B ) Structural model of profilin at filament barbed ends (Materials and methods). The incoming profilin-actin complex is transparent. Actin is shown as green surface while profilin as magenta ribbons. Inset highlights the clash between the incoming actin monomer and profilin. ( C ) Profilin-actin measurements in HT1080 cells. Left to right: single cell volume histogram, western blots of actin, profilin1 (left: cell titration, right: standard curve of recombinant proteins), values are mean (N = 3) and SD, Materials and methods. ( D ) Table of total concentrations of actin and profilin-1/2 in various mammalian cell types ( Figure 1--figure supplement 1 ). ( E ) Scheme of a linearly substrate-dependent actin elongation rate. Top axis: Profilin-actin amounts for various cell types as indicated. ( F ) Scheme (left) and TIRFM images (right) of elongating filaments at indicated profilin-actin concentrations visualized with top- Alexa488-labeled monomers (20% labeled), middle - 10 nM Alexa488-lifeact, bottom - 10 nM Cy5-UTRN 261 . Figure 1--source data 1. Data Figure 1 . Figure 1--figure supplement 1. Quantification of profilin-actin levels and purification of mammalian profilin-actin. ( A ) Profilin-actin concentration determination in mammalian cells. Left to right: name of cell type and origin, histograms of t
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- Figure 6--figure supplement 2. Profilin1-actin overexpression and in vivo formin speeds at different profilin1-actin levels. ( A ) Profilin-actin concentration determination in mammalian HT1080 cells overexpressing profilin1 and beta-actin. Left to right: name of cell type and origin, histograms of the single cell volume from fluorescence eXclusion measurements, quantitative western blot analysis of cellular actin, profilin1 amount (left: titration of cell number, right: standard curve of recombinant proteins), calculated mean protein concentration [muM] per cell with experimental error (SD, N = 3 independent experiments, see Materials and methods). ( B ) Histogram from FACS analysis showing the ScarletI intensity distribution from a polyclonal population of HT1080 cells overexpressing profilin1, mScarletI and beta-actin. This population was sorted into subpopulations as indicated (+one to +4). ( C ) Mean velocities of either mDia1 (top) and mDia2 (bottom) in different mammalian cell types (wt HT080, EL4 and HT1080 overexpressing profilin-actin) plotted as a function of the quantified profilin-actin concentration. Error indicators are SD. Dashed lines are the formin speeds determined in vitro (see Figure 5C ), dotted lines are linear fits through the origin to the in vivo data. Continuous lines fit to the in vivo data by a hyperbolic model with only one free parameter (vmax, the maximal growth velocity). K 0.5 (the profilin-actin concentration at half-maximal elongation speed
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- Figure 6. Formin single molecule imaging reveals buffered elongation rates in mammalian cells. ( A ) Scheme of TIRFM imaging of single formins in the actin cortex of cells. ( B ) Maximum intensity projection of a TIRFM time-lapse shows growth trajectories of single mNeonGreen-mDia1 molecules in the cortex of a HT1080 cell. Inset: Close-up of a single trajectory as in ( C ). ( C ) TIRFM time-lapse images (left) and intensity projection (right) of an individual mNeonGreen-mDia1 molecule. ( D ) Measurements of mDia1/2 elongation velocities in vivo. Left to right: Scheme of HT1080 (top) and EL4 (lower) cells, kymographs of single mNeonGreen- mDia1 (left) or mDia2 (right) molecules followed by velocity distributions. Lines are Gaussian fits. Means and SD are indicated. [N cells >= 10, n molecules/cell >=30, n total >=650 per condition]. ( E ) Workflow to generate profilin1 and beta-actin overexpressing HT1080 cells. Polycistronic constructs for beta-actin, mScarletI and profilin1 were integrated into the genome. Cells were sorted into four sub-populations dependent on mScarletI fluorescence intensity ( Figure 6--figure supplement 2B , Materials and methods). ( F ) Top: Western blot of HT1080 cells (wt or overexpressing sub-populations). No translational read-through is visible (1xRP: actin-mScarletI, 2xRP: actin-mScarletI-profilin1 at expected Mw). Bottom: Relative profilin1 and actin levels (fold over wt) for indicated sub-populations. ( G ) mDia1/2 velocities in profilin-actin o
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- FIGURE 8 Effects of exposure to 30 mmol l -1 NH 4 Cl on the protein abundance of Na + /K + -ATPase alpha-subunit (Nkaalpha) isoforms in the gills of Heteropneustes fossilis. Protein abundances of Nkaalpha1c1, Nkaalpha1c2, and total Nkaalpha (as reflected by immunostaining with the alpha5 comprehensive anti-Nkaalpha antibody) in the gills of H. fossilis kept in fresh water (control; FW) or exposed to 30 mmol l -1 NH 4 Cl for 6 days (6 d A). (A) An example of the immunoblot of Nkaalpha1c1, Nkaalpha1c2, and total Nkaalpha. (B) An example of the immunoblot of actin. (C) The protein abundance of the various Nka bands normalized with respect to that of actin. Results represent mean + SEM ( N = 4). *Significance difference between the NH 4 Cl-exposed group (6 d A; closed bar) and the corresponding freshwater group (FW; open bar) ( P < 0.05).
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- 2 Figure Expression and function of P2X7R in hOBs and hWJ-MSCs. (a) Representative immunostaining of P2X7R in freshly isolated hOBs. (b) Representative western blot in the early stage (ES) and in the late stage (LS) of hOBs differentiation is reported with densitometric analysis of all samples analyzed. Data are expressed as mean +- standard deviation ( SD ) of P2X7R/Actin ratio. Data were analyzed by Student's t test, p < .05. (c) Representative trace showing the intracellular Ca 2+ rise following hOBs stimulation with 500 uM BzATP. (d) Representative immunostaining of P2X7R in hWJ-MSCs. (e) Representative western blot in the early stage (ES) and in the LS of differentiation of hWJ-MSCs is reported with densitometric analysis of all samples analyzed. Data are expressed as mean +- SD of P2X7R/Actin ratio. (f) Representative trace showing the intracellular Ca 2+ rise following hWJ-MSCs stimulation with 500 uM BzATP. (g) Intracellular Ca 2+ rise following stimulation with 500 uM BzATP. All experiments were carried out at least three times. hOBs, human primary osteoblast; hWJ-MSC, Wharton's jelly mesenchymal stromal cells